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Volumn 14, Issue 8, 2009, Pages 1008-1020

Recent advances in using Drosophila to model neurodegenerative diseases

Author keywords

Alzheimer's disease; Amyotrophic lateral sclerosis; Batten disease; Mitochondrial dynamics; Parkinson's disease; Polyglutamine diseases; Prion disease; Spinal muscular atrophy; Synaptic dysfunction; Tauopathies

Indexed keywords

ALPHA SYNUCLEIN; DJ 1 PROTEIN; LEUCINE RICH REPEAT KINASE 2; MICRORNA; PARKIN; POLYGLUTAMINE; RNA; SIRTUIN 2;

EID: 68149154977     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-009-0347-5     Document Type: Article
Times cited : (29)

References (142)
  • 1
    • 0042035602 scopus 로고    scopus 로고
    • Human neurodegenerative disease modeling using Drosophila
    • DOI 10.1146/annurev.neuro.26.041002.131425
    • NM Bonini ME Fortini 2003 Human neurodegenerative disease modeling using Drosophila Annu Rev Neurosci 26 627 656 10.1146/annurev.neuro.26.041002.131425 (Pubitemid 37064946)
    • (2003) Annual Review of Neuroscience , vol.26 , pp. 627-656
    • Bonini, N.M.1    Fortini, M.E.2
  • 2
    • 0036514504 scopus 로고    scopus 로고
    • Modelling neurodegenerative diseases in Drosophila: A fruitful approach?
    • DOI 10.1038/nrn751
    • MM Muqit MB Feany 2002 Modelling neurodegenerative diseases in Drosophila: a fruitful approach? Nat Rev Neurosci 3 237 243 10.1038/nrn751 (Pubitemid 135706593)
    • (2002) Nature Reviews Neuroscience , vol.3 , Issue.3 , pp. 237-243
    • Muqit, M.M.K.1    Feany, M.B.2
  • 3
    • 0037373633 scopus 로고    scopus 로고
    • Dying for a cause: Invertebrate genetics takes on human neurodegeneration
    • DOI 10.1038/nrg1018
    • M Driscoll B Gerstbrein 2003 Dying for a cause: invertebrate genetics takes on human neurodegeneration Nat Rev Genet 4 181 194 10.1038/nrg1018 (Pubitemid 36267889)
    • (2003) Nature Reviews Genetics , vol.4 , Issue.3 , pp. 181-194
    • Driscoll, M.1    Gerstbrein, B.2
  • 4
    • 66149135641 scopus 로고    scopus 로고
    • Drosophila models of neurodegenerative diseases
    • B Lu H Vogel 2008 Drosophila models of neurodegenerative diseases Annu Rev Pathol 4 315 342
    • (2008) Annu Rev Pathol , vol.4 , pp. 315-342
    • Lu, B.1    Vogel, H.2
  • 6
    • 0030864464 scopus 로고    scopus 로고
    • The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila
    • D Kretzschmar G Hasan S Sharma M Heisenberg S Benzer 1997 The swiss cheese mutant causes glial hyperwrapping and brain degeneration in Drosophila J Neurosci 17 7425 7432
    • (1997) J Neurosci , vol.17 , pp. 7425-7432
    • Kretzschmar, D.1    Hasan, G.2    Sharma, S.3    Heisenberg, M.4    Benzer, S.5
  • 8
    • 0032168160 scopus 로고    scopus 로고
    • Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons
    • DOI 10.1016/S0896-6273(00)80573-5
    • GR Jackson I Salecker X Dong 1998 Polyglutamine-expanded human huntingtin transgenes induce degeneration of Drosophila photoreceptor neurons Neuron 21 633 642 10.1016/S0896-6273(00)80573-5 (Pubitemid 28475514)
    • (1998) Neuron , vol.21 , Issue.3 , pp. 633-642
    • Jackson, G.R.1    Salecker, I.2    Dong, X.3    Yao, X.4    Arnheim, N.5    Faber, P.W.6    MacDonald, M.E.7    Zipursky, S.L.8
  • 9
    • 18544392423 scopus 로고    scopus 로고
    • Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila
    • DOI 10.1016/S0092-8674(00)81200-3
    • JM Warrick HL Paulson GL Gray-Board 1998 Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila Cell 93 939 949 10.1016/S0092-8674(00)81200-3 (Pubitemid 28280788)
    • (1998) Cell , vol.93 , Issue.6 , pp. 939-949
    • Warrick, J.M.1    Paulson, H.L.2    Gray-Board, G.L.3    Bui, Q.T.4    Fischbeck, K.H.5    Pittman, R.N.6    Bonini, N.M.7
  • 10
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • DOI 10.1038/35006074
    • MB Feany WW Bender 2000 A Drosophila model of Parkinson's disease Nature 404 394 398 10.1038/35006074 (Pubitemid 30164341)
    • (2000) Nature , vol.404 , Issue.6776 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 14
    • 0037468831 scopus 로고    scopus 로고
    • Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila
    • DOI 10.1016/S0896-6273(03)00143-0
    • Y Yang I Nishimura Y Imai R Takahashi B Lu 2003 Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila Neuron 37 911 924 10.1016/S0896-6273(03)00143-0 (Pubitemid 36398298)
    • (2003) Neuron , vol.37 , Issue.6 , pp. 911-924
    • Yang, Y.1    Nishimura, I.2    Imai, Y.3    Takahashi, R.4    Lu, B.5
  • 15
    • 0034674713 scopus 로고    scopus 로고
    • Gene targeting by homologous recombination in Drosophila
    • DOI 10.1126/science.288.5473.2013
    • YS Rong KG Golic 2000 Gene targeting by homologous recombination in Drosophila Science 288 2013 2018 10.1126/science.288.5473.2013 (Pubitemid 30397675)
    • (2000) Science , vol.288 , Issue.5473 , pp. 2013-2018
    • Rong, Y.S.1    Golic, K.G.2
  • 16
    • 10044292870 scopus 로고    scopus 로고
    • Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster
    • DOI 10.1523/JNEUROSCI.2993-04.2004
    • H Coulom S Birman 2004 Chronic exposure to rotenone models sporadic Parkinson's disease in Drosophila melanogaster J Neurosci 24 10993 10998 10.1523/JNEUROSCI.2993-04.2004 (Pubitemid 39602410)
    • (2004) Journal of Neuroscience , vol.24 , Issue.48 , pp. 10993-10998
    • Coulom, H.1    Birman, S.2
