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Volumn 399, Issue SUPPL., 1999, Pages

Prospects for new restorative and neuroprotective treatments in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; ALPHA SYNUCLEIN; ALPHA TOCOPHEROL; CATECHOL METHYLTRANSFERASE; DNA FRAGMENT; LEVODOPA; METHAMPHETAMINE; SELEGILINE;

EID: 0040368216     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/399a032     Document Type: Review
Times cited : (526)

References (99)
  • 1
    • 0010899576 scopus 로고
    • (ed. Stern, G.) Chapman & Hall, London
    • Forno, L. S. in Parkinson's Disease (ed. Stern, G.) 185-238 (Chapman & Hall, London, 1990).
    • (1990) Parkinson's Disease , pp. 185-238
    • Forno, L.S.1
  • 3
    • 0032936755 scopus 로고    scopus 로고
    • Etiology and pathogenesis of Parkinson's disease
    • Olanow, C. W. & Tatton, WG. Etiology and pathogenesis of Parkinson's disease. Annu. Rev. Neurosci. 22, 123-144 (1999).
    • (1999) Annu. Rev. Neurosci. , vol.22 , pp. 123-144
    • Olanow, C.W.1    Tatton, W.G.2
  • 4
    • 0031719117 scopus 로고    scopus 로고
    • Alzheimer's disease and Parkinson's disease; distinct entities or extremes of a spectrum of neurodegeneration?
    • Perl, D. P., Olanow, C. W. & Calne, D. B. Alzheimer's disease and Parkinson's disease; distinct entities or extremes of a spectrum of neurodegeneration? Ann. Neurol. (suppl.) 44, S19-S31 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Perl, D.P.1    Olanow, C.W.2    Calne, D.B.3
  • 5
    • 0031670136 scopus 로고    scopus 로고
    • Genetics of Parkinson's disease
    • Gasser, T. Genetics of Parkinson's disease. Ann. Neurol. 44, S53-S57 (1998).
    • (1998) Ann. Neurol. , vol.44
    • Gasser, T.1
  • 6
    • 0033608187 scopus 로고    scopus 로고
    • Parkinson's disease in twins: An etiologic study
    • Tanner, C. M. et al. Parkinson's disease in twins: an etiologic study. J. Am. Med. Assoc. 281, 341-346 (1999).
    • (1999) J. Am. Med. Assoc. , vol.281 , pp. 341-346
    • Tanner, C.M.1
  • 7
    • 0031668924 scopus 로고    scopus 로고
    • The early diagnosis of Parkinson's disease
    • Brooks, D. J. The early diagnosis of Parkinson's disease. Ann. Neurol. (suppl.) 44, S10-S18 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Brooks, D.J.1
  • 8
    • 0031715849 scopus 로고    scopus 로고
    • Epidemiology versus genetics in Parkinson's disease: Progress in resolving an age-old debate
    • Langston, J. W. Epidemiology versus genetics in Parkinson's disease: progress in resolving an age-old debate. Ann. Neurol. (suppl.) 44, S45-S52 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Langston, J.W.1
  • 9
    • 0030882856 scopus 로고    scopus 로고
    • α-Synuclein in Lewy bodies
    • Spillantini, M. G. et al. α-Synuclein in Lewy bodies. Nature 388, 839-890 (1997).
    • (1997) Nature , vol.388 , pp. 839-890
    • Spillantini, M.G.1
  • 10
    • 0031824780 scopus 로고    scopus 로고
    • α-Synuclein in neurodegenerative disorders: Murderer or accomplice?
    • Mezey, E. et al. α-Synuclein in neurodegenerative disorders: murderer or accomplice? Nature Med. 4, 755-757 (1998).
    • (1998) Nature Med. , vol.4 , pp. 755-757
    • Mezey, E.1
  • 11
    • 0031787871 scopus 로고    scopus 로고
    • Accelerated in vitro fibril formation by a mutant α-synuclein linked to early onset Parkinson's disease
    • Conway, K. A., Harper, J. D. & Lansbury, P. T. Accelerated in vitro fibril formation by a mutant α-synuclein linked to early onset Parkinson's disease. Nature Med. 4, 1318-1320 (1998).
    • (1998) Nature Med. , vol.4 , pp. 1318-1320
    • Conway, K.A.1    Harper, J.D.2    Lansbury, P.T.3
  • 13
    • 0017344150 scopus 로고
    • Success and problems of long-term levodopa therapy in Parkinson's disease
    • Marsden, C. D. & Parkes, J. D. Success and problems of long-term levodopa therapy in Parkinson's disease. Lancet 1, 345-349 (1977).
    • (1977) Lancet , vol.1 , pp. 345-349
    • Marsden, C.D.1    Parkes, J.D.2
  • 14
    • 0030632235 scopus 로고    scopus 로고
    • An introduction to the new surgery for Parkinson's disease: Past and present problems
    • Marsden, C. D., Linazasoro, G. & Obeso, J. A. An introduction to the new surgery for Parkinson's disease: past and present problems. Adv. Neurol. 74, 143-147 (1997).
