Identification of two RNA-binding proteins associated with human telomerase RNA

Molecular Biology of the Cell

Volumn 11, Issue 3, 2000, Pages 999-1010

  Le, Siyuan ^a   Sternglanz, Rolf ^b   Greider, Carol W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b STONY BROOK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RIBONUCLEOPROTEIN; RNA; RNA BINDING PROTEIN; RNA DIRECTED DNA POLYMERASE; TELOMERASE;

ARTICLE; CYTOPLASM; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NUCLEOLUS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN RNA BINDING;

MAMMALIA;

EID: 0034099225     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.11.3.999     Document Type: Article

References (70)

1. Autexier, C., Pruzan, R., Funk, W.D., and Greider, C.W. (1996). Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J. 15, 5928-5935.
2. Avilion, A.A. (1995). Characterization and expression of human telomerase. In: Program in Cellular and Developmental Biology, Stony Brook, NY: State University of New York at Stony Brook.
3. Baserga, S.J., and Steitz, J.A. (1993). The diverse world of small ribonucleoproteins. In: The RNA World, ed. R.F. Gesteland and J.F. Atkins, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 359-381.
4. Beattie, T.L., Zhou, W., Robinson, M.O., and Harrington, L. (1998). Reconstitution of human telomerase activity in vitro. Curr. Biol. 8, 177-180.
5. Blasco, M.A., Funk, W., Villeponteau, B., and Greider, C.W. (1995). Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267-1270.
6. Blasco, M.A., Lee, H.W., Hande, M.P., Samper, E., Lansdorp, P.M., DePinho, R.A., and Greider, C.W. (1997). Telomere shortening and tumor formation by mouse cells lacking telomerase RNA [see comments]. Cell 91, 25-34.
7. Bodnar, A.G., Ouellette, M., Frolkis, M., Holt, S.E., Chiu, C.P., Morin, G.B., Harley, C.B., Shay, J.W., Lichtsteiner, S., and Wright, W.E. (1998). Extension of life-span by introduction of telomerase into normal human cells [see comments]. Science 279, 349-352.
8. Broadus, J., Fuerstenberg, S., and Doe, C.Q. (1998). Staufen-dependent localization of prospero mRNA contributes to neuroblast daughter-cell fate. Nature 391, 792-795.
9. Chen, J., Jackson, P.K., Kirschner, M.W., and Dutta, A. (1995). Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature 374, 386-388.
10. Chrivia, J.C., Kwok, R.P., Lamb, N., Hagiwara, M., Montminy, M.R., and Goodman, R.H. (1993). Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365, 855-859.
11. Chugani, D.C., Rome, L.H., and Kedersha, N.L. (1993). Evidence that vault ribonucleoprotein particles localize to the nuclear pore complex. J. Cell Sci. 106, 23-29.
12. Collins, K., and Greider, C.W. (1993). Tetrahymena telomerase catalyzes nucleolytic cleavage and nonprocessive elongation. Genes Dev. 7, 1364-1376.
13. Collins, K., and Greider, C.W. (1995). Utilization of ribonucleotides and RNA primers by Tetrahymena telomerase. EMBO J. 14, 5422-5432.
14. Collins, K., Kobayashi, R., and Greider, C.W. (1995). Purification of Tetrahymena telomerase and cloning of genes encoding the two protein components of the enzyme. Cell 81, 677-686.
15. Counter, C.M., Avilion, A.A., LeFeuvre, C.E., Stewart, N.G., Greider, C.W., Harley, C.B., and Bacchetti, S. (1992). Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J. 11, 1921-1929.
16. Counter, C.M., Hahn, W.C., Wei, W., Caddle, S.D., Beijersbergen, R.L., Lansdorp, P.M., Sedivy, J.M., and Weinberg, R.A. (1998). Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization. Proc. Natl. Acad. Sci. USA 95, 14723-14728.
17. Darnell, J.E., Jr. (1997). STATs and gene regulation. Science 277, 1630-1635.
18. Dobbelstein, M., and Shenk, T. (1995). In vitro selection of RNA ligands for the ribosomal L22 protein associated with Epstein-Barr virus-expressed RNA by using randomized and cDNA-derived RNA libraries. J. Virol. 69, 8027-8034.
19. Feng, J., et al. (1995). The RNA component of human telomerase. Science 269, 1236-1241.
20. Ferrandon, D., Elphick, L., Nusslein-Volhard, C., and St. Johnston, D. (1994). Staufen protein associates with the 3'UTR of bicoid mRNA to form particles that move in a microtubule-dependent manner. Cell 79, 1221-1232.
21. Gandhi, L., and Collins, K. (1998). Interaction of recombinant Tetrahymena telomerase proteins p80 and p95 with telomerase RNA and telomeric DNA substrates. Genes Dev. 12, 721-733.