  • 18
    • 0028091176 scopus 로고
    • Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease
    • 10.1002/ana.410350107
    • DT Dexter J Sian S Rose 1994 Indices of oxidative stress and mitochondrial function in individuals with incidental Lewy body disease Ann Neurol 35 38 44 10.1002/ana.410350107
    • (1994) Ann Neurol , vol.35 , pp. 38-44
    • Dexter, D.T.1    Sian, J.2    Rose, S.3
  • 19
    • 0040368216 scopus 로고    scopus 로고
    • Prospects for new restorative and neuroprotective treatments in Parkinson's disease
    • 10.1038/19899
    • SB Dunnett A Bjorklund 1999 Prospects for new restorative and neuroprotective treatments in Parkinson's disease Nature 399 A32 A39 10.1038/19899
    • (1999) Nature , vol.399
    • Dunnett, S.B.1    Bjorklund, A.2
  • 20
    • 2542458419 scopus 로고    scopus 로고
    • Chasing genes in Alzheimer's and Parkinson's disease
    • AM Bertoli-Avella BA Oostra P Heutink 2004 Chasing genes in Alzheimer's and Parkinson's disease Hum Genet 114 5 413 438
    • (2004) Hum Genet , vol.114 , Issue.5 , pp. 413-438
    • Bertoli-Avella, A.M.1    Oostra, B.A.2    Heutink, P.3
  • 21
    • 0242363670 scopus 로고    scopus 로고
    • Molecular Pathways of Neurodegeneration in Parkinson's Disease
    • DOI 10.1126/science.1087753
    • TM Dawson VL Dawson 2003 Molecular pathways of neurodegeneration in Parkinson's disease Science 302 819 822 10.1126/science.1087753 (Pubitemid 37339614)
    • (2003) Science , vol.302 , Issue.5646 , pp. 819-822
    • Dawson, T.M.1    Dawson, V.L.2
  • 29
    • 0036468432 scopus 로고    scopus 로고
    • Chaperone suppression of α-synuclein toxicity in a Drosophila model for Parkinson's disease
    • DOI 10.1126/science.1067389
    • PK Auluck HY Chan JQ Trojanowski VM Lee NM Bonini 2002 Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 865 868 10.1126/science.1067389 (Pubitemid 34118369)
    • (2002) Science , vol.295 , Issue.5556 , pp. 865-868
    • Auluck, P.K.1    Chan, H.Y.E.2    Trojanowski, J.Q.3    Lee, V.M.-Y.4    Bonini, N.M.5
  • 32
    • 10944241135 scopus 로고    scopus 로고
    • Hsp70 gene transfer by adeno-associated virusi inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease
    • DOI 10.1016/j.ymthe.2004.09.007, PII S1525001604014480
    • Z Dong DP Wolfer HP Lipp H Bueler 2005 Hsp70 gene transfer by adeno-associated virus inhibits MPTP-induced nigrostriatal degeneration in the mouse model of Parkinson disease Mol Ther 11 80 88 10.1016/j.ymthe.2004.09.007 (Pubitemid 40012001)
    • (2005) Molecular Therapy , vol.11 , Issue.1 , pp. 80-88
    • Dong, Z.1    Wolfer, D.P.2    Lipp, H.-P.3    Bueler, H.4
  • 34
    • 17844406856 scopus 로고    scopus 로고
    • α-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease
    • DOI 10.1038/nn1443
    • L Chen MB Feany 2005 Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nat Neurosci 8 657 663 10.1038/nn1443 (Pubitemid 40594208)
    • (2005) Nature Neuroscience , vol.8 , Issue.5 , pp. 657-663
    • Chen, L.1    Feany, M.B.2
  • 35
    • 33947505619 scopus 로고    scopus 로고
    • Aggregated α-synuclein mediates dopaminergic neurotoxicity in vivo
    • DOI 10.1523/JNEUROSCI.0285-07.2007
    • M Periquet T Fulga L Myllykangas MG Schlossmacher MB Feany 2007 Aggregated alpha-synuclein mediates dopaminergic neurotoxicity in vivo J Neurosci 27 3338 3346 10.1523/JNEUROSCI.0285-07.2007 (Pubitemid 46474139)
    • (2007) Journal of Neuroscience , vol.27 , Issue.12 , pp. 3338-3346
    • Periquet, M.1    Fulga, T.2    Myllykangas, L.3    Schlossmacher, M.G.4    Feany, M.B.5
  • 37
    • 40849130108 scopus 로고    scopus 로고
    • Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease
    • 10.1016/j.nbd.2007.11.013
    • JA Botella F Bayersdorfer S Schneuwly 2008 Superoxide dismutase overexpression protects dopaminergic neurons in a Drosophila model of Parkinson's disease Neurobiol Dis 30 65 73 10.1016/j.nbd.2007.11.013
    • (2008) Neurobiol Dis , vol.30 , pp. 65-73
    • Botella, J.A.1    Bayersdorfer, F.2    Schneuwly, S.3
  • 39
    • 0141841634 scopus 로고    scopus 로고
    • Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease
    • DOI 10.1093/hmg/ddg265
    • CR Scherzer RV Jensen SR Gullans MB Feany 2003 Gene expression changes presage neurodegeneration in a Drosophila model of Parkinson's disease Hum Mol Genet 12 2457 2466 10.1093/hmg/ddg265 (Pubitemid 37220410)
    • (2003) Human Molecular Genetics , vol.12 , Issue.19 , pp. 2457-2466
    • Scherzer, C.R.1    Jensen, R.V.2    Gullans, S.R.3    Feany, M.B.4
  • 40
    • 47849083301 scopus 로고    scopus 로고
    • Quantitative proteomics of a presymptomatic A53T α-synuclein Drosophila model of Parkinson disease
    • DOI 10.1074/mcp.M700467-MCP200
    • Z Xun RA Sowell TC Kaufman DE Clemmer 2008 Quantitative proteomics of a presymptomatic A53T alpha-synuclein Drosophila model of Parkinson disease Mol Cell Proteomics 7 1191 1203 10.1074/mcp.M700467-MCP200 (Pubitemid 352038266)
    • (2008) Molecular and Cellular Proteomics , vol.7 , Issue.7 , pp. 1191-1203
    • Xun, Z.1    Sowell, R.A.2    Kaufman, T.C.3    Clemmer, D.E.4
  • 43
    • 0035967883 scopus 로고    scopus 로고
    • An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin
    • DOI 10.1016/S0092-8674(01)00407-X
