The Toll→NFκB signaling pathway mediates the neuropathological effects of the human Alzheimer's Aβ42 polypeptide in Drosophila

PLoS ONE

Volumn 3, Issue 12, 2008, Pages

  Tan, Lihua ^a   Schedl, Paul ^a   Song, Ho Juhn ^b   Garza, Dan ^b   Konsolaki, Mary ^c  

^a PRINCETON UNIVERSITY   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^c RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID BETA PROTEIN[1-42]; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR; TOLL LIKE RECEPTOR; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA-PROTEIN (1-42); CACTUS PROTEIN, DROSOPHILA; DNA BINDING PROTEIN; DROSOPHILA PROTEIN; PEPTIDE FRAGMENT; PHOSPHOPROTEIN; TL PROTEIN, DROSOPHILA;

ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DROSOPHILA; FEMALE; GENE IDENTIFICATION; GENE MUTATION; GENETIC MANIPULATION; INFLAMMATION; INNATE IMMUNITY; MALE; NERVE CELL NECROSIS; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; ANIMAL DISEASE; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; DRUG EFFECT; EYE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEAD; HUMAN; INNERVATION; LONGEVITY; METABOLISM; PATHOLOGY; PHYSIOLOGY; TRANSGENIC ANIMAL;

MAMMALIA;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; EYE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEAD; HUMANS; LONGEVITY; MODELS, BIOLOGICAL; NERVE DEGENERATION; NF-KAPPA B; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 58049196869     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0003966     Document Type: Article

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