A Drosophila model for LRRK2-linked parkinsonism

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 7, 2008, Pages 2693-2698

  Liu, Zhaohui ^a   Wang, Xiaoyue ^a   Yu, Yi ^a   Li, Xueping ^a   Wang, Tao ^a   Jiang, Haibing ^a   Ren, Qiuting ^a   Jiao, Yuchen ^a   Sawa, Akira ^a   Moran, Timothy ^a   Ross, Christopher A ^a   Montell, Craig ^a   Smith, Wanli W ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Dopaminergic neuron; Parkinson's disease

Indexed keywords

LEUCINE RICH REPEAT KINASE 2; LEVODOPA; AROMATIC LEVO AMINO ACID DECARBOXYLASE; DOPAMINE; LRRK2 PROTEIN, HUMAN; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; DROSOPHILA; GENE EXPRESSION; GENE MUTATION; LOCOMOTION; MORTALITY; NERVE CELL LESION; NONHUMAN; PARKINSONISM; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; RETINA DEGENERATION; WILD TYPE; ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; ELECTRON MICROSCOPY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NERVE DEGENERATION; NEUROLOGIC DISEASE; PATHOLOGY; RETINA; TRANSGENIC ANIMAL; ULTRASTRUCTURE;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; DISEASE MODELS, ANIMAL; DOPA DECARBOXYLASE; DOPAMINE; DROSOPHILA MELANOGASTER; GAIT DISORDERS, NEUROLOGIC; GENE EXPRESSION REGULATION; MICROSCOPY, ELECTRON; NERVE DEGENERATION; PARKINSONIAN DISORDERS; PROTEIN-SERINE-THREONINE KINASES; RETINA;

EID: 40649108102     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708452105     Document Type: Article

References (36)

1. Paisan-Ruiz C, Jain S, Evans EW, Gilks WP, Simon J, van der Brug M, Lopez de Munain A, Aparicio S, Gil AM, Khan N, et al. (2004) Neuron 44:595-600.
2. Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, et al. (2004) Neuron 44:601-607.
3. Ross OA, Toft M, Whittle AJ, Johnson JL, Papapetropoulos S, Mash DC, Litvan I, Gordon MF, Wszolek ZK, Farrer MJ, et al. (2006) Ann Neurol 59:388-393.
4. Rajput A, Dickson DW, Robinson CA, Ross OA, Dachsel JC, Lincoln SJ, Cobb SA, Rajput ML, Farrer MJ (2006) Neurology 67:1506-1508.
5. MacLeod D, Dowman J, Hammond R, Leete T, Inoue K, Abeliovich A (2006) Neuron 52:587-593.
6. Cookson MR, Dauer W, Dawson T, Fon EA, Guo M, Shen J (2007) J Neurosci 27:11865-11868.
7. Nichols WC, Pankratz N, Hernandez D, Paisan-Ruiz C, Jain S, Halter CA, Michaels VE, Reed T, Rudolph A, Shults CW, et al. (2005) Lancet 365:410-412.
8. Di Fonzo A, Rohe CF, Ferreira J, Chien HF, Vacca L, Stocchi F, Guedes L, Fabrizio E, Manfredi M, Vanacore N, et al. (2005) Lancet 365:412-415.
9. Gilks WP, Abou-Sleiman PM, Gandhi S, Jain S, Singleton A, Lees AJ, Shaw K, Bhatia KP, Bonifati V, Quinn NP, et al. (2005) Lancet 365:415-416.
10. West AB, Moore DJ, Biskup S, Bugayenko A, Smith WW, Ross CA, Dawson VL, Dawson TM (2005) Proc Natl Acad Sci USA 102:16842-16847.
11. Greggio E, Jain S, Kingsbury A, Bandopadhyay R, Lewis P, Kaganovich A, van der Brug MP, Beilina A, Blackinton J, Thomas KJ, et al. (2006) Neurobiol Dis 23:329-341.
12. Smith WW, Pei Z, Jiang H, Dawson VL, Dawson TM, Ross CA (2006) Nat Neurosci 9:1231-1233.
13. Luzon-Toro B, de la Torre ER, Delgado A, Perez-Tur J, Hilfiker S (2007) Hum Mol Genet 16:2031-2039.
14. Jaleel M, Nichols RJ, Deak M, Campbell DG, Gillardon F, Knebel A, Alessi DR (2007) Biochem J 405:307-317.
15. Gloeckner CJ, Kinkl N, Schumacher A, Braun RJ, O'Neill E, Meitinger T, Kolch W, Prokisch H, Ueffing M (2006) Hum Mol Genet 15:223-232.
16. Cauchi RJ, van den Heuvel M (2006) Neurodegener Dis 3:338-356.
17. Marsh JL, Thompson LM (2006) Neuron 52:169-178.
18. Feany MB, Bender WW (2000) Nature 404:394-398.
19. Lee SB, Kim W, Lee S, Chung J (2007) Biochem Biophys Res Commun 358:534-539.
20. Brand AH, Perrimon N (1993) Development 118:401-415.
21. Haass C, Kahle PJ (2000) Nature 404:341:343.
22. Budnik V, White K (1988) J Comp Neurol 268:400-413.
23. Friggi-Grelin F, Coulom H, Meller M, Gomez D, Hirsh J, Birman S (2003) J Neurobiol 54:618-627.
24. Hardy J, Cai H, Cookson MR, Gwinn-Hardy K, Singleton A (2006) Ann Neurol 60:389-398.
25. Dauer W, Przedborski S (2003) Neuron 39:889-909.
26. Forno LS (1996) J Neuropathol Exp Neurol 55:259-272.
27. Mouradian MM (2002) Neurology 58:179-185.
28. Singleton AB, Farrer M, Johnson J, Singleton A, Hague S, Kachergus J, Hulihan M, Peuralinna T, Dutra A, Nussbaum R, et al. (2003) Science 302:841.
29. Ishihara L, Warren L, Gibson R, Amouri R, Lesage S, Durr A, Tazir M, Wszolek ZK, Uitti RJ, Nichols WC, et al. (2006) Arch Neurol 63:1250-1254.
30. Li X, Tan YC, Poulose S, Olanow CW, Huang XY, Yue Z (2007) J Neurochem 103:238 -247.
31. Auluck PK, Meulener MC, Bonini NM (2005) J Biol Chem 280:2873-2878.
32. Li H, Chaney S, Roberts IJ, Forte M, Hirsh J (2000) Curr Biol 10:211-214.
33. Xu H, Lee SJ, Suzuki E, Dugan KD, Stoddard A, Li HS, Chodosh LA, Montell C (2004) EMBO J 23:811-822.
34. Rothenfluh A, Abodeely M, Price JL, Young MW (2000) Genetics 156:665-675.
35. Chaudhuri A, Bowling K, Funderburk C, Lawal H, Inamdar A, Wang Z, O'Donnell JM (2007) J Neurosci 27:2457-2467.
36. Monastirioti M (1999) Microsc Res Tech 45:106-121.