22. Greenberg, R.A., Allsopp, R.C., Chin, L., Morin, G.G., and DePinho, R.A. (1998). Expression of mouse telomerase reverse transcriptase during development, differentiation and proliferation. Oncogene 16, 1723-1730.
23. Greider, C.W., and Blackburn, E.H. (1987). The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51, 887-898.
24. Greider, C.W., and Blackburn, E.H. (1989). A telomeric sequence in the RNA of Tetrahymena telomerase required for felomere repeat synthesis. Nature 337, 331-337.
25. Gulbis, J.M., Kelman, Z., Hurwitz, J., O'Donnell, M., and Kuriyan, J. (1996). Structure of the C-terminal region of p21 (WAF1/CIP1) complexed with human PCNA. Cell 87, 297-306.
26. Hahn, W.C., Counter, C.M., Lundberg, A.S., Beijersbergen, R.L., Brooks, M.W., and Weinberg, R.A. (1999). Creation of human tumor cells with defined genetic elements [see comments]. Nature 400, 464-468.
27. Harlow, E., and Lane, D. (1988). Antibodies. A Laboratory Manual, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
28. Harrington, L., McPhail, T., Mar, V., Zhou, W., Oulton, R., Bass, M.B., Arruda, I., and Robinson, M.O. (1997a). A mammalian telomerase-associated protein [see comments]. Science 275, 973-977.
29. Harrington, L., Zhou, W., McPhail, T., Oulton, R., Yeung, D.S., Mar, V., Bass, M.B., and Robinson, M.O. (1997b). Human telomerase contains evolutionary conserved catalytic and structural subunits. Genes Dev. 11, 3109-3115.
30. Harrington, L.A., and Greider, C.W. (1991). Telomerase primer specificity and chromosome healing. Nature 353, 451-454.
31. Holt, S.E., et al. (1999). Functional requirement of p23 and Hsp90 in telomerase complexes. Genes Dev. 13, 817-826.
32. Kickhoefer, V.A., Stephen, A.G., Harrington, L., Robinson, M.O., and Rome, L.H. (1999). Vaults and telomerase share a common subunit, TEP1. J. Biol. Chem. 274, 32712-32717.
33. Kickhoefer, V.A., Vasu, S.K., and Rome, L.H. (1996). Vaults are the answer, what is the question. Trends Cell Biol. 6, 174-178.
34. Kim, N.W., Piatyszek, M.A., Prowse, K.R., Harley, C.B., West, M.D., Ho, P.L., Coviello, G.M., Wright, W.E., Weinrich, S.L., and Shay, J.W. (1994). Specific association of human telomerase activity with immortal cells and cancer [see comments]. Science 266, 2011-2015.
35. Kim, N.W., and Wu, F. (1997). Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Res. 25, 2595-2597.
36. Korzus, E., Torchia, J., Rose, D.W., Xu, L., Kurokawa, R., McInerney, E.M., Mullen, T.M., Glass, C.K., and Rosenfeld, M.G. (1998). Transcription factor-specific requirements for coactivators and their acetyltransferase functions. Science 279, 703-707.
37. Krainer, A.R., Mayeda, A., Kozak, D., and Binns, G. (1991). Functional expression of cloned human splicing factor SF2: homology to RNA-binding proteins, U1 70K, and Drosophila splicing regulators. Cell 66, 383-394.
38. Kwok, R.P., Lundblad, J.R., Chrivia, J.C., Richards, J.P., Bachinger, H.P., Brennan, R.G., Roberts, S.G., Green, M.R., and Goodman, R.H. (1994). Nuclear protein CBP is a coactivator for the transcription factor CREB [see comments]. Nature 370, 223-226.
39. Lavergne, J.P., Conquet, F., Reboud, J.P., and Reboud, A.M. (1987). Role of acidic phosphoproteins in the partial reconstitution of the active 60 S ribosomal subunit. FEBS Lett. 216, 83-88.
40. Lee, H.W., Blasco, M.A., Gottlieb, G.J., Horner, J.W., II, Greider, C.W., and DePinho, R.A. (1998). Essential role of mouse telomerase in highly proliferative organs. Nature 392, 569-574.
41. Lendvay, T.S., Morris, D.K., Sah, J., Balasubramanian, B., and Lundblad, V. (1996). Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics 144, 1399-1412.
42. Lin, J.J., and Zakian, V.A. (1995). An in vitro assay for Saccharomyces telomerase requires EST1. Cell 81, 1127-1135.
43. Lingner, J., and Cech, T.R. (1996). Purification of telomerase from Euplotes aediculatus: requirement of a primer 3′ overhang. Proc. Natl. Acad. Sci. USA 93, 10712-10717.
44. Lingner, J., Cech, T.R., Hughes, T.R., and Lundblad, V. (1997a). Three ever shorter telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc. Natl. Acad. Sci. USA 94, 11190-11195.
45. Lingner, J., Hendrick, L.L., and Cech, T.R. (1994). Telomerase RNAs of different ciliates have a common secondary structure and a permuted template. Genes Dev. 8, 1984-1998.