    • (1997) Adv. Neurol. , vol.74 , pp. 143-147
    • Marsden, C.D.1    Linazasoro, G.2    Obeso, J.A.3
  • 15
    • 0025298139 scopus 로고
    • Primate models of movement disorders of basal ganglia origin
    • DeLong, M. R. Primate models of movement disorders of basal ganglia origin. Trends Neurosci. 13, 281-285 (1990).
    • (1990) Trends Neurosci. , vol.13 , pp. 281-285
    • DeLong, M.R.1
  • 16
    • 0031756782 scopus 로고    scopus 로고
    • Ablative surgery and deep brain stimulation for Parkinson's disease
    • Starr, P. A., Vitek, J. L. & Bakay, R. A. E. Ablative surgery and deep brain stimulation for Parkinson's disease. Neurosurgery 43, 989-1013 (1998).
    • (1998) Neurosurgery , vol.43 , pp. 989-1013
    • Starr, P.A.1    Vitek, J.L.2    Bakay, R.A.E.3
  • 17
    • 0030624095 scopus 로고    scopus 로고
    • Chronic intracerebral stimulation in Parkinson's disease
    • Pollak, P., Benabid, A. L., Limousin, P. & Benazzouz, A. Chronic intracerebral stimulation in Parkinson's disease. Adv. Neurol. 74, 213-220 (1997).
    • (1997) Adv. Neurol. , vol.74 , pp. 213-220
    • Pollak, P.1    Benabid, A.L.2    Limousin, P.3    Benazzouz, A.4
  • 18
    • 0015745743 scopus 로고
    • Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations
    • Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. & Seitelberger, F. Brain dopamine and the syndromes of Parkinson and Huntington. Clinical, morphological and neurochemical correlations. J. Neurol. Sci. 20, 415-455 (1973).
    • (1973) J. Neurol. Sci. , vol.20 , pp. 415-455
    • Bernheimer, H.1    Birkmayer, W.2    Hornykiewicz, O.3    Jellinger, K.4    Seitelberger, F.5
  • 19
    • 0025954066 scopus 로고
    • Parkinson's disease: Neuropathology
    • Fearnley, J. & Lees, A. J. Parkinson's disease: neuropathology. Brain 114, 2283-2301 (1991).
    • (1991) Brain , vol.114 , pp. 2283-2301
    • Fearnley, J.1    Lees, A.J.2
  • 20
    • 0023740773 scopus 로고
    • Rate of cell death in parkinsonism indicates active neuropathological process
    • McGeer, P. L., Itagaki, S., Akiyama, H. & McGeer, E. G. Rate of cell death in parkinsonism indicates active neuropathological process. Ann. Neurol. 24, 574-576 (1989).
    • (1989) Ann. Neurol. , vol.24 , pp. 574-576
    • McGeer, P.L.1    Itagaki, S.2    Akiyama, H.3    McGeer, E.G.4
  • 21
    • 0021089452 scopus 로고
    • Aetiology of Parkinson's disease
    • Calne, D. B. & Langston, J. W. Aetiology of Parkinson's disease. Lancet 2, 1457-1459 (1983).
    • (1983) Lancet , vol.2 , pp. 1457-1459
    • Calne, D.B.1    Langston, J.W.2
  • 22
    • 0031716026 scopus 로고    scopus 로고
    • Cell death and neuroprotection in Parkinson's disease
    • Olanow, C. W., Jenner, P. & Beal, M. F. Cell death and neuroprotection in Parkinson's disease. Ann. Neurol. (suppl.) 44, S1-S196 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Olanow, C.W.1    Jenner, P.2    Beal, M.F.3
  • 24
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner, P. & Olanow, C. W. Understanding cell death in Parkinson's disease. Ann. Neurol. (suppl.) 44, S72-S84 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 25
    • 0030001780 scopus 로고    scopus 로고
    • Oxidative stress and antioxidant therapy in Parkinson's disease
    • Ebadi, M., Srinivasan, S. K. & Baxi, M. D. Oxidative stress and antioxidant therapy in Parkinson's disease. Prog. Neurobiol. 48, 1-19 (1996).
    • (1996) Prog. Neurobiol. , vol.48 , pp. 1-19
    • Ebadi, M.1    Srinivasan, S.K.2    Baxi, M.D.3
  • 26
    • 0024390719 scopus 로고
    • Mitochondrial complex I deficiency in Parkinson's disease
    • Schapira, A. H. V., Cooper, J. M. & Dexter, D. Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1, 1269 (1989).
    • (1989) Lancet , vol.1 , pp. 1269
    • Schapira, A.H.V.1    Cooper, J.M.2    Dexter, D.3
  • 27
    • 0031668930 scopus 로고    scopus 로고
    • Programmed cell death: Does it play a role in Parkinson's disease?
    • Burke, R. E. & Kholodilov, N. G. Programmed cell death: does it play a role in Parkinson's disease? Ann. Neurol. (suppl.) 44, S126-S133 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Burke, R.E.1    Kholodilov, N.G.2
  • 28
    • 0031696403 scopus 로고    scopus 로고
    • A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease
    • Tatton, N. A., Maclean-Fraser, A., Tatton, W. G., Perl, D. P. & Olanow, C. W. A fluorescent double-labeling method to detect and confirm apoptotic nuclei in Parkinson's disease. Ann. Neurol. (suppl.) 44, S142-S148 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Tatton, N.A.1    Maclean-Fraser, A.2    Tatton, W.G.3    Perl, D.P.4    Olanow, C.W.5
  • 29
    • 0031668934 scopus 로고    scopus 로고
    • The causes of Parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality
    • Marsden, C. D. & Olanow, C. W. The causes of Parkinson's disease are being unraveled and rational neuroprotective therapy is close to reality. Ann. Neurol. (suppl.) 44, S189-S196 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Marsden, C.D.1    Olanow, C.W.2
  • 30
    • 0031893241 scopus 로고    scopus 로고
    • Mortality in DATATOP: A multicenter trial in early Parkinson's disease
    • Shoulson, I. et al. Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Ann. Neurol. 43, 318-325 (1998).
    • (1998) Ann. Neurol. , vol.43 , pp. 318-325
    • Shoulson, I.1
  • 31
    • 0031719124 scopus 로고    scopus 로고
    • Neuroprotection for Parkinson's disease
    • Koller, W. C. Neuroprotection for Parkinson's disease. Ann. Neurol. (suppl.) 44, S155-S159 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Koller, W.C.1
  • 32
    • 0031716026 scopus 로고    scopus 로고
    • Dopamine agonists and neuroprotection in Parkinson's disease
    • Olanow, C. W., Jenner, P. & Brooks, D. Dopamine agonists and neuroprotection in Parkinson's disease. Ann. Neurol. (suppl.) 44, S167-S174 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Olanow, C.W.1    Jenner, P.2    Brooks, D.3
  • 33
    • 0031696407 scopus 로고    scopus 로고
    • Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: A target for neuroprotection
    • Rodriguez, M. C., Obeso, J. & Olanow, C. W. Subthalamic nucleus-mediated excitotoxicity in Parkinson's disease: a target for neuroprotection. Ann. Neurol. (suppl.) 44, S175-S188 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Rodriguez, M.C.1    Obeso, J.2    Olanow, C.W.3
  • 34
    • 0031888498 scopus 로고    scopus 로고
    • Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo
    • Hagg, T. Neurotrophins prevent death and differentially affect tyrosine hydroxylase of adult rat nigrostriatal neurons in vivo. Exp. Neurol. 149, 183-192 (1998).
    • (1998) Exp. Neurol. , vol.149 , pp. 183-192
    • Hagg, T.1
  • 35
    • 0030330849 scopus 로고    scopus 로고
    • Growth factor function in the development and maintenance of midbrain dopaminergic neurons: Concepts, facts and prospects for TGF-β
    • Unsicker, K., Suter-Crazzolara, C. & Krieglstein, K. Growth factor function in the development and maintenance of midbrain dopaminergic neurons: concepts, facts and prospects for TGF-β. Ciba Found. Symp. 196, 70-80 (1996).
    • (1996) Ciba Found. Symp. , vol.196 , pp. 70-80
    • Unsicker, K.1    Suter-Crazzolara, C.2    Krieglstein, K.3
  • 36
    • 0031662603 scopus 로고    scopus 로고
    • Neuroprotective and neurorestorative properties of GDNF
    • Gash, D. M., Zhang, Z. M. & Gerhardt, G. Neuroprotective and neurorestorative properties of GDNF. Ann. Neurol. (suppl.) 44, S121-S125 (1998).
    • (1998) Ann. Neurol. (Suppl.) , vol.44
    • Gash, D.M.1    Zhang, Z.M.2    Gerhardt, G.3
  • 37
    • 0030725572 scopus 로고    scopus 로고
    • Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease
    • Björklund, A., Rosenblad, C., Winkler, C. & Kirik, D. Studies on neuroprotective and regenerative effects of GDNF in a partial lesion model of Parkinson's disease. Neurobiol. Dis. 4, 186-200 (1997).
    • (1997) Neurobiol. Dis. , vol.4 , pp. 186-200
    • Björklund, A.1    Rosenblad, C.2    Winkler, C.3    Kirik, D.4
  • 38
    • 0003239972 scopus 로고    scopus 로고
    • Clinical and pathological evaluation of patient with Parkinson's disease (PD) following intracerebroventricular (icv) GDNF
    • Palfi, S. et al. Clinical and pathological evaluation of patient with Parkinson's disease (PD) following intracerebroventricular (icv) GDNF. Soc. Neurosci. Abstr. 24, 41 (1998).
    • (1998) Soc. Neurosci. Abstr. , vol.24 , pp. 41
    • Palfi, S.1
  • 39
    • 0031594542 scopus 로고    scopus 로고
    • Neural actions of immunophilin ligands
    • Snyder, S. H. et al. Neural actions of immunophilin ligands. Trends Pharmacol. Sci. 19, 21-26 (1998).
