Overexpression of neprilysin reduces alzheimer amyloid-β42 (Aβ42)-induced neuron loss and intraneuronal Aβ42 deposits but causes a reduction in cAMP-responsive element-binding protein-mediated transcription, age-dependent axon pathology, and premature death in Drosophila

Journal of Biological Chemistry

Volumn 283, Issue 27, 2008, Pages 19066-19076

  Iijima Ando, Kanae ^a,b,e   Hearn, Stephen A ^c   Granger, Linda ^a   Shenton, Christopher ^a   Gatt, Anthony ^a   Chiang, Hsueh Cheng ^c,d   Hakker, Inessa ^c   Zhong, Yi ^c   Iijima, Koichi ^a,b,e  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c Howard Hughes Medical Institute Cold Spring Harbor Laboratory Cold Spring Harbor   (United States)

^d Stony Brook University   (United States)

^e NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; FETAL MONITORING; GLYCOPROTEINS; MAMMALS; PATHOLOGY; PLANTS (BOTANY); PROTEINS; TRANSCRIPTION;

ALZHEIMER AMYLOIDS; ALZHEIMER DISEASES; BINDING PROTEINS; DEGRADING ENZYMES; DETRIMENTAL EFFECTS; EXTRACELLULAR; LIFE SPANS; MEDIATED TRANSCRIPTIONS; MEMORY DEFECTS; MOUSE MODELS; NEPRILYSIN; NEURODEGENERATION; OVEREXPRESSION; PREMATURE DEATHS; PROTECTIVE EFFECTS; SYNAPTIC DYSFUNCTIONS; TRANSGENIC;

BRAIN;

AMYLOID BETA PROTEIN[1-42]; CCAAT BINDING FACTOR; MEMBRANE METALLOENDOPEPTIDASE; MESSENGER RNA; PHOSPHORAMIDON; AMYLOID BETA PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN;

AGE; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CELL LOSS; CONTROLLED STUDY; DEATH; DOWN REGULATION; DROSOPHILA; GENETIC TRANSCRIPTION; LIFESPAN; NERVE FIBER DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TRANSGENIC ANIMAL; AGING; AMYLOIDOSIS; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; ENZYMOLOGY; EVOLUTION; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MOUSE; NERVE FIBER;

MAMMALIA;

AGING; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; AMYLOIDOSIS; ANIMALS; ANIMALS, GENETICALLY MODIFIED; AXONS; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; EVOLUTION; GENE EXPRESSION REGULATION; HUMANS; MICE; NEPRILYSIN;

EID: 49649123892     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M710509200     Document Type: Article

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