Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter

Cancer Research

Volumn 61, Issue 1, 2001, Pages 27-32

  Hoare, S F ^a   Bryce, L A ^a   Wisman, G B A ^a   Burns, S ^a   Going, J J ^a   Van der Zee, A G J ^a   Keith, N W ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; GENE PRODUCT; PROTEIN TERC; RNA; TELOMERASE; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL IMMORTALIZATION; CELL LINE; CONTROLLED STUDY; CPG ISLAND; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN TISSUE; METHYLATION; NORTHERN BLOTTING; PHENOTYPE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TELOMERE;

BIOPSY; BLOTTING, NORTHERN; DNA METHYLATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; NEOPLASMS; PROMOTER REGIONS (GENETICS); REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, NEOPLASM; TELOMERASE; TELOMERE; TUMOR CELLS, CULTURED;

EID: 0035135973     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Role of telomerase in cellular proliferation and cancer
2. A survey of telomerase activity in human cancer
3. Telomere elongation in immortal human cells without detectable telomerase activity
4. Telomere dynamics and telomerase activity in in vitro immortalised human cells
5. The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit
6. Cloning and characterization of human and mouse telomerase RNA gene promoter sequences
7. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
8. Cloning and characterization of the promoter region of human telomerase reverse transcriptase gene
9. The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
10. Number of CpG islands and genes in human and mouse
11. CpG-rich islands and the function of DNA methylation
12. High levels of de novo methylation and altered chromatin structure at CpG islands in cell lines
13. Alterations in DNA methylation: A fundamental aspect of neoplasia
14. Cancer epigenetics comes of age
15. Cytosine methylation and human cancer
16. DNA methylation and cancer
17. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
18. Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer
19. Methylation of the human telomerase gene CpG island
20. DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene
21. Telomere length dynamics in telomerase-positive immortal human cell populations