    • (1998) Trends Pharmacol. Sci. , vol.19 , pp. 21-26
    • Snyder, S.H.1
  • 40
    • 12644257556 scopus 로고    scopus 로고
    • Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models
    • Steiner, J. P., Hamilton, G. S., Ross, D. T. & Valentine, H. L. Neurotrophic immunophilin ligands stimulate structural and functional recovery in neurodegenerative animal models. Proc. Natl Acad. Sci. USA 94, 2019-2124 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 2019-2124
    • Steiner, J.P.1    Hamilton, G.S.2    Ross, D.T.3    Valentine, H.L.4
  • 41
    • 0031660913 scopus 로고    scopus 로고
    • A novel immunophilin ligand: Distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease
    • Constantini, L. C. et al. A novel immunophilin ligand: distinct branching effects on dopaminergic neurons in culture and neurotrophic actions after oral administration in an animal model of Parkinson's disease. Neurobiol. Dis. 5, 97-106 (1998).
    • (1998) Neurobiol. Dis. , vol.5 , pp. 97-106
    • Constantini, L.C.1
  • 42
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green, D. R. & Reed, J. C. Mitochondria and apoptosis. Science 281, 1309-1312 (1999).
    • (1999) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 43
    • 0033008216 scopus 로고    scopus 로고
    • Caspase inhibition reduces apoptosis and increases survival of nigral transplants
    • Schierle, G. S. et al. Caspase inhibition reduces apoptosis and increases survival of nigral transplants. Nature Med. 5, 97-100 (1999).
    • (1999) Nature Med. , vol.5 , pp. 97-100
    • Schierle, G.S.1
  • 45
    • 0030873946 scopus 로고    scopus 로고
    • Neural transplantation: A hope for patients with Parkinson's disease?
    • Lindvall, O. Neural transplantation: a hope for patients with Parkinson's disease? NeuroReport 8, iii-x (1997).
    • (1997) Neuroreport , vol.8
    • Lindvall, O.1
  • 46
    • 0030632592 scopus 로고    scopus 로고
    • Neural transplantation as a therapy for Parkinson's disease
    • Olanow, C. W., Freeman, T. B. & Kordower, J. H. Neural transplantation as a therapy for Parkinson's disease. Adv. Neurol. 74, 249-269 (1997).
    • (1997) Adv. Neurol. , vol.74 , pp. 249-269
    • Olanow, C.W.1    Freeman, T.B.2    Kordower, J.H.3
  • 47
    • 0030834093 scopus 로고    scopus 로고
    • Short-and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease
    • Wenning, G. K. et al. Short-and long-term survival and function of unilateral intrastriatal dopaminergic grafts in Parkinson's disease. Ann. Neurol. 42, 95-107 (1997).
    • (1997) Ann. Neurol. , vol.42 , pp. 95-107
    • Wenning, G.K.1
  • 48
    • 0031947943 scopus 로고    scopus 로고
    • Neuropathotogy of fetal nigral grafts in patients with Parkinson's disease
    • Kordower, J. H., Freeman, T. B. & Olanow, C. W. Neuropathotogy of fetal nigral grafts in patients with Parkinson's disease. Mov. Dis. 13, 88-95 (1998).
    • (1998) Mov. Dis. , vol.13 , pp. 88-95
    • Kordower, J.H.1    Freeman, T.B.2    Olanow, C.W.3
  • 49
    • 0031010545 scopus 로고    scopus 로고
    • Fetal grafting for Parkinson's disease: Expression of immune markers in two patients with functional fetal nigral implants
    • Kordower, J. H. et al. Fetal grafting for Parkinson's disease: expression of immune markers in two patients with functional fetal nigral implants. Cell Transplant. 6, 213-219 (1997).
    • (1997) Cell Transplant. , vol.6 , pp. 213-219
    • Kordower, J.H.1
  • 50
    • 0028104614 scopus 로고
    • Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research
    • Boer, G. J. Ethical guidelines for the use of human embryonic or fetal tissue for experimental and clinical neurotransplantation and research. J. Neurol. 242, 1-13 (1994).
    • (1994) J. Neurol. , vol.242 , pp. 1-13
    • Boer, G.J.1
  • 51
    • 0031106244 scopus 로고    scopus 로고
    • Dopaminergic transplants in patients with Parkinson's disease: Neuroanatomical correlates of clinical recovery
    • Kordower, J. H., Goetz, C. G., Freeman, T. B. & Olanow, C. W. Dopaminergic transplants in patients with Parkinson's disease: neuroanatomical correlates of clinical recovery. Exp. Neurol. 144, 41-46 (1997).
    • (1997) Exp. Neurol. , vol.144 , pp. 41-46
    • Kordower, J.H.1    Goetz, C.G.2    Freeman, T.B.3    Olanow, C.W.4
  • 52
    • 0032498835 scopus 로고    scopus 로고
    • Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats
    • Zawada, W. M. et al. Growth factors improve immediate survival of embryonic dopamine neurons after transplantation into rats. Brain Res. 786, 96-103 (1998).
    • (1998) Brain Res. , vol.786 , pp. 96-103
    • Zawada, W.M.1
  • 53
    • 0029851904 scopus 로고    scopus 로고
    • The effects of glial cell line-derived neurotrophic factor (GDNF) on embryonic nigral grafts
    • Sinclair, S. R., Svendsen, C. N., Torres, E. M., Fawcett, J. W. & Dunnett, S. B. The effects of glial cell line-derived neurotrophic factor (GDNF) on embryonic nigral grafts. NeuroReport 7, 2547-2552 (1996).
    • (1996) Neuroreport , vol.7 , pp. 2547-2552
    • Sinclair, S.R.1    Svendsen, C.N.2    Torres, E.M.3    Fawcett, J.W.4    Dunnett, S.B.5
  • 54
    • 0030298512 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts
    • Rosenblad, C., Martinez-Serrano, A. & Björklund, A. Glial cell line-derived neurotrophic factor increases survival, growth and function of intrastriatal fetal nigral dopaminergic grafts. Neuroscience 75, 979-985 (1996).
    • (1996) Neuroscience , vol.75 , pp. 979-985
    • Rosenblad, C.1    Martinez-Serrano, A.2    Björklund, A.3
  • 55
    • 0032192007 scopus 로고    scopus 로고
    • Glial cell line-derived neurotrophic factor improves survival of dopaminergic neurons in transplants of fetal ventral mesencephalic tissue
    • Yurek, D. M. Glial cell line-derived neurotrophic factor improves survival of dopaminergic neurons in transplants of fetal ventral mesencephalic tissue. Exp. Neurol. 153, 195-202 (1998).
    • (1998) Exp. Neurol. , vol.153 , pp. 195-202
    • Yurek, D.M.1
  • 56
    • 0028171918 scopus 로고
    • Neural xenotransplantation: Reconstruction of neuronal circuitry across species barriers
    • Pakzaban, P. & Isacson, O. Neural xenotransplantation: reconstruction of neuronal circuitry across species barriers. Neuroscience 62, 989-1001 (1994).
    • (1994) Neuroscience , vol.62 , pp. 989-1001
    • Pakzaban, P.1    Isacson, O.2
  • 57
    • 0030866841 scopus 로고    scopus 로고
    • Benefits and risks of hosting animal cells in the human brain
    • Isacson, O. & Breakefield, X. O. Benefits and risks of hosting animal cells in the human brain. Nature Med. 3, 964-969 (1997).
    • (1997) Nature Med. , vol.3 , pp. 964-969
    • Isacson, O.1    Breakefield, X.O.2
  • 58
    • 16944366484 scopus 로고    scopus 로고
    • Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease
    • Deacon, T. et al. Histological evidence of fetal pig neural cell survival after transplantation into a patient with Parkinson's disease. Nature Med. 3, 350-353 (1997).
    • (1997) Nature Med. , vol.3 , pp. 350-353
    • Deacon, T.1
  • 59
    • 0032556891 scopus 로고    scopus 로고
    • Last chance to stop and think on risks of xenotransplants
    • Butler, D. Last chance to stop and think on risks of xenotransplants. Nature 391, 320-324 (1998).
    • (1998) Nature , vol.391 , pp. 320-324
    • Butler, D.1
  • 60
    • 0027407368 scopus 로고
    • Mitogenic effect of basic fibroblast growth factor on embryonic ventral mesencephalic dopaminergic neurone precursors
    • Mayer, E., Dunnett, S. B. & Fawcett, J. W. Mitogenic effect of basic fibroblast growth factor on embryonic ventral mesencephalic dopaminergic neurone precursors. Dev. Brain. Res. 72, 253-258 (1993).
    • (1993) Dev. Brain. Res. , vol.72 , pp. 253-258
    • Mayer, E.1    Dunnett, S.B.2    Fawcett, J.W.3
  • 61
    • 0028882094 scopus 로고
    • Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro
    • Bouvier, M. M. & Mytilineou, C. Basic fibroblast growth factor increases division and delays differentiation of dopamine precursors in vitro. J. Neurosci. 15, 7141-7149 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 7141-7149
    • Bouvier, M.M.1    Mytilineou, C.2
  • 62
    • 33644684826 scopus 로고    scopus 로고
    • Transplantaton of expanded mesencephalic precursors leads to recovery in parkinsonian rats
    • Studer, L., Tabar, V. & McKay, R. D. G. Transplantaton of expanded mesencephalic precursors leads to recovery in parkinsonian rats. Nature Neurosci. 1, 290-295 (1998).
    • (1998) Nature Neurosci. , vol.1 , pp. 290-295
    • Studer, L.1    Tabar, V.2    McKay, R.D.G.3
  • 63
    • 0032007097 scopus 로고    scopus 로고
    • Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines
    • Ling, Z. D., Potter, E. D., Lipton, J. W. & Carvey, P. M. Differentiation of mesencephalic progenitor cells into dopaminergic neurons by cytokines. Exp. Neurol. 149, 411-423 (1998).
    • (1998) Exp. Neurol. , vol.149 , pp. 411-423
    • Ling, Z.D.1    Potter, E.D.2    Lipton, J.W.3    Carvey, P.M.4
  • 64
    • 0032577445 scopus 로고    scopus 로고
    • FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate
    • Ye, W. L., Shimamura, K., Rubenstein, J. L. R., Hynes, M. A. & Rosenthal, A. FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell 93, 755-766 (1998).
    • (1998) Cell , vol.93 , pp. 755-766
    • Ye, W.L.1    Shimamura, K.2    Rubenstein, J.L.R.3    Hynes, M.A.4    Rosenthal, A.5
  • 66
    • 0025935786 scopus 로고
    • United Parkinson Foundation neurotransplantation registry on adrenal medullary transplants: Presurgical, and 1-year and 2-year follow up
    • Goetz, C. G. et al. United Parkinson Foundation neurotransplantation registry on adrenal medullary transplants: presurgical, and 1-year and 2-year follow up. Neurology 41, 1719-1722 (1991).
    • (1991) Neurology , vol.41 , pp. 1719-1722
    • Goetz, C.G.1
  • 67
    • 0024433446 scopus 로고
    • An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats
    • Winn, S. R., Wahlberg, L., Tresco, P. A. & Aebischer, P. An encapsulated dopamine-releasing polymer alleviates experimental parkinsonism in rats. Exp. Neurol. 105, 244-250 (1989).
    • (1989) Exp. Neurol. , vol.105 , pp. 244-250
    • Winn, S.R.1    Wahlberg, L.2    Tresco, P.A.3    Aebischer, P.4
  • 68
    • 0025190819 scopus 로고
    • Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum
    • Becker, J. B et al. Sustained behavioral recovery from unilateral nigrostriatal damage produced by the controlled release of dopamine from a silicone polymer pellet placed into the denervated striatum. Brain Res. 508, 60-64 (1990).
    • (1990) Brain Res. , vol.508 , pp. 60-64
    • Becker, J.B.1
  • 69
    • 0028214265 scopus 로고
    • Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells
    • Aebischer, P., Goddard, M., Signore, A. P. & Timpson, R. L. Functional recovery in hemiparkinsonian primates transplanted with polymer-encapsulated PC12 cells. Exp. Neurol. 126, 151-158 (1994).
    • (1994) Exp. Neurol. , vol.126 , pp. 151-158
    • Aebischer, P.1    Goddard, M.2    Signore, A.P.3    Timpson, R.L.4
  • 70
    • 0027308140 scopus 로고
    • Polymer-encapsulated PC12 cells promote recovery of motor function in aged rats
    • Emerich, D. F. et al. Polymer-encapsulated PC12 cells promote recovery of motor function in aged rats. Exp. Neurol. 122, 37-47 (1993).
    • (1993) Exp. Neurol. , vol.122 , pp. 37-47
    • Emerich, D.F.1
  • 71
    • 0032005461 scopus 로고    scopus 로고
    • Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantaton of carotid body cell aggregates
    • Espejo, E. F., Montoro, R. J., Armengol, J. A. & López-Barneo, J. Cellular and functional recovery of Parkinsonian rats after intrastriatal transplantaton of carotid body cell aggregates. Neuron 20, 197-206 (1998).
    • (1998) Neuron , vol.20 , pp. 197-206
    • Espejo, E.F.1    Montoro, R.J.2    Armengol, J.A.3    López-Barneo, J.4
  • 72
    • 0025963275 scopus 로고
    • Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce 1-DOPA
    • Fisher, L. J., Jinnah, H. A., Kale, L. C., Higgins, G. A. & Gage, F. H. Survival and function of intrastriatally grafted primary fibroblasts genetically modified to produce 1-DOPA. Neuron 6, 371-380 (1991).
    • (1991) Neuron , vol.6 , pp. 371-380
    • Fisher, L.J.1    Jinnah, H.A.2    Kale, L.C.3    Higgins, G.A.4    Gage, F.H.5
  • 73
    • 0029973056 scopus 로고    scopus 로고
    • Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxytase gene: In vitro characterisation and in vivo effects in the rat Parkinson model
    • Lundberg, C., Horellou, P., Mallet, J. & Björklund, A. Generation of DOPA-producing astrocytes by retroviral transduction of the human tyrosine hydroxytase gene: in vitro characterisation and in vivo effects in the rat Parkinson model. Exp. Neurol. 139, 39-53 (1996).
    • (1996) Exp. Neurol. , vol.139 , pp. 39-53
    • Lundberg, C.1    Horellou, P.2    Mallet, J.3    Björklund, A.4
  • 74
    • 0028169809 scopus 로고
    • Neural-targeted gene therapy for rodent and primate hemiparkinsonism
    • Anton, R. et al. Neural-targeted gene therapy for rodent and primate hemiparkinsonism. Exp. Neurol. 127, 207-218 (1994).