    • Y Imai M Soda H Inoue N Hattori Y Mizuno R Takahashi 2001 An unfolded putative transmembrane polypeptide, which can lead to endoplasmic reticulum stress, is a substrate of Parkin Cell 105 891 902 10.1016/S0092-8674(01)00407-X (Pubitemid 32635090)
    • (2001) Cell , vol.105 , Issue.7 , pp. 891-902
    • Imai, Y.1    Soda, M.2    Inoue, H.3    Hattori, N.4    Mizuno, Y.5    Takahashi, R.6
  • 46
    • 34547885021 scopus 로고    scopus 로고
    • Drosophila overexpressing parkin R275W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities
    • DOI 10.1523/JNEUROSCI.0218-07.2007
    • C Wang R Lu X Ouyang 2007 Drosophila overexpressing parkin R275 W mutant exhibits dopaminergic neuron degeneration and mitochondrial abnormalities J Neurosci 27 8563 8570 10.1523/JNEUROSCI.0218-07.2007 (Pubitemid 47254271)
    • (2007) Journal of Neuroscience , vol.27 , Issue.32 , pp. 8563-8570
    • Wang, C.1    Lu, R.2    Ouyang, X.3    Ho, M.W.L.4    Chia, W.5    Yu, F.6    Lim, K.-L.7
  • 47
    • 33745589773 scopus 로고    scopus 로고
    • Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin
    • DOI 10.1038/nature04779, PII N04779
    • IE Clark MW Dodson C Jiang 2006 Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin Nature 441 1162 1166 10.1038/nature04779 (Pubitemid 43990738)
    • (2006) Nature , vol.441 , Issue.7097 , pp. 1162-1166
    • Clark, I.E.1    Dodson, M.W.2    Jiang, C.3    Cao, J.H.4    Huh, J.R.5    Seol, J.H.6    Yoo, S.J.7    Hay, B.A.8    Guo, M.9
  • 51
    • 56049091236 scopus 로고    scopus 로고
    • PINK1 controls mitochondrial localization of Parkin through direct phosphorylation
    • 10.1016/j.bbrc.2008.10.104
    • Y Kim J Park S Kim 2008 PINK1 controls mitochondrial localization of Parkin through direct phosphorylation Biochem Biophys Res Commun 377 975 980 10.1016/j.bbrc.2008.10.104
    • (2008) Biochem Biophys Res Commun , vol.377 , pp. 975-980
    • Kim, Y.1    Park, J.2    Kim, S.3
  • 54
    • 55749090654 scopus 로고    scopus 로고
    • The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
    • 10.1073/pnas.0803998105
    • H Deng MW Dodson H Huang M Guo 2008 The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila Proc Natl Acad Sci USA 105 14503 14508 10.1073/pnas.0803998105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14503-14508
    • Deng, H.1    Dodson, M.W.2    Huang, H.3    Guo, M.4
  • 55
    • 57749194390 scopus 로고    scopus 로고
    • The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process
    • 10.1016/j.bbrc.2008.11.086
    • J Park G Lee J Chung 2009 The PINK1-Parkin pathway is involved in the regulation of mitochondrial remodeling process Biochem Biophys Res Commun 378 518 523 10.1016/j.bbrc.2008.11.086
    • (2009) Biochem Biophys Res Commun , vol.378 , pp. 518-523
    • Park, J.1    Lee, G.2    Chung, J.3
  • 56
    • 33745274726 scopus 로고    scopus 로고
    • Mitochondria: Dynamic Organelles in Disease, Aging, and Development
    • DOI 10.1016/j.cell.2006.06.010, PII S0092867406007689
    • DC Chan 2006 Mitochondria: dynamic organelles in disease, aging, and development Cell 125 1241 1252 10.1016/j.cell.2006.06.010 (Pubitemid 43929096)
    • (2006) Cell , vol.125 , Issue.7 , pp. 1241-1252
    • Chan, D.C.1
  • 57
    • 10944269186 scopus 로고    scopus 로고
    • The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses
    • DOI 10.1016/j.cell.2004.11.003, PII S0092867404010451
    • Z Li K Okamoto Y Hayashi M Sheng 2004 The importance of dendritic mitochondria in the morphogenesis and plasticity of spines and synapses Cell 119 873 887 10.1016/j.cell.2004.11.003 (Pubitemid 40017692)
    • (2004) Cell , vol.119 , Issue.6 , pp. 873-887
    • Li, Z.1    Okamoto, K.-I.2    Hayashi, Y.3    Sheng, M.4
  • 60
    • 0017187807 scopus 로고
    • Biochemical adaptations for flight in the insect
    • B Sacktor 1976 Biochemical adaptations for flight in the insect Biochem Soc Symp 41 111 131
    • (1976) Biochem Soc Symp , vol.41 , pp. 111-131
    • Sacktor, B.1
  • 61
    • 36248929304 scopus 로고    scopus 로고
    • Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by α-synuclein
    • DOI 10.1111/j.1460-9568.2007.05929.x
    • SS Park EM Schulz D Lee 2007 Disruption of dopamine homeostasis underlies selective neurodegeneration mediated by alpha-synuclein Eur J Neurosci 26 3104 3112 10.1111/j.1460-9568.2007.05929.x (Pubitemid 350135175)
    • (2007) European Journal of Neuroscience , vol.26 , Issue.11 , pp. 3104-3112
    • Park, S.S.1    Schulz, E.M.2    Lee, D.3
  • 63
    • 24044506249 scopus 로고    scopus 로고
    • Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress
    • DOI 10.1016/j.cub.2005.07.036, PII S0960982205007918
    • FM Menzies SC Yenisetti KT Min 2005 Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress Curr Biol 15 1578 1582 10.1016/j.cub.2005.07.036 (Pubitemid 41219598)
    • (2005) Current Biology , vol.15 , Issue.17 , pp. 1578-1582
    • Menzies, F.M.1    Yenisetti, S.C.2    Min, K.-T.3
  • 66
    • 48249145149 scopus 로고    scopus 로고
    • RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways
    • 10.1073/pnas.0708518105
    • MP van der Brug J Blackinton J Chandran 2008 RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways Proc Natl Acad Sci USA 105 10244 10249 10.1073/pnas.0708518105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 10244-10249
    • Van Der Brug, M.P.1    Blackinton, J.2    Chandran, J.3
  • 67
    • 34248574535 scopus 로고    scopus 로고
    • Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila
    • DOI 10.1016/j.bbrc.2007.04.156, PII S0006291X07008972
    • SB Lee W Kim S Lee J Chung 2007 Loss of LRRK2/PARK8 induces degeneration of dopaminergic neurons in Drosophila Biochem Biophys Res Commun 358 534 539 10.1016/j.bbrc.2007.04.156 (Pubitemid 46755736)
    • (2007) Biochemical and Biophysical Research Communications , vol.358 , Issue.2 , pp. 534-539
    • Lee, S.B.1    Kim, W.2    Lee, S.3    Chung, J.4
  • 68
    • 40649108102 scopus 로고    scopus 로고
    • A Drosophila model for LRRK2-linked parkinsonism
    • 10.1073/pnas.0708452105
    • Z Liu X Wang Y Yu 2008 A Drosophila model for LRRK2-linked parkinsonism Proc Natl Acad Sci USA 105 2693 2698 10.1073/pnas.0708452105
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 2693-2698
    • Liu, Z.1    Wang, X.2    Yu, Y.3
  • 69
    • 51949090816 scopus 로고    scopus 로고
    • Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila
    • 10.1038/emboj.2008.163
    • Y Imai S Gehrke HQ Wang 2008 Phosphorylation of 4E-BP by LRRK2 affects the maintenance of dopaminergic neurons in Drosophila EMBO J 27 2432 2443 10.1038/emboj.2008.163
    • (2008) EMBO J , vol.27 , pp. 2432-2443
    • Imai, Y.1    Gehrke, S.2    Wang, H.Q.3
  • 70
    • 0037431082 scopus 로고    scopus 로고
    • Aph-1, Pen-2, and Nicastrin with Presenilin generate an active γ-Secretase complex
    • DOI 10.1016/S0896-6273(03)00205-8
    • B De Strooper 2003 Aph-1, Pen-2, and nicastrin with presenilin generate an active γ-secretase complex Neuron 38 9 12 10.1016/S0896-6273(03)00205-8 (Pubitemid 36423348)
    • (2003) Neuron , vol.38 , Issue.1 , pp. 9-12
    • De Strooper, B.1
  • 71
    • 0017649032 scopus 로고
    • Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin
    • 10.1016/0022-2836(77)90213-3
    • DW Cleveland SY Hwo MW Kirschner 1977 Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin J Mol Biol 116 207 225 10.1016/0022-2836(77)90213-3
    • (1977) J Mol Biol , vol.116 , pp. 207-225
    • Cleveland, D.W.1    Hwo, S.Y.2    Kirschner, M.W.3
  • 72
    • 0022744803 scopus 로고
    • Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology
    • 10.1073/pnas.83.13.4913
    • I Grundke-Iqbal K Iqbal YC Tung M Quinlan HM Wisniewski LI Binder 1986 Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology Proc Natl Acad Sci USA 83 4913 4917 10.1073/pnas.83.13.4913
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 4913-4917
    • Grundke-Iqbal, I.1    Iqbal, K.2    Tung, Y.C.3    Quinlan, M.4    Wisniewski, H.M.5    Binder, L.I.6
  • 73
    • 0025292866 scopus 로고
    • A preparation of Alzheimer paired helical filaments that displays distinct τ proteins by polyacrylamide gel electrophoresis
    • DOI 10.1073/pnas.87.15.5827
    • SG Greenberg P Davies 1990 A preparation of Alzheimer paired helical filaments that displays distinct tau proteins by polyacrylamide gel electrophoresis Proc Natl Acad Sci USA 87 5827 5831 10.1073/pnas.87.15.5827 (Pubitemid 20240381)
    • (1990) Proceedings of the National Academy of Sciences of the United States of America , vol.87 , Issue.15 , pp. 5827-5831
    • Greenberg, S.G.1    Davies, P.2
  • 74
    • 0025904444 scopus 로고
    • A68: A major subunit of paired helical filaments and derivatized forms of normal Tau
    • 10.1126/science.1899488
    • VM Lee BJ Balin L Otvos Jr JQ Trojanowski 1991 A68: a major subunit of paired helical filaments and derivatized forms of normal Tau Science 251 675 678 10.1126/science.1899488
    • (1991) Science , vol.251 , pp. 675-678
    • Lee, V.M.1    Balin, B.J.2    Otvos Jr, L.3    Trojanowski, J.Q.4
  • 75
    • 0030977392 scopus 로고    scopus 로고
    • Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference
    • DOI 10.1002/ana.410410606
    • NL Foster K Wilhelmsen AA Sima MZ Jones CJ D'Amato S Gilman 1997 Frontotemporal dementia and parkinsonism linked to chromosome 17: a consensus conference. Conference participants Ann Neurol 41 706 715 10.1002/ana.410410606 (Pubitemid 27249175)
    • (1997) Annals of Neurology , vol.41 , Issue.6 , pp. 706-715
    • Foster, N.L.1    Wilhelmsen, K.2    Sima, A.A.F.3    Jones, M.Z.4    D'Amato, C.J.5    Gilman, S.6
  • 79
    • 0026783241 scopus 로고
    • Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene
    • 10.1016/0896-6273(92)90024-8
    • L Luo T Tully K White 1992 Human amyloid precursor protein ameliorates behavioral deficit of flies deleted for Appl gene Neuron 9 595 605 10.1016/0896-6273(92)90024-8
    • (1992) Neuron , vol.9 , pp. 595-605
    • Luo, L.1    Tully, T.2    White, K.3
  • 80
    • 58149503769 scopus 로고    scopus 로고
    • Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function
    • K Carmine-Simmen T Proctor J Tschape 2008 Neurotoxic effects induced by the Drosophila amyloid-beta peptide suggest a conserved toxic function Neurobiol Dis 33 2 274 281
    • (2008) Neurobiol Dis , vol.33 , Issue.2 , pp. 274-281
    • Carmine-Simmen, K.1    Proctor, T.2    Tschape, J.3
  • 81
    • 3242809725 scopus 로고    scopus 로고
    • A model for studying Alzheimer's Aβ42-induced toxicity in Drosophila melanogaster
    • DOI 10.1016/j.mcn.2004.03.001, PII S1044743104000521
    • A Finelli A Kelkar HJ Song H Yang M Konsolaki 2004 A model for studying Alzheimer's Abeta42-induced toxicity in Drosophila melanogaster Mol Cell Neurosci 26 365 375 10.1016/j.mcn.2004.03.001 (Pubitemid 38968431)
