Telomerase and cancer

Journal of Experimental and Clinical Cancer Research

Volumn 22, Issue 2, 2003, Pages 165-169

  Testorelli, Carla ^a,b  

^a UNIVERSITY OF MILAN   (Italy)

^b NONE   (Italy)

Author keywords

Cancer; Senescence; Telomerase

Indexed keywords

HOLOENZYME; OLIGONUCLEOTIDE; TELOMERASE; TELOMERASE INHIBITOR; TUMOR MARKER;

AMINO ACID SEQUENCE; CANCER; CANCER GROWTH; CANCER IMMUNOTHERAPY; CELL DIVISION; CELL PROLIFERATION; DNA REPLICATION; DOMINANT GENE; ENZYME ACTIVITY; GENE THERAPY; HUMAN; PRIORITY JOURNAL; PROGNOSIS; REVIEW; SENESCENCE; TELOMERE;

AGING; ANIMALS; CELL DIVISION; HUMANS; NEOPLASMS; PROGNOSIS; TELOMERASE; TUMOR MARKERS, BIOLOGICAL;

EID: 0038714517     PISSN: 03929078     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (42)

1. Moyzis R.K., Buchingam J.M., Cram L.S., et al.: A highly conserved repetitive DNA sequence (TTAGGG)n, present at the telomeres of human chromosomes. Proc. Natl. Acad. Sci. 85, 6622-6626, 1988.
2. Blackburn E.: Telomerase. Annu. Rev. Biochem. 61:113-129, 1992.
3. Holt S.E., Shay J.W.: Role of telomerase in cellular proliferation and cancer. J. Cell. Physiol 180:10-18, 1999.
4. Shay J.W., Wright W.E.: Implication of mapping the human te-lomere gene (hTERT) as the most distal gene on chromosome p5. Neoplasia 2: 195-196, 2000.
5. Meaghan P.G., Woodring E.W., Shay J.W.: Telomerase in cancer and aging. Critical Rev. Onc/Haem. 41: 29-40, 2002.
6. Pardue M.-L.: Telomeres and telomerases: more than the end of the line. Chromosoma 108:73-82, 1999.
7. Franzese O., Lombardi A., Comandini A., Cannavò E., Tes-torelli C., Cirello I., Bonmassar E.: Effect of Saquinavir on proliferation and telomerase activity of human peropheral blood mononuclear cells. Life Sciences 69: 1509-1520, 2001.
8. Meyerson M.: Role of telomerase in normal and Cancer cells. J. Clin. Onc. 18:2626-2634, 2000.
9. Krupp G., Klapper W., Parwaresch R.: Cell proliferation, carc-inogenesis, and diverse mechanism of telomerase regulation. Cell. Mol. Life Science 346:866-868, 2000.
10. Shay J.W., Bacchetti S.: A survey of telomerase activity in human cancer. Eur. J. Cancer 33:787-791, 1997.
11. Norback K.F., Enblad G., Erlandson M.: Telomerase activity in Hdgking's disease. Blood 92:567-573, 1998.
12. Hanahan D. Weinber RA. The hallmarks of cancer. Cell 100: 57-70, 2000.
13. Hiyama E., Gollahon L., Kataoka T. et al.: Telomerase activity in human breast tumours. J. Natl. Cancer Inst. 88:116-122, 1996.
14. Broccoli D., Young J.W., de Lange T.: Telomerase activity in normal and malignant hemopoietic cells. Proc. Natl. Acad. Sci. 92:9082-9086, 1995.
15. Steinert S., Shay J.W., Wright W.E.: Transient expression of human telomerase extends the lifespan of normal human fibroblast. Biochem. Biophys. Res. Comm. 273:1095-1098, 2000.
16. Wright W.E., Shay W.J.: Cellular senescence as tumor-protection mechanism:the essential role of counting. Curr. Opin. Genet. Dev. 11:98-103, 2001.
17. Ramirez R., Morales C.P., Shea-Herbert B. et al.: Putative telo-merase-indipendent mechanisms of aging effect inadequate growth conditions. Gene dev. 15:398-403, 2001.
18. Duhnam M.A., Neuman A.A., Fasching C.L., Redded R.R.: Telomerase maintenance by recombination in human cells. Nature Genet. 26:447-450, 2000.
19. Oulette M., Mc Daniel L.D., Wright W.E., Shay J.W., Schultz R.A.: The establishment of telomerase-immortalized cell lines representing human chromosome instability syndromes. Hum. Mol. Genet. 9:403-411, 2000.
20. Bodnar A., Ouellette M., Frolkis M. et al.: Extension of life span by introduction of telomerase into normal human cells. Science 279:349-352, 1998.
