-
1
-
-
0042035602
-
Human neurodegenerative disease modeling using Drosophila
-
DOI 10.1146/annurev.neuro.26.041002.131425
-
NM Bonini ME Fortini 2003 Human neurodegenerative disease modeling using Drosophila Annu Rev Neurosci 26 627 656 10.1146/annurev.neuro.26.041002.131425 (Pubitemid 37064946)
-
(2003)
Annual Review of Neuroscience
, vol.26
, pp. 627-656
-
-
Bonini, N.M.1
Fortini, M.E.2
-
2
-
-
0036514504
-
Modelling neurodegenerative diseases in Drosophila: A fruitful approach?
-
DOI 10.1038/nrn751
-
MM Muqit MB Feany 2002 Modelling neurodegenerative diseases in Drosophila: a fruitful approach? Nat Rev Neurosci 3 237 243 10.1038/nrn751 (Pubitemid 135706593)
-
(2002)
Nature Reviews Neuroscience
, vol.3
, Issue.3
, pp. 237-243
-
-
Muqit, M.M.K.1
Feany, M.B.2
-
3
-
-
0037373633
-
Dying for a cause: Invertebrate genetics takes on human neurodegeneration
-
DOI 10.1038/nrg1018
-
M Driscoll B Gerstbrein 2003 Dying for a cause: invertebrate genetics takes on human neurodegeneration Nat Rev Genet 4 181 194 10.1038/nrg1018 (Pubitemid 36267889)
-
(2003)
Nature Reviews Genetics
, vol.4
, Issue.3
, pp. 181-194
-
-
Driscoll, M.1
Gerstbrein, B.2
-
4
-
-
66149135641
-
Drosophila models of neurodegenerative diseases
-
B Lu H Vogel 2008 Drosophila models of neurodegenerative diseases Annu Rev Pathol 4 315 342
-
(2008)
Annu Rev Pathol
, vol.4
, pp. 315-342
-
-
Lu, B.1
Vogel, H.2
-
6
-
-
0030864464
-
The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila
-
D Kretzschmar G Hasan S Sharma M Heisenberg S Benzer 1997 The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila J Neurosci 17 7425 7432
-
(1997)
J Neurosci
, vol.17
, pp. 7425-7432
-
-
Kretzschmar, D.1
Hasan, G.2
Sharma, S.3
Heisenberg, M.4
Benzer, S.5
-
8
-
-
0032168160
-
Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
-
DOI 10.1016/S0896-6273(00)80573-5
-
GR Jackson I Salecker X Dong 1998 Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons Neuron 21 633 642 10.1016/S0896-6273(00)80573-5 (Pubitemid 28475514)
-
(1998)
Neuron
, vol.21
, Issue.3
, pp. 633-642
-
-
Jackson, G.R.1
Salecker, I.2
Dong, X.3
Yao, X.4
Arnheim, N.5
Faber, P.W.6
MacDonald, M.E.7
Zipursky, S.L.8
-
9
-
-
18544392423
-
Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
-
DOI 10.1016/S0092-8674(00)81200-3
-
JM Warrick HL Paulson GL Gray-Board 1998 Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila Cell 93 939 949 10.1016/S0092-8674(00)81200-3 (Pubitemid 28280788)
-
(1998)
Cell
, vol.93
, Issue.6
, pp. 939-949
-
-
Warrick, J.M.1
Paulson, H.L.2
Gray-Board, G.L.3
Bui, Q.T.4
Fischbeck, K.H.5
Pittman, R.N.6
Bonini, N.M.7
-
10
-
-
0034704752
-
A Drosophila model of Parkinson's disease
-
DOI 10.1038/35006074
-
MB Feany WW Bender 2000 A Drosophila model of Parkinson's disease Nature 404 394 398 10.1038/35006074 (Pubitemid 30164341)
-
(2000)
Nature
, vol.404
, Issue.6776
, pp. 394-398
-
-
Feany, M.B.1
Bender, W.W.2
-
11
-
-
0034597833
-
Identification of genes that modify ataxin-1-induced neurodegeneration
-
DOI 10.1038/35040584
-
P Fernandez-Funez ML Nino-Rosales B de Gouyon 2000 Identification of genes that modify ataxin-1-induced neurodegeneration Nature 408 101 106 10.1038/35040584 (Pubitemid 30828268)
-
(2000)
Nature
, vol.408
, Issue.6808
, pp. 101-106
-
-
Fernandez-Funez, P.1
Nino-Rosales, M.L.2
De Gouyon, B.3
She, W.-C.4
Luchak, J.M.5
Martinez, P.6
Turiegano, E.7
Benito, J.8
Capovilla, M.9
Skinner, P.J.10
McCall, A.11
Canal, I.12
Orr, H.T.13
Zoghbi, H.Y.14
Botas, J.15
-
13
-
-
2542560342
-
Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress
-
DOI 10.1242/dev.01095
-
Y Pesah T Pham H Burgess 2004 Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress Development 131 2183 2194 10.1242/dev.01095 (Pubitemid 38702049)
-
(2004)
Development
, vol.131
, Issue.9
, pp. 2183-2194
-
-
Pesah, Y.1
Pham, T.2
Burgess, H.3
Middlebrooks, B.4
Verstreken, P.5
Zhou, Y.6
Harding, M.7
Bellen, H.8
Mardon, G.9
-
14
-
-
0037468831
-
Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
-
DOI 10.1016/S0896-6273(03)00143-0
-
Y Yang I Nishimura Y Imai R Takahashi B Lu 2003 Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila Neuron 37 911 924 10.1016/S0896-6273(03)00143-0 (Pubitemid 36398298)
-
(2003)
Neuron
, vol.37
, Issue.6
, pp. 911-924
-
-
Yang, Y.1
Nishimura, I.2
Imai, Y.3
Takahashi, R.4
Lu, B.5
-
15
-
-
0034674713
-
Gene targeting by homologous recombination in Drosophila
-
DOI 10.1126/science.288.5473.2013
-
YS Rong KG Golic 2000 Gene targeting by homologous recombination in Drosophila Science 288 2013 2018 10.1126/science.288.5473.2013 (Pubitemid 30397675)
-
(2000)
Science
, vol.288
, Issue.5473
, pp. 2013-2018
-
-
Rong, Y.S.1
Golic, K.G.2
-
16
-
-
10044292870
-
Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster
-
DOI 10.1523/JNEUROSCI.2993-04.2004
-
H Coulom S Birman 2004 Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster J Neurosci 24 10993 10998 10.1523/JNEUROSCI.2993-04.2004 (Pubitemid 39602410)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.48
, pp. 10993-10998
-
-
Coulom, H.1
Birman, S.2
-
17
-
-
33847769245
-
Interaction of genetic and environmental factors in a Drosophila parkinsonism model
-
DOI 10.1523/JNEUROSCI.4239-06.2007
-
A Chaudhuri K Bowling C Funderburk 2007 Interaction of genetic and environmental factors in a Drosophila parkinsonism model J Neurosci 27 2457 2467 10.1523/JNEUROSCI.4239-06.2007 (Pubitemid 46393605)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.10
, pp. 2457-2467
-
-
Chaudhuri, A.1
Bowling, K.2
Funderburk, C.3
Lawal, H.4
Inamdar, A.5
Wang, Z.6
O'Donnell, J.M.7
-
18
-
-
0028091176
-
Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
-
10.1002/ana.410350107
-
DT Dexter J Sian S Rose 1994 Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease Ann Neurol 35 38 44 10.1002/ana.410350107
-
(1994)
Ann Neurol
, vol.35
, pp. 38-44
-
-
Dexter, D.T.1
Sian, J.2
Rose, S.3
-
19
-
-
0040368216
-
Prospects for new restorative and neuroprotective treatments in Parkinson's disease
-
10.1038/19899
-
SB Dunnett A Bjorklund 1999 Prospects for new restorative and neuroprotective treatments in Parkinson's disease Nature 399 A32 A39 10.1038/19899
-
(1999)
Nature
, vol.399
-
-
Dunnett, S.B.1
Bjorklund, A.2
-
20
-
-
2542458419
-
Chasing genes in Alzheimer's and Parkinson's disease
-
AM Bertoli-Avella BA Oostra P Heutink 2004 Chasing genes in Alzheimer's and Parkinson's disease Hum Genet 114 5 413 438
-
(2004)
Hum Genet
, vol.114
, Issue.5
, pp. 413-438
-
-
Bertoli-Avella, A.M.1
Oostra, B.A.2
Heutink, P.3
-
21
-
-
0242363670
-
Molecular Pathways of Neurodegeneration in Parkinson's Disease
-
DOI 10.1126/science.1087753
-
TM Dawson VL Dawson 2003 Molecular pathways of neurodegeneration in Parkinson's disease Science 302 819 822 10.1126/science.1087753 (Pubitemid 37339614)
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 819-822
-
-
Dawson, T.M.1
Dawson, V.L.2
-
22
-
-
0030744876
-
Mutation in the α-synuclein gene identified in families with Parkinson's disease
-
DOI 10.1126/science.276.5321.2045
-
MH Polymeropoulos C Lavedan E Leroy 1997 Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 2045 2047 10.1126/science.276.5321.2045 (Pubitemid 27443610)
-
(1997)
Science
, vol.276
, Issue.5321
, pp. 2045-2047
-
-
Polymeropoulos, M.H.1
Lavedan, C.2
Leroy, E.3
Ide, S.E.4
Dehejia, A.5
Dutra, A.6
Pike, B.7
Root, H.8
Rubenstein, J.9
Boyer, R.10
Stenroos, E.S.11
Chandrasekharappa, S.12
Athanassiadou, A.13
Papapetropoulos, T.14
Johnson, W.G.15
Lazzarini, A.M.16
Duvoisin, R.C.17
Di Iorio, G.18
Golbe, L.I.19
Nussbaum, R.L.20
more..
