RNA binding activity of the recessive parkinsonism protein DJ-1 supports involvement in multiple cellular pathways

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 29, 2008, Pages 10244-10249

  Van Der Brug, Marcel P ^a   Blackinton, Jeff ^a,d   Chandran, Jayanth ^a   Hao, Ling Yang ^c   Lal, Ashish ^b   Mazan Mamczarz, Krystyna ^b   Martindale, Jennifer ^b   Xie, Chengsong ^a   Ahmad, Rili ^a   Thomas, Kelly J ^a   Beilina, Alexandra ^a   Gibbs, J Raphael ^a   Ding, Jinhui ^a   Myers, Amanda J ^a   Zhan, Ming ^b   Cai, Huaibin ^a   Bonini, Nancy M ^c   Gorospe, Myriam ^b   Cookson, Mark R ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Gene expression; Oxidative stress; Parkinson's disease; Translation

Indexed keywords

DJ 1 PROTEIN; GLUTATHIONE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RNA;

ANIMAL EXPERIMENT; ARTICLE; BRAIN; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ENZYME ACTIVITY; GENE TARGETING; GLUTATHIONE METABOLISM; HUMAN; HUMAN CELL; MITOCHONDRION; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PARKINSONISM; PLEIOTROPY; PRIORITY JOURNAL; RNA BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASE SEQUENCE; BRAIN; CELL LINE; DROSOPHILA; DROSOPHILA PROTEINS; GENES, MITOCHONDRIAL; GENES, RECESSIVE; GLUTATHIONE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; ONCOGENE PROTEINS; OXIDATIVE STRESS; PARKINSONIAN DISORDERS; PTEN PHOSPHOHYDROLASE; RECOMBINANT PROTEINS; RNA, MESSENGER; RNA, SMALL INTERFERING; RNA-BINDING PROTEINS; TRANSFECTION;

EID: 48249145149     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0708518105     Document Type: Article

References (35)

1. Cookson MR (2005) The biochemistry of Parkinson's disease. Annu Rev Biochem 74:29-52.
2. Clark IE, et al. (2006) Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin. Nature 441:1162-1166.
3. Park J, et al. (2006) Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin. Nature: 441:1157-1161.
4. Bandopadhyay R, et al. (2004) The expression of DJ-1 (PARK7) in normal human CNS and idiopathic Parkinson's disease. Brain 127:420-430.
5. Choi J, et al. (2006) Oxidative damage of DJ-1 is linked to sporadic Parkinson and Alzheimer diseases. J Biol Chem 281:10816-10824.
6. Canet-Aviles RM, et al. (2004) The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 101:9103-9108.
7. Kinumi T, et al. (2004) Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells. Biochem Biophys Res Commun 317:722-728.
8. Betarbet R, et al. (2006) Intersecting pathways to neurodegeneration in Parkinson's disease: Effects of the pesticide rotenone on DJ-1, α-synuclein, and the ubiquitin-proteasome system. Neurobiol Dis 22:404-420.
9. Kim RH, et al. (2005) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA 102:5215-5220.
10. Menzies FM, Yenisetti SC, Min KT (2005) Roles of Drosophila DJ-1 in survival of dopaminergic neurons and oxidative stress. Curr Biol 15:1578-1582.
11. Meulener M, et al. (2005) Drosophila DJ-1 mutants are selectively sensitive to environmental toxins associated with Parkinson's disease. Curr Biol 15:1572-1577.
12. Meulener MC, et al. (2006) Mutational analysis of DJ-1 in Drosophila implicates functional inactivation by oxidative damage and aging. Proc Natl Acad Sci USA 103:12517-12522.
13. Ved R, et al. (2005) Similar patterns of mitochondrial vulnerability and rescue induced by genetic modification of α-synuclein, parkin, and DJ-1 in Caenorhabditis elegans. J Biol Chem 280:42655-42668.
14. Bandyopadhyay S, Cookson MR (2004) Evolutionary and functional relationships within the DJ1 superfamily. BMC Evol Biol 4:6.
15. Lucas JI, Marin I (2007) A new evolutionary paradigm for the Parkinson disease gene DJ-1. Mol Biol Evol 24:551-561.
16. Nagakubo D, et al. (1997) DJ-1, a novel oncogene which transformsmouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231:509-513.
17. Yang Y, et al. (2005) Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling. Proc Natl Acad Sci USA 102:13670-13675.
18. Kim RH, et al. (2005) DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7:263-273.
19. Junn E, et al. (2005) Interaction of DJ-1 with Daxx inhibits apoptosis signal-regulating kinase 1 activity and cell death. Proc Natl Acad Sci USA 102:9691-9696.
20. Zhou W, Freed CR (2005) DJ-1 up-regulates glutathione synthesis during oxidative stress and inhibits A53T α-synuclein toxicity. J Biol Chem 280:43150-43158.
21. Xu J, et al. (2005) The Parkinson's disease-associated DJ-1 protein is a transcriptional coactivator that protects against neuronal apoptosis. Hum Mol Genet 14:1231-1241.
22. Zhong N, et al. (2006) DJ-1 transcriptionally up-regulates the human tyrosine hydroxylase by inhibiting the sumoylation of pyrimidine tract-binding protein-associated splicing factor. J Biol Chem 281:20940-20948.
23. Wilson MA, et al. (2003) The 1.1-A resolution crystal structure of DJ-1, the protein mutated in autosomal recessive early-onset Parkinson's disease. Proc Natl Acad Sci USA 100:9256-9261.
24. Hod Y, Pentyala SN, Whyard TC, El-Maghrabi MR (1999) Identification and characterization of a novel protein that regulates RNA-protein interaction. J Cell Biochem 72:435-444.
25. Baptista MJ, et al. (2003) Coordinate transcriptional regulation of dopamine synthesis genes by α-synuclein in human neuroblastoma cell lines. J Neurochem 85:957-968.
26. Ule J, Jensen K, Mele A, Darnell RB (2005) CLIP: Amethod for identifying protein-RNA interaction sites in living cells. Methods 37:376-386.
27. Chandran JS, et al. (2008) Progressive behavioral deficits in DJ-1-deficient mice are associated with normal nigrostriatal function. Neurobiol Dis 29:505-514.
28. Zhang L, et al. (2005) Mitochondrial localization of the Parkinson's disease-related protein DJ-1: Implications for pathogenesis. Hum Mol Genet 14:2063-2073.
29. Brown V, et al. (2001) Microarray identification of FMRP-associated brain mRNAs and altered mRNA translational profiles in fragile X syndrome. Cell 107:477-487.
30. Ule J, et al. (2003) CLIP identifies Nova-regulated RNA networks in the brain. Science 302:1212-1215.
31. Lopez de Silanes I, et al. (2004) Identification of a target RNA motif for RNA-binding protein HuR. Proc Natl Acad Sci USA 101:2987-2992.
32. Holcik M, Sonenberg N (2005) Translational control in stress and apoptosis. Nat Rev Mol Cell Biol 6:318-327.
33. Bramham CR, Wells DG (2007) Dendritic mRNA: Transport, translation, and function. Nat Rev Neurosci 8:776-789.
34. Blackinton J, et al. (2005) Effects of DJ-1 mutations and polymorphisms on protein stability and subcellular localization. Brain Res Mol Brain Res 134:76-83.
35. Miller DW, et al. (2003) L166P mutant DJ-1, causative for recessive Parkinson's disease, is degraded through the ubiquitin-proteasome system. J Biol Chem 278:36588-36595.