46. Lingner, J., Hughes, T.R., Shevchenko, A., Mann, M., Lundblad, V., and Cech, T.R. (1997b). Reverse transcriptase motifs in the catalytic subunit of telomerase [see comments]. Science 276, 561-567.
47. Marion, R.M., Fortes, P., Beloso, A., Dotti, C., and Ortin, J. (1999). A human sequence homologue of staufen is an RNA-binding protein that is associated with polysomes and localizes to the rough endoplasmic reticulum. Mol. Cell. Biol. 19, 2212-2219.
48. Martin-Rivera, L., Herrera, E., Albar, J.P., and Blasco, M.A. (1998). Expression of mouse telomerase catalytic subunit in embryos and adult tissues. Proc. Natl. Acad. Sci. USA 95, 10471-10476.
49. McEachern, M.J., and Blackburn, E.H. (1996). Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10, 1822-1834.
50. Melek, M., Greene, E.C., and Shippen, D.E. (1996). Processing of nontelomeric 3′ ends by telomerase: default template alignment and endonucleolytic cleavage. Mol. Cell. Biol. 16, 3437-3445.
51. Meyerson, M., et al. (1997). hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90, 785-795.
52. Mitchell, J.R., Cheng, J., and Collins, K. (1999). A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end. Mol. Cell. Biol. 19, 567-576.
53. Nakamura, T.M., Morin, G.B., Chapman, K.B., Weinrich, S.L., Andrews, W.H., Lingner, J., Harley, C.B., and Cech, T.R. (1997). Telomerase catalytic subunit homologs from fission yeast and human [see comments]. Science 277, 955-959.
54. Nakayama, J., Saito, M., Nakamura, H., Matsuura, A., and Ishikawa, F. (1997). TLP1: a gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88, 875-884.
55. Narayanan, A., Lukowiak, A., Jady, B.E., Dragon, F., Kiss, T., Terns, R.M., and Terns, M.P. (1999). Nucleolar localization signals of box H/ACA small nucleolar RNAs. EMBO J. 18, 5120-5130.
56. Pederson, T. (1998). The plurifunctional nucleolus. Nucleic Acids Res. 26, 3871-3876.
57. Romero, D.P., and Blackburn, E.H. (1991). A conserved secondary structure for telomerase RNA. Cell 67, 343-353.
58. Schnapp, G., Rodi, H.P., Rettig, W.J., Schnapp, A., and Damm, K. (1998). One-step affinity purification protocol for human telomerase. Nucleic Acids Res. 26, 3311-3313.
59. SenGupta, D.J., Zhang, B., Kraemer, B., Pochart, P., Fields, S., and Wickens, M. (1996). A three-hybrid system to detect RNA-protein interactions in vivo. Proc. Natl. Acad. Sci. USA 93, 8496-8501.
60. Singer, M.S., and Gottschling, D.E. (1994). TLC1: template RNA component of Saccharomyces cerevisiae telomerase [see comments]. Science 266, 404-409.
61. Steiner, B.R., Hidaka, K., and Futcher, B. (1996). Association of the Est1 protein with telomerase activity in yeast. Proc. Natl. Acad. Sci. USA 93, 2817-2821.
62. St. Johnston, D., Beuchle, D., and Nusslein-Volhard, C. (1991). Staufen, a gene required to localize maternal RNAs in the Drosophila egg. Cell 66, 51-63.
63. St. Johnston, D., Brown, N.H., Gall, J.G., and Jantsch, M. (1992). A conserved double-stranded RNA-binding domain. Proc. Natl. Acad. Sci. USA 89, 10979-10983.
64. Toczyski, D.P., Matera, A.G., Ward, D.C., and Steitz, J.A. (1994). The Epstein-Barr virus (EBV) small RNA EBER1 binds and relocalizes ribosomal protein L22 in EBV-infected human B lymphocytes. Proc. Natl. Acad. Sci. USA 91, 3463-3467.
65. Vaziri, H., and Benchimol, S. (1998). Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279-282.
66. Warbrick, E., Lane, D.P., Glover, D.M., and Cox, L.S. (1995). A small peptide inhibitor of DNA replication defines the site of interaction between the cyclin-dependent kinase inhibitor p21WAF1 and proliferating cell nuclear antigen. Curr. Biol. 5, 275-282.
67. Weinrich, S.L., et al. (1997). Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 77, 498-502.
68. Wickham, L., Duchane, T., Luo, M., Nabi, I.R., and DesGroseillers, L. (1999). Mammalian staufen is a double-stranded-RNA-and tubulin-binding protein which localizes to the rough endoplasmic reticulum. Mol. Cell. Biol. 29, 2220-2230.
69. Wolin, S.L., and Matera, A.C. (1999). The trials and travels of tRNA. Genes Dev. 13, 1-10.
70. Xiong, Y., Hannon, G.J., Zhang, H., Casso, D., Kobayashi, R., and Beach, D. (1993). p21 is a universal inhibitor of cyclin kinases [see comments]. Nature 366, 701-704.