-
23
-
-
0032499264
-
Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
-
DOI 10.1038/33416
-
T Kitada S Asakawa N Hattori 1998 Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Nature 392 605 608 10.1038/33416 (Pubitemid 28207717)
-
(1998)
Nature
, vol.392
, Issue.6676
, pp. 605-608
-
-
Kitada, T.1
Asakawa, S.2
Hattori, N.3
Matsumine, H.4
Yamamura, Y.5
Minoshima, S.6
Yokochi, M.7
Mizuno, Y.8
Shimizu, N.9
-
24
-
-
0032190090
-
The ubiquitin pathway in Parkinson's disease [6]
-
DOI 10.1038/26652
-
E Leroy R Boyer G Auburger 1998 The ubiquitin pathway in Parkinson's disease Nature 395 451 452 10.1038/26652 (Pubitemid 28462431)
-
(1998)
Nature
, vol.395
, Issue.6701
, pp. 451-452
-
-
Leroy, E.1
Boyer, R.2
Auburger, G.3
Leube, B.4
Ulm, G.5
Mezey, E.6
Harta, G.7
Brownstein, M.J.8
Jonnalagada, S.9
Chernova, T.10
Dehejia, A.11
Lavedan, C.12
Gasser, T.13
Steinbach, P.J.14
Wilkinson, K.D.15
Polymeropoulos, M.H.16
-
25
-
-
0142217556
-
DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism
-
DOI 10.1007/s10072-003-0108-0
-
V Bonifati P Rizzu F Squitieri 2003 DJ-1 (PARK7), a novel gene for autosomal recessive, early onset parkinsonism Neurol Sci 24 159 160 10.1007/s10072-003-0108-0 (Pubitemid 37304291)
-
(2003)
Neurological Sciences
, vol.24
, Issue.3
, pp. 159-160
-
-
Bonifati, V.1
Rizzu, P.2
Squitieri, F.3
Krieger, E.4
Vanacore, N.5
Van Swieten, J.C.6
Brice, A.7
Van Duijn, C.M.8
Oostra, B.9
Meco, G.10
Heutink, P.11
-
26
-
-
2442668926
-
Hereditary early-onset Parkinson's disease caused by mutations in PINK1
-
DOI 10.1126/science.1096284
-
EM Valente PM Abou-Sleiman V Caputo 2004 Hereditary early-onset Parkinson's disease caused by mutations in PINK1 Science 304 1158 1160 10.1126/science.1096284 (Pubitemid 38661852)
-
(2004)
Science
, vol.304
, Issue.5674
, pp. 1158-1160
-
-
Valente, E.M.1
Abou-Sleiman, P.M.2
Caputo, V.3
Muqit, M.M.K.4
Harvey, K.5
Gispert, S.6
Ali, Z.7
Del Turco, D.8
Bentivoglio, A.R.9
Healy, D.G.10
Albanese, A.11
Nussbaum, R.12
Gonzalez-Maldonado, R.13
Deller, T.14
Salvi, S.15
Cortelli, P.16
Gilks, W.P.17
Latchman, D.S.18
Harvey, R.J.19
Dallapiccola, B.20
Auburger, G.21
Wood, N.W.22
more..
-
27
-
-
8844233579
-
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology
-
DOI 10.1016/j.neuron.2004.11.005, PII S0896627304007202
-
A Zimprich S Biskup P Leitner 2004 Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology Neuron 44 601 607 10.1016/j.neuron.2004.11.005 (Pubitemid 39531225)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 601-607
-
-
Zimprich, A.1
Biskup, S.2
Leitner, P.3
Lichtner, P.4
Farrer, M.5
Lincoln, S.6
Kachergus, J.7
Hulihan, M.8
Uitti, R.J.9
Calne, D.B.10
Stoessl, A.J.11
Pfeiffer, R.F.12
Patenge, N.13
Carbajal, I.C.14
Vieregge, P.15
Asmus, F.16
Muller-Myhsok, B.17
Dickson, D.W.18
Meitinger, T.19
Strom, T.M.20
Wszolek, Z.K.21
Gasser, T.22
more..
-
28
-
-
8844266996
-
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
-
DOI 10.1016/j.neuron.2004.10.023, PII S0896627304006890
-
C Paisan-Ruiz S Jain EW Evans 2004 Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease Neuron 44 595 600 10.1016/j.neuron.2004.10.023 (Pubitemid 39531224)
-
(2004)
Neuron
, vol.44
, Issue.4
, pp. 595-600
-
-
Paisan-Ruiz, C.1
Jain, S.2
Evans, E.W.3
Gilks, W.P.4
Simon, J.5
Van Der Brug, M.6
De Munain, A.L.7
Aparicio, S.8
Gil, A.M.9
Khan, N.10
Johnson, J.11
Martinez, J.R.12
Nicholl, D.13
Carrera, I.M.14
Pena, A.S.15
De Silva, R.16
Lees, A.17
Marti-Masso, J.F.18
Perez-Tur, J.19
Wood, N.W.20
Singleton, A.B.21
more..
-
29
-
-
0036468432
-
Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
-
DOI 10.1126/science.1067389
-
PK Auluck HY Chan JQ Trojanowski VM Lee NM Bonini 2002 Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 865 868 10.1126/science.1067389 (Pubitemid 34118369)
-
(2002)
Science
, vol.295
, Issue.5556
, pp. 865-868
-
-
Auluck, P.K.1
Chan, H.Y.E.2
Trojanowski, J.Q.3
Lee, V.M.-Y.4
Bonini, N.M.5
-
30
-
-
0242300619
-
α-Synuclein Locus Triplication Causes Parkinson's Disease
-
DOI 10.1126/science.1090278
-
AB Singleton M Farrer J Johnson 2003 Alpha-synuclein locus triplication causes Parkinson's disease Science 302 841 10.1126/science.1090278 (Pubitemid 37339619)
-
(2003)
Science
, vol.302
, Issue.5646
, pp. 841
-
-
Singleton, A.B.1
Farrer, M.2
Johnson, J.3
Singleton, A.4
Hague, S.5
Kachergus, J.6
Hulihan, M.7
Peuralinna, T.8
Dutra, A.9
Nussbaum, R.10
Lincoln, S.11
Crawley, A.12
Hanson, M.13
Maraganore, D.14
Adler, C.15
Cookson, M.R.16
Muenter, M.17
Baptista, M.18
Miller, D.19
Blancato, J.20
Hardy, J.21
Gwinn-Hardy, K.22
more..
