Inhibition of human telomerase by rubromycins: Implication of spiroketal system of the compounds as an active moiety

Biochemistry

Volumn 39, Issue 20, 2000, Pages 5995-6002

  Ueno, Takamasa ^a,b   Takahashi, Hirotada ^b   Oda, Masako ^b   Mizunuma, Makiko ^b   Yokoyama, Akihisa ^b   Goto, Yuso ^b   Mizushina, Yoshiyuki ^c   Sakaguchi, Kengo ^c   Hayashi, Hideya ^b  

^a KUMAMOTO UNIVERSITY   (Japan)

^b JAPAN ENERGY CORPORATION   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBONUCLEASE; DNA POLYMERASE; DNA TOPOISOMERASE; ENZYME INHIBITOR; GRISEORHODIN A; GRISEORHODIN C; QUINONE DERIVATIVE; RNA DIRECTED DNA POLYMERASE; RNA POLYMERASE; RUBROMYCIN DERIVATIVE; TELOMERASE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CYTOTOXICITY; ENZYME INHIBITION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; ENZYME ACTIVATION; GROWTH INHIBITORS; HELA CELLS; HUMANS; K562 CELLS; NAPHTHOQUINONES; POLYMERASE CHAIN REACTION; QUINONES; REVERSE TRANSCRIPTASE INHIBITORS; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TELOMERASE;

EID: 0034705013     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi992661i     Document Type: Article

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