Treatment of malignant glioma cells with the transfer of constitutively active caspase-6 using the human telomerase catalytic subunit (human telomerase reverse transcriptase) gene promoter

Cancer Research

Volumn 61, Issue 15, 2001, Pages 5796-5802

  Komata, Tadashi ^a,b,c   Kondo, Yasuko ^b,c   Koga, Shoji ^b   Kondo, Seiji ^b,c   Hirohata, Satoshi ^a   Kanzawa, Takao ^c   Germano, Isabelle M ^c   Sumiyoshi, Hideaki ^c   Srinivasula, Srinivasa M ^d   Alnemri, Emad S ^d   Barna, Barbara P ^e   Takakura, Masahiro ^f   Inoue, Masaki ^f   Kyo, Satoru ^f   Shay, Jerry W ^g  

^a LERNER RESEARCH INSTITUTE   (United States)

^b The Mount Sinai School of Medicine ^*

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d THOMAS JEFFERSON UNIVERSITY   (United States)

^e METROHEALTH MEDICAL CENTER   (United States)

^f KANAZAWA UNIVERSITY   (Japan)

^g UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 6; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BRAIN CELL; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; GENE EXPRESSION SYSTEM; GENE TARGETING; GENE TRANSFER; GLIOBLASTOMA; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSCRIPTION REGULATION;

ANIMALS; APOPTOSIS; CASPASE 6; CASPASES; DNA-BINDING PROTEINS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GLIOMA; HUMANS; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; PROMOTER REGIONS (GENETICS); RNA; RNA, MESSENGER; TELOMERASE; TRANS-ACTIVATION (GENETICS); TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 0035422652     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (46)

1. The epidemiology of central nervous system tumors
2. National survey of patterns of care for brain-tumor patients
3. Apoptosis in the pathogenesis and treatment of disease
4. Cell death: The significance of apoptosis
5. Apoptosis, cancer and cancer therapy
6. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. Elegans cell death gene ced-3
7. Mch3, a novel human apoptotic cysteine protease highly related to CPP32
8. Human ICE/CED-3 protease nomenclature
9. Apoptosis by death factor
10. Generation of constitutively active recombinant caspases-3 and -6 by rearrangement of their subunits
11. Interleukin-1β-converting enzyme (ICE) mediates cisplatin-induced apoptosis in malignant glioma cells
12. Retroviral transfer of CPP32β gene into malignant gliomas in vitro and in vivo
13. Specific association of human telomerase activity with immortal cells and cancer
14. Telomerase activity in human brain tumors
15. Telomerase activity in human gliomas
16. Differential telomerase expression in human primary intracranial tumors
17. Telomerase activity in primary and secondary glioblastomas multiforme as a novel molecular tumor marker
18. The RNA component of human telomerase
19. hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization
20. Telomerase catalytic subunit homologs from fission yeast and human
21. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
22. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells
23. The human telomerase catalytic subunit hTERT: Organization of the gene and characterization of the promoter
24. Kip1, is required for IL-4 regulation of astrocyte proliferation
25. A novel telomerase-specific gene therapy: Gene transfer of caspase-8 utilizing the human telomerase catalytic subunit gene promoter
26. Combination therapy of malignant glioma cells with 2-5A-antisense telomerase RNA and recombinant adenovirus p53
27. Lack of telomerase RNA gene hTERC expression in alternative lengthening of telomeres cells is associated with methylation of the hTERC promoter
28. Progesterone regulates human telomerase reverse transcriptase gene expression via activation of mitogen-activated protein kinase signaling pathway
29. Selective astrocytic transgene expression in vitro and in vivo from the GFAP promoter in a HSV RL1 null mutant vector-potential glioblastoma targeting
30. Differential susceptibility of primary and established human glioma cells to adenovirus infection: Targeting via the epidermal growth factor receptor achieves fiber receptor-independent gene transfer
31. Telomerase. A target for anticancer therapy
32. Antisense telomerase treatment: Induction of two distinct pathways, apoptosis and differentiation
33. Targeted therapy of human malignant glioma in a mouse model by 2-5A antisense directed against telomerase RNA
34. Inhibition of human telomerase activity by peptide nucleic acids
35. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death
36. Inhibition of telomerase limits the growth of human cancer cells
37. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells
38. The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes
39. Cytotoxic T-cell immunity against telomerase reverse transcriptase in humans
40. HSV-tk "suicide" gene therapy using human telomerase reverse transcriptase (hTERT) promoter
41. Tumor-specific transgene expression from the human telomerase reverse transcriptase promoter enables targeting of the therapeutic effects of the Bax gene to cancers
42. Regulated expression of telomerase activity in human T lymphocyte development and activation
43. Expression profile of the putative catalytic subunit of the telomerase gene
44. Telomerase activity in human germ-line and embryonic tissues and cells
45. Differential expression of telomerase activity in hematopoietic progenitors from adult human bone marrow
46. Human neural precursor cells express low levels of telomerase in vitro and show diminishing cell proliferation with extensive axonal out growth following transplantation