-
31
-
-
1142287448
-
Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease
-
DOI 10.1007/s00439-003-1050-1
-
YR Wu CK Wang CM Chen 2004 Analysis of heat-shock protein 70 gene polymorphisms and the risk of Parkinson's disease Hum Genet 114 236 241 10.1007/s00439-003-1050-1 (Pubitemid 38208300)
-
(2004)
Human Genetics
, vol.114
, Issue.3
, pp. 236-241
-
-
Wu, Y.-R.1
Wang, C.-K.2
Chen, C.-M.3
Hsu, Y.4
Lin, S.-J.5
Lin, Y.-Y.6
Fung, H.-C.7
Chang, K.-H.8
Lee-Chen, G.-J.9
-
32
-
-
10944241135
-
Hsp70 gene transfer by adeno-associated virusi inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease
-
DOI 10.1016/j.ymthe.2004.09.007, PII S1525001604014480
-
Z Dong DP Wolfer HP Lipp H Bueler 2005 Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease Mol Ther 11 80 88 10.1016/j.ymthe.2004.09.007 (Pubitemid 40012001)
-
(2005)
Molecular Therapy
, vol.11
, Issue.1
, pp. 80-88
-
-
Dong, Z.1
Wolfer, D.P.2
Lipp, H.-P.3
Bueler, H.4
-
34
-
-
17844406856
-
α-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
-
DOI 10.1038/nn1443
-
L Chen MB Feany 2005 Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nat Neurosci 8 657 663 10.1038/nn1443 (Pubitemid 40594208)
-
(2005)
Nature Neuroscience
, vol.8
, Issue.5
, pp. 657-663
-
-
Chen, L.1
Feany, M.B.2
-
36
-
-
34547599329
-
Sirtuin 2 inhibitors rescue α-synuclein-mediated toxicity in models of Parkinson's disease
-
DOI 10.1126/science.1143780
-
TF Outeiro E Kontopoulos SM Altmann 2007 Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease Science 317 516 519 10.1126/science.1143780 (Pubitemid 47196116)
-
(2007)
Science
, vol.317
, Issue.5837
, pp. 516-519
-
-
Outeiro, T.F.1
Kontopoulos, E.2
Altmann, S.M.3
Kufareva, I.4
Strathearn, K.E.5
Amore, A.M.6
Volk, C.B.7
Maxwell, M.M.8
Rochet, J.-C.9
McLean, P.J.10
Young, A.B.11
Abagyan, R.12
Feany, M.B.13
Hyman, B.T.14
Kazantsev, A.G.15
-
37
-
-
40849130108
-
Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease
-
10.1016/j.nbd.2007.11.013
-
JA Botella F Bayersdorfer S Schneuwly 2008 Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease Neurobiol Dis 30 65 73 10.1016/j.nbd.2007.11.013
-
(2008)
Neurobiol Dis
, vol.30
, pp. 65-73
-
-
Botella, J.A.1
Bayersdorfer, F.2
Schneuwly, S.3
-
38
-
-
33746533924
-
α-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models
-
DOI 10.1126/science.1129462
-
AA Cooper AD Gitler A Cashikar 2006 Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models Science 313 324 328 10.1126/science.1129462 (Pubitemid 44480951)
-
(2006)
Science
, vol.313
, Issue.5785
, pp. 324-328
-
-
Cooper, A.A.1
Gitler, A.D.2
Cashikar, A.3
Haynes, C.M.4
Hill, K.J.5
Bhullar, B.6
Liu, K.7
Xu, K.8
Strathearn, K.E.9
Liu, F.10
Cao, S.11
Caldwell, K.A.12
Caldwell, G.A.13
Marsischky, G.14
Kolodner, R.D.15
LaBaer, J.16
Rochet, J.-C.17
Bonini, N.M.18
Lindquist, S.19
-
39
-
-
0141841634
-
Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
-
DOI 10.1093/hmg/ddg265
-
CR Scherzer RV Jensen SR Gullans MB Feany 2003 Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease Hum Mol Genet 12 2457 2466 10.1093/hmg/ddg265 (Pubitemid 37220410)
-
(2003)
Human Molecular Genetics
, vol.12
, Issue.19
, pp. 2457-2466
-
-
Scherzer, C.R.1
Jensen, R.V.2
Gullans, S.R.3
Feany, M.B.4
-
40
-
-
47849083301
-
Quantitative proteomics of a presymptomatic A53T α-synuclein Drosophila model of Parkinson disease
-
DOI 10.1074/mcp.M700467-MCP200
-
Z Xun RA Sowell TC Kaufman DE Clemmer 2008 Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease Mol Cell Proteomics 7 1191 1203 10.1074/mcp.M700467-MCP200 (Pubitemid 352038266)
-
(2008)
Molecular and Cellular Proteomics
, vol.7
, Issue.7
, pp. 1191-1203
-
-
Xun, Z.1
Sowell, R.A.2
Kaufman, T.C.3
Clemmer, D.E.4
-
41
-
-
22544458436
-
Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila
-
DOI 10.1073/pnas.0500346102
-
GH Cha S Kim J Park 2005 Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila Proc Natl Acad Sci USA 102 10345 10350 10.1073/pnas.0500346102 (Pubitemid 41023373)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.29
, pp. 10345-10350
-
-
Cha, G.-H.1
Kim, S.2
Park, J.3
Lee, E.4
Kim, M.5
Lee, S.B.6
Kim, J.M.7
Chung, J.8
Cho, K.S.9
-
43
-
-
0035967883
-
An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
-
DOI 10.1016/S0092-8674(01)00407-X
-
Y Imai M Soda H Inoue N Hattori Y Mizuno R Takahashi 2001 An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Cell 105 891 902 10.1016/S0092-8674(01)00407-X (Pubitemid 32635090)
-
(2001)
Cell
, vol.105
, Issue.7
, pp. 891-902
-
-
Imai, Y.1
Soda, M.2
Inoue, H.3
Hattori, N.4
Mizuno, Y.5
Takahashi, R.6
-
44
-
-
33846511271
-
Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation
-
DOI 10.1093/hmg/ddl439
-
Y Kitao Y Imai K Ozawa 2007 Pael receptor induces death of dopaminergic neurons in the substantia nigra via endoplasmic reticulum stress and dopamine toxicity, which is enhanced under condition of parkin inactivation Hum Mol Genet 16 50 60 10.1093/hmg/ddl439 (Pubitemid 46152544)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.1
, pp. 50-60
-
-
Kitao, Y.1
Imai, Y.2
Ozawa, K.3
Kataoka, A.4
Ikeda, T.5
Soda, M.6
Nakimawa, K.7
Kiyama, H.8
Stern, D.M.9
Hori, O.10
Wakamatsu, K.11
Ito, S.12
Itohara, S.13
Takahashi, R.14
Ogawa, S.15
-
45
-
-
33846804056
-
A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine
-
DOI 10.1523/JNEUROSCI.4810-06.2007
-
TK Sang HY Chang GM Lawless 2007 A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine J Neurosci 27 981 992 10.1523/JNEUROSCI.4810-06. 2007 (Pubitemid 46203305)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.5
, pp. 981-992
-
-
Sang, T.-K.1
Chang, H.-Y.2
Lawless, G.M.3
Ratnaparkhi, A.4
Mee, L.5
Ackerson, L.C.6
Maidment, N.T.7
Krantz, D.E.8
Jackson, G.R.9
-
46
-
-
34547885021
-
Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
-
DOI 10.1523/JNEUROSCI.0218-07.2007
-
C Wang R Lu X Ouyang 2007 Drosophila overexpressing parkin R275 W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities J Neurosci 27 8563 8570 10.1523/JNEUROSCI.0218-07.2007 (Pubitemid 47254271)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.32
, pp. 8563-8570
-
-
Wang, C.1
Lu, R.2
Ouyang, X.3
Ho, M.W.L.4
Chia, W.5
Yu, F.6
Lim, K.-L.7
-
47
-
-
33745589773
-
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
-
DOI 10.1038/nature04779, PII N04779
-
IE Clark MW Dodson C Jiang 2006 Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 441 1162 1166 10.1038/nature04779 (Pubitemid 43990738)
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1162-1166
-
-
Clark, I.E.1
Dodson, M.W.2
Jiang, C.3
Cao, J.H.4
Huh, J.R.5
Seol, J.H.6
Yoo, S.J.7
Hay, B.A.8
Guo, M.9
-
48
-
-
33745602748
-
Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin
-
DOI 10.1038/nature04788, PII N04788
-
J Park SB Lee S Lee 2006 Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin Nature 441 1157 1161 10.1038/nature04788 (Pubitemid 43990737)
-
(2006)
Nature
, vol.441
, Issue.7097
, pp. 1157-1161
-
-
Park, J.1
Lee, S.B.2
Lee, S.3
Kim, Y.4
Song, S.5
Kim, S.6
Bae, E.7
Kim, J.8
Shong, M.9
Kim, J.-M.10
Chung, J.11
-
49
-
-
33746080412
-
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin
-
DOI 10.1073/pnas.0602493103
-
Y Yang S Gehrke Y Imai 2006 Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin Proc Natl Acad Sci USA 103 10793 10798 10.1073/pnas.0602493103 (Pubitemid 44078055)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.28