    • (1994) Exp. Neurol. , vol.127 , pp. 207-218
    • Anton, R.1
  • 75
    • 0024820634 scopus 로고
    • Rationale for continuous dopaminomimetic therapy of Parkinson's disease
    • Chase, T. N. et al. Rationale for continuous dopaminomimetic therapy of Parkinson's disease. Neurology 39, 7-10 (1989).
    • (1989) Neurology , vol.39 , pp. 7-10
    • Chase, T.N.1
  • 76
    • 0031105522 scopus 로고    scopus 로고
    • Application of ex vivo gene therapy in the treatment of Parkinson's disease
    • Raymon, H. K., Thode, S. & Gage, F. H. Application of ex vivo gene therapy in the treatment of Parkinson's disease. Exp. Neurol. 144, 82-91 (1997).
    • (1997) Exp. Neurol. , vol.144 , pp. 82-91
    • Raymon, H.K.1    Thode, S.2    Gage, F.H.3
  • 77
    • 0031945063 scopus 로고    scopus 로고
    • Potential of gene therapy for Parkinson's disease: Neurobiologic issues and new developments in gene transfer methodologies
    • Kang, U. J. Potential of gene therapy for Parkinson's disease: neurobiologic issues and new developments in gene transfer methodologies. Mov. Dis. 13, 59-72 (1998).
    • (1998) Mov. Dis. , vol.13 , pp. 59-72
    • Kang, U.J.1
  • 78
    • 0030006065 scopus 로고    scopus 로고
    • Double transduction with GTP cyclohydrolase L and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts
    • Bencsics, C. et al. Double transduction with GTP cyclohydrolase L and tyrosine hydroxylase is necessary for spontaneous synthesis of L-DOPA by primary fibroblasts. J. Neurosci. 16, 4449-4456 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 4449-4456
    • Bencsics, C.1
  • 79
    • 0032102936 scopus 로고    scopus 로고
    • In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via compression of GTP cyclohydrolase 1 with tyrosine hydroxylase
    • Left, S. E., Rendahl, K. G., Spratt, S. K., Kang, U. J. & Mandel, R. J. In vivo L-DOPA production by genetically modified primary rat fibroblast or 9L gliosarcoma cell grafts via compression of GTP cyclohydrolase 1 with tyrosine hydroxylase. Exp. Neurol. 151, 249-264 (1998).
    • (1998) Exp. Neurol. , vol.151 , pp. 249-264
    • Left, S.E.1    Rendahl, K.G.2    Spratt, S.K.3    Kang, U.J.4    Mandel, R.J.5
  • 80
    • 0027970324 scopus 로고
    • Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat
    • Barker, R. A & Dunnett, S. B. Ibotenic acid lesions of the striatum reduce drug-induced rotation in the 6-hydroxydopamine-lesioned rat. Exp. Brain Res. 101, 365-374 (1994).
    • (1994) Exp. Brain Res. , vol.101 , pp. 365-374
    • Barker, R.A.1    Dunnett, S.B.2
  • 81
    • 0029097513 scopus 로고
    • Behavioral effects and gene delivery in a rat model of Parkinson's disease
    • Isacson, O. Behavioral effects and gene delivery in a rat model of Parkinson's disease. Science 269, 856-856 (1995).
    • (1995) Science , vol.269 , pp. 856-856
    • Isacson, O.1
  • 82
    • 0028276809 scopus 로고    scopus 로고
    • Implanted fibroblasts genetically engineered to produce brain derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat
    • Frim, D. M. et al. Implanted fibroblasts genetically engineered to produce brain derived neurotrophic factor prevent 1-methyl-4-phenylpyridinium toxicity to dopaminergic neurons in the rat. Proc. Natl Acad. Sci. USA 91, 5104-5108 (1999).
    • (1999) Proc. Natl Acad. Sci. USA , vol.91 , pp. 5104-5108
    • Frim, D.M.1
  • 83
    • 0029610630 scopus 로고
    • Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease
    • Levivier, M., Przedborski, S., Bencsics, C. & Kang, U. J. Intrastriatal implantation of fibroblasts genetically engineered to produce brain-derived neurotrophic factor prevents degeneration of dopaminergic neurons in a rat model of Parkinson's disease. J. Neurosci. 15, 7810-7820 (1995).
    • (1995) J. Neurosci. , vol.15 , pp. 7810-7820
    • Levivier, M.1    Przedborski, S.2    Bencsics, C.3    Kang, U.J.4
  • 84
    • 0031031008 scopus 로고    scopus 로고
    • GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine
    • Tseng, J. L., Baetge, E. E., Zurn, A. D. & Aebischer, P. GDNF reduces drug-induced rotational behavior after medial forebrain bundle transection by a mechanism not involving striatal dopamine. J. Neurosci. 17, 325-333 (1997).
    • (1997) J. Neurosci. , vol.17 , pp. 325-333
    • Tseng, J.L.1    Baetge, E.E.2    Zurn, A.D.3    Aebischer, P.4
  • 85
    • 0031019795 scopus 로고    scopus 로고
    • Dopaminergic neurons protected from degeneration by GDNF gene therapy
    • Choi-Lundberg, D. L. et al. Dopaminergic neurons protected from degeneration by GDNF gene therapy. Science 275, 838-841 (1997).
