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Volumn 288, Issue 2, 2003, Pages 277-287

Catalytically active human telomerase mutants with allele-specific biological properties

Author keywords

Human telomerase; Immortalization; IMR90 cells; Primary fibroblasts; Telomerase mutants; Telomere length; Telomeres; Viral oncogenes

Indexed keywords

ALLELE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CATALYSIS; CATALYST; CELL IMMORTALIZATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIFESPAN; LUNG FIBROBLAST; MUTANT; ONCOGENE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DOMAIN; SENESCENCE; TELOMERE;

EID: 0041562482     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-4827(03)00217-9     Document Type: Article
Times cited : (41)

References (58)
  • 1
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick L., Moorhead P.S. The serial cultivation of human diploid cell strains. Exp. Cell Res. 25:1961;585-621.
    • (1961) Exp. Cell Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 2
    • 76549200302 scopus 로고
    • Tissue cultures and mycoplasmas
    • Hayflick L. Tissue cultures and mycoplasmas. Tex. Rep. Biol. Med. 23:(Suppl 1):1965;285+.
    • (1965) Tex. Rep. Biol. Med. , vol.23 , Issue.SUPPL. 1
    • Hayflick, L.1
  • 3
    • 0016796018 scopus 로고
    • Aging of human fibroblasts in vitro. Correlations between DNA synthetic ability and cell size
    • Bowman P.D., Meek R.L., Daniel C.W. Aging of human fibroblasts in vitro. Correlations between DNA synthetic ability and cell size. Exp. Cell Res. 93:1975;184-190.
    • (1975) Exp. Cell Res. , vol.93 , pp. 184-190
    • Bowman, P.D.1    Meek, R.L.2    Daniel, C.W.3
  • 6
    • 0035252089 scopus 로고    scopus 로고
    • Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes
    • Romanov S.R., Kozakiewicz B.K., Holst C.R., Stampfer M.R., Haupt L.M., Tlsty T.D. Normal human mammary epithelial cells spontaneously escape senescence and acquire genomic changes. Nature. 409:2001;633-637.
    • (2001) Nature , vol.409 , pp. 633-637
    • Romanov, S.R.1    Kozakiewicz, B.K.2    Holst, C.R.3    Stampfer, M.R.4    Haupt, L.M.5    Tlsty, T.D.6
  • 7
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu J., Wang H., Bishop J.M., Blackburn E.H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA. 96:1999;3723-3728.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4
  • 8
    • 0024426688 scopus 로고
    • Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen
    • Shay J.W., Wright W.E. Quantitation of the frequency of immortalization of normal human diploid fibroblasts by SV40 large T-antigen. Exp. Cell Res. 184:1989;109-118.
    • (1989) Exp. Cell Res. , vol.184 , pp. 109-118
    • Shay, J.W.1    Wright, W.E.2
  • 9
    • 0029162563 scopus 로고
    • Telomere elongation in immortal human cells without detectable telomerase activity
    • Bryan T.M., Englezou A., Gupta J., Bacchetti S., Reddel R.R. Telomere elongation in immortal human cells without detectable telomerase activity. EMBO J. 14:1995;4240-4248.
    • (1995) EMBO J. , vol.14 , pp. 4240-4248
    • Bryan, T.M.1    Englezou, A.2    Gupta, J.3    Bacchetti, S.4    Reddel, R.R.5
  • 10
  • 12
    • 0033788565 scopus 로고    scopus 로고
    • The end of the (DNA) line
    • Blackburn E.H. The end of the (DNA) line. Nat. Struct. Biol. 7:2000;847-850.
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 847-850
    • Blackburn, E.H.1
  • 14
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell. 106:2001;661-673.
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 16
    • 0036677405 scopus 로고    scopus 로고
    • MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae
    • Enomoto S., Glowczewski L., Berman J. MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae. Mol. Biol. Cell. 13:2002;2626-2638.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2626-2638
    • Enomoto, S.1    Glowczewski, L.2    Berman, J.3
  • 17
    • 0037047068 scopus 로고    scopus 로고