, pp. 10793-10798
-
-
Yang, Y.1
Gehrke, S.2
Imai, Y.3
Huang, Z.4
Ouyang, Y.5
Wang, J.-W.6
Yang, L.7
Beal, M.F.8
Vogel, H.9
Lu, B.10
-
50
-
-
33748600694
-
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila
-
DOI 10.1073/pnas.0604661103
-
D Wang L Qian H Xiong 2006 Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila Proc Natl Acad Sci USA 103 13520 13525 10.1073/pnas.0604661103 (Pubitemid 44380140)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.36
, pp. 13520-13525
-
-
Wang, D.1
Qian, L.2
Xiong, H.3
Liu, J.4
Neckameyer, W.S.5
Oldham, S.6
Xia, K.7
Wang, J.8
Bodmer, R.9
Zhang, Z.10
-
51
-
-
56049091236
-
PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
-
10.1016/j.bbrc.2008.10.104
-
Y Kim J Park S Kim 2008 PINK1 controls mitochondrial localization of Parkin through direct phosphorylation Biochem Biophys Res Commun 377 975 980 10.1016/j.bbrc.2008.10.104
-
(2008)
Biochem Biophys Res Commun
, vol.377
, pp. 975-980
-
-
Kim, Y.1
Park, J.2
Kim, S.3
-
52
-
-
44349195101
-
Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery
-
DOI 10.1073/pnas.0711845105
-
Y Yang Y Ouyang L Yang 2008 Pink1 regulates mitochondrial dynamics through interaction with the fission/fusion machinery Proc Natl Acad Sci USA 105 7070 7075 10.1073/pnas.0711845105 (Pubitemid 351754531)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.19
, pp. 7070-7075
-
-
Yang, Y.1
Ouyang, Y.2
Yang, L.3
Beal, M.F.4
McQuibban, A.5
Vogel, H.6
Lu, B.7
-
54
-
-
55749090654
-
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
-
10.1073/pnas.0803998105
-
H Deng MW Dodson H Huang M Guo 2008 The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila Proc Natl Acad Sci USA 105 14503 14508 10.1073/pnas.0803998105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 14503-14508
-
-
Deng, H.1
Dodson, M.W.2
Huang, H.3
Guo, M.4
-
55
-
-
57749194390
-
The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
-
10.1016/j.bbrc.2008.11.086
-
J Park G Lee J Chung 2009 The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process Biochem Biophys Res Commun 378 518 523 10.1016/j.bbrc.2008.11.086
-
(2009)
Biochem Biophys Res Commun
, vol.378
, pp. 518-523
-
-
Park, J.1
Lee, G.2
Chung, J.3
-
56
-
-
33745274726
-
Mitochondria: Dynamic Organelles in Disease, Aging, and Development
-
DOI 10.1016/j.cell.2006.06.010, PII S0092867406007689
-
DC Chan 2006 Mitochondria: dynamic organelles in disease, aging, and development Cell 125 1241 1252 10.1016/j.cell.2006.06.010 (Pubitemid 43929096)
-
(2006)
Cell
, vol.125
, Issue.7
, pp. 1241-1252
-
-
Chan, D.C.1
-
57
-
-
10944269186
-
The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
-
DOI 10.1016/j.cell.2004.11.003, PII S0092867404010451
-
Z Li K Okamoto Y Hayashi M Sheng 2004 The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses Cell 119 873 887 10.1016/j.cell.2004.11.003 (Pubitemid 40017692)
-
(2004)
Cell
, vol.119
, Issue.6
, pp. 873-887
-
-
Li, Z.1
Okamoto, K.-I.2
Hayashi, Y.3
Sheng, M.4
-
58
-
-
0344413426
-
Mitochondrial fission in apoptosis, neurodegeneration and aging
-
DOI 10.1016/j.ceb.2003.10.015
-
E Bossy-Wetzel MJ Barsoum A Godzik R Schwarzenbacher SA Lipton 2003 Mitochondrial fission in apoptosis, neurodegeneration and aging Curr Opin Cell Biol 15 706 716 10.1016/j.ceb.2003.10.015 (Pubitemid 37487964)
-
(2003)
Current Opinion in Cell Biology
, vol.15
, Issue.6
, pp. 706-716
-
-
Bossy-Wetzel, E.1
Barsoum, M.J.2
Godzik, A.3
Schwarzenbacher, R.4
Lipton, S.A.5
-
59
-
-
0037137702
-
Parkin protects against the toxicity associated with mutant α-Synuclein: Proteasome dysfunction selectively affects catecholaminergic neurons
-
DOI 10.1016/S0896-6273(02)01125-X
-
L Petrucelli C O'Farrell PJ Lockhart 2002 Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons Neuron 36 1007 1019 10.1016/S0896-6273(02)01125-X (Pubitemid 36044504)
-
(2002)
Neuron
, vol.36
, Issue.6
, pp. 1007-1019
-
-
Petrucelli, L.1
O'Farrell, C.2
Lockhart, P.J.3
Baptista, M.4
Kehoe, K.5
Vink, L.6
Choi, P.7
Wolozin, B.8
Farrer, M.9
Hardy, J.10
Cookson, M.R.11
-
60
-
-
0017187807
-
Biochemical adaptations for flight in the insect
-
B Sacktor 1976 Biochemical adaptations for flight in the insect Biochem Soc Symp 41 111 131
-
(1976)
Biochem Soc Symp
, vol.41
, pp. 111-131
-
-
Sacktor, B.1
-
61
-
-
36248929304
-
Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by α-synuclein
-
DOI 10.1111/j.1460-9568.2007.05929.x
-
SS Park EM Schulz D Lee 2007 Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein Eur J Neurosci 26 3104 3112 10.1111/j.1460-9568.2007.05929.x (Pubitemid 350135175)
-
(2007)
European Journal of Neuroscience
, vol.26
, Issue.11
, pp. 3104-3112
-
-
Park, S.S.1
Schulz, E.M.2
Lee, D.3
-
62
-
-
24044472010
-
Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease
-
DOI 10.1016/j.cub.2005.07.064, PII S0960982205008481
-
M Meulener AJ Whitworth CE Armstrong-Gold 2005 Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease Curr Biol 15 1572 1577 10.1016/j.cub.2005.07.064 (Pubitemid 41219597)
-
(2005)
Current Biology
, vol.15
, Issue.17
, pp. 1572-1577
-
-
Meulener, M.1
Whitworth, A.J.2
Armstrong-Gold, C.E.3
Rizzu, P.4
Heutink, P.5
Wes, P.D.6
Pallanck, L.J.7
Bonini, N.M.8
-
63
-
-
24044506249
-
Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
-
DOI 10.1016/j.cub.2005.07.036, PII S0960982205007918
-
FM Menzies SC Yenisetti KT Min 2005 Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress Curr Biol 15 1578 1582 10.1016/j.cub.2005.07.036 (Pubitemid 41219598)
-
(2005)
Current Biology
, vol.15
, Issue.17
, pp. 1578-1582
-
-
Menzies, F.M.1
Yenisetti, S.C.2
Min, K.-T.3
-
64
-
-
26444489693
-
Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling
-
DOI 10.1073/pnas.0504610102
-
Y Yang S Gehrke ME Haque 2005 Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling Proc Natl Acad Sci USA 102 13670 13675 10.1073/pnas.0504610102 (Pubitemid 41420906)
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, Issue.38
, pp. 13670-13675
-
-
Yang, Y.1
Gehrke, S.2
Haque, Md.E.3
Imai, Y.4
Kosek, J.5
Yang, L.6
Beal, M.F.7
Nishimura, I.8
Wakamatsu, K.9
Ito, S.10
Takahashi, R.11
Lu, B.12
-
65
-
-
20244365801
-
DJ-1, a novel regulator of the tumor suppressor PTEN
-
DOI 10.1016/j.ccr.2005.02.010
-
RH Kim M Peters Y Jang 2005 DJ-1, a novel regulator of the tumor suppressor PTEN Cancer Cell 7 263 273 10.1016/j.ccr.2005.02.010 (Pubitemid 40568685)
-
(2005)
Cancer Cell
, vol.7
, Issue.3
, pp. 263-273
-
-
Kim, R.H.1
Peters, M.2
Jang, Y.3
Shi, W.4
Pintilie, M.5
Fletcher, G.C.6
DeLuca, C.7
Liepa, J.8
Zhou, L.9
Snow, B.10
Binari, R.C.11
Manoukian, A.S.12
Bray, M.R.13
Liu, F.-F.14
Tsao, M.-S.15
Mak, T.W.16
-
66
-
-
48249145149
-
RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
-
10.1073/pnas.0708518105
-
MP van der Brug J Blackinton J Chandran 2008 RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways Proc Natl Acad Sci USA 105 10244 10249 10.1073/pnas.0708518105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 10244-10249
-
-
Van Der Brug, M.P.1
Blackinton, J.2
Chandran, J.3
-
67
-
-
34248574535
-
Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
-
DOI 10.1016/j.bbrc.2007.04.156, PII S0006291X07008972
-
SB Lee W Kim S Lee J Chung 2007 Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila Biochem Biophys Res Commun 358 534 539 10.1016/j.bbrc.2007.04.156 (Pubitemid 46755736)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.358
, Issue.2
