Stress, DNA damage and ageing - An integrative approach

Experimental Gerontology

Volumn 36, Issue 7, 2001, Pages 1049-1062

  Von Zglinicki, Thomas ^a   Bürkle, Alexander ^a   Kirkwood, Thomas B L ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Cell replicative senescence; DNA repair; Mathematical models; Mitochondrial mutations; Oxidative damage; Poly(ADP ribose)polymerase (PARP); Stress; Telomere loss

Indexed keywords

POLY(ADENOSINE DIPHOSPHATE RIBOSE); REACTIVE OXYGEN METABOLITE;

AGING; APOPTOSIS; DNA DAMAGE; DNA REPAIR; GENE MUTATION; HUMAN; LIFESPAN; MATHEMATICAL MODEL; MITOCHONDRION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SENESCENCE; TELOMERE;

EID: 0034992999     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(01)00111-5     Document Type: Article

References (88)

1. Selective loss of poly(ADP-ribose) and the 85-kDa fragment of poly(ADP-ribose) polymerase in nucleoli during alkylation-induced apoptosis of HeLa cells
2. Telomere states and cell fates
3. Extension of life-span by introduction of telomerase into normal human cells
4. Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle.
5. Poly(ADP-ribosyl)ation: A posttranslational protein modification linked with genome protection and mammalian longevity
6. Poly(ADP-ribosyl)ation, genomic instability, and longevity
7. Poly(ADP-ribose) immunostaining to detect apoptosis induced by a neurotoxic fragment of prion protein
8. Replicative senescence and immortalization
9. Control of replicative senescence
10. Telomere length and replicative aging in human vascular tissues
11. Oxidative DNA damage and senescence of human diploid fibroblast cells
12. Thermolabile 8-hydroxyguanine DNA glycosylase with low activity in senescence-accelerated mice due to a single-base mutation
13. There is substantial agreement among interspecies estimates of DNA repair activity
14. Neuropathological and histochemical changes in a multiple mitochondrial DNA deletion disorder
15. Role of mitochondrial DNA mutations in human ageing: cytochrome c oxidase negative fibres accululate in the CNS with age
16. Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation
17. A biomarker that identifies senescent human cells in culture and in aging skin in vivo
18. Replicative senescence: impact on T cell immunity in the elderly
19. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability
20. Telomere erosion varies during in vitro aging of normal human fibroblasts from young and adult donors
21. Telomerase expression restores dermal integrity to in vitro-aged fibroblasts in a reconstituted skin model
22. Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress
23. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals
24. A proposed refinement of the mitochondrial free radical theory of aging
25. Mammalian telomeres end in a large duplex loop
26. Poly(ADP-ribose) polymerase activity in mononuclear leukocytes of 13 mammalian species correlates with species-specific life span
27. Sir2 links chromatin silencing, metabolism, and aging
28. Inhibition of telomerase limits the growth of human cancer cells
29. Postnatal growth failure, short life span, and early onset of cellular senescence and subsequent immortalization in mice lacking the xeroderma pigmentosum group G gene
30. Telomere loss: mitotic clock or genetic time bomb?
31. Correlation between deoxyribonucleic acid excision-repair and life-span in a number of mammalian species
32. The cellular basis for biological aging
33. The serial cultivation of human diploid cell strains
34. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
35. Positive correlation between mammalian life span and cellular resistance to stress
36. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
37. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis
38. Evolution of ageing
39. Human senescence
40. Why do we age?
41. Network theory of aging
42. Is aging as complex as it would appear?
43. A network theory of ageing: the interactions of defective mitochondria, aberrant proteins, free radicals and scavengers in the ageing process
44. Accumulation of defective mitochondria through delayed degradation of damaged organelles and its possible role in the ageing of post-mitotic and dividing cells
45. Trans-dominant inhibition of poly(ADP-ribosyl)ation sensitizes cells against gamma-irradiation and N-methyl-N′-nitro-N-nitrosoguanidine but does not limit DNA replication of a polyoma virus replicon
46. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates carcinogen-induced gene amplification in SV40-transformed Chinese hamster cells
47. Mammalian mitochondrial genetics: heredity, heteroplasmy and disease
48. Cataloging altered gene expression in young and senescent cells using enhanced differential display
49. DNA ends: maintenance of chromosome termini versus repair of double strand breaks
50. Accumulation of short telomeres in human fibroblasts prior to replicative senescence
51. Genetic analysis of ageing: role of oxidative damage and environmental stresses
52. Extension of life-span with superoxide dismutase/catalase mimetics
53. Negative regulation of alkylation-induced sister-chromatid exchanges by poly(ADP-ribose) polymerase-1 activity
54. shc adaptor protein controls oxidative stress response and life span in mammals
55. The poly(ADP-ribose) polymerase DNA-binding domain blocks alkylation-induced DNA repair synthesis in living cells
56. Increased poly(ADP-ribose) polymerase activity in lymphoblastoid cell lines from centenarians
57. Cytochrome-c-oxidase deficient cardiomyocytes in the human heart - an age-related phenomenon. A histochemical ultracytochemical study
58. Different in situ hybridization patterns of mitochondrial DNA in cytochrome c oxidase-deficient extraocular muscle fibres in the elderly
59. Poly(ADP-ribose) polymerase: a molecular nick-sensor
60. Multiparametric staining to identify apoptotic human cells
61. Position effect of human telomeric repeats on replication timing
62. Resistance to endotoxic shock as a consequence of defective NF-κB activation in poly(ADP-ribose)polymerase-1 deficient mice
63. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
64. DNA repair and the evolution of longevity: a critical analysis
65. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts
66. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
67. Microarray analysis of replicative senescence
68. Accelerated telomere shortening in fibroblasts after extended periods of confluency
69. Tankyrase promotes telomere elongation in human cells
70. A stochastic model of cell replicative senescence based on telomere shortening, oxidative stress, and somatic mutations in nuclear and mitochondrial DNA
71. Trans-dominant inhibition of poly(ADP-ribosyl)ation potentiates alkylation-induced shuttle-vector mutagenesis in Chinese hamster cells
72. Cellular and molecular mechanisms of stress-induced senescence (SIPS) of human diploi dpremature fibroblasts and melanocytes
73. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: the telomere loss/DNA damage model of cell aging
74. ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase
75. DNA sequence changes in aging: how frequent, how important?
76. Deletion of Ku86 causes early onset of senescence in mice
77. Mitochondrial genetics: a paradigm for aging and degenerative diseases?
78. Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence
79. Correlation between senescence and DNA repair in cells from young and old individuals and in premature aging syndromes
80. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation
81. Telomeres: beginning to understand the end
82. The role of oxidative stress in telomere length regulation and replicative senescence
83. Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts, a model for senescence
84. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
85. Short telomeres in patients with vascular dementia: an indicator of low antioxidative capacity and a possible prognostic factor?