    • The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae
    • Nautiyal S., DeRisi J.L., Blackburn E.H. The genome-wide expression response to telomerase deletion in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA. 99:2002;9316-9321.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 9316-9321
    • Nautiyal, S.1    DeRisi, J.L.2    Blackburn, E.H.3
  • 18
    • 0035960043 scopus 로고    scopus 로고
    • The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita
    • Vulliamy T., Marrone A., Goldman F., Dearlove A., Bessler M., Mason P.J., Dokal I. The RNA component of telomerase is mutated in autosomal dominant dyskeratosis congenita. Nature. 413:2001;432-435.
    • (2001) Nature , vol.413 , pp. 432-435
    • Vulliamy, T.1    Marrone, A.2    Goldman, F.3    Dearlove, A.4    Bessler, M.5    Mason, P.J.6    Dokal, I.7
  • 20
    • 0033518188 scopus 로고    scopus 로고
    • A telomerase component is defective in the human disease dyskeratosis congenita
    • Mitchell J.R., Wood E., Collins K. A telomerase component is defective in the human disease dyskeratosis congenita. Nature. 402:1999;551-555.
    • (1999) Nature , vol.402 , pp. 551-555
    • Mitchell, J.R.1    Wood, E.2    Collins, K.3
  • 21
    • 0037157582 scopus 로고    scopus 로고
    • Association between aplastic anaemia and mutations in telomerase RNA
    • Vulliamy T., Marrone A., Dokal I., Mason P.J. Association between aplastic anaemia and mutations in telomerase RNA. Lancet. 359:2002;2168-2170.
    • (2002) Lancet , vol.359 , pp. 2168-2170
    • Vulliamy, T.1    Marrone, A.2    Dokal, I.3    Mason, P.J.4
  • 22
    • 0033595174 scopus 로고    scopus 로고
    • Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process
    • Ducray C., Pommier J.P., Martins L., Boussin F.D., Sabatier L. Telomere dynamics, end-to-end fusions and telomerase activation during the human fibroblast immortalization process. Oncogene. 18:1999;4211-4223.
    • (1999) Oncogene , vol.18 , pp. 4211-4223
    • Ducray, C.1    Pommier, J.P.2    Martins, L.3    Boussin, F.D.4    Sabatier, L.5
  • 24
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri H., Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8:1998;279-282.
    • (1998) Curr. Biol. , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 26
    • 0025352187 scopus 로고
    • Advanced mammalian gene transfer: High titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line
    • Morgenstern J.P., Land H. Advanced mammalian gene transfer high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line . Nucleic Acids Res. 18:1990;3587-3596.
    • (1990) Nucleic Acids Res. , vol.18 , pp. 3587-3596
    • Morgenstern, J.P.1    Land, H.2
  • 27
    • 0026523228 scopus 로고
    • Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
    • Counter C.M., Avilion A.A., LeFeuvre C.E., Stewart N.G., Greider C.W., Harley C.B., Bacchetti S. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11:1992;1921-1929.
    • (1992) EMBO J. , vol.11 , pp. 1921-1929
    • Counter, C.M.1    Avilion, A.A.2    LeFeuvre, C.E.3    Stewart, N.G.4    Greider, C.W.5    Harley, C.B.6    Bacchetti, S.7
  • 28
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay J.W., Pereira-Smith O.M., Wright W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196:1991;33-39.
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 29
    • 0033948026 scopus 로고    scopus 로고
    • Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase
    • Xia J., Peng Y., Mian I.S., Lue N.F. Identification of functionally important domains in the N-terminal region of telomerase reverse transcriptase. Mol. Cell. Biol. 20:2000;5196-5207.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5196-5207
    • Xia, J.1    Peng, Y.2    Mian, I.S.3    Lue, N.F.4
  • 30
    • 0034775749 scopus 로고    scopus 로고
    • N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo
    • Armbruster B.N., Banik S.S., Guo C., Smith A.C., Counter C.M. N-terminal domains of the human telomerase catalytic subunit required for enzyme activity in vivo. Mol. Cell. Biol. 21:2001;7775-7786.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7775-7786
    • Armbruster, B.N.1    Banik, S.S.2    Guo, C.3    Smith, A.C.4    Counter, C.M.5
  • 31
    • 0035723994 scopus 로고    scopus 로고
    • Functional multimerization of the human telomerase reverse transcriptase
    • Beattie T.L., Zhou W., Robinson M.O., Harrington L. Functional multimerization of the human telomerase reverse transcriptase. Mol. Cell. Biol. 21:2001;6151-6160.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6151-6160
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 32
    • 0033790120 scopus 로고    scopus 로고
    • Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding
    • Beattie T.L., Zhou W., Robinson M.O., Harrington L. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol. Biol. Cell. 11:2000;3329-3340.
    • (2000) Mol. Biol. Cell , vol.11 , pp. 3329-3340
    • Beattie, T.L.1    Zhou, W.2    Robinson, M.O.3    Harrington, L.4
  • 34
    • 0033636319 scopus 로고    scopus 로고
    • Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase
    • Bryan T.M., Goodrich K.J., Cech T.R. Telomerase RNA bound by protein motifs specific to telomerase reverse transcriptase. Mol. Cell. 6:2000;493-499.
    • (2000) Mol. Cell , vol.6 , pp. 493-499
    • Bryan, T.M.1    Goodrich, K.J.2    Cech, T.R.3
  • 35
    • 0034604578 scopus 로고    scopus 로고
    • A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity
    • Bryan T.M., Goodrich K.J., Cech T.R. A mutant of Tetrahymena telomerase reverse transcriptase with increased processivity. J. Biol. Chem. 275:2000;24199-24207.
    • (2000) J. Biol. Chem. , vol.275 , pp. 24199-24207
    • Bryan, T.M.1    Goodrich, K.J.2    Cech, T.R.3
  • 36
    • 0035824558 scopus 로고    scopus 로고
    • Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase
    • Bosoy D., Lue N.F. Functional analysis of conserved residues in the putative "finger" domain of telomerase reverse transcriptase. J. Biol. Chem. 276:2001;46305-46312.
    • (2001) J. Biol. Chem. , vol.276 , pp. 46305-46312
    • Bosoy, D.1    Lue, N.F.2
  • 37
    • 0035895954 scopus 로고    scopus 로고
    • Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase
    • Hardy C.D., Schultz C.S., Collins K. Requirements for the dGTP-dependent repeat addition processivity of recombinant Tetrahymena telomerase. J. Biol. Chem. 276:2001;4863-4871.
    • (2001) J. Biol. Chem. , vol.276 , pp. 4863-4871
    • Hardy, C.D.1    Schultz, C.S.2    Collins, K.3
  • 38
    • 0029155795 scopus 로고
    • Telomerase in yeast
    • Cohn M., Blackburn E.H. Telomerase in yeast. Science. 269:1995;396-400.
    • (1995) Science , vol.269 , pp. 396-400
    • Cohn, M.1    Blackburn, E.H.2
  • 39
    • 0030881688 scopus 로고    scopus 로고
    • Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity
    • Lingner J., Cech T.R., Hughes T.R., Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc. Natl. Acad. Sci. USA. 94:1997;11190-11195.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11190-11195
    • Lingner, J.1    Cech, T.R.2    Hughes, T.R.3    Lundblad, V.4
  • 40
    • 0033214013 scopus 로고    scopus 로고
    • Est1 and Cdc13 as comediators of telomerase access
    • Evans S.K., Lundblad V. Est1 and Cdc13 as comediators of telomerase access. Science. 286:1999;117-120.
    • (1999) Science , vol.286 , pp. 117-120
    • Evans, S.K.1    Lundblad, V.2
  • 42
    • 0033568462 scopus 로고    scopus 로고
    • Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
    • Zhang X., Mar V., Zhou W., Harrington L., Robinson M.O. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev. 13:1999;2388-2399.
    • (1999) Genes Dev. , vol.13 , pp. 2388-2399
    • Zhang, X.1    Mar, V.2    Zhou, W.3    Harrington, L.4    Robinson, M.O.5
  • 43
    • 0029102354 scopus 로고
    • Runaway telomere elongation caused by telomerase RNA gene mutations
    • McEachern M.J., Blackburn E.H. Runaway telomere elongation caused by telomerase RNA gene mutations. Nature. 376:1995;403-409.
    • (1995) Nature , vol.376 , pp. 403-409
    • McEachern, M.J.1    Blackburn, E.H.2
  • 45
    • 0034175814 scopus 로고    scopus 로고
    • Cell cycle restriction of telomere elongation
    • Marcand S., Brevet V., Mann C., Gilson E. Cell cycle restriction of telomere elongation. Curr. Biol. 10:2000;487-490.
    • (2000) Curr. Biol. , vol.10 , pp. 487-490
    • Marcand, S.1    Brevet, V.2    Mann, C.3    Gilson, E.4
  • 47
    • 0035812845 scopus 로고    scopus 로고
    • The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability
    • Hemann M.T., Strong M.A., Hao L.Y., Greider C.W. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell. 107:2001;67-77.
    • (2001) Cell , vol.107 , pp. 67-77
    • Hemann, M.T.1    Strong, M.A.2    Hao, L.Y.3    Greider, C.W.4
  • 48
    • 0037133668 scopus 로고    scopus 로고
    • Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert
    • Liu Y., Kha H., Ungrin M., Robinson M.O., Harrington L. Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert. Proc. Natl. Acad. Sci. USA. 99:2002;3597-3602.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 3597-3602
    • Liu, Y.1    Kha, H.2    Ungrin, M.3    Robinson, M.O.4    Harrington, L.5
  • 50
    • 0031029377 scopus 로고    scopus 로고
    • Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro
    • Prescott J., Blackburn E.H. Telomerase RNA mutations in Saccharomyces cerevisiae alter telomerase action and reveal nonprocessivity in vivo and in vitro. Genes Dev. 11:1997;528-540.
    • (1997) Genes Dev. , vol.11 , pp. 528-540
    • Prescott, J.1    Blackburn, E.H.2
  • 51
    • 0034068910 scopus 로고    scopus 로고
    • Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres
    • Prescott J.C., Blackburn E.H. Telomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres. Mol. Cell. Biol. 20:2000;2941-2948.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 2941-2948
    • Prescott, J.C.1    Blackburn, E.H.2
  • 52
    • 0032532428 scopus 로고    scopus 로고
    • Specific telomerase RNA residues distant from the template are essential for telomerase function
    • Roy J., Fulton T.B., Blackburn E.H. Specific telomerase RNA residues distant from the template are essential for telomerase function. Genes Dev. 12:1998;3286-3300.
    • (1998) Genes Dev. , vol.12 , pp. 3286-3300
    • Roy, J.1    Fulton, T.B.2    Blackburn, E.H.3
  • 53
    • 0029655485 scopus 로고    scopus 로고
    • Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
    • Strahl C., Blackburn E.H. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines. Mol. Cell. Biol. 16:1996;53-65.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 53-65
    • Strahl, C.1    Blackburn, E.H.2
  • 55
    • 0033598944 scopus 로고    scopus 로고
    • Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta
    • Diede S.J., Gottschling D.E. Telomerase-mediated telomere addition in vivo requires DNA primase and DNA polymerases alpha and delta. Cell. 99:1999;723-733.
    • (1999) Cell , vol.99 , pp. 723-733
    • Diede, S.J.1    Gottschling, D.E.2
  • 56
    • 0037047643 scopus 로고    scopus 로고
    • Est1p as a cell cycle-regulated activator of telomere-bound telomerase
    • Taggart A.K., Teng S.C., Zakian V.A. Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science. 297:2002;1023-1026.
    • (2002) Science , vol.297 , pp. 1023-1026
    • Taggart, A.K.1    Teng, S.C.2    Zakian, V.A.3
  • 57
    • 0037326054 scopus 로고    scopus 로고
    • Telomeric protein distributions and remodeling through the cell cycle in S. cerevisiae
    • C.D. Smith, D.L. Smith, J.L. DeRisi, E.H. Blackburn, Telomeric protein distributions and remodeling through the cell cycle in S. cerevisiae, Mol. Biol. Cell, 14 (2002) 556-570.
    • (2002) Mol. Biol. Cell , vol.14 , pp. 556-570
    • Smith, C.D.1    Smith, D.L.2    DeRisi, J.L.3    Blackburn, E.H.4


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