, pp. 534-539
-
-
Lee, S.B.1
Kim, W.2
Lee, S.3
Chung, J.4
-
68
-
-
40649108102
-
A Drosophila model for LRRK2-linked parkinsonism
-
10.1073/pnas.0708452105
-
Z Liu X Wang Y Yu 2008 A Drosophila model for LRRK2-linked parkinsonism Proc Natl Acad Sci USA 105 2693 2698 10.1073/pnas.0708452105
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 2693-2698
-
-
Liu, Z.1
Wang, X.2
Yu, Y.3
-
69
-
-
51949090816
-
Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
-
10.1038/emboj.2008.163
-
Y Imai S Gehrke HQ Wang 2008 Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila EMBO J 27 2432 2443 10.1038/emboj.2008.163
-
(2008)
EMBO J
, vol.27
, pp. 2432-2443
-
-
Imai, Y.1
Gehrke, S.2
Wang, H.Q.3
-
70
-
-
0037431082
-
Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-Secretase complex
-
DOI 10.1016/S0896-6273(03)00205-8
-
B De Strooper 2003 Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex Neuron 38 9 12 10.1016/S0896-6273(03)00205-8 (Pubitemid 36423348)
-
(2003)
Neuron
, vol.38
, Issue.1
, pp. 9-12
-
-
De Strooper, B.1
-
71
-
-
0017649032
-
Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
-
10.1016/0022-2836(77)90213-3
-
DW Cleveland SY Hwo MW Kirschner 1977 Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin J Mol Biol 116 207 225 10.1016/0022-2836(77)90213-3
-
(1977)
J Mol Biol
, vol.116
, pp. 207-225
-
-
Cleveland, D.W.1
Hwo, S.Y.2
Kirschner, M.W.3
-
72
-
-
0022744803
-
Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
-
10.1073/pnas.83.13.4913
-
I Grundke-Iqbal K Iqbal YC Tung M Quinlan HM Wisniewski LI Binder 1986 Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 4913 4917 10.1073/pnas.83.13.4913
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 4913-4917
-
-
Grundke-Iqbal, I.1
Iqbal, K.2
Tung, Y.C.3
Quinlan, M.4
Wisniewski, H.M.5
Binder, L.I.6
-
73
-
-
0025292866
-
A preparation of Alzheimer paired helical filaments that displays distinct τ proteins by polyacrylamide gel electrophoresis
-
DOI 10.1073/pnas.87.15.5827
-
SG Greenberg P Davies 1990 A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis Proc Natl Acad Sci USA 87 5827 5831 10.1073/pnas.87.15.5827 (Pubitemid 20240381)
-
(1990)
Proceedings of the National Academy of Sciences of the United States of America
, vol.87
, Issue.15
, pp. 5827-5831
-
-
Greenberg, S.G.1
Davies, P.2
-
74
-
-
0025904444
-
A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
-
10.1126/science.1899488
-
VM Lee BJ Balin L Otvos Jr JQ Trojanowski 1991 A68: a major subunit of paired helical filaments and derivatized forms of normal Tau Science 251 675 678 10.1126/science.1899488
-
(1991)
Science
, vol.251
, pp. 675-678
-
-
Lee, V.M.1
Balin, B.J.2
Otvos Jr, L.3
Trojanowski, J.Q.4
-
75
-
-
0030977392
-
Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
-
DOI 10.1002/ana.410410606
-
NL Foster K Wilhelmsen AA Sima MZ Jones CJ D'Amato S Gilman 1997 Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference participants Ann Neurol 41 706 715 10.1002/ana.410410606 (Pubitemid 27249175)
-
(1997)
Annals of Neurology
, vol.41
, Issue.6
, pp. 706-715
-
-
Foster, N.L.1
Wilhelmsen, K.2
Sima, A.A.F.3
Jones, M.Z.4
D'Amato, C.J.5
Gilman, S.6
-
76
-
-
0032543684
-
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
-
DOI 10.1038/31508
-
M Hutton CL Lendon P Rizzu 1998 Association of missense and 5?-splice-site mutations in tau with the inherited dementia FTDP-17 Nature 393 702 705 10.1038/31508 (Pubitemid 28289662)
-
(1998)
Nature
, vol.393
, Issue.6686
, pp. 702-704
-
-
Hutton, M.1
Lendon, C.L.2
Rizzu, P.3
Baker, M.4
Froelich, S.5
Houlden, H.H.6
Pickering-Brown, S.7
Chakraverty, S.8
Isaacs, A.9
Grover, A.10
Hackett, J.11
Adamson, J.12
Lincoln, S.13
Dickson, D.14
Davies, P.15
Petersen, R.C.16
Stevena, M.17
De Graaff, E.18
Wauters, E.19
Van Baren, J.20
Hillebrand, M.21
Joosse, M.22
Kwon, J.M.23
Nowotny, P.24
Che, L.K.25
Norton, J.26
Morris, J.C.27
Reed, L.A.28
Trojanowski, J.29
Basun, H.30
Lannfelt, L.31
Neystat, M.32
Fahn, S.33
Dark, F.34
Tannenberg, T.35
Dodd, P.R.36
Hayward, N.37
Kwok, J.B.J.38
Schofield, P.R.39
Andreadis, A.40
Snowden, J.41
Craufurd, D.42
Neary, D.43
Owen, F.44
Costra, B.A.45
Hardy, J.46
Goate, A.47
Van Swieten, J.48
Mann, D.49
Lynch, T.50
Heutink, P.51
more..
-
77
-
-
14444284106
-
Tau is a candidate gene for chromosome 17 frontotemporal dementia
-
DOI 10.1002/ana.410430617
-
P Poorkaj TD Bird E Wijsman 1998 Tau is a candidate gene for chromosome 17 frontotemporal dementia Ann Neurol 43 815 825 10.1002/ana.410430617 (Pubitemid 28280226)
-
(1998)
Annals of Neurology
, vol.43
, Issue.6
, pp. 815-825
-
-
Poorkaj, P.1
Bird, T.D.2
Wijsman, E.3
Nemens, E.4
Garruto, R.M.5
Anderson, L.6
Andreadis, A.7
Wiederholt, W.C.8
Raskind, M.9
Schellenberg, G.D.10
-
79
-
-
0026783241
-
Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
-
10.1016/0896-6273(92)90024-8
-
L Luo T Tully K White 1992 Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene Neuron 9 595 605 10.1016/0896-6273(92)90024-8
-
(1992)
Neuron
, vol.9
, pp. 595-605
-
-
Luo, L.1
Tully, T.2
White, K.3
-
80
-
-
58149503769
-
Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
-
K Carmine-Simmen T Proctor J Tschape 2008 Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function Neurobiol Dis 33 2 274 281
-
(2008)
Neurobiol Dis
, vol.33
, Issue.2
, pp. 274-281
-
-
Carmine-Simmen, K.1
Proctor, T.2
Tschape, J.3
-
81
-
-
3242809725
-
A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster
-
DOI 10.1016/j.mcn.2004.03.001, PII S1044743104000521
-
A Finelli A Kelkar HJ Song H Yang M Konsolaki 2004 A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster Mol Cell Neurosci 26 365 375 10.1016/j.mcn.2004.03.001 (Pubitemid 38968431)
-
(2004)
Molecular and Cellular Neuroscience
, vol.26
, Issue.3
, pp. 365-375
-
-
Finelli, A.1
Kelkar, A.2
Song, H.-J.3
Yang, H.4
Konsolaki, M.5
-
83
-
-
54949151536
-
Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides
-
10.1093/hmg/ddn240
-
GB Stokin A Almenar-Queralt S Gunawardena 2008 Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides Hum Mol Genet 17 3474 3486 10.1093/hmg/ddn240
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3474-3486
-
-
Stokin, G.B.1
Almenar-Queralt, A.2
Gunawardena, S.3
-
84
-
-
58049196869
-
The Toll - >nFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila
-
10.1371/journal.pone.0003966
-
L Tan P Schedl HJ Song D Garza M Konsolaki 2008 The Toll - >NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila PLoS One 3 e3966 10.1371/journal.pone.0003966
-
(2008)
PLoS One
, vol.3
, pp. 3966
-
-
Tan, L.1
Schedl, P.2
Song, H.J.3
Garza, D.4
Konsolaki, M.5
-
85
-
-
49649123892
-
Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
-
10.1074/jbc.M710509200
-
K Iijima-Ando SA Hearn L Granger 2008 Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila J Biol Chem 283 19066 19076 10.1074/jbc.M710509200
-
(2008)
J Biol Chem
, vol.283
, pp. 19066-19076
-
-
Iijima-Ando, K.1
Hearn, S.A.2
Granger, L.3
-
86
-
-
0034716223
-
Tau and tau reporters disrupt central projections of sensory neurons in Drosophila
-
10.1002/1096-9861(20001225)428:4?630::AID-CNE4?3.0.CO;2-X
-
DW Williams M Tyrer D Shepherd 2000 Tau and tau reporters disrupt central projections of sensory neurons in Drosophila J Comp Neurol 428 630 640 10.1002/1096-9861(20001225)428:4?630::AID-CNE4?3.0.CO;2-X
-
(2000)
J Comp Neurol
, vol.428
, pp. 630-640
-
-
Williams, D.W.1
Tyrer, M.2
