CREB-binding protein modulates repeat instability in a Drosophila model for polyQ disease

Science

Volumn 315, Issue 5820, 2007, Pages 1857-1859

  Jung, Joonil ^a   Bonini, Nancy ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; POLYGLUTAMINE; DROSOPHILA PROTEIN; HISTONE DEACETYLASE; HYDROXAMIC ACID; PEPTIDE; TRICHOSTATIN A;

CHEMICAL BINDING; DISEASE; DISEASE TREATMENT; DNA; ENZYME ACTIVITY; FLY; GENE EXPRESSION; PROTEIN; TOXICITY;

ACETYLATION; ARTICLE; DROSOPHILA; EXCISION REPAIR; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; SPINOCEREBELLAR DEGENERATION; TRINUCLEOTIDE REPEAT; ALLELE; ANIMAL; ANIMAL MODEL; CHEMISTRY; DNA REPAIR; DROSOPHILA MELANOGASTER; DRUG ANTAGONISM; FEMALE; FRAGILE X SYNDROME; GENETIC SUSCEPTIBILITY; GENETICS; GENOMIC INSTABILITY; HUMAN; HUNTINGTON CHOREA; MACHADO JOSEPH DISEASE; MALE; METABOLISM; TRANSGENE; TRANSGENIC ANIMAL;

ALLELES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTICIPATION, GENETIC; CREB-BINDING PROTEIN; DNA REPAIR; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FRAGILE X SYNDROME; GENOMIC INSTABILITY; HISTONE DEACETYLASES; HUMANS; HUNTINGTON DISEASE; HYDROXAMIC ACIDS; MACHADO-JOSEPH DISEASE; MALE; MODELS, ANIMAL; PEPTIDES; TRANSCRIPTION, GENETIC; TRANSGENES; TRINUCLEOTIDE REPEAT EXPANSION; TRINUCLEOTIDE REPEATS;

EID: 34147136044     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1139517     Document Type: Article

References (31)

1. J. R. Gatchel H. Y. Zoghbi, Nat Rev. Genet. 6, 743 (2005).
2. C. E. Pearson, K. N. Edamura, J. D. Cleary, Nat. Rev. Genet. 6, 729 (2005).
3. L. Mangiarini et al., Nat. Genet. 15, 197 (1997).
4. J. M. Warrick et al., Cell 93, 939 (1998).
5. P. Maciel et al., Eur. J. Hum. Genet. 7, 147 (1999).
6. S. M. Jackson et al., Gene 347, 35 (2005).
7. Y. Kawaguchi et al., Nat. Genet. 8, 221 (1994).
8. F. Tanaka et al., Am. J. Hum. Genet. 65, 966 (1999).
9. Y. Zhang, D. G. Monckton, M. J. Siciliano, T. H. Connor, M. L. Meistrich, Hum. Mol. Genet 11, 791 (2002).
10. Y, Takiyama et al., Hum. Mol. Genet. 6, 1063 (1997).
11. V. C. Wheeler et al., Hum. Mol. Genet. 8, 115 (1999).
12. T. Sato et al., Hum. Mol. Genet. 8, 99 (1999).
13. M. D. Kaytor, E. N. Burright, L. A. Duvick, H. Y. Zoghbi, H. T. Orr, Hum. Mol. Genet. 6, 2135 (1997).
14. R. D. Wells, R. Dere, M. L. Hebert, M. Napierala, L. S. Son, Nucleic Acids Res. 33, 3785 (2005).
15. K. Manley, T. L. Shirley, L. Flaherty, A. Messer, Nat. Genet. 23, 471 (1999).
16. C. Savouret et al., EMBO J. 22, 2264 (2003).
17. Y. Lin, V. Dion, J. H. Wilson, Nat. Struct. Mol. Biol. 13, 179 (2006).
18. S. Hasan, M. O. Hottiger, J. Mol. Med. 80, 463 (2002).
19. M. Tini et al., Mol. Cell 9, 265 (2002).
20. F. C. Nucifora Jr. et al., Science 291, 2423 (2001).
21. Y. Chai, J. Shao, V. M. Miller, A. Williams, H. L. Paulson, Proc. Natl. Acad. Sci. U.S.A. 99, 9310 (2002).
22. H. Jiang, F. C. Nucifora Jr., C. A. Ross, D. B. DeFranco, Hum. Mol. Genet. 12, 1 (2003).
23. G. Schaffar et al., Mol Cell 15, 95 (2004).
24. J. P. Taylor et al., Genes Dev. 17, 1463 (2003).
25. J. S. Steffan et al., Nature 413, 739 (2001).
26. L. Bodai, J. Pallos, L. M. Thompson, J. L. Marsh, Curr. Med. Chem. 10, 2577 (2003).
27. P. Jin et al., Neuron 39, 739 (2003).
28. L. Kennedy et al., Hum. Mol. Genet. 12, 3359 (2003).
29. M. DiFiglia et al., Science 277, 1990 (1997).
30. J. Marx, Science 310, 43 (2005).
31. We thank R. Pittman, H. Paulson, A. Cashmore, D. Lessing, L. Li, M. Watson for comments; S. DiNardo, L. Thompson, L. Goldstein, and P. Jin for reagents; and K. Xu and X. Teng for technical assistance. Supported by grants from the Hereditary Disease Foundation (to J.J.), the Packard Foundation, and NINDS (to N.M.B.). N.M.B. is an investigator of the Howard Hughes Medical Institute.