    • (2004) Molecular and Cellular Neuroscience , vol.26 , Issue.3 , pp. 365-375
    • Finelli, A.1    Kelkar, A.2    Song, H.-J.3    Yang, H.4    Konsolaki, M.5
  • 83
    • 54949151536 scopus 로고    scopus 로고
    • Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides
    • 10.1093/hmg/ddn240
    • GB Stokin A Almenar-Queralt S Gunawardena 2008 Amyloid precursor protein-induced axonopathies are independent of amyloid-beta peptides Hum Mol Genet 17 3474 3486 10.1093/hmg/ddn240
    • (2008) Hum Mol Genet , vol.17 , pp. 3474-3486
    • Stokin, G.B.1    Almenar-Queralt, A.2    Gunawardena, S.3
  • 84
    • 58049196869 scopus 로고    scopus 로고
    • The Toll - >nFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila
    • 10.1371/journal.pone.0003966
    • L Tan P Schedl HJ Song D Garza M Konsolaki 2008 The Toll - >NFkappaB signaling pathway mediates the neuropathological effects of the human Alzheimer's Abeta42 polypeptide in Drosophila PLoS One 3 e3966 10.1371/journal.pone.0003966
    • (2008) PLoS One , vol.3 , pp. 3966
    • Tan, L.1    Schedl, P.2    Song, H.J.3    Garza, D.4    Konsolaki, M.5
  • 85
    • 49649123892 scopus 로고    scopus 로고
    • Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila
    • 10.1074/jbc.M710509200
    • K Iijima-Ando SA Hearn L Granger 2008 Overexpression of neprilysin reduces alzheimer amyloid-beta42 (Abeta42)-induced neuron loss and intraneuronal Abeta42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila J Biol Chem 283 19066 19076 10.1074/jbc.M710509200
    • (2008) J Biol Chem , vol.283 , pp. 19066-19076
    • Iijima-Ando, K.1    Hearn, S.A.2    Granger, L.3
  • 86
    • 0034716223 scopus 로고    scopus 로고
    • Tau and tau reporters disrupt central projections of sensory neurons in Drosophila
    • 10.1002/1096-9861(20001225)428:4?630::AID-CNE4?3.0.CO;2-X
    • DW Williams M Tyrer D Shepherd 2000 Tau and tau reporters disrupt central projections of sensory neurons in Drosophila J Comp Neurol 428 630 640 10.1002/1096-9861(20001225)428:4?630::AID-CNE4?3.0.CO;2-X
    • (2000) J Comp Neurol , vol.428 , pp. 630-640
    • Williams, D.W.1    Tyrer, M.2    Shepherd, D.3
  • 87
    • 0035958642 scopus 로고    scopus 로고
    • Tauopathy in Drosophila: Neurodegeneration without neurofibrillary tangles
    • 10.1126/science.1062382
    • CW Wittmann MF Wszolek JM Shulman 2001 Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles Science 293 711 714 10.1126/science.1062382
    • (2001) Science , vol.293 , pp. 711-714
    • Wittmann, C.W.1    Wszolek, M.F.2    Shulman, J.M.3
  • 88
    • 0037118247 scopus 로고    scopus 로고
    • Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila
    • DOI 10.1016/S0896-6273(02)00706-7
    • GR Jackson M Wiedau-Pazos TK Sang 2002 Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila Neuron 34 509 519 10.1016/S0896-6273(02)00706-7 (Pubitemid 34628749)
    • (2002) Neuron , vol.34 , Issue.4 , pp. 509-519
    • Jackson, G.R.1    Wiedau-Pazos, M.2    Sang, T.-K.3    Wagle, N.4    Brown, C.A.5    Massachi, S.6    Geschwind, D.H.7
  • 91
    • 1542358895 scopus 로고    scopus 로고
    • PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila
    • DOI 10.1016/S0092-8674(04)00170-9, PII S0092867404001709
    • I Nishimura Y Yang B Lu 2004 PAR-1 kinase plays an initiator role in a temporally ordered phosphorylation process that confers tau toxicity in Drosophila Cell 116 671 682 10.1016/S0092-8674(04)00170-9 (Pubitemid 38326726)
    • (2004) Cell , vol.116 , Issue.5 , pp. 671-682
    • Nishimura, I.1    Yang, Y.2    Lu, B.3
  • 92
    • 0029024475 scopus 로고
    • Par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed
    • 10.1016/0092-8674(95)90082-9
    • S Guo KJ Kemphues 1995 par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed Cell 81 611 620 10.1016/0092-8674(95)90082-9
    • (1995) Cell , vol.81 , pp. 611-620
    • Guo, S.1    Kemphues, K.J.2
  • 93
    • 0030969575 scopus 로고    scopus 로고
    • MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption
    • 10.1016/S0092-8674(00)80208-1
    • G Drewes A Ebneth U Preuss EM Mandelkow E Mandelkow 1997 MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption Cell 89 297 308 10.1016/S0092-8674(00)80208-1
    • (1997) Cell , vol.89 , pp. 297-308
    • Drewes, G.1    Ebneth, A.2    Preuss, U.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 94
    • 0031213571 scopus 로고    scopus 로고
    • Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity
    • 10.1016/S0960-9822(06)00260-0
    • H Bohm V Brinkmann M Drab A Henske TV Kurzchalia 1997 Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity Curr Biol 7 603 606 10.1016/S0960-9822(06) 00260-0
    • (1997) Curr Biol , vol.7 , pp. 603-606
    • Bohm, H.1    Brinkmann, V.2    Drab, M.3    Henske, A.4    Kurzchalia, T.V.5
  • 96
    • 0346361872 scopus 로고    scopus 로고
    • Genetic modifiers of tauopathy in Drosophila
    • JM Shulman MB Feany 2003 Genetic modifiers of tauopathy in Drosophila Genetics 165 1233 1242
    • (2003) Genetics , vol.165 , pp. 1233-1242
    • Shulman, J.M.1    Feany, M.B.2
  • 97
    • 0031741247 scopus 로고    scopus 로고
    • New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry
    • DP Hanger JC Betts TL Loviny WP Blackstock BH Anderton 1998 New phosphorylation sites identified in hyperphosphorylated tau (paired helical filament-tau) from Alzheimer's disease brain using nanoelectrospray mass spectrometry J Neurochem 71 2465 2476