Shepherd, D.3
-
87
-
-
0035958642
-
Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
-
10.1126/science.1062382
-
CW Wittmann MF Wszolek JM Shulman 2001 Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles Science 293 711 714 10.1126/science.1062382
-
(2001)
Science
, vol.293
, pp. 711-714
-
-
Wittmann, C.W.1
Wszolek, M.F.2
Shulman, J.M.3
-
88
-
-
0037118247
-
Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
-
DOI 10.1016/S0896-6273(02)00706-7
-
GR Jackson M Wiedau-Pazos TK Sang 2002 Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 34 509 519 10.1016/S0896-6273(02)00706-7 (Pubitemid 34628749)
-
(2002)
Neuron
, vol.34
, Issue.4
, pp. 509-519
-
-
Jackson, G.R.1
Wiedau-Pazos, M.2
Sang, T.-K.3
Wagle, N.4
Brown, C.A.5
Massachi, S.6
Geschwind, D.H.7
-
91
-
-
1542358895
-
PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
-
DOI 10.1016/S0092-8674(04)00170-9, PII S0092867404001709
-
I Nishimura Y Yang B Lu 2004 PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila Cell 116 671 682 10.1016/S0092-8674(04)00170-9 (Pubitemid 38326726)
-
(2004)
Cell
, vol.116
, Issue.5
, pp. 671-682
-
-
Nishimura, I.1
Yang, Y.2
Lu, B.3
-
92
-
-
0029024475
-
Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
-
10.1016/0092-8674(95)90082-9
-
S Guo KJ Kemphues 1995 par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed Cell 81 611 620 10.1016/0092-8674(95)90082-9
-
(1995)
Cell
, vol.81
, pp. 611-620
-
-
Guo, S.1
Kemphues, K.J.2
-
93
-
-
0030969575
-
MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
-
10.1016/S0092-8674(00)80208-1
-
G Drewes A Ebneth U Preuss EM Mandelkow E Mandelkow 1997 MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption Cell 89 297 308 10.1016/S0092-8674(00)80208-1
-
(1997)
Cell
, vol.89
, pp. 297-308
-
-
Drewes, G.1
Ebneth, A.2
Preuss, U.3
Mandelkow, E.M.4
Mandelkow, E.5
-
94
-
-
0031213571
-
Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity
-
10.1016/S0960-9822(06)00260-0
-
H Bohm V Brinkmann M Drab A Henske TV Kurzchalia 1997 Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity Curr Biol 7 603 606 10.1016/S0960-9822(06) 00260-0
-
(1997)
Curr Biol
, vol.7
, pp. 603-606
-
-
Bohm, H.1
Brinkmann, V.2
Drab, M.3
Henske, A.4
Kurzchalia, T.V.5
-
95
-
-
0036854327
-
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity
-
DOI 10.1091/mbc.02-03-0046
-
J Biernat YZ Wu T Timm 2002 Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity Mol Biol Cell 13 4013 4028 10.1091/mbc.02-03-0046 (Pubitemid 35398567)
-
(2002)
Molecular Biology of the Cell
, vol.13
, Issue.11
, pp. 4013-4028
-
-
Biernat, J.1
Wu, Y.-Z.2
Timm, T.3
Zheng-Fischhofer, Q.4
Mandelkow, E.5
Meijer, L.6
Mandelkow, E.-M.7
-
96
-
-
0346361872
-
Genetic modifiers of tauopathy in Drosophila
-
JM Shulman MB Feany 2003 Genetic modifiers of tauopathy in Drosophila Genetics 165 1233 1242
-
(2003)
Genetics
, vol.165
, pp. 1233-1242
-
-
Shulman, J.M.1
Feany, M.B.2
-
97
-
-
0031741247
-
New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
-
DP Hanger JC Betts TL Loviny WP Blackstock BH Anderton 1998 New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry J Neurochem 71 2465 2476
-
(1998)
J Neurochem
, vol.71
, pp. 2465-2476
-
-
Hanger, D.P.1
Betts, J.C.2
Loviny, T.L.3
Blackstock, W.P.4
Anderton, B.H.5
-
98
-
-
57649203362
-
Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model
-
10.1093/hmg/ddn326
-
S Chatterjee TK Sang GM Lawless GR Jackson 2009 Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model Hum Mol Genet 18 164 177 10.1093/hmg/ddn326
-
(2009)
Hum Mol Genet
, vol.18
, pp. 164-177
-
-
Chatterjee, S.1
Sang, T.K.2
Lawless, G.M.3
Jackson, G.R.4
-
100
-
-
33748174617
-
A Genomic Screen for Modifiers of Tauopathy Identifies Puromycin-Sensitive Aminopeptidase as an Inhibitor of Tau-Induced Neurodegeneration
-
DOI 10.1016/j.neuron.2006.07.019, PII S0896627306005824
-
SL Karsten TK Sang LT Gehman 2006 A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration Neuron 51 549 560 10.1016/j.neuron.2006.07.019 (Pubitemid 44314079)
-
(2006)
Neuron
, vol.51
, Issue.5
, pp. 549-560
-
-
Karsten, S.L.1
Sang, T.-K.2
Gehman, LaurenT.3
Chatterjee, S.4
Liu, J.5
Lawless, G.M.6
Sengupta, S.7
Berry, RobertW.8
Pomakian, J.9
Oh, H.S.10
Schulz, C.11
Hui, K.-S.12
Wiedau-Pazos, M.13
Vinters, H.V.14
Binder, LesterI.15
Geschwind, D.H.16
Jackson, G.R.17
-
101
-
-
33846448743
-
Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
-
DOI 10.1523/JNEUROSCI.5094-06.2007
-
JW Wang Y Imai B Lu 2007 Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1 J Neurosci 27 574 581 10.1523/JNEUROSCI.5094-06.2007 (Pubitemid 46143761)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.3
, pp. 574-581
-
-
Wang, J.-W.1
Imai, Y.2
Lu, B.3
-
102
-
-
0037174618
-
Alzheimer's disease is a synaptic failure
-
DOI 10.1126/science.1074069
-
DJ Selkoe 2002 Alzheimer's disease is a synaptic failure Science 298 789 791 10.1126/science.1074069 (Pubitemid 35231524)
-
(2002)
Science
, vol.298
, Issue.5594
, pp. 789-791
-
-
Selkoe, D.J.1
-
103
-
-
13944274830
-
Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-like protein 2
-
DOI 10.1523/JNEUROSCI.4660-04.2005
-
P Wang G Yang DR Mosier 2005 Defective neuromuscular synapses in mice lacking amyloid precursor protein (APP) and APP-Like protein 2 J Neurosci 25 1219 1225 10.1523/JNEUROSCI.4660-04.2005 (Pubitemid 40268964)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.5
, pp. 1219-1225
-
-
Wang, P.1
Yang, G.2
Mosier, D.R.3
Chang, P.4
Zaidi, T.5
Gong, Y.-D.6
Zhao, N.-M.7
Dominguez, B.8
Lee, K.-F.9
Gan, W.-B.10
Zheng, H.11
-
104
-
-
0034502319
-
Synaptic structure and function in transgenic APP mice
-
KH Ashe 2000 Synaptic structure and function in transgenic APP mice Ann N Y Acad Sci 924 39 41
-
(2000)
Ann N y Acad Sci
, vol.924
, pp. 39-41
-
-
Ashe, K.H.1
-
105
-
-
34248181511
-
Reducing endogenous tau ameliorates amyloid β-induced deficits in an Alzheimer's disease mouse model
-
DOI 10.1126/science.1141736
-
ED Roberson K Scearce-Levie JJ Palop 2007 Reducing endogenous tau ameliorates amyloid beta-induced deficits in an Alzheimer's disease mouse model Science 316 750 754 10.1126/science.1141736 (Pubitemid 46717684)
-
(2007)
Science
, vol.316
, Issue.5825
, pp. 750-754
-
-
Roberson, E.D.1
Scearce-Levie, K.2
Palop, J.J.3
Yan, F.4
Cheng, I.H.5
Wu, T.6
Gerstein, H.7
Yu, G.-Q.8
Mucke, L.9
-
106
-
-
27744600579
-
Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
-
DOI 10.1016/j.nbd.2005.05.029, PII S0969996105001622
-
FC Chee A Mudher MF Cuttle 2005 Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions Neurobiol Dis 20 918 928 10.1016/j.nbd.2005.05.029 (Pubitemid 41619367)
-
(2005)
Neurobiology of Disease
, vol.20
, Issue.3
, pp. 918-928
-
-
Chee, F.C.1
Mudher, A.2
Cuttle, M.F.3
Newman, T.A.4
MacKay, D.5
Lovestone, S.6
Shepherd, D.7
-
107
-
-
33846538660
-
Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
-
DOI 10.1016/j.neuron.2007.01.010, PII S089662730700030X
-
Y Yoshiyama M Higuchi B Zhang 2007 Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model Neuron 53 337 351 10.1016/j.neuron.2007.01.010 (Pubitemid 46161268)
-
(2007)
Neuron
, vol.53
, Issue.3
, pp. 337-351
-
-
Yoshiyama, Y.1
Higuchi, M.2
Zhang, B.3
Huang, S.-M.4
Iwata, N.5
Saido, TakaomiC.6
Maeda, J.7
Suhara, T.8
Trojanowski, J.Q.9
Lee, V.M.-Y.10
-
108
-
-
34047106848
-
Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila
-
DOI 10.1093/hmg/ddm011
-
O Blard S Feuillette J Bou 2007 Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila Hum Mol Genet 16 555 566 10.1093/hmg/ddm011 (Pubitemid 46522618)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.5
, pp. 555-566
-
-
Blard, O.1
Feuillette, S.2
Bou, J.3
Chaumette, B.4
Frebourg, T.5
Campion, D.6
Lecourtois, M.7
-
109
-
-
33846075630
-
PAR-1 Kinase Phosphorylates Dlg and Regulates Its Postsynaptic Targeting at the Drosophila Neuromuscular Junction
-
DOI 10.1016/j.neuron.2006.12.016, PII S089662730601021X
-
Y Zhang H Guo H Kwan JW Wang J Kosek B Lu 2007 par-1 kinase phosphorylates dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction Neuron 53 201 215 10.1016/j.neuron.2006.12.016 (Pubitemid 46074401)
-
(2007)
Neuron
, vol.53
, Issue.2
, pp. 201-215
-
-
Zhang, Y.1
Guo, H.2
Kwan, H.3
Wang, J.-W.4
Kosek, J.5
Lu, B.6
-
110
-
-
26944467176
-
Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses
-
DOI 10.1016/j.nbd.2005.02.008, PII S0969996105000720
-
CG Almeida D Tampellini RH Takahashi 2005 Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses Neurobiol Dis 20 187 198 10.1016/j.nbd.2005.02.008 (Pubitemid 41476246)
-
(2005)
Neurobiology of Disease
, vol.20
, Issue.2
, pp. 187-198
-
-
Almeida, C.G.1
Tampellini, D.2
Takahashi, R.H.3
Greengard, P.4
Lin, M.T.5
Snyder, E.M.6
Gouras, G.K.7
-
111
-
-
7244223228
-
Synaptic changes in Alzheimer's disease: Increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
-
KH Gylys JA Fein F Yang DJ Wiley CA Miller GM Cole 2004 Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence Am J Pathol 165 1809 1817
-
(2004)
Am J Pathol
, vol.165
, pp. 1809-1817
-
-
Gylys, K.H.1
Fein, J.A.2
Yang, F.3
Wiley, D.J.4
Miller, C.A.5
Cole, G.M.6
-
112
-
-
30644475475
-
1-40 induces NMDA-Dependent Degradation of Postsynaptic Density-95 at Glutamatergic Synapses
-
DOI 10.1523/JNEUROSCI.3034-05.2005
-
F Roselli M Tirard J Lu 2005 Soluble beta-amyloid1-40 induces NMDA-dependent degradation of postsynaptic density-95 at glutamatergic synapses J Neurosci 25 11061 11070 10.1523/JNEUROSCI.3034-05.2005 (Pubitemid 43089551)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.48
, pp. 11061-11070
-
-
Roselli, F.1
Tirard, M.2
Lu, J.3
Hutzler, P.4
Lamberti, P.5
Livrea, P.6
Morabito, M.7
Almeida, O.F.X.8
-
113
-
-
34848875120
-
Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant
-
DOI 10.1002/dneu.20532
-
D Knight K Iliadi MP Charlton HL Atwood GL Boulianne 2007 Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant Dev Neurobiol 67 1598 1613 10.1002/dneu.20532 (Pubitemid 47509697)
-
(2007)
Developmental Neurobiology
, vol.67
, Issue.12
, pp. 1598-1613
-
-
Knight, D.1
Iliadi, K.2
Charlton, M.P.3
Atwood, H.L.4
Boulianne, G.L.5
-
114
-
-
35448970692
-
Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: In vivo interaction with early-onset Alzheimer disease genes
-
DOI 10.1093/hmg/ddm219
-
A Li Z Xie Y Dong KM [tmp] McKay ML [tmp] McKee RE Tanzi 2007 Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes Hum Mol Genet 16 2626 2639 10.1093/hmg/ddm219 (Pubitemid 47617729)
-
(2007)
Human Molecular Genetics
, vol.16
, Issue.21
, pp. 2626-2639
-
-
Li, A.1
Xie, Z.2
Dong, Y.3
Mckay, K.M.4
Mckee, M.L.5
Tanzi, R.E.6
-
115
-
-
0034329159
-
Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease
-
10.1038/35039051
-
JF Gusella ME [tmp] MacDonald 2000 Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease Nat Rev Neurosci 1 109 115 10.1038/35039051
-
(2000)
Nat Rev Neurosci
, vol.1
, pp. 109-115
-
-
Gusella, J.F.1
MacDonald, M.E.2
-
116
-
-
11144305102
-
Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila
-
DOI 10.1002/glia.20098
-
D Kretzschmar J Tschape A Bettencourt Da Cruz 2005 Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila Glia 49 59 72 10.1002/glia.20098 (Pubitemid 40023653)
-
(2005)
GLIA
, vol.49
, Issue.1
, pp. 59-72
-
-
Kretzschmar, D.1
Tschape, J.2
Da Cruz, A.B.3
Asan, E.4
Poeck, B.5
Strauss, R.6
Pflugfelder, G.O.7
-
117
-
-
14644430451
-
Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
-
DOI 10.1093/hmg/ddi067
-
JC Lievens T Rival M Iche H Chneiweiss S Birman 2005 Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila Hum Mol Genet 14 713 724 10.1093/hmg/ddi067 (Pubitemid 40309596)
-
(2005)
Human Molecular Genetics
, vol.14
, Issue.5
, pp. 713-724
-
-
Liavens, J.-C.1
Rival, T.2
Iche, M.3
Chneiweiss, H.4
Birman, S.5
-
118
-
-
40549084657
-
AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease
-
DOI 10.1093/hmg/ddm360
-
JC Lievens M Iche M Laval C Faivre-Sarrailh S Birman 2008 AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease Hum Mol Genet 17 882 894 10.1093/hmg/ddm360 (Pubitemid 351359704)
-
(2008)
Human Molecular Genetics
, vol.17
, Issue.6
, pp. 882-894
-
-
Lievens, J.-C.1
Iche, M.2
Laval, M.3
Faivre-Sarrailh, C.4
Birman, S.5
-
119
-
-
35949001344
-
Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
-
DOI 10.1371/journal.pgen.0030177
-
J Bilen NM Bonini 2007 Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila PLoS Genet 3 1950 1964 10.1371/journal.pgen. 0030177 (Pubitemid 350072059)
-
(2007)
PLoS Genetics
, vol.3
, Issue.10
, pp. 1950-1964
-
-
Bilen, J.1
Bonini, N.M.2
-
120
-
-
45749147456
-
RNA toxicity is a component of ataxin-3 degeneration in Drosophila
-
DOI 10.1038/nature06909, PII NATURE06909
-
LB Li Z Yu X Teng NM Bonini 2008 RNA toxicity is a component of ataxin-3 degeneration in Drosophila Nature 453 1107 1111 10.1038/nature06909 (Pubitemid 351871727)
-
(2008)
Nature
, vol.453
, Issue.7198
, pp. 1107-1111
-
-
Li, L.-B.1
Yu, Z.2
Teng, X.3
Bonini, N.M.4
-
121
-
-
33749078547
-
MicroRNA Pathways Modulate Polyglutamine-Induced Neurodegeneration
-
DOI 10.1016/j.molcel.2006.07.030, PII S1097276506005326
-
J Bilen N Liu BG Burnett RN Pittman NM Bonini 2006 MicroRNA pathways modulate polyglutamine-induced neurodegeneration Mol Cell 24 157 163 10.1016/j.molcel.2006.07.030 (Pubitemid 44466675)
-
(2006)
Molecular Cell
, vol.24
, Issue.1
, pp. 157-163
-
-
Bilen, J.1
Liu, N.2
Burnett, B.G.3
Pittman, R.N.4
Bonini, N.M.5
-
122
-
-
0037726598
-
Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1
-
DOI 10.1016/S0092-8674(03)00349-0
-
HK Chen P Fernandez-Funez SF Acevedo 2003 Interaction of Akt-phosphorylated ataxin-1 with 14-3-3 mediates neurodegeneration in spinocerebellar ataxia type 1 Cell 113 457 468 10.1016/S0092-8674(03)00349-0 (Pubitemid 36588749)
-
(2003)
Cell
, vol.113
, Issue.4
, pp. 457-468
-
-
Chen, H.-K.1
Fernandez-Funez, P.2
Acevedo, S.F.3
Lam, Y.C.4
Kaytor, M.D.5
Fernandez, M.H.6
Aitken, A.7
Skoulakis, E.M.C.8
Orr, H.T.9
Botas, J.10
Zoghbi, H.Y.11
-
123
-
-
42049086100
-
Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
-
10.1038/nature06731
-
J Lim J Crespo-Barreto P Jafar-Nejad 2008 Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 Nature 452 713 718 10.1038/nature06731
-
(2008)
Nature
, vol.452
, pp. 713-718
-
-
Lim, J.1
Crespo-Barreto, J.2
Jafar-Nejad, P.3
-
124
-
-
40149101562
-
Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila
-
DOI 10.1371/journal.pbio.0060029
-
D Lessing NM Bonini 2008 Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila PLoS Biol 6 e29 10.1371/journal.pbio.0060029 (Pubitemid 351329048)
-
(2008)
PLoS Biology
, vol.6
, Issue.2
, pp. 0266-0274
-
-
Lessing, D.1
Bonini, N.M.2
-
125
-
-
37749039120
-
DAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1
-
10.1371/journal.pgen.0030234
-
