Recognition of 2′-deoxy-L-ribonucleoside 5′-triphosphates by human telomerase

Biochemical and Biophysical Research Communications

Volumn 279, Issue 2, 2000, Pages 475-481

  Yamaguchi, Toyofumi ^a   Yamada, Rieko ^a   Tomikawa, Aki ^a   Shudo, Koichi ^b   Saito, Motoki ^c   Ishikawa, Fuyuki ^c   Saneyoshi, Mineo ^a  

^a TEIKYO UNIVERSITY OF SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Chiral discrimination; Chirality; Enantiomer; Inhibition; Inhibitor; L dGTP; L dTTP; Nucleo tide; Telomerase

Indexed keywords

DEOXYRIBONUCLEOSIDE TRIPHOSPHATE; GUANOSINE TRIPHOSPHATE; RIBONUCLEOSIDE; RNA DIRECTED DNA POLYMERASE; TELOMERASE; 2'-DEOXYADENOSINE TRIPHOSPHATE; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; DEOXYADENOSINE PHOSPHATE; DEOXYADENOSINE TRIPHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DEOXYGUANOSINE TRIPHOSPHATE; DEOXYRIBONUCLEOTIDE; PYRIMIDINE NUCLEOTIDE; THYMIDINE 5'-TRIPHOSPHATE; THYMIDINE TRIPHOSPHATE;

ARTICLE; CHIRALITY; ENANTIOMER; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME ASSAY; ENZYME KINETICS; ENZYME MECHANISM; HUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; CHEMISTRY; ENZYME SPECIFICITY; KINETICS; METABOLISM; STEREOISOMERISM;

DEOXYADENINE NUCLEOTIDES; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DEOXYRIBONUCLEOTIDES; HUMANS; KINETICS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TELOMERASE; THYMINE NUCLEOTIDES;

EID: 0034694517     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2000.3982     Document Type: Article

References (27)

1. Structure and function of telomeres
2. Telomeres shorten during ageing of human fibroblasts
3. The human telomere terminal transferase enzyme is a ribonucleoprotein that synthesizes TTAGGG repeats
4. Telomerases
5. Reverse transcriptase motifs in the catalytic subunit of telomerase
6. Telomerase activity in normal and malignant hematopoietic cells
7. Telomerase activity in normal leukocytes and in hematologic malignancies
8. Specific association of human telomerase activity with immortal cells and cancer
9. Telomeres and telomerase in normal and malignant haematopoietic cells
10. Developmental and tissue-specific regulation of mouse telomerase and telomere length
11. A survey of telomerase activity in human cancer
12. Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity
13. Is telomerase a universal cancer target?
14. Do telomerase antagonists represent a novel anti-cancer strategy?
15. Short dysfunctional telomeres impair tumorigenesis in the INK4a(delta2/3) cancer-prone mouse
16. Chiral discrimination of enantiomeric 2′-deoxythymidine 5′-triphosphate by HIV-1 reverse transcriptase and eukaryotic DNA polymerases
17. Stereospecificity of human DNA polymerases alpha, beta, gamma, delta and epsilon, HIV-reverse transcriptase, HSV-1 DNA polymerase, calf thymus terminal transferase and Escherichia coli DNA polymerase I in recognizing D- and L-thymidine 5′-triphosphate as substrate
18. The separated enantiomers of 2′-deoxy-3′-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro
19. Anti-human immunodeficiency virus type 1 activity and in vitro toxicity of 2′deoxy-3′-thiacytidine (BCH-189), a novel heterocyclic nucleoside analog
20. Interaction of deoxyguanosine nucleotide analogs with human telomerase
21. Telomerase from human leukemia cells: Properties and its interaction with deoxynucleoside analogues
22. A novel quantitative 'stretch PCR assay', that detects a dramatic increase in telomerase activity during the progression of myeloid leukemias
23. Chiral discrimination of 2′-deoxy-L-cytidine and L-nucleotides by mouse deoxycytidine kinase: Low stereospecificities for substrates and effectors
24. Inhibitory effects of 9-β-D-arabinofuranosylguanine 5′-triphosphate and 9-β-D-arabinofuranosyladenine 5′-triphosphate on DNA polymerases from murine cells and oncornavirus
25. The effects of nucleoside analogs on telomerase and telomeres in Tetrahymena
26. Effects of reverse transcriptase inhibitors on telomere length and telomerase activity in two immortalized human cell lines
27. L-ATP is recognized by some cellular and viral enzymes: Does chance drive enzymatic enantioselectivity?