    • (1998) J Neurochem , vol.71 , pp. 2465-2476
    • Hanger, D.P.1    Betts, J.C.2    Loviny, T.L.3    Blackstock, W.P.4    Anderton, B.H.5
  • 98
    • 57649203362 scopus 로고    scopus 로고
    • Dissociation of tau toxicity and phosphorylation: Role of GSK-3beta, MARK and Cdk5 in a Drosophila model
    • 10.1093/hmg/ddn326
    • S Chatterjee TK Sang GM Lawless GR Jackson 2009 Dissociation of tau toxicity and phosphorylation: role of GSK-3beta, MARK and Cdk5 in a Drosophila model Hum Mol Genet 18 164 177 10.1093/hmg/ddn326
    • (2009) Hum Mol Genet , vol.18 , pp. 164-177
    • Chatterjee, S.1    Sang, T.K.2    Lawless, G.M.3    Jackson, G.R.4
  • 101
    • 33846448743 scopus 로고    scopus 로고
    • Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1
    • DOI 10.1523/JNEUROSCI.5094-06.2007
    • JW Wang Y Imai B Lu 2007 Activation of PAR-1 kinase and stimulation of tau phosphorylation by diverse signals require the tumor suppressor protein LKB1 J Neurosci 27 574 581 10.1523/JNEUROSCI.5094-06.2007 (Pubitemid 46143761)
    • (2007) Journal of Neuroscience , vol.27 , Issue.3 , pp. 574-581
    • Wang, J.-W.1    Imai, Y.2    Lu, B.3
  • 102
    • 0037174618 scopus 로고    scopus 로고
    • Alzheimer's disease is a synaptic failure
    • DOI 10.1126/science.1074069
    • DJ Selkoe 2002 Alzheimer's disease is a synaptic failure Science 298 789 791 10.1126/science.1074069 (Pubitemid 35231524)
    • (2002) Science , vol.298 , Issue.5594 , pp. 789-791
    • Selkoe, D.J.1
  • 104
    • 0034502319 scopus 로고    scopus 로고
    • Synaptic structure and function in transgenic APP mice
    • KH Ashe 2000 Synaptic structure and function in transgenic APP mice Ann N Y Acad Sci 924 39 41
    • (2000) Ann N y Acad Sci , vol.924 , pp. 39-41
    • Ashe, K.H.1
  • 105
  • 106
    • 27744600579 scopus 로고    scopus 로고
    • Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions
    • DOI 10.1016/j.nbd.2005.05.029, PII S0969996105001622
    • FC Chee A Mudher MF Cuttle 2005 Over-expression of tau results in defective synaptic transmission in Drosophila neuromuscular junctions Neurobiol Dis 20 918 928 10.1016/j.nbd.2005.05.029 (Pubitemid 41619367)
    • (2005) Neurobiology of Disease , vol.20 , Issue.3 , pp. 918-928
    • Chee, F.C.1    Mudher, A.2    Cuttle, M.F.3    Newman, T.A.4    MacKay, D.5    Lovestone, S.6    Shepherd, D.7
  • 109
    • 33846075630 scopus 로고    scopus 로고
    • PAR-1 Kinase Phosphorylates Dlg and Regulates Its Postsynaptic Targeting at the Drosophila Neuromuscular Junction
    • DOI 10.1016/j.neuron.2006.12.016, PII S089662730601021X
    • Y Zhang H Guo H Kwan JW Wang J Kosek B Lu 2007 par-1 kinase phosphorylates dlg and regulates its postsynaptic targeting at the Drosophila neuromuscular junction Neuron 53 201 215 10.1016/j.neuron.2006.12.016 (Pubitemid 46074401)
    • (2007) Neuron , vol.53 , Issue.2 , pp. 201-215
    • Zhang, Y.1    Guo, H.2    Kwan, H.3    Wang, J.-W.4    Kosek, J.5    Lu, B.6
  • 111
    • 7244223228 scopus 로고    scopus 로고
    • Synaptic changes in Alzheimer's disease: Increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence
    • KH Gylys JA Fein F Yang DJ Wiley CA Miller GM Cole 2004 Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence Am J Pathol 165 1809 1817
    • (2004) Am J Pathol , vol.165 , pp. 1809-1817
    • Gylys, K.H.1    Fein, J.A.2    Yang, F.3    Wiley, D.J.4    Miller, C.A.5    Cole, G.M.6
  • 113
    • 34848875120 scopus 로고    scopus 로고
    • Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant
    • DOI 10.1002/dneu.20532
    • D Knight K Iliadi MP Charlton HL Atwood GL Boulianne 2007 Presynaptic plasticity and associative learning are impaired in a Drosophila presenilin null mutant Dev Neurobiol 67 1598 1613 10.1002/dneu.20532 (Pubitemid 47509697)
    • (2007) Developmental Neurobiology , vol.67 , Issue.12 , pp. 1598-1613
    • Knight, D.1    Iliadi, K.2    Charlton, M.P.3    Atwood, H.L.4    Boulianne, G.L.5
  • 114
    • 35448970692 scopus 로고    scopus 로고
    • Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: In vivo interaction with early-onset Alzheimer disease genes
    • DOI 10.1093/hmg/ddm219
    • A Li Z Xie Y Dong KM [tmp] McKay ML [tmp] McKee RE Tanzi 2007 Isolation and characterization of the Drosophila ubiquilin ortholog dUbqln: in vivo interaction with early-onset Alzheimer disease genes Hum Mol Genet 16 2626 2639 10.1093/hmg/ddm219 (Pubitemid 47617729)
    • (2007) Human Molecular Genetics , vol.16 , Issue.21 , pp. 2626-2639
    • Li, A.1    Xie, Z.2    Dong, Y.3    Mckay, K.M.4    Mckee, M.L.5    Tanzi, R.E.6
  • 115
    • 0034329159 scopus 로고    scopus 로고
    • Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease
    • 10.1038/35039051
    • JF Gusella ME [tmp] MacDonald 2000 Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease Nat Rev Neurosci 1 109 115 10.1038/35039051
    • (2000) Nat Rev Neurosci , vol.1 , pp. 109-115
    • Gusella, J.F.1    MacDonald, M.E.2
  • 116
    • 11144305102 scopus 로고    scopus 로고
    • Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila
    • DOI 10.1002/glia.20098
    • D Kretzschmar J Tschape A Bettencourt Da Cruz 2005 Glial and neuronal expression of polyglutamine proteins induce behavioral changes and aggregate formation in Drosophila Glia 49 59 72 10.1002/glia.20098 (Pubitemid 40023653)