    • (1997) Science , vol.275 , pp. 838-841
    • Choi-Lundberg, D.L.1
  • 86
    • 0031456051 scopus 로고    scopus 로고
    • Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats
    • Mandel, R. J., Spratt, S. K., Snyder, R. O. & Leff, S. E. Midbrain injection of recombinant adeno-associated virus encoding rat glial cell line-derived neurotrophic factor protects nigral neurons in a progressive 6-hydroxydopamine-induced degeneration model of Parkinson's disease in rats. Proc. Natl Acad. Sci. USA 94, 14083-14088 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 14083-14088
    • Mandel, R.J.1    Spratt, S.K.2    Snyder, R.O.3    Leff, S.E.4
  • 87
    • 0030795798 scopus 로고    scopus 로고
    • Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease
    • Bilang-Bleuel, A. et al. Intrastriatal injection of an adenoviral vector expressing glial cell line-derived neurotrophic factor prevents dopaminergic neuron degeneration and behavioral impairment in a rat model of Parkinson's disease. Proc. Natl Acad. Sci. USA 94, 8818-8823 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 8818-8823
    • Bilang-Bleuel, A.1
  • 88
    • 0032423612 scopus 로고    scopus 로고
    • Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor
    • Choi-Lundberg, D. L. et al. Behavioral and cellular protection of rat dopaminergic neurons by an adenoviral vector encoding glial cell line-derived neurotrophic factor. Exp. Neurol. 154, 261-275 (1998).
    • (1998) Exp. Neurol. , vol.154 , pp. 261-275
    • Choi-Lundberg, D.L.1
  • 90
    • 0029071968 scopus 로고
    • Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth-factor
    • Jordan, J. et al. Expression of human copper/zinc-superoxide dismutase inhibits the death of rat sympathetic neurons caused by withdrawal of nerve growth-factor. Mol. Pharmacol. 47, 1095-1100 (1995).
    • (1995) Mol. Pharmacol. , vol.47 , pp. 1095-1100
    • Jordan, J.1
  • 91
    • 0029981856 scopus 로고    scopus 로고
    • 18F]dopa-PET and clinical study of the rate of progression in Parkinson's disease
    • 18F]dopa-PET and clinical study of the rate of progression in Parkinson's disease. Brain 119, 585-591 (1996).
    • (1996) Brain , vol.119 , pp. 585-591
    • Morrish, P.K.1    Sawle, G.V.2    Brooks, D.J.3
  • 92
    • 0027944855 scopus 로고
    • Metals and free radicals in neurodegeneration
    • Olanow, C. W. & Arendash, G. W. Metals and free radicals in neurodegeneration. Curr. Opin. Neurol. 7, 548-558 (1994).
    • (1994) Curr. Opin. Neurol. , vol.7 , pp. 548-558
    • Olanow, C.W.1    Arendash, G.W.2
  • 93
    • 0030744876 scopus 로고    scopus 로고
    • Mutation in the alpha-synuclein gene identified in families with Parkinson's disease
    • Polymeropoulos, M. H. et al. Mutation in the alpha-synuclein gene identified in families with Parkinson's disease. Science 276, 2045-2047 (1997).
    • (1997) Science , vol.276 , pp. 2045-2047
    • Polymeropoulos, M.H.1
  • 94
    • 0032499264 scopus 로고    scopus 로고
    • Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism
    • Kitada, T. et al. Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism. Nature 392, 605-608 (1998).
    • (1998) Nature , vol.392 , pp. 605-608
    • Kitada, T.1
  • 95
    • 0032190090 scopus 로고    scopus 로고
    • The ubiquitin pathway in Parkinson's disease
    • Leroy, M. et al. The ubiquitin pathway in Parkinson's disease. Nature 395, 451-452 (1998).
    • (1998) Nature , vol.395 , pp. 451-452
    • Leroy, M.1
  • 96
    • 2642607011 scopus 로고    scopus 로고
    • Low frequency of α-synuclein mutations in familial Parkinson's disease
    • Farrer, M. et al. Low frequency of α-synuclein mutations in familial Parkinson's disease. Ann. Neurol. 43, 394-397 (1998).
    • (1998) Ann. Neurol. , vol.43 , pp. 394-397
    • Farrer, M.1
  • 97
    • 0031951197 scopus 로고    scopus 로고
    • A susceptibility locus for Parkinson's disease maps to chromosome 2p13
    • Gasser, T. et al. A susceptibility locus for Parkinson's disease maps to chromosome 2p13. Nature Genet. 18, 262-265 (1998).
    • (1998) Nature Genet. , vol.18 , pp. 262-265
    • Gasser, T.1
  • 98
    • 0031990490 scopus 로고    scopus 로고
    • Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease
    • Kruger, R. et al. Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease. Nature Genet. 18, 106-108 (1998).
    • (1998) Nature Genet. , vol.18 , pp. 106-108
    • Kruger, R.1


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