21. Morales C.P., Holt S.E., Ouellette M., et al.: Absence of cancer-associated changes in human fibroblast immortalized with telomerase. Nature genet. 21:115-118, 1999.
22. Jiang X.R., Jimenez G., Chang E., et al.: Telomerase expression in human somatic cells does not induce changes associated with a transformed phenotype. Nature Genet. 21:111-114, 1999.
23. Hanh W.C., Counter C.M., Lunberg A.S., Bieijersbergen R.L., Brooks M.W., Weinberg R.A.: Creation of human tumor cells with defined genetic elements. Nature 400:464-468, 1999.
24. Zhu J., Wang H., Bishop J.M., Blackburn E.H.: Telomerase extends the lifespan of virus-transformed cells without net telomere lengthening. Proc. Natl. Acad. Sci. 96:3723-3728, 1999.
25. Shay J.W.: Telomerase in cancer: diagnostic, prognostic, and therapeutic implications. Cancer J. Sci. Am. Suppl 1:S26-34, 1998.
26. Miracco C., Pacenti L., Santopietro R., Laurini L., Biagioli M., Luzi P.: Evaluation of telomerase activity in cutaneous melanocytic proliferation. Hum. Pathol. 108-121, 2000.
27. Herbert B., Wrigth W.E., Shay J.W.: Telomerase and breast cancer. Breast Cancer Res. 3, 2001.
28. Tastumoto N., Hiyama E., Murakami Y., et al.: High telomerase activity is an indipendent prognostic indicator of poor outcome in colorectal carcinoma. Clin. Cancer Res. 6: 2696-2701, 2000.
29. Langford L.A., Piatyszeck M.A., Xu R., Schold S.C., Shay J.W.: Telomerase activity: a prognostic indicator in ordinary meningiomas. Hum. Pathol. 28:416-420, 1997.
30. Shay J.Q., Gadzar A.F.: Telomerase in the early detection of cancer. J. Clin. Pathol. 50:106-109, 1997.
31. Kleinschnidt-Demasters B.K., Evans L.C., Bobak J.B., et al.: Quantitative telomerase expression in glioblastoma shows regional variation and down-regulation with therapy but no correlation with patient outcome. Hum. Pathol. 31:905-913, 2000.
32. Hijyama E., Saeki T., Hiyama K. et al.: Telomerase activity as marker of breast carcinoma in fine-needle aspirated samples. Cancer Cytopathol. 90:235-238, 2000.
33. White L.K., Wright W.E., Shay J.W.: Telomerase inhibitors. Trends Biotechnol. 19: 114-120, 2001.
34. Corey D.R.: Telomerase inhitition, oligonucleotides, and clinical trials. Oncogene 631-637, 2002.
35. Herbert B.-S., Pitts A.E., Baker S.E., Hamilton S.E., Wright W.E., Shay J.W., Corey D.R.: Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc. Natl. Acad. Sci. 96:14726-14781, 1999.
36. Elayadi A., Damieville A., Wncrwicz E.V., Monia B.P., Corey D.R.: Inhibition of telomerase by 2′-O-(2-methoxyethyl)RNA oligomers: effect of length, phosphorotioate substitution and time inside cells. Nucl. Acids Res. 29:1683-1689, 2001.
37. Hiyama E., Hiyama K.: Clinical utility of telomerase in cancer. Oncogene 21:643-649, 2002.
38. Hahn W.C.: Inhibition of telomerase limits the growth of cancer cells. Trends Biotechnol. 19:114-120, 2001.
39. Vonderheide R.H., Hahn W.C., Schultze J.L., Nadler L.M.: The telomerase catalytic subunit is a widely expressed tumor-associated antigen recognized by cytotoxic T lymphocytes. Immunity 10:673-679, 1999.
40. Minev B., Hipp J., Firat H., Scmidt J.D., Demoyen P.L., Za-netti M.: Cytotoxic T cell immunity against telomerase reverse transcriptase in human. Proc. Natl. Acad. Sci. 97:4796-4801, 2000.
41. Vondherheide R.H.: Telomerase as a universal tumor-associated antigen for cancer immunotherapy. Oncogene 21:674-679, 2002.
42. Hanah W.C.: Inhibition of telomerase limits the growth of cancer cells. Nature Med. 5:1164-1170, 1999.