    • (2005) GLIA , vol.49 , Issue.1 , pp. 59-72
    • Kretzschmar, D.1    Tschape, J.2    Da Cruz, A.B.3    Asan, E.4    Poeck, B.5    Strauss, R.6    Pflugfelder, G.O.7
  • 117
    • 14644430451 scopus 로고    scopus 로고
    • Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila
    • DOI 10.1093/hmg/ddi067
    • JC Lievens T Rival M Iche H Chneiweiss S Birman 2005 Expanded polyglutamine peptides disrupt EGF receptor signaling and glutamate transporter expression in Drosophila Hum Mol Genet 14 713 724 10.1093/hmg/ddi067 (Pubitemid 40309596)
    • (2005) Human Molecular Genetics , vol.14 , Issue.5 , pp. 713-724
    • Liavens, J.-C.1    Rival, T.2    Iche, M.3    Chneiweiss, H.4    Birman, S.5
  • 118
    • 40549084657 scopus 로고    scopus 로고
    • AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease
    • DOI 10.1093/hmg/ddm360
    • JC Lievens M Iche M Laval C Faivre-Sarrailh S Birman 2008 AKT-sensitive or insensitive pathways of toxicity in glial cells and neurons in Drosophila models of Huntington's disease Hum Mol Genet 17 882 894 10.1093/hmg/ddm360 (Pubitemid 351359704)
    • (2008) Human Molecular Genetics , vol.17 , Issue.6 , pp. 882-894
    • Lievens, J.-C.1    Iche, M.2    Laval, M.3    Faivre-Sarrailh, C.4    Birman, S.5
  • 119
    • 35949001344 scopus 로고    scopus 로고
    • Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila
    • DOI 10.1371/journal.pgen.0030177
    • J Bilen NM Bonini 2007 Genome-wide screen for modifiers of ataxin-3 neurodegeneration in Drosophila PLoS Genet 3 1950 1964 10.1371/journal.pgen. 0030177 (Pubitemid 350072059)
    • (2007) PLoS Genetics , vol.3 , Issue.10 , pp. 1950-1964
    • Bilen, J.1    Bonini, N.M.2
  • 120
    • 45749147456 scopus 로고    scopus 로고
    • RNA toxicity is a component of ataxin-3 degeneration in Drosophila
    • DOI 10.1038/nature06909, PII NATURE06909
    • LB Li Z Yu X Teng NM Bonini 2008 RNA toxicity is a component of ataxin-3 degeneration in Drosophila Nature 453 1107 1111 10.1038/nature06909 (Pubitemid 351871727)
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1107-1111
    • Li, L.-B.1    Yu, Z.2    Teng, X.3    Bonini, N.M.4
  • 121
    • 33749078547 scopus 로고    scopus 로고
    • MicroRNA Pathways Modulate Polyglutamine-Induced Neurodegeneration
    • DOI 10.1016/j.molcel.2006.07.030, PII S1097276506005326
    • J Bilen N Liu BG Burnett RN Pittman NM Bonini 2006 MicroRNA pathways modulate polyglutamine-induced neurodegeneration Mol Cell 24 157 163 10.1016/j.molcel.2006.07.030 (Pubitemid 44466675)
    • (2006) Molecular Cell , vol.24 , Issue.1 , pp. 157-163
    • Bilen, J.1    Liu, N.2    Burnett, B.G.3    Pittman, R.N.4    Bonini, N.M.5
  • 123
    • 42049086100 scopus 로고    scopus 로고
    • Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1
    • 10.1038/nature06731
    • J Lim J Crespo-Barreto P Jafar-Nejad 2008 Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1 Nature 452 713 718 10.1038/nature06731
    • (2008) Nature , vol.452 , pp. 713-718
    • Lim, J.1    Crespo-Barreto, J.2    Jafar-Nejad, P.3
  • 124
    • 40149101562 scopus 로고    scopus 로고
    • Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila
    • DOI 10.1371/journal.pbio.0060029
    • D Lessing NM Bonini 2008 Polyglutamine genes interact to modulate the severity and progression of neurodegeneration in Drosophila PLoS Biol 6 e29 10.1371/journal.pbio.0060029 (Pubitemid 351329048)
    • (2008) PLoS Biology , vol.6 , Issue.2 , pp. 0266-0274
    • Lessing, D.1    Bonini, N.M.2
  • 125
    • 37749039120 scopus 로고    scopus 로고
    • DAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1
    • 10.1371/journal.pgen.0030234
    • I Al-Ramahi AM Perez J Lim 2007 dAtaxin-2 mediates expanded Ataxin-1-induced neurodegeneration in a Drosophila model of SCA1 PLoS Genet 3 e234 10.1371/journal.pgen.0030234
    • (2007) PLoS Genet , vol.3 , pp. 234
    • Al-Ramahi, I.1    Perez, A.M.2    Lim, J.3
  • 126
    • 34147136044 scopus 로고    scopus 로고
    • CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease
    • DOI 10.1126/science.1139517
    • J Jung N Bonini 2007 CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease Science 315 1857 1859 10.1126/science. 1139517 (Pubitemid 46580147)
    • (2007) Science , vol.315 , Issue.5820 , pp. 1857-1859
    • Jung, J.1    Bonini, N.2
  • 127
    • 37549004790 scopus 로고    scopus 로고
    • Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm
    • 10.1016/j.neuron.2007.11.025
    • E Romero GH Cha P Verstreken 2008 Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasm Neuron 57 27 40 10.1016/j.neuron.2007.11.025
    • (2008) Neuron , vol.57 , pp. 27-40
    • Romero, E.1    Cha, G.H.2    Verstreken, P.3
  • 128
    • 54949140807 scopus 로고    scopus 로고
    • Protective role of engrailed in a Drosophila model of Huntington's disease
    • 10.1093/hmg/ddn255
    • B Mugat ML Parmentier N Bonneaud HY Chan F Maschat 2008 Protective role of engrailed in a Drosophila model of Huntington's disease Hum Mol Genet 17 3601 3616 10.1093/hmg/ddn255
    • (2008) Hum Mol Genet , vol.17 , pp. 3601-3616
    • Mugat, B.1    Parmentier, M.L.2    Bonneaud, N.3    Chan, H.Y.4    Maschat, F.5
  • 129
    • 44449137435 scopus 로고    scopus 로고
    • Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease
    • DOI 10.1139/G08-012
    • S Bahadorani AJ Hilliker 2008 Antioxidants cannot suppress the lethal phenotype of a Drosophila melanogaster model of Huntington's disease Genome 51 392 395 10.1139/G08-012 (Pubitemid 351768973)
    • (2008) Genome , vol.51 , Issue.5 , pp. 392-395
    • Bahadorani, S.1    Hilliker, A.J.2
  • 130
    • 53249114029 scopus 로고    scopus 로고
    • Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease
    • 10.1093/hmg/ddn273
    • J Pallos L Bodai T Lukacsovich 2008 Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease Hum Mol Genet 17 3767 3775 10.1093/hmg/ddn273
    • (2008) Hum Mol Genet , vol.17 , pp. 3767-3775
    • Pallos, J.1    Bodai, L.2    Lukacsovich, T.3
  • 132
    • 38349171781 scopus 로고    scopus 로고
    • Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases
    • 10.1093/hmg/ddm315
    • J Branco I Al-Ramahi L Ukani 2008 Comparative analysis of genetic modifiers in Drosophila points to common and distinct mechanisms of pathogenesis among polyglutamine diseases Hum Mol Genet 17 376 390 10.1093/hmg/ddm315
    • (2008) Hum Mol Genet , vol.17 , pp. 376-390
    • Branco, J.1    Al-Ramahi, I.2    Ukani, L.3
  • 134
    • 0041880131 scopus 로고    scopus 로고
    • RNA-mediated neurodegeneration caused by the fragile X premutation rCGG repeats in Drosophila
    • DOI 10.1016/S0896-6273(03)00533-6
    • P Jin DC Zarnescu F Zhang 2003 RNA-mediated neurodegeneration caused by the fragile × premutation rCGG repeats in Drosophila Neuron 39 739 747 10.1016/S0896-6273(03)00533-6 (Pubitemid 37088087)
    • (2003) Neuron , vol.39 , Issue.5 , pp. 739-747
    • Jin, P.1    Zarnescu, D.C.2    Zhang, F.3    Pearson, C.E.4    Lucchesi, J.C.5    Moses, K.6    Warren, S.T.7
  • 135
    • 34547681603 scopus 로고    scopus 로고
    • Pur α Binds to rCGG Repeats and Modulates Repeat-Mediated Neurodegeneration in a Drosophila Model of Fragile X Tremor/Ataxia Syndrome
    • DOI 10.1016/j.neuron.2007.07.020, PII S0896627307005417
    • P Jin R Duan A Qurashi 2007 Pur alpha binds to rCGG repeats and modulates repeat-mediated neurodegeneration in a Drosophila model of fragile × tremor/ataxia syndrome Neuron 55 556 564 10.1016/j.neuron.2007.07.020 (Pubitemid 47223639)
    • (2007) Neuron , vol.55 , Issue.4 , pp. 556-564
    • Jin, P.1    Duan, R.2    Qurashi, A.3    Qin, Y.4    Tian, D.5    Rosser, T.C.6    Liu, H.7    Feng, Y.8    Warren, S.T.9
  • 136
    • 1542380523 scopus 로고    scopus 로고
    • The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila
    • M Mutsuddi CM Marshall KA Benzow MD Koob I Rebay 2004 The spinocerebellar ataxia 8 noncoding RNA causes neurodegeneration and associates with staufen in Drosophila Curr Biol 14 302 308
    • (2004) Curr Biol , vol.14 , pp. 302-308
    • Mutsuddi, M.1    Marshall, C.M.2    Benzow, K.A.3    Koob, M.D.4    Rebay, I.5
  • 137
    • 33845234260 scopus 로고    scopus 로고
    • Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Sträussler-Scheinker syndrome
    • DOI 10.1523/JNEUROSCI.3372-06.2006
    • BA Gavin MJ Dolph NR Deleault 2006 Accelerated accumulation of misfolded prion protein and spongiform degeneration in a Drosophila model of Gerstmann-Straussler-Scheinker syndrome J Neurosci 26 12408 12414 10.1523/JNEUROSCI.3372-06.2006 (Pubitemid 44864505)
    • (2006) Journal of Neuroscience , vol.26 , Issue.48 , pp. 12408-12414
    • Gavin, B.A.1    Dolph, M.J.2    Deleault, N.R.3    Geoghegan, J.C.4    Khurana, V.5    Feany, M.B.6    Dolph, P.J.7    Supattapone, S.8
  • 138
    • 54049142949 scopus 로고    scopus 로고
    • A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1
    • 10.1074/jbc.M804817200
    • MR Watson RD Lagow K Xu B Zhang NM Bonini 2008 A drosophila model for amyotrophic lateral sclerosis reveals motor neuron damage by human SOD1 J Biol Chem 283 24972 24981 10.1074/jbc.M804817200
    • (2008) J Biol Chem , vol.283 , pp. 24972-24981
    • Watson, M.R.1    Lagow, R.D.2    Xu, K.3    Zhang, B.4    Bonini, N.M.5
  • 139
    • 48449098142 scopus 로고    scopus 로고
    • A Drosophila model of ALS: Human ALS-associated mutation in VAP33A suggests a dominant negative mechanism
    • 10.1371/journal.pone.0002334
    • A Ratnaparkhi GM Lawless FE Schweizer P Golshani GR Jackson 2008 A Drosophila model of ALS: human ALS-associated mutation in VAP33A suggests a dominant negative mechanism PLoS One 3 e2334 10.1371/journal.pone.0002334
    • (2008) PLoS One , vol.3 , pp. 2334
    • Ratnaparkhi, A.1    Lawless, G.M.2    Schweizer, F.E.3    Golshani, P.4    Jackson, G.R.5
  • 141
    • 52449095571 scopus 로고    scopus 로고
    • Modeling spinal muscular atrophy in Drosophila
    • 10.1371/journal.pone.0003209
    • HC Chang DN Dimlich T Yokokura 2008 Modeling spinal muscular atrophy in Drosophila PLoS One 3 e3209 10.1371/journal.pone.0003209
    • (2008) PLoS One , vol.3 , pp. 3209
    • Chang, H.C.1    Dimlich, D.N.2    Yokokura, T.3
  • 142
    • 58949100352 scopus 로고    scopus 로고
    • Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways
    • RI Tuxworth V Vivancos MB O'Hare G Tear 2008 Interactions between the juvenile Batten disease gene, CLN3, and the Notch and JNK signalling pathways Hum Mol Genet 18 4 667 678
    • (2008) Hum Mol Genet , vol.18 , Issue.4 , pp. 667-678
    • Tuxworth, R.I.1    Vivancos, V.2    O'Hare, M.B.3    Tear, G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.