Mammalian homologues of C. elegans PAR-1 are asymmetrically localized in epithelial cells and may influence their polarity

Current Biology

Volumn 7, Issue 8, 1997, Pages 603-606

  Böhm, Hans ^a   Brinkmann, Volker ^a   Drab, Marek ^a   Henske, Annemarie ^a   Kurzchalia, Teymuras V ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CAENORHABDITIS ELEGANS; CANIS FAMILIARIS; MAMMALIA; RICKETTSIA SP. PAR; VERMES;

EID: 0031213571     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0960-9822(06)00260-0     Document Type: Article

References (14)

1. Horvitz HR, Herskowitz I: Mechanisms of asymmetric cell division: two Bs or not two Bs, that is the question. Cell 1992, 68:237-255.
2. Sulston JE, Schierenberg E, White JG, Thomson JN: The embryonic cell lineage of the nematode Caenorhabditis elegans. Dev Biol 1983, 100:64-119.
3. Priess JR: Establishment of initial asymmetry in early Caenorhabditis elegans embryos. Curr Opin Genet Dev 1994, 4:563-568.
4. White J, Strome S: Cleavage plane specification in C. elegans: how to divide the spoils. Cell 1996, 84:195-198.
5. Kemphues KJ, Priess JR, Morton DG, Cheng NS: Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 1988, 52:311-320.
6. Watts JL, Etemadmoghadam B, Guo S, Boyd L, Draper BW, Mello CC, et al.: Par 6, a gene involved in the establishment of asymmetry in early C. elegans embryos, mediates the asymmetric localization of par 3. Development 1996, 122:3133-3140.
7. Guo S, Kemphues KJ: par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed. Cell 1995, 81:611-620.
8. Parsa I: Loss of a Mr 78,000 marker in chemically induced transplantable carcinomas and primary carcinoma of human pancreas. Cancer Res 1988, 48:2265-2272.
9. Inglis JD, Lee M, Hill RE: Emk, a protein kinase with homologs in yeast maps to mouse chromosome 19. Mamm Genome 1993, 4:401-403.
10. Etemad-Moghadam B, Guo S, Kemphues KJ: Asymmetrically distributed PAR-3 protein contributes to cell polarity and spindle aligment in early C. elegans embryos. Cell 1995, 83:743-752.
11. Woods DF, Bryant PJ: The discs-large tumor suppressor gene of Drosophila encodes a guanylate kinase homolog localized at septate junctions. Cell 1991, 66:451-464.
12. Kurzchalia T, Hartmann E: Are there similarities between the polarization of the C. elegans embryo and of an epithelial cell? Trends Cell Biol 1996, 6:131-132.
13. Reinsch S, Karsenti E: Orientation of spindle axis and distribution of plasma membrane proteins during cell division in polarized MDCKII cells. J Cell Biol 1994, 126:1509-1526.
14. Drewes G, Ebneth A, Preuss U, Mandelkow E-M, Mandelkow E: MARK, a novel family of protein kinases that phosphorylate microtubule-associated proteins and trigger microtubule disruption. Cell 1997, 89:297-308.