I Al-Ramahi AM Perez J Lim 2007 dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1 PLoS Genet 3 e234 10.1371/journal.pgen.0030234
-
(2007)
PLoS Genet
, vol.3
, pp. 234
-
-
Al-Ramahi, I.1
Perez, A.M.2
Lim, J.3
-
126
-
-
34147136044
-
CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease
-
DOI 10.1126/science.1139517
-
J Jung N Bonini 2007 CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease Science 315 1857 1859 10.1126/science. 1139517 (Pubitemid 46580147)
-
(2007)
Science
, vol.315
, Issue.5820
, pp. 1857-1859
-
-
Jung, J.1
Bonini, N.2
-
127
-
-
37549004790
-
Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
-
10.1016/j.neuron.2007.11.025
-
E Romero GH Cha P Verstreken 2008 Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm Neuron 57 27 40 10.1016/j.neuron.2007.11.025
-
(2008)
Neuron
, vol.57
, pp. 27-40
-
-
Romero, E.1
Cha, G.H.2
Verstreken, P.3
-
128
-
-
54949140807
-
Protective role of engrailed in a Drosophila model of Huntington's disease
-
10.1093/hmg/ddn255
-
B Mugat ML Parmentier N Bonneaud HY Chan F Maschat 2008 Protective role of engrailed in a Drosophila model of Huntington's disease Hum Mol Genet 17 3601 3616 10.1093/hmg/ddn255
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3601-3616
-
-
Mugat, B.1
Parmentier, M.L.2
Bonneaud, N.3
Chan, H.Y.4
Maschat, F.5
-
129
-
-
44449137435
-
Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease
-
DOI 10.1139/G08-012
-
S Bahadorani AJ Hilliker 2008 Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease Genome 51 392 395 10.1139/G08-012 (Pubitemid 351768973)
-
(2008)
Genome
, vol.51
, Issue.5
, pp. 392-395
-
-
Bahadorani, S.1
Hilliker, A.J.2
-
130
-
-
53249114029
-
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
-
10.1093/hmg/ddn273
-
J Pallos L Bodai T Lukacsovich 2008 Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease Hum Mol Genet 17 3767 3775 10.1093/hmg/ddn273
-
(2008)
Hum Mol Genet
, vol.17
, pp. 3767-3775
-
-
Pallos, J.1
Bodai, L.2
Lukacsovich, T.3
-
131
-
-
34250183177
-
HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS
-
DOI 10.1038/nature05853, PII NATURE05853
-
UB Pandey Z Nie Y Batlevi 2007 HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS Nature 447 859 863 10.1038/nature05853 (Pubitemid 46920134)
-
(2007)
Nature
, vol.447
, Issue.7146
, pp. 859-863
-
-
Pandey, U.B.1
Nie, Z.2
Batlevi, Y.3
McCray, B.A.4
Ritson, G.P.5
Nedelsky, N.B.6
Schwartz, S.L.7
Diprospero, N.A.8
Knight, M.A.9
Schuldiner, O.10
Padmanabhan, R.11
Hild, M.12
Berry, D.L.13
Garza, D.14
Hubbert, C.C.15
Yao, T.-P.16
Baehrecke, E.H.17
Taylor, J.P.18
-
132
-
-
38349171781
-
Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases
-
10.1093/hmg/ddm315
-
J Branco I Al-Ramahi L Ukani 2008 Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases Hum Mol Genet 17 376 390 10.1093/hmg/ddm315
-
(2008)
Hum Mol Genet
, vol.17
, pp. 376-390
-
-
Branco, J.1
Al-Ramahi, I.2
Ukani, L.3
-
133
-
-
33847769390
-
A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes
-
DOI 10.1523/JNEUROSCI.5453-06.2007
-
M Latouche C Lasbleiz E Martin 2007 A conditional pan-neuronal Drosophila model of spinocerebellar ataxia 7 with a reversible adult phenotype suitable for identifying modifier genes J Neurosci 27 2483 2492 10.1523/JNEUROSCI.5453- 06.2007 (Pubitemid 46393606)
-
(2007)
Journal of Neuroscience
, vol.27
, Issue.10
, pp. 2483-2492
-
-
Latouche, M.1
Lasbleiz, C.2
Martin, E.3
Monnier, V.4
Debeir, T.5
Mouatt-Prigent, A.6
Muriel, M.-P.7
Morel, L.8
Ruberg, M.9
Brice, A.10
Stevanin, G.11
Tricoire, H.12
-
134
-
-
0041880131
-
RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila
-
DOI 10.1016/S0896-6273(03)00533-6
-
P Jin DC Zarnescu F Zhang 2003 RNA-mediated neurodegeneration caused by the fragile × premutation rCGG repeats in Drosophila Neuron 39 739 747 10.1016/S0896-6273(03)00533-6 (Pubitemid 37088087)
-
(2003)
Neuron
, vol.39
, Issue.5
, pp. 739-747
-
-
Jin, P.1
Zarnescu, D.C.2
Zhang, F.3
Pearson, C.E.4
Lucchesi, J.C.5
Moses, K.6
Warren, S.T.7
-
135
-
-
34547681603
-
Pur α Binds to rCGG Repeats and Modulates Repeat-Mediated Neurodegeneration in a Drosophila Model of Fragile X Tremor/Ataxia Syndrome
-
DOI 10.1016/j.neuron.2007.07.020, PII S0896627307005417
-
P Jin R Duan A Qurashi 2007 Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile × tremor/ataxia syndrome Neuron 55 556 564 10.1016/j.neuron.2007.07.020 (Pubitemid 47223639)
-
(2007)
Neuron
, vol.55
, Issue.4
, pp. 556-564
-
-
Jin, P.1
Duan, R.2
Qurashi, A.3
Qin, Y.4
Tian, D.5
Rosser, T.C.6
Liu, H.7
Feng, Y.8
Warren, S.T.9
-
136
-
-
1542380523
-
The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila
-
M Mutsuddi CM Marshall KA Benzow MD Koob I Rebay 2004 The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila Curr Biol 14 302 308
-
(2004)
Curr Biol
, vol.14
, pp. 302-308
-
-
Mutsuddi, M.1
Marshall, C.M.2
Benzow, K.A.3
Koob, M.D.4
Rebay, I.5
-
137
-
-
33845234260
-
Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome
-
DOI 10.1523/JNEUROSCI.3372-06.2006
-
BA Gavin MJ Dolph NR Deleault 2006 Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Straussler-Scheinker syndrome J Neurosci 26 12408 12414 10.1523/JNEUROSCI.3372-06.2006 (Pubitemid 44864505)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.48
, pp. 12408-12414
-
-
Gavin, B.A.1
Dolph, M.J.2
Deleault, N.R.3
Geoghegan, J.C.4
Khurana, V.5
Feany, M.B.6
Dolph, P.J.7
Supattapone, S.8
-
138
-
-
54049142949
-
A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1
-
10.1074/jbc.M804817200
-
MR Watson RD Lagow K Xu B Zhang NM Bonini 2008 A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1 J Biol Chem 283 24972 24981 10.1074/jbc.M804817200
-
(2008)
J Biol Chem
, vol.283
, pp. 24972-24981
-
-
Watson, M.R.1
Lagow, R.D.2
Xu, K.3
Zhang, B.4
Bonini, N.M.5
-
139
-
-
48449098142
-
A Drosophila model of ALS: Human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
-
10.1371/journal.pone.0002334
-
A Ratnaparkhi GM Lawless FE Schweizer P Golshani GR Jackson 2008 A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism PLoS One 3 e2334 10.1371/journal.pone.0002334
-
(2008)
PLoS One
, vol.3
, pp. 2334
-
-
Ratnaparkhi, A.1
Lawless, G.M.2
Schweizer, F.E.3
Golshani, P.4
Jackson, G.R.5
-
140
-
-
43449099127
-
The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors
-
DOI 10.1016/j.cell.2008.04.039, PII S0092867408006132
-
H Tsuda SM Han Y Yang 2008 The amyotrophic lateral sclerosis 8 protein VAPB is cleaved, secreted, and acts as a ligand for Eph receptors Cell 133 963 977 10.1016/j.cell.2008.04.039 (Pubitemid 351787741)
-
(2008)
Cell
, vol.133
, Issue.6
, pp. 963-977
-
-
Tsuda, H.1
Han, S.M.2
Yang, Y.3
Tong, C.4
Lin, Y.Q.5
Mohan, K.6
Haueter, C.7
Zoghbi, A.8
Harati, Y.9
Kwan, J.10
Miller, M.A.11
Bellen, H.J.12
-
141
-
-
52449095571
-
Modeling spinal muscular atrophy in Drosophila
-
10.1371/journal.pone.0003209
-
HC Chang DN Dimlich T Yokokura 2008 Modeling spinal muscular atrophy in Drosophila PLoS One 3 e3209 10.1371/journal.pone.0003209
-
(2008)
PLoS One
, vol.3
, pp. 3209
-
-
Chang, H.C.1
Dimlich, D.N.2
Yokokura, T.3
-
142
-
-
58949100352
-
Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways
-
RI Tuxworth V Vivancos MB O'Hare G Tear 2008 Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways Hum Mol Genet 18 4 667 678
-
(2008)
Hum Mol Genet
, vol.18
, Issue.4
, pp. 667-678
-
-
Tuxworth, R.I.1
Vivancos, V.2
O'Hare, M.B.3
Tear, G.4
|