Telomeres and replicative senescence: Is it only length that counts?

Cancer Letters

Volumn 168, Issue 2, 2001, Pages 111-116

  Von Zglinicki, Thomas ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Fibroblast; Hayflick limit; Human; Senescence; Telomerase; Telomere

Indexed keywords

BIOLOGICAL RHYTHM; CELL CULTURE; CELL CYCLE; CHROMOSOME BREAKAGE; CHROMOSOME REPLICATION; CHROMOSOME SIZE; CHROMOSOME STRUCTURE; ENVIRONMENTAL FACTOR; GENETIC STABILITY; HEREDITY; HUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; SENESCENCE; SHORT SURVEY; TELOMERE;

EID: 0035954831     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0304-3835(01)00546-8     Document Type: Review

References (43)

1. The limited in vitro lifetime of human diploid cell strains
2. Accelerated telomere shortening in fibroblasts after extended periods of confluency
3. Cellular senescence and cancer
4. Cellular senescence: Mitotic clock or culture shock?
5. The two-stage mechanism controlling senescence and immortalization
6. Lack of replicative senescence in cultured rat oligodendrocyte precursor cells
7. Lack of replicative senescence in normal rodent glia
8. Low oxygen concentration extends the lifespan of cultured human diploid cells
9. The effect of oxygen and vitamin E on the lifespan of human diploid cells in vitro
10. Oxidative DNA damage and senescence of human diploid fibroblast cells
11. Mild hyperoxia shortens telomeres and inhibits proliferation of human fibroblasts: A model for senescence?
12. Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
13. Short telomeres in patients with vascular dementia: An indicator of low antioxidative capacity and a possible prognostic factor?
14. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes
15. Telomeres shorten during ageing of human fibroblasts
16. Telomere length predicts replicative capacity of human fibroblasts
17. Evidence for a critical telomere length in senescent human fibroblasts
18. Role of telomerase in normal and cancer cells
19. Telomere maintenance by recombination in human cells
20. Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT
21. Extension of life-span by introduction of telomerase into normal human cells
22. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
23. Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype
24. Absence of cancer-associated changes in human fibroblasts immortalized with telomerase
25. DNA methyltransferase inhibition in normal human fibroblasts induces A p21 dependent-cell cycle withdrawal
26. Both Rb/p16INK4A inactivation and telomerase activity are required to immortalize human epithelial cells
27. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
28. From telomere loss to p53 induction and activation of a DNA-damage pathway at senescence: The telomere loss/DNA damage model of cell aging
29. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
30. Mammalian telomeres end in a large duplex loop
31. TIN2, a new regulator of telomere length in human cells
32. p53- and ATM-dependent apoptosis induced by telomeres lacking TRF2
33. Telomere shortening triggers a p53-dependent cell cycle arrest via accumulation of G-rich single stranded DNA fragments
34. Telomere erosion varies during in vitro aging of normal human fibroblasts from young and adult donors
35. Accumulation of short telomeres in human fibroblasts prior to replicative senescence
36. Subsenescent telomere lengths in fibroblasts immortalized with limiting amounts of telomerase
37. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
38. Ribozyme cleavage of telomerase mRNA sensitizes breast tumor cells to inhibitors of topoisomerase
39. Telomere states and cell fates
40. Role of oxidative stress in telomere length regulation and replicative senescence
41. DNA topoisomerase II cleavage of telomeres in vitro and in vivo
42. DNA topoisomerase inhibitors induce reversible senescence in normal human fibroblasts
43. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts