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Volumn 9, Issue 5, 2009, Pages 539-559

Cannabinoid system in neurodegeneration: New perspectives in Alzheimer's disease

Author keywords

Alzheimer's disease; Cannabinoid; Cannabinoid receptors; CB2 agonist; Dementia; Endocannabinoid

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLDOPAMINE; 2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; AMYLOID; ANANDAMIDE; CANNABIDIOL; CANNABINOID; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOL; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DEXANABINOL; DRONABINOL; ENDOCANNABINOID; NABILONE; NOLADIN ETHER; PRAVADOLINE; RIMONABANT; TAU PROTEIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRODHAMINE; CANNABINOID RECEPTOR; LIGAND;

EID: 67649881952     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955709788167628     Document Type: Review
Times cited : (30)

References (248)
  • 1
    • 69949132072 scopus 로고    scopus 로고
    • Martinez-Gil, A. Ed, Transworkd Research Network: India
    • Martinez-Gil, A. Ed. Medicinal Chemistry of Alzheimer's disease. Transworkd Research Network: India, 2008.
    • (2008) Medicinal Chemistry of Alzheimer's disease
  • 2
    • 70349096270 scopus 로고    scopus 로고
    • WHO World Health Statistics
    • WHO World Health Statistics 2008. www.who.int 2008.
    • (2008)
  • 3
    • 42349099119 scopus 로고    scopus 로고
    • Endocannabinoids and the brain immune system: New neurones at the horizon?
    • Wolf, S. A.; Ullrich, O. Endocannabinoids and the brain immune system: new neurones at the horizon? J. Neuroendocrinol., 2008, 20 (Suppl 1), 15-19.
    • (2008) J. Neuroendocrinol , vol.20 , Issue.SUPPL. 1 , pp. 15-19
    • Wolf, S.A.1    Ullrich, O.2
  • 5
    • 33947128224 scopus 로고    scopus 로고
    • Endocannabinoids and the regulation of their levels in health and disease
    • Di Marzo, V.; Petrosino, S. Endocannabinoids and the regulation of their levels in health and disease. Curr. Opin. Lipidol., 2007, 18, 129-40.
    • (2007) Curr. Opin. Lipidol , vol.18 , pp. 129-140
    • Di Marzo, V.1    Petrosino, S.2
  • 6
    • 43449092524 scopus 로고    scopus 로고
    • The cannabinoid system in Parkinson's disease: Multiple targets to motor effects
    • Papa, S.M. The cannabinoid system in Parkinson's disease: multiple targets to motor effects. Exp. Neurol., 2008, 211, 334-38.
    • (2008) Exp. Neurol , vol.211 , pp. 334-338
    • Papa, S.M.1
  • 8
    • 35648944275 scopus 로고    scopus 로고
    • Alzheimer's disease; taking the edge off with cannabinoids?
    • Campbell, V.A.; Gowran, A. Alzheimer's disease; taking the edge off with cannabinoids? Br. J. Pharmacol., 2007, 152, 655-62.
    • (2007) Br. J. Pharmacol , vol.152 , pp. 655-662
    • Campbell, V.A.1    Gowran, A.2
  • 9
    • 0021124870 scopus 로고
    • Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds
    • Howlett, A.C. Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds. Life Sci., 1984, 35, 1803-10.
    • (1984) Life Sci , vol.35 , pp. 1803-1810
    • Howlett, A.C.1
  • 10
    • 0021722983 scopus 로고
    • Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes
    • Howlett, A.C.; Fleming, R.M. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membranes. Mol. Pharmacol., 1984, 26, 532-38.
    • (1984) Mol. Pharmacol , vol.26 , pp. 532-538
    • Howlett, A.C.1    Fleming, R.M.2
  • 11
    • 0021966402 scopus 로고
    • Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes
    • Howlett, A.C. Cannabinoid inhibition of adenylate cyclase. Biochemistry of the response in neuroblastoma cell membranes. Mol. Pharmacol., 1985, 27, 429-36.
    • (1985) Mol. Pharmacol , vol.27 , pp. 429-436
    • Howlett, A.C.1
  • 12
    • 0022559942 scopus 로고
    • Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs
    • Howlett, A.C.; Qualy, J.M.; Khachatrian, L.L. Involvement of Gi in the inhibition of adenylate cyclase by cannabimimetic drugs. Mol. Pharmacol., 1986, 29, 307-13.
    • (1986) Mol. Pharmacol , vol.29 , pp. 307-313
    • Howlett, A.C.1    Qualy, J.M.2    Khachatrian, L.L.3
  • 13
    • 0025325535 scopus 로고
    • Structure of a cannabinoid receptor and functional expression of the cloned cDNA
    • Matsuda, L.A.; Lolait, S.J.; Brownstein, M.J.; Young, A.C.; Bonner, T.I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature, 1990, 346, 561-64.
    • (1990) Nature , vol.346 , pp. 561-564
    • Matsuda, L.A.1    Lolait, S.J.2    Brownstein, M.J.3    Young, A.C.4    Bonner, T.I.5
  • 14
    • 0027515373 scopus 로고
    • Molecular characterization of a peripheral receptor for cannabinoids
    • Munro, S.; Thomas, K.L.; Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature, 1993, 365, 61-65.
    • (1993) Nature , vol.365 , pp. 61-65
    • Munro, S.1    Thomas, K.L.2    Abu-Shaar, M.3
  • 16
    • 0035053627 scopus 로고    scopus 로고
    • Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells
    • Kreitzer, A.C.; Regehr, W.G. Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto Purkinje cells. Neuron, 2001, 29, 717-27.
    • (2001) Neuron , vol.29 , pp. 717-727
    • Kreitzer, A.C.1    Regehr, W.G.2
  • 17
    • 0032821216 scopus 로고    scopus 로고
    • Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons
    • Sullivan, J.M. Mechanisms of cannabinoid-receptor-mediated inhibition of synaptic transmission in cultured hippocampal pyramidal neurons. J Neurophysiol., 1999, 82, 1286-94.
    • (1999) J Neurophysiol , vol.82 , pp. 1286-1294
    • Sullivan, J.M.1
  • 18
    • 0034175606 scopus 로고    scopus 로고
    • Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus
    • Hoffman, A.F.; Lupica, C.R. Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus. J. Neurosci., 2000, 20, 2470-79.
    • (2000) J. Neurosci , vol.20 , pp. 2470-2479
    • Hoffman, A.F.1    Lupica, C.R.2
  • 19
    • 0036867665 scopus 로고    scopus 로고
    • Retrograde signaling in the regulation of synaptic transmission: Focus on endocannabinoids
    • Alger, B.E. Retrograde signaling in the regulation of synaptic transmission: focus on endocannabinoids. Prog. Neurobiol., 2002, 68, 247-86.
    • (2002) Prog. Neurobiol , vol.68 , pp. 247-286
    • Alger, B.E.1
  • 20
    • 33748579212 scopus 로고    scopus 로고
    • Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons
    • Fisyunov, A.; Tsintsadze, V.; Min, R.; Burnashev, N.; Lozovaya, N. Cannabinoids modulate the P-type high-voltage-activated calcium currents in purkinje neurons. J. Neurophysiol., 2006, 96, 1267-77.
    • (2006) J. Neurophysiol , vol.96 , pp. 1267-1277
    • Fisyunov, A.1    Tsintsadze, V.2    Min, R.3    Burnashev, N.4    Lozovaya, N.5
  • 22
    • 0035150352 scopus 로고    scopus 로고
    • Cannabinoid receptors and pain
    • Pertwee, R.G. Cannabinoid receptors and pain. Prog. Neurobiol., 2001, 63, 569-611.
    • (2001) Prog. Neurobiol , vol.63 , pp. 569-611
    • Pertwee, R.G.1
  • 23
    • 0035042362 scopus 로고    scopus 로고
    • Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart
    • Szabo, B.; Nordheim, U.; Niederhoffer, N. Effects of cannabinoids on sympathetic and parasympathetic neuroeffector transmission in the rabbit heart. J. Pharmacol. Exp. Ther., 2001, 297, 819-26.
    • (2001) J. Pharmacol. Exp. Ther , vol.297 , pp. 819-826
    • Szabo, B.1    Nordheim, U.2    Niederhoffer, N.3
  • 24
    • 0035816432 scopus 로고    scopus 로고
    • Hemodynamic effects of cannabinoids: Coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors
    • Wagner, J.A.; Jarai, Z.; Batkai, S.; Kunos, G. Hemodynamic effects of cannabinoids: coronary and cerebral vasodilation mediated by cannabinoid CB(1) receptors. Eur. J. Pharmacol., 2001, 423, 203-10.
    • (2001) Eur. J. Pharmacol , vol.423 , pp. 203-210
    • Wagner, J.A.1    Jarai, Z.2    Batkai, S.3    Kunos, G.4
  • 25
    • 0030611978 scopus 로고    scopus 로고
    • Pharmacology of cannabinoid CB1 and CB2 receptors
    • Pertwee, R.G. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther., 1997, 74, 129-80.
    • (1997) Pharmacol. Ther , vol.74 , pp. 129-180
    • Pertwee, R.G.1
  • 27
    • 33244493807 scopus 로고    scopus 로고
    • Expression of the cannabinoid CB2 receptor in the rat cerebellum: An immunohistochemical study
    • Ashton, J.C.; Friberg, D.; Darlington, C.L.; Smith, P.F. Expression of the cannabinoid CB2 receptor in the rat cerebellum: an immunohistochemical study. Neurosci. Lett., 2006, 396, 113-16.
    • (2006) Neurosci. Lett , vol.396 , pp. 113-116
    • Ashton, J.C.1    Friberg, D.2    Darlington, C.L.3    Smith, P.F.4
  • 29
    • 0029870716 scopus 로고    scopus 로고
    • The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed post-glutamate paradigm of excitotoxic death in cerebellar granule neurons
    • Skaper, S.D.; Buriani, A.; Dal Toso, R.; Petrelli, L.; Romanello, S.; Facci, L.; Leon, A. The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed post-glutamate paradigm of excitotoxic death in cerebellar granule neurons. Proc. Natl. Acad. Sci. USA, 1996, 93, 3984-89.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3984-3989
    • Skaper, S.D.1    Buriani, A.2    Dal Toso, R.3    Petrelli, L.4    Romanello, S.5    Facci, L.6    Leon, A.7
  • 30
    • 48749103773 scopus 로고    scopus 로고
    • Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review
    • Svizenska, I.; Dubovy, P.; Sulcova, A. Cannabinoid receptors 1 and 2 (CB1 and CB2), their distribution, ligands and functional involvement in nervous system structures - A short review. Pharmacol. Biochem. Behav., 2008, 90, 501-11.
    • (2008) Pharmacol. Biochem. Behav , vol.90 , pp. 501-511
    • Svizenska, I.1    Dubovy, P.2    Sulcova, A.3
  • 32
    • 0025760879 scopus 로고
    • Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum
    • Herkenham, M.; Groen, B.G.; Lynn, A.B.; De Costa, B.R.; Richfield, E.K. Neuronal localization of cannabinoid receptors and second messengers in mutant mouse cerebellum. Brain Res., 1991, 552, 301-10.
    • (1991) Brain Res , vol.552 , pp. 301-310
    • Herkenham, M.1    Groen, B.G.2    Lynn, A.B.3    De Costa, B.R.4    Richfield, E.K.5
  • 36
    • 3843066799 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: An immunohistochemical study
    • Nunez, E.; Benito, C.; Pazos, M.R.; Barbachano, A.; Fajardo, O.; Gonzalez, S.; Tolon, R.M.; Romero, J. Cannabinoid CB2 receptors are expressed by perivascular microglial cells in the human brain: an immunohistochemical study. Synapse, 2004, 53, 208-13.
    • (2004) Synapse , vol.53 , pp. 208-213
    • Nunez, E.1    Benito, C.2    Pazos, M.R.3    Barbachano, A.4    Fajardo, O.5    Gonzalez, S.6    Tolon, R.M.7    Romero, J.8
  • 37
    • 9644268887 scopus 로고    scopus 로고
    • Cannabinoid signaling in glial cells
    • Stella, N. Cannabinoid signaling in glial cells. Glia, 2004, 48, 267-77.
    • (2004) Glia , vol.48 , pp. 267-277
    • Stella, N.1
  • 38
    • 26844448746 scopus 로고    scopus 로고
    • Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli
    • Maresz, K.; Carrier, E. J.; Ponomarev, E. D.; Hillard, C. J.; Dittel, B. N. Modulation of the cannabinoid CB2 receptor in microglial cells in response to inflammatory stimuli. J. Neurochem., 2005, 95, 437-45.
    • (2005) J. Neurochem , vol.95 , pp. 437-445
    • Maresz, K.1    Carrier, E.J.2    Ponomarev, E.D.3    Hillard, C.J.4    Dittel, B.N.5
  • 39
    • 33845603466 scopus 로고    scopus 로고
    • Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation
    • Palazuelos, J.; Aguado, T.; Egia, A.; Mechoulam, R.; Guzman, M.; Galve-Roperh, I. Non-psychoactive CB2 cannabinoid agonists stimulate neural progenitor proliferation. FASEB J., 2006, 20, 2405-07.
    • (2006) FASEB J , vol.20 , pp. 2405-2407
    • Palazuelos, J.1    Aguado, T.2    Egia, A.3    Mechoulam, R.4    Guzman, M.5    Galve-Roperh, I.6
  • 40
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado, E.; Vela, J.M.; Arevalo-Martin, A.; Almazan, G.; Molina-Holgado, F.; Borrell, J.; Guaza, C. Cannabinoids promote oligodendrocyte progenitor survival: involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. J. Neurosci., 2002, 22, 9742-53.
    • (2002) J. Neurosci , vol.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.M.2    Arevalo-Martin, A.3    Almazan, G.4    Molina-Holgado, F.5    Borrell, J.6    Guaza, C.7
  • 42
    • 20044386244 scopus 로고    scopus 로고
    • Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin
    • Stander, S.; Schmelz, M.; Metze, D.; Luger, T.; Rukwied, R. Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J. Dermatol. Sci., 2005, 38, 177-88.
    • (2005) J. Dermatol. Sci , vol.38 , pp. 177-188
    • Stander, S.1    Schmelz, M.2    Metze, D.3    Luger, T.4    Rukwied, R.5
  • 44
    • 24044458606 scopus 로고    scopus 로고
    • Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons
    • Wotherspoon, G.; Fox, A.; McIntyre, P.; Colley, S.; Bevan, S.; Winter, J. Peripheral nerve injury induces cannabinoid receptor 2 protein expression in rat sensory neurons. Neuroscience, 2005, 135, 235-45.
    • (2005) Neuroscience , vol.135 , pp. 235-245
    • Wotherspoon, G.1    Fox, A.2    McIntyre, P.3    Colley, S.4    Bevan, S.5    Winter, J.6
  • 46
    • 0032586885 scopus 로고    scopus 로고
    • Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: Implication for intracellular signalization cross-regulation
    • Bouaboula, M.; Desnoyer, N.; Carayon, P.; Combes, T.; Casellas, P. Gi protein modulation induced by a selective inverse agonist for the peripheral cannabinoid receptor CB2: implication for intracellular signalization cross-regulation. Mol. Pharmacol., 1999, 55, 473-80.
    • (1999) Mol. Pharmacol , vol.55 , pp. 473-480
    • Bouaboula, M.1    Desnoyer, N.2    Carayon, P.3    Combes, T.4    Casellas, P.5
  • 47
    • 0032407482 scopus 로고    scopus 로고
    • 2+ currents by reversal of tonic CB1 cannabinoid receptor activity
    • 2+ currents by reversal of tonic CB1 cannabinoid receptor activity. Mol. Pharmacol., 1998, 54, 1064-72.
    • (1998) Mol. Pharmacol , vol.54 , pp. 1064-1072
    • Pan, X.1    Ikeda, S.R.2    Lewis, D.L.3
  • 48
    • 0037123850 scopus 로고    scopus 로고
    • Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain
    • Mato, S.; Pazos, A.; Valdizan, E.M. Cannabinoid receptor antagonism and inverse agonism in response to SR141716A on cAMP production in human and rat brain. Eur. J. Pharmacol., 2002, 443, 43-46.
    • (2002) Eur. J. Pharmacol , vol.443 , pp. 43-46
    • Mato, S.1    Pazos, A.2    Valdizan, E.M.3
  • 49
    • 0034333417 scopus 로고    scopus 로고
    • Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor
    • Meschler, J.P.; Kraichely, D.M.; Wilken, G.H.; Howlett, A.C. Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxylic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor. Biochem. Pharmacol., 2000, 60, 1315-23.
    • (2000) Biochem. Pharmacol , vol.60 , pp. 1315-1323
    • Meschler, J.P.1    Kraichely, D.M.2    Wilken, G.H.3    Howlett, A.C.4
  • 50
    • 0032973339 scopus 로고    scopus 로고
    • Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange
    • Kearn, C.S.; Greenberg, M.J.; DiCamelli, R.; Kurzawa, K.; Hillard, C.J. Relationships between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange. J. Neurochem., 1999, 72, 2379-87.
    • (1999) J. Neurochem , vol.72 , pp. 2379-2387
    • Kearn, C.S.1    Greenberg, M.J.2    DiCamelli, R.3    Kurzawa, K.4    Hillard, C.J.5
  • 54
    • 4344581120 scopus 로고    scopus 로고
    • The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure
    • Okada, T.; Sugihara, M.; Bondar, A.N.; Elstner, M.; Entel, P.; Buss, V. The retinal conformation and its environment in rhodopsin in light of a new 2.2 A crystal structure. J. Mol. Biol., 2004, 342, 571-83.
    • (2004) J. Mol. Biol , vol.342 , pp. 571-583
    • Okada, T.1    Sugihara, M.2    Bondar, A.N.3    Elstner, M.4    Entel, P.5    Buss, V.6
  • 55
    • 0032199006 scopus 로고    scopus 로고
    • Binding, gating, affinity and efficacy: The interpretation of structure-activity relationships for agonists and of the effects of mutating receptors
    • Colquhoun, D. Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors. Br. J. Pharmacol., 1998, 125, 924-47.
    • (1998) Br. J. Pharmacol , vol.125 , pp. 924-947
    • Colquhoun, D.1
  • 56
    • 0034464742 scopus 로고    scopus 로고
    • Uncovering molecular mechanisms involved in activation of G protein-coupled receptors
    • Gether, U. Uncovering molecular mechanisms involved in activation of G protein-coupled receptors. Endocr. Rev., 2000, 21, 90-113.
    • (2000) Endocr. Rev , vol.21 , pp. 90-113
    • Gether, U.1
  • 63
    • 0027489995 scopus 로고
    • Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor
    • Hanus, L.; Gopher, A.; Almog, S.; Mechoulam, R. Two new unsaturated fatty acid ethanolamides in brain that bind to the cannabinoid receptor. J. Med. Chem., 1993, 36, 3032-34.
    • (1993) J. Med. Chem , vol.36 , pp. 3032-3034
    • Hanus, L.1    Gopher, A.2    Almog, S.3    Mechoulam, R.4
  • 64
    • 0032756226 scopus 로고    scopus 로고
    • Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors
    • Glass, M.; Northup, J. K. Agonist selective regulation of G proteins by cannabinoid CB(1) and CB(2) receptors. Mol. Pharmacol., 1999, 56, 1362-69.
    • (1999) Mol. Pharmacol , vol.56 , pp. 1362-1369
    • Glass, M.1    Northup, J.K.2
  • 67
    • 0033653297 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol and the cannabinoid receptors
    • Sugiura, T.; Waku, K. 2-Arachidonoylglycerol and the cannabinoid receptors. Chem. Phys. Lipids, 2000, 108, 89-106.
    • (2000) Chem. Phys. Lipids , vol.108 , pp. 89-106
    • Sugiura, T.1    Waku, K.2
  • 68
    • 0032104721 scopus 로고    scopus 로고
    • Cannabis and endogenous cannabinoid systems
    • Childers, S. R.; Breivogel, C. S. Cannabis and endogenous cannabinoid systems. Drug Alcohol Depend, 1998, 51, 173-87.
    • (1998) Drug Alcohol Depend , vol.51 , pp. 173-187
    • Childers, S.R.1    Breivogel, C.S.2
  • 70
    • 0037181180 scopus 로고    scopus 로고
    • Fezza, F.; Bisogno, T.; Minassi, A.; Appendino, G.; Mechoulam, R.; Di Marzo, V. Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues. FEBS Lett., 2002, 513, 294-98.
    • Fezza, F.; Bisogno, T.; Minassi, A.; Appendino, G.; Mechoulam, R.; Di Marzo, V. Noladin ether, a putative novel endocannabinoid: inactivation mechanisms and a sensitive method for its quantification in rat tissues. FEBS Lett., 2002, 513, 294-98.
  • 71
    • 0034332637 scopus 로고    scopus 로고
    • N-acyl-dopamines: Novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo
    • Bisogno, T.; Melck, D.; Bobrov, M.; Gretskaya, N. M.; Bezuglov, V. V.; De Petrocellis, L.; Di Marzo, V. N-acyl-dopamines: novel synthetic CB(1) cannabinoid-receptor ligands and inhibitors of anandamide inactivation with cannabimimetic activity in vitro and in vivo. Biochem. J., 2000, 351 Pt 3, 817-24.
    • (2000) Biochem. J , vol.351 , Issue.PART 3 , pp. 817-824
    • Bisogno, T.1    Melck, D.2    Bobrov, M.3    Gretskaya, N.M.4    Bezuglov, V.V.5    De Petrocellis, L.6    Di Marzo, V.7
  • 72
    • 35648960873 scopus 로고    scopus 로고
    • The complications of promiscuity: Endocannabinoid action and metabolism
    • Alexander, S. P.; Kendall, D. A. The complications of promiscuity: endocannabinoid action and metabolism. Br. J. Pharmacol., 2007, 152, 602-23.
    • (2007) Br. J. Pharmacol , vol.152 , pp. 602-623
    • Alexander, S.P.1    Kendall, D.A.2
  • 73
    • 34848863139 scopus 로고    scopus 로고
    • Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors
    • Saario, S. M.; Laitinen, J. T. Therapeutic potential of endocannabinoid-hydrolysing enzyme inhibitors. Basic Clin. Pharmacol. Toxicol., 2007, 101, 287-93.
    • (2007) Basic Clin. Pharmacol. Toxicol , vol.101 , pp. 287-293
    • Saario, S.M.1    Laitinen, J.T.2
  • 75
    • 48249097797 scopus 로고    scopus 로고
    • Endocannabinoids: Synthesis and degradation
    • Di Marzo, V. Endocannabinoids: synthesis and degradation. Rev. Physiol. Biochem. Pharmacol., 2008, 160, 1-24.
    • (2008) Rev. Physiol. Biochem. Pharmacol , vol.160 , pp. 1-24
    • Di Marzo, V.1
  • 77
    • 1242294480 scopus 로고    scopus 로고
    • Molecular characterization of a phospholipase d generating anandamide and its congeners
    • Okamoto, Y.; Morishita, J.; Tsuboi, K.; Tonai, T.; Ueda, N. Molecular characterization of a phospholipase d generating anandamide and its congeners. J. Biol. Chem., 2004, 279, 5298-5305.
    • (2004) J. Biol. Chem , vol.279 , pp. 5298-5305
    • Okamoto, Y.1    Morishita, J.2    Tsuboi, K.3    Tonai, T.4    Ueda, N.5
  • 78
    • 38049132293 scopus 로고    scopus 로고
    • Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain
    • Astarita, G.; Ahmed, F.; Piomelli, D. Identification of biosynthetic precursors for the endocannabinoid anandamide in the rat brain. J. Lipid Res., 2008, 49, 48-57.
    • (2008) J. Lipid Res , vol.49 , pp. 48-57
    • Astarita, G.1    Ahmed, F.2    Piomelli, D.3
  • 80
    • 0033006123 scopus 로고    scopus 로고
    • Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin
    • Bisogno, T.; Melck, D.; De Petrocellis, L.; Di Marzo, V. Phosphatidic acid as the biosynthetic precursor of the endocannabinoid 2-arachidonoylglycerol in intact mouse neuroblastoma cells stimulated with ionomycin. J. Neurochem., 1999, 72, 2113-19.
    • (1999) J. Neurochem , vol.72 , pp. 2113-2119
    • Bisogno, T.1    Melck, D.2    De Petrocellis, L.3    Di Marzo, V.4
  • 81
    • 1842428537 scopus 로고    scopus 로고
    • Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism
    • Carrier, E. J.; Kearn, C. S.; Barkmeier, A. J.; Breese, N. M.; Yang, W.; Nithipatikom, K.; Pfister, S. L.; Campbell, W. B.; Hillard, C. J. Cultured rat microglial cells synthesize the endocannabinoid 2-arachidonylglycerol, which increases proliferation via a CB2 receptor-dependent mechanism. Mol. Pharmacol., 2004, 65, 999-1007.
    • (2004) Mol. Pharmacol , vol.65 , pp. 999-1007
    • Carrier, E.J.1    Kearn, C.S.2    Barkmeier, A.J.3    Breese, N.M.4    Yang, W.5    Nithipatikom, K.6    Pfister, S.L.7    Campbell, W.B.8    Hillard, C.J.9
  • 82
    • 0030852614 scopus 로고    scopus 로고
    • Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion
    • Hillard, C. J.; Edgemond, W. S.; Jarrahian, A.; Campbell, W. B. Accumulation of N-arachidonoylethanolamine (anandamide) into cerebellar granule cells occurs via facilitated diffusion. J. Neurochem., 1997, 69, 631-38.
    • (1997) J. Neurochem , vol.69 , pp. 631-638
    • Hillard, C.J.1    Edgemond, W.S.2    Jarrahian, A.3    Campbell, W.B.4
  • 83
    • 0030865871 scopus 로고    scopus 로고
    • Functional role of high-affinity anandamide transport, as revealed by selective inhibition
    • Beltramo, M.; Stella, N.; Calignano, A.; Lin, S. Y.; Makriyannis, A.; Piomelli, D. Functional role of high-affinity anandamide transport, as revealed by selective inhibition. Science, 1997, 277, 1094-97.
    • (1997) Science , vol.277 , pp. 1094-1097
    • Beltramo, M.1    Stella, N.2    Calignano, A.3    Lin, S.Y.4    Makriyannis, A.5    Piomelli, D.6
  • 85
    • 40349114245 scopus 로고    scopus 로고
    • Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors
    • Vandevoorde, S. Overview of the chemical families of fatty acid amide hydrolase and monoacylglycerol lipase inhibitors. Curr. Top. Med. Chem., 2008, 8, 247-67.
    • (2008) Curr. Top. Med. Chem , vol.8 , pp. 247-267
    • Vandevoorde, S.1
  • 86
    • 33646068357 scopus 로고    scopus 로고
    • New insights into endocannabinoid degradation and its therapeutic potential
    • Bari, M.; Battista, N.; Fezza, F.; Gasperi, V.; Maccarrone, M. New insights into endocannabinoid degradation and its therapeutic potential. Mini. Rev. Med. Chem., 2006, 6, 257-68.
    • (2006) Mini. Rev. Med. Chem , vol.6 , pp. 257-268
    • Bari, M.1    Battista, N.2    Fezza, F.3    Gasperi, V.4    Maccarrone, M.5
  • 87
    • 33645299083 scopus 로고    scopus 로고
    • Fatty acid amide hydrolase: A potential target for next generation therapeutics
    • Maccarrone, M. Fatty acid amide hydrolase: a potential target for next generation therapeutics. Curr. Pharm. Des., 2006, 12, 759-72.
    • (2006) Curr. Pharm. Des , vol.12 , pp. 759-772
    • Maccarrone, M.1
  • 88
    • 37849049077 scopus 로고    scopus 로고
    • Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome
    • Nunez, E.; Benito, C.; Tolon, R. M.; Hillard, C. J.; Griffin, W. S.; Romero, J. Glial expression of cannabinoid CB(2) receptors and fatty acid amide hydrolase are beta amyloid-linked events in Down's syndrome. Neuroscience, 2008, 151, 104-10.
    • (2008) Neuroscience , vol.151 , pp. 104-110
    • Nunez, E.1    Benito, C.2    Tolon, R.M.3    Hillard, C.J.4    Griffin, W.S.5    Romero, J.6
  • 89
    • 42749089148 scopus 로고    scopus 로고
    • FAAH and anandamide: Is 2-AG really the odd one out?
    • Di Marzo, V.; Maccarrone, M. FAAH and anandamide: is 2-AG really the odd one out? Trends Pharmacol. Sci., 2008, 29, 229-33.
    • (2008) Trends Pharmacol. Sci , vol.29 , pp. 229-233
    • Di Marzo, V.1    Maccarrone, M.2
  • 92
  • 93
    • 33747177333 scopus 로고    scopus 로고
    • Cannabinoids, immune system and cytokine network
    • Massi, P.; Vaccani, A.; Parolaro, D. Cannabinoids, immune system and cytokine network. Curr. Pharm. Des., 2006, 12, 3135-46.
    • (2006) Curr. Pharm. Des , vol.12 , pp. 3135-3146
    • Massi, P.1    Vaccani, A.2    Parolaro, D.3
  • 94
    • 33847047729 scopus 로고    scopus 로고
    • Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors
    • Woods, S. C. Role of the endocannabinoid system in regulating cardiovascular and metabolic risk factors. Am. J. Med., 2007, 120, S19-25.
    • (2007) Am. J. Med , vol.120
    • Woods, S.C.1
  • 95
    • 34247199450 scopus 로고    scopus 로고
    • Hiley, C. R.; Hoi, P. M. Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? Cardiovasc. Drug Rev., 2007, 25, 46-60.
    • Hiley, C. R.; Hoi, P. M. Oleamide: a fatty acid amide signaling molecule in the cardiovascular system? Cardiovasc. Drug Rev., 2007, 25, 46-60.
  • 96
    • 34547573035 scopus 로고    scopus 로고
    • Cannabinoids and cardiovascular disease: The outlook for clinical treatments
    • Ashton, J. C.; Smith, P. F. Cannabinoids and cardiovascular disease: the outlook for clinical treatments. Curr. Vasc. Pharmacol., 2007, 5, 175-85.
    • (2007) Curr. Vasc. Pharmacol , vol.5 , pp. 175-185
    • Ashton, J.C.1    Smith, P.F.2
  • 97
    • 32944456073 scopus 로고    scopus 로고
    • Effects of cannabinoids on hypothalamic and reproductive function
    • Maccarrone, M.; Wenger, T. Effects of cannabinoids on hypothalamic and reproductive function. Handb. Exp. Pharmacol., 2005, 555-71.
    • (2005) Handb. Exp. Pharmacol , pp. 555-571
    • Maccarrone, M.1    Wenger, T.2
  • 99
    • 38349184209 scopus 로고    scopus 로고
    • CB2 receptors in reproduction
    • Maccarrone, M. CB2 receptors in reproduction. Br. J. Pharmacol., 2008, 153, 189-98.
    • (2008) Br. J. Pharmacol , vol.153 , pp. 189-198
    • Maccarrone, M.1
  • 100
    • 33845673559 scopus 로고    scopus 로고
    • Endocannabinoids and the control of energy balance
    • Matias, I.; Di Marzo, V. Endocannabinoids and the control of energy balance. Trends Endocrinol. Metab., 2007, 18, 27-37.
    • (2007) Trends Endocrinol. Metab , vol.18 , pp. 27-37
    • Matias, I.1    Di Marzo, V.2
  • 101
    • 36749088074 scopus 로고    scopus 로고
    • Endocannabinoid signaling in the spinal locomotor circuitry
    • El Manira, A.; Kyriakatos, A.; Nanou, E.; Mahmood, R. Endocannabinoid signaling in the spinal locomotor circuitry. Brain Res. Rev., 2008, 57, 29-36.
    • (2008) Brain Res. Rev , vol.57 , pp. 29-36
    • El Manira, A.1    Kyriakatos, A.2    Nanou, E.3    Mahmood, R.4
  • 102
    • 34547569805 scopus 로고    scopus 로고
    • Endocannabinoids in basal ganglia circuits: Implications for Parkinson disease
    • Benarroch, E. Endocannabinoids in basal ganglia circuits: implications for Parkinson disease. Neurology, 2007, 69, 306-09.
    • (2007) Neurology , vol.69 , pp. 306-309
    • Benarroch, E.1
  • 103
    • 33845309977 scopus 로고    scopus 로고
    • An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments
    • Lastres-Becker, I.; Fernandez-Ruiz, J. An overview of Parkinson's disease and the cannabinoid system and possible benefits of cannabinoid-based treatments. Curr. Med. Chem., 2006, 13, 3705-18.
    • (2006) Curr. Med. Chem , vol.13 , pp. 3705-3718
    • Lastres-Becker, I.1    Fernandez-Ruiz, J.2
  • 104
  • 105
    • 34047139505 scopus 로고    scopus 로고
    • The endocannabinoid pathway in Huntington's disease: A comparison with other neurodegenerative diseases
    • Maccarrone, M.; Battista, N.; Centonze, D. The endocannabinoid pathway in Huntington's disease: a comparison with other neurodegenerative diseases. Prog. Neurobiol., 2007, 81, 349-79.
    • (2007) Prog. Neurobiol , vol.81 , pp. 349-379
    • Maccarrone, M.1    Battista, N.2    Centonze, D.3
  • 106
    • 35648993493 scopus 로고    scopus 로고
    • Endocannabinoids and neurodegenerative diseases
    • Micale, V.; Mazzola, C.; Drago, F. Endocannabinoids and neurodegenerative diseases. Pharmacol. Res., 2007, 56, 382-92.
    • (2007) Pharmacol. Res , vol.56 , pp. 382-392
    • Micale, V.1    Mazzola, C.2    Drago, F.3
  • 107
    • 34548703835 scopus 로고    scopus 로고
    • Cannabinoids:their role in pain and palliation
    • McCarberg, B. H. Cannabinoids:their role in pain and palliation. J. Pain Palliat. Care Pharmacother., 2007, 21, 19-28.
    • (2007) J. Pain Palliat. Care Pharmacother , vol.21 , pp. 19-28
    • McCarberg, B.H.1
  • 108
    • 38349119715 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors: A therapeutic target for the treatment of inflammatory and neuropathic pain
    • Guindon, J.; Hohmann, A. G. Cannabinoid CB2 receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain. Br. J. Pharmacol., 2008, 153, 319-34.
    • (2008) Br. J. Pharmacol , vol.153 , pp. 319-334
    • Guindon, J.1    Hohmann, A.G.2
  • 109
    • 38049028807 scopus 로고    scopus 로고
    • Cannabinoids for the treatment of neuropathic pain: Clinical evidence
    • Ashton, J. C.; Milligan, E. D. Cannabinoids for the treatment of neuropathic pain: clinical evidence. Curr. Opin. Investig. Drugs, 2008, 9, 65-75.
    • (2008) Curr. Opin. Investig. Drugs , vol.9 , pp. 65-75
    • Ashton, J.C.1    Milligan, E.D.2
  • 110
    • 35648999552 scopus 로고    scopus 로고
    • Endocannabinoid metabolism and uptake: Novel targets for neuropathic and inflammatory pain
    • Jhaveri, M. D.; Richardson, D.; Chapman, V. Endocannabinoid metabolism and uptake: novel targets for neuropathic and inflammatory pain. Br. J. Pharmacol., 2007, 152, 624-32.
    • (2007) Br. J. Pharmacol , vol.152 , pp. 624-632
    • Jhaveri, M.D.1    Richardson, D.2    Chapman, V.3
  • 111
    • 43449127219 scopus 로고    scopus 로고
    • The endocannabinoid system in brain reward processes
    • Solinas, M.; Goldberg, S. R.; Piomelli, D. The endocannabinoid system in brain reward processes. Br. J. Pharmacol., 2008, 154, 369-83.
    • (2008) Br. J. Pharmacol , vol.154 , pp. 369-383
    • Solinas, M.1    Goldberg, S.R.2    Piomelli, D.3
  • 112
    • 21644456317 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in cognition and emotionality
    • Wotjak, C. T. Role of endogenous cannabinoids in cognition and emotionality. Mini Rev. Med. Chem., 2005, 5, 659-70.
    • (2005) Mini Rev. Med. Chem , vol.5 , pp. 659-670
    • Wotjak, C.T.1
  • 113
    • 52949104790 scopus 로고    scopus 로고
    • The endocannabinoid system and multiple sclerosis
    • Baker, D.; Pryce, G. The endocannabinoid system and multiple sclerosis. Curr. Pharm. Des., 2008, 14, 2326-36.
    • (2008) Curr. Pharm. Des , vol.14 , pp. 2326-2336
    • Baker, D.1    Pryce, G.2
  • 116
    • 27844525479 scopus 로고    scopus 로고
    • Chemical constituents of marijuana: The complex mixture of natural cannabinoids
    • Elsohly, M. A.; Slade, D. Chemical constituents of marijuana: the complex mixture of natural cannabinoids. Life Sci., 2005, 78, 539-48.
    • (2005) Life Sci , vol.78 , pp. 539-548
    • Elsohly, M.A.1    Slade, D.2
  • 117
    • 23144460515 scopus 로고    scopus 로고
    • Recent developments in cannabinoid ligands
    • Padgett, L. W. Recent developments in cannabinoid ligands. Life Sci., 2005, 77, 1767-98.
    • (2005) Life Sci , vol.77 , pp. 1767-1798
    • Padgett, L.W.1
  • 118
    • 21644464904 scopus 로고    scopus 로고
    • Huffman, J. W. CB2 receptor ligands. Mini Rev. Med. Chem., 2005, 5, 641-49.
    • Huffman, J. W. CB2 receptor ligands. Mini Rev. Med. Chem., 2005, 5, 641-49.
  • 119
    • 32844458669 scopus 로고    scopus 로고
    • Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: New selective ligands for the cannabinoid CB2 receptor
    • Marriott, K. S.; Huffman, J. W.; Wiley, J. L.; Martin, B. R. Synthesis and pharmacology of 11-nor-1-methoxy-9-hydroxyhexahydrocannabinols and 11-nor-1-deoxy-9-hydroxyhexahydrocannabinols: new selective ligands for the cannabinoid CB2 receptor. Bioorg. Med. Chem., 2006, 14, 2386-97.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 2386-2397
    • Marriott, K.S.1    Huffman, J.W.2    Wiley, J.L.3    Martin, B.R.4
  • 120
    • 42949150269 scopus 로고    scopus 로고
    • Indoles and related compounds as cannabinoid ligands
    • Manera, C.; Tuccinardi, T.; Martinelli, A. Indoles and related compounds as cannabinoid ligands. Mini Rev. Med. Chem., 2008, 8, 370-87.
    • (2008) Mini Rev. Med. Chem , vol.8 , pp. 370-387
    • Manera, C.1    Tuccinardi, T.2    Martinelli, A.3
  • 121
    • 40349101686 scopus 로고    scopus 로고
    • Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor
    • Marriott, K. S.; Huffman, J. W. Recent advances in the development of selective ligands for the cannabinoid CB(2) receptor. Curr. Top. Med. Chem., 2008, 8, 187-204.
    • (2008) Curr. Top. Med. Chem , vol.8 , pp. 187-204
    • Marriott, K.S.1    Huffman, J.W.2
  • 123
    • 38349184206 scopus 로고    scopus 로고
    • Targeting the cannabinoid CB2 receptor: Modelling and structural determinants of CB2 selective ligands
    • Poso, A.; Huffman, J. W. Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands. Br. J. Pharmacol., 2008, 153, 335-46.
    • (2008) Br. J. Pharmacol , vol.153 , pp. 335-346
    • Poso, A.1    Huffman, J.W.2
  • 125
    • 0032787760 scopus 로고    scopus 로고
    • The development of cannabinoid antagonists
    • Barth, F.; Rinaldi-Carmona, M. The development of cannabinoid antagonists. Curr. Med. Chem., 1999, 6, 745-55.
    • (1999) Curr. Med. Chem , vol.6 , pp. 745-755
    • Barth, F.1    Rinaldi-Carmona, M.2
  • 127
    • 34347336599 scopus 로고    scopus 로고
    • Rimonabant: Just an antiobesity drug? Current evidence on its pleiotropic effects
    • Bifulco, M.; Grimaldi, C.; Gazzerro, P.; Pisanti, S.; Santoro, A. Rimonabant: just an antiobesity drug? Current evidence on its pleiotropic effects. Mol. Pharmacol., 2007, 71, 1445-56.
    • (2007) Mol. Pharmacol , vol.71 , pp. 1445-1456
    • Bifulco, M.1    Grimaldi, C.2    Gazzerro, P.3    Pisanti, S.4    Santoro, A.5
  • 128
    • 12744258029 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    • Pertwee, R. G. Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci., 2005, 76, 1307-24.
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 129
    • 40349113029 scopus 로고    scopus 로고
    • CB1 cannabinoid antagonists: Structure-activity relationships and potential therapeutic applications
    • Jagerovic, N.; Fernandez-Fernandez, C.; Goya, P. CB1 cannabinoid antagonists: structure-activity relationships and potential therapeutic applications. Curr. Top. Med. Chem., 2008, 8, 205-30.
    • (2008) Curr. Top. Med. Chem , vol.8 , pp. 205-230
    • Jagerovic, N.1    Fernandez-Fernandez, C.2    Goya, P.3
  • 130
    • 34347336422 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptor inverse agonists and neutral antagonists: Effects on food intake, food-reinforced behavior and food aversions
    • Salamone, J. D.; McLaughlin, P. J.; Sink, K.; Makriyannis, A.; Parker, L. A. Cannabinoid CB1 receptor inverse agonists and neutral antagonists: effects on food intake, food-reinforced behavior and food aversions. Physiol. Behav., 2007, 91, 383-88.
    • (2007) Physiol. Behav , vol.91 , pp. 383-388
    • Salamone, J.D.1    McLaughlin, P.J.2    Sink, K.3    Makriyannis, A.4    Parker, L.A.5
  • 132
    • 34548515486 scopus 로고    scopus 로고
    • Blocking the cannabinoid receptors: Drug candidates and therapeutic promises
    • Muccioli, G. G. Blocking the cannabinoid receptors: drug candidates and therapeutic promises. Chem. Biodivers., 2007, 4, 1805-27.
    • (2007) Chem. Biodivers , vol.4 , pp. 1805-1827
    • Muccioli, G.G.1
  • 133
    • 33845569474 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists
    • Raitio, K. H.; Savinainen, J. R.; Nevalainen, T.; Jarvinen, T.; Vepsalainen, J. Synthesis and in vitro evaluation of novel 2-oxo-1,2-dihydroquinoline CB2 receptor inverse agonists. Chem. Biol. Drug Des., 2006, 68, 334-40.
    • (2006) Chem. Biol. Drug Des , vol.68 , pp. 334-340
    • Raitio, K.H.1    Savinainen, J.R.2    Nevalainen, T.3    Jarvinen, T.4    Vepsalainen, J.5
  • 134
    • 19444368081 scopus 로고    scopus 로고
    • Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists
    • Lange, J. H.; Kruse, C. G. Keynote review: Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists. Drug Discov. Today, 2005, 10, 693-702.
    • (2005) Drug Discov. Today , vol.10 , pp. 693-702
    • Lange, J.H.1    Kruse, C.G.2
  • 135
    • 22744435568 scopus 로고    scopus 로고
    • Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor
    • Savinainen, J. R.; Kokkola, T.; Salo, O. M.; Poso, A.; Jarvinen, T.; Laitinen, J. T. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2 receptor. Br. J. Pharmacol., 2005, 145, 636-45.
    • (2005) Br. J. Pharmacol , vol.145 , pp. 636-645
    • Savinainen, J.R.1    Kokkola, T.2    Salo, O.M.3    Poso, A.4    Jarvinen, T.5    Laitinen, J.T.6
  • 139
    • 33947489961 scopus 로고
    • The Isolation and Structure of A'-Tetrahydrocannabinol and Other Neutral Cannabinoids from Hashish
    • Gaoni, Y.; Mechoulam, R. The Isolation and Structure of A'-Tetrahydrocannabinol and Other Neutral Cannabinoids from Hashish. J. Am. Chem. Soc., 1964, 86, 1646-47.
    • (1964) J. Am. Chem. Soc , vol.86 , pp. 1646-1647
    • Gaoni, Y.1    Mechoulam, R.2
  • 140
    • 0035142746 scopus 로고    scopus 로고
    • In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor
    • Iwamura, H.; Suzuki, H.; Ueda, Y.; Kaya, T.; Inaba, T. In vitro and in vivo pharmacological characterization of JTE-907, a novel selective ligand for cannabinoid CB2 receptor. J. Pharmacol. Exp. Ther., 2001, 296, 420-25.
    • (2001) J. Pharmacol. Exp. Ther , vol.296 , pp. 420-425
    • Iwamura, H.1    Suzuki, H.2    Ueda, Y.3    Kaya, T.4    Inaba, T.5
  • 141
    • 28444433385 scopus 로고    scopus 로고
    • Evidence that the plant cannabinoid Delta(9)-tetrahydrocannabivarin is a cannabinoid CB(1) and CB(2) receptor antagonist
    • Thomas, A.; Stevenson, L. A.; Wease, K. N.; Price, M. R.; Baillie, G.; Ross, R. A.; Pertwee, R. G. Evidence that the plant cannabinoid Delta(9)-tetrahydrocannabivarin is a cannabinoid CB(1) and CB(2) receptor antagonist. Br. J. Pharmacol., 2005, 146, 917-26.
    • (2005) Br. J. Pharmacol , vol.146 , pp. 917-926
    • Thomas, A.1    Stevenson, L.A.2    Wease, K.N.3    Price, M.R.4    Baillie, G.5    Ross, R.A.6    Pertwee, R.G.7
  • 142
    • 34548482940 scopus 로고    scopus 로고
    • On the pharmacological properties of Delta9-tetrahydrocannabinol (THC)
    • Costa, B. On the pharmacological properties of Delta9-tetrahydrocannabinol (THC). Chem. Biodivers., 2007, 4, 1664-77.
    • (2007) Chem. Biodivers , vol.4 , pp. 1664-1677
    • Costa, B.1
  • 143
    • 38349158960 scopus 로고    scopus 로고
    • The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: Delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin
    • Pertwee, R. G. The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin. Br. J. Pharmacol., 2008, 153, 199-215.
    • (2008) Br. J. Pharmacol , vol.153 , pp. 199-215
    • Pertwee, R.G.1
  • 145
    • 33847653702 scopus 로고    scopus 로고
    • Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro
    • Thomas, A.; Baillie, G. L.; Phillips, A. M.; Razdan, R. K.; Ross, R. A.; Pertwee, R. G. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br. J. Pharmacol., 2007, 150, 613-23.
    • (2007) Br. J. Pharmacol , vol.150 , pp. 613-623
    • Thomas, A.1    Baillie, G.L.2    Phillips, A.M.3    Razdan, R.K.4    Ross, R.A.5    Pertwee, R.G.6
  • 146
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
    • Herkenham, M.; Lynn, A. B.; Johnson, M. R.; Melvin, L. S.; de Costa, B. R.; Rice, K. C. Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J. Neurosci., 1991, 11, 563-83.
    • (1991) J. Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 147
    • 0030046270 scopus 로고    scopus 로고
    • Gareau, Y. D., Claude; Gallant, Michel; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Weech, Philip K.; Metters, Kathleen M.; Labelle, Marc Structure activity relationships of tetrahydrocanabinol analogs on human cannabinoid receptors. Bioorg. Med. Chem. Lett., 1996, 6, 189-94.
    • Gareau, Y. D., Claude; Gallant, Michel; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; Tremblay, Nathalie; Weech, Philip K.; Metters, Kathleen M.; Labelle, Marc Structure activity relationships of tetrahydrocanabinol analogs on human cannabinoid receptors. Bioorg. Med. Chem. Lett., 1996, 6, 189-94.
  • 149
    • 0024377764 scopus 로고
    • Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs
    • Little, P. J.; Compton, D. R.; Mechoulam, R.; Martin, B. R. Stereochemical effects of 11-OH-delta 8-THC-dimethylheptyl in mice and dogs. Pharmacol. Biochem. Behav., 1989, 32, 661-66.
    • (1989) Pharmacol. Biochem. Behav , vol.32 , pp. 661-666
    • Little, P.J.1    Compton, D.R.2    Mechoulam, R.3    Martin, B.R.4
  • 150
    • 0024441853 scopus 로고
    • Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons
    • Jarbe, T. U.; Hiltunen, A. J.; Mechoulam, R. Stereospecificity of the discriminative stimulus functions of the dimethylheptyl homologs of 11-hydroxy-delta 8-tetrahydrocannabinol in rats and pigeons. J. Pharmacol. Exp. Ther., 1989, 250, 1000-05.
    • (1989) J. Pharmacol. Exp. Ther , vol.250 , pp. 1000-1005
    • Jarbe, T.U.1    Hiltunen, A.J.2    Mechoulam, R.3
  • 151
    • 5644244290 scopus 로고    scopus 로고
    • Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors
    • Govaerts, S. J.; Hermans, E.; Lambert, D. M. Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors. Eur. J. Pharm. Sci., 2004, 23, 233-43.
    • (2004) Eur. J. Pharm. Sci , vol.23 , pp. 233-243
    • Govaerts, S.J.1    Hermans, E.2    Lambert, D.M.3
  • 155
    • 27744550205 scopus 로고    scopus 로고
    • Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl-delta8-tetrahydrocannabinols: New selective ligands for the CB2 receptor
    • Huffman, J. W.; Bushell, S. M.; Joshi, S. N.; Wiley, J. L.; Martin, B. R. Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl-delta8-tetrahydrocannabinols: new selective ligands for the CB2 receptor. Bioorg. Med. Chem., 2006, 14, 247-62.
    • (2006) Bioorg. Med. Chem , vol.14 , pp. 247-262
    • Huffman, J.W.1    Bushell, S.M.2    Joshi, S.N.3    Wiley, J.L.4    Martin, B.R.5
  • 158
    • 34250179461 scopus 로고    scopus 로고
    • Biaryl cannabinoid mimetics - synthesis and structure-activity relationship
    • Worm, K.; Zhou, Q. J.; Stabley, G. J.; DeHaven, R. N.; Dolle, R. E. Biaryl cannabinoid mimetics - synthesis and structure-activity relationship. Bioorg. Med. Chem. Lett., 2007, 17, 3652-56.
    • (2007) Bioorg. Med. Chem. Lett , vol.17 , pp. 3652-3656
    • Worm, K.1    Zhou, Q.J.2    Stabley, G.J.3    DeHaven, R.N.4    Dolle, R.E.5
  • 160
    • 0026598734 scopus 로고
    • Conformationally restrained analogues of pravadoline: Nanomolar potent, enantioselective, (aminoalkyl) indole agonists of the cannabinoid receptor
    • D'Ambra, T. E.; Estep, K. G.; Bell, M. R.; Eissenstat, M. A.; Josef, K. A.; Ward, S. J.; Haycock, D. A.; Baizman, E. R.; Casiano, F. M.; Beglin, N. C.; et al. Conformationally restrained analogues of pravadoline: nanomolar potent, enantioselective, (aminoalkyl) indole agonists of the cannabinoid receptor. J. Med. Chem., 1992, 35, 124-35.
    • (1992) J. Med. Chem , vol.35 , pp. 124-135
    • D'Ambra, T.E.1    Estep, K.G.2    Bell, M.R.3    Eissenstat, M.A.4    Josef, K.A.5    Ward, S.J.6    Haycock, D.A.7    Baizman, E.R.8    Casiano, F.M.9    Beglin, N.C.10
  • 161
    • 21044448570 scopus 로고    scopus 로고
    • Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes
    • Huffman, J. W.; Padgett, L. W. Recent developments in the medicinal chemistry of cannabimimetic indoles, pyrroles and indenes. Curr. Med. Chem., 2005, 12, 1395-411.
    • (2005) Curr. Med. Chem , vol.12 , pp. 1395-1411
    • Huffman, J.W.1    Padgett, L.W.2
  • 162
    • 0030425575 scopus 로고    scopus 로고
    • Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): Identification of cannabinoid receptor subtype selective ligands
    • Showalter, V. M.; Compton, D. R.; Martin, B. R.; Abood, M. E. Evaluation of binding in a transfected cell line expressing a peripheral cannabinoid receptor (CB2): identification of cannabinoid receptor subtype selective ligands. J. Pharmacol. Exp. Ther., 1996, 278, 989-99.
    • (1996) J. Pharmacol. Exp. Ther , vol.278 , pp. 989-999
    • Showalter, V.M.1    Compton, D.R.2    Martin, B.R.3    Abood, M.E.4
  • 163
    • 0030575620 scopus 로고    scopus 로고
    • Gallant, M. D., Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petipibbon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; et al. New class of potent ligands for the human peripheral cannabinoid receptor. Bioorg. Med. Chem. Lett., 1996, 6, 2263-68.
    • Gallant, M. D., Claude; Gareau, Yves; Guay, Daniel; Leblanc, Yves; Prasit, Petipibbon; Rochette, Chantal; Sawyer, Nicole; Slipetz, Deborah M.; et al. New class of potent ligands for the human peripheral cannabinoid receptor. Bioorg. Med. Chem. Lett., 1996, 6, 2263-68.
  • 171
    • 28544438920 scopus 로고    scopus 로고
    • Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors
    • Brizzi, A.; Brizzi, V.; Cascio, M. G.; Bisogno, T.; Sirianni, R.; Di Marzo, V. Design, synthesis, and binding studies of new potent ligands of cannabinoid receptors. J. Med. Chem., 2005, 48, 7343-50.
    • (2005) J. Med. Chem , vol.48 , pp. 7343-7350
    • Brizzi, A.1    Brizzi, V.2    Cascio, M.G.3    Bisogno, T.4    Sirianni, R.5    Di Marzo, V.6
  • 172
    • 33748305610 scopus 로고    scopus 로고
    • 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors
    • Huffman, J. W.; Padgett, L. W.; Isherwood, M. L.; Wiley, J. L.; Martin, B. R. 1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: new high affinity ligands for the cannabinoid CB1 and CB2 receptors. Bioorg. Med. Chem. Lett., 2006, 16, 5432-35.
    • (2006) Bioorg. Med. Chem. Lett , vol.16 , pp. 5432-5435
    • Huffman, J.W.1    Padgett, L.W.2    Isherwood, M.L.3    Wiley, J.L.4    Martin, B.R.5
  • 174
    • 1642543378 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors
    • Ferrarini, P. L.; Calderone, V.; Cavallini, T.; Manera, C.; Saccomanni, G.; Pani, L.; Ruiu, S.; Gessa, G. L. Synthesis and biological evaluation of 1,8-naphthyridin-4(1H)-on-3-carboxamide derivatives as new ligands of cannabinoid receptors. Bioorg. Med. Chem., 2004, 12, 1921-33.
    • (2004) Bioorg. Med. Chem , vol.12 , pp. 1921-1933
    • Ferrarini, P.L.1    Calderone, V.2    Cavallini, T.3    Manera, C.4    Saccomanni, G.5    Pani, L.6    Ruiu, S.7    Gessa, G.L.8
  • 175
    • 1842832439 scopus 로고    scopus 로고
    • Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2 Cannabinoid Receptors
    • Mussinu, J.-M.; Ruiu, S.; Mule, A. C.; Pau, A.; Carai, M. A. M.; Loriga, G.; Murineddu, G.; Pinna, G. A. Tricyclic Pyrazoles. Part 1: Synthesis and Biological Evaluation of Novel 1,4-Dihydroindeno[1,2-c]pyrazol-based Ligands for CB1and CB2 Cannabinoid Receptors. Bioorg. Med. Chem., 2003, 11, 251-63.
    • (2003) Bioorg. Med. Chem , vol.11 , pp. 251-263
    • Mussinu, J.-M.1    Ruiu, S.2    Mule, A.C.3    Pau, A.4    Carai, M.A.M.5    Loriga, G.6    Murineddu, G.7    Pinna, G.A.8
  • 177
    • 30444443786 scopus 로고    scopus 로고
    • Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: Synthesis, pharmacological properties and molecular modeling
    • Stern, E.; Muccioli, G. G.; Millet, R.; Goossens, J. F.; Farce, A.; Chavatte, P.; Poupaert, J. H.; Lambert, D. M.; Depreux, P.; Henichart, J. P. Novel 4-oxo-1,4-dihydroquinoline-3-carboxamide derivatives as new CB2 cannabinoid receptors agonists: synthesis, pharmacological properties and molecular modeling. J. Med. Chem., 2006, 49, 70-79.
    • (2006) J. Med. Chem , vol.49 , pp. 70-79
    • Stern, E.1    Muccioli, G.G.2    Millet, R.3    Goossens, J.F.4    Farce, A.5    Chavatte, P.6    Poupaert, J.H.7    Lambert, D.M.8    Depreux, P.9    Henichart, J.P.10
  • 178
    • 34547924400 scopus 로고    scopus 로고
    • Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates
    • Gonsiorek, W.; Lunn, C. A.; Fan, X.; Deno, G.; Kozlowski, J.; Hipkin, R. W. Sch35966 is a potent, selective agonist at the peripheral cannabinoid receptor (CB2) in rodents and primates. Br. J. Pharmacol., 2007, 151, 1262-71.
    • (2007) Br. J. Pharmacol , vol.151 , pp. 1262-1271
    • Gonsiorek, W.1    Lunn, C.A.2    Fan, X.3    Deno, G.4    Kozlowski, J.5    Hipkin, R.W.6
  • 181
    • 70349086400 scopus 로고    scopus 로고
    • Eatherton, A.J.G, Paul, G.M, Howard, G.R, Leonard, M.W, Rawlings, N.A, Anthony, D, Peter, S.B, Richard, W.A. Preparation of aminopyrimidinecarboxamides and their use as CB2-type cannabinoid receptor modulators. In 129 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR, English, World Intellectual Property Organization, Ge: PCT Int. Appl. WO 2004018433 A1 4 Mar 2004
    • Eatherton, A.J.G.; Paul, G.M.; Howard, G.R.; Leonard, M.W.; Rawlings, N.A.; Anthony, D.; Peter, S.B.; Richard, W.A. Preparation of aminopyrimidinecarboxamides and their use as CB2-type cannabinoid receptor modulators. In 129 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). Ge: PCT Int. Appl. WO 2004018433 A1 4 Mar 2004.
  • 185
    • 0029078977 scopus 로고
    • Construction of a 3D model of the cannabinoid CB1 receptor: Determination of helix ends and helix orientation
    • Bramblett, R. D.; Panu, A. M.; Ballesteros, J. A.; Reggio, P. H. Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation. Life Sci., 1995, 56, 1971-82.
    • (1995) Life Sci , vol.56 , pp. 1971-1982
    • Bramblett, R.D.1    Panu, A.M.2    Ballesteros, J.A.3    Reggio, P.H.4
  • 186
    • 0032860406 scopus 로고    scopus 로고
    • The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)
    • Song, Z. H.; Slowey, C. A.; Hurst, D. P.; Reggio, P. H. The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2). Mol. Pharmacol., 1999, 56, 834-40.
    • (1999) Mol. Pharmacol , vol.56 , pp. 834-840
    • Song, Z.H.1    Slowey, C.A.2    Hurst, D.P.3    Reggio, P.H.4
  • 188
    • 0031458958 scopus 로고    scopus 로고
    • The cannabinoid receptor: Computer-aided molecular modeling and docking of ligand
    • Mahmoudian, M. The cannabinoid receptor: computer-aided molecular modeling and docking of ligand. J. Mol. Graph Model, 1997, 15, 149-153, 179.
    • (1997) J. Mol. Graph Model , vol.15 , Issue.149-153 , pp. 179
    • Mahmoudian, M.1
  • 189
    • 0025292355 scopus 로고
    • Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy
    • Henderson, R.; Baldwin, J. M.; Ceska, T. A.; Zemlin, F.; Beckmann, E.; Downing, K. H. Model for the structure of bacteriorhodopsin based on high-resolution electron cryo-microscopy. J. Mol. Biol., 1990, 213, 899-929.
    • (1990) J. Mol. Biol , vol.213 , pp. 899-929
    • Henderson, R.1    Baldwin, J.M.2    Ceska, T.A.3    Zemlin, F.4    Beckmann, E.5    Downing, K.H.6
  • 191
    • 0141704146 scopus 로고    scopus 로고
    • 3D structural model of the Gprotein-coupled cannabinoid CB2 receptor
    • Xie, X. Q.; Chen, J. Z.; Billings, E. M. 3D structural model of the Gprotein-coupled cannabinoid CB2 receptor. Proteins, 2003, 53, 307-19.
    • (2003) Proteins , vol.53 , pp. 307-319
    • Xie, X.Q.1    Chen, J.Z.2    Billings, E.M.3
  • 192
    • 11844249400 scopus 로고    scopus 로고
    • Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study
    • Montero, C.; Campillo, N. E.; Goya, P.; Paez, J. A. Homology models of the cannabinoid CB1 and CB2 receptors. A docking analysis study. Eur. J. Med. Chem., 2005, 40, 75-83.
    • (2005) Eur. J. Med. Chem , vol.40 , pp. 75-83
    • Montero, C.1    Campillo, N.E.2    Goya, P.3    Paez, J.A.4
  • 193
    • 22844447651 scopus 로고    scopus 로고
    • Chemical modification of the naphthoyl 3-position of JWH-015: In search of a fluorescent probe to the cannabinoid CB2 receptor
    • Yates, A. S.; Doughty, S. W.; Kendall, D. A.; Kellam, B. Chemical modification of the naphthoyl 3-position of JWH-015: in search of a fluorescent probe to the cannabinoid CB2 receptor. Bioorg. Med. Chem. Lett., 2005, 15, 3758-62.
    • (2005) Bioorg. Med. Chem. Lett , vol.15 , pp. 3758-3762
    • Yates, A.S.1    Doughty, S.W.2    Kendall, D.A.3    Kellam, B.4
  • 194
    • 22344436829 scopus 로고    scopus 로고
    • Zhang, R.; Hurst, D. P.; Barnett-Norris, J.; Reggio, P. H.; Song, Z. H. Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template. Mol. Pharmacol., 2005, 68, 69-83.
    • Zhang, R.; Hurst, D. P.; Barnett-Norris, J.; Reggio, P. H.; Song, Z. H. Cysteine 2.59(89) in the second transmembrane domain of human CB2 receptor is accessible within the ligand binding crevice: evidence for possible CB2 deviation from a rhodopsin template. Mol. Pharmacol., 2005, 68, 69-83.
  • 195
    • 33744916587 scopus 로고    scopus 로고
    • Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects
    • Raduner, S.; Majewska, A.; Chen, J. Z.; Xie, X. Q.; Hamon, J.; Faller, B.; Altmann, K. H.; Gertsch, J. Alkylamides from Echinacea are a new class of cannabinomimetics. Cannabinoid type 2 receptor-dependent and -independent immunomodulatory effects. J. Biol. Chem., 2006, 281, 14192-206.
    • (2006) J. Biol. Chem , vol.281 , pp. 14192-14206
    • Raduner, S.1    Majewska, A.2    Chen, J.Z.3    Xie, X.Q.4    Hamon, J.5    Faller, B.6    Altmann, K.H.7    Gertsch, J.8
  • 197
    • 0038119607 scopus 로고    scopus 로고
    • Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction
    • Shim, J. Y.; Welsh, W. J.; Howlett, A. C. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers, 2003, 71, 169-89.
    • (2003) Biopolymers , vol.71 , pp. 169-189
    • Shim, J.Y.1    Welsh, W.J.2    Howlett, A.C.3
  • 200
    • 0036892304 scopus 로고    scopus 로고
    • Hurst, D. P.; Lynch, D. L.; Barnett-Norris, J.; Hyatt, S. M.; Seltzman, H. H.; Zhong, M.; Song, Z. H.; Nie, J.; Lewis, D.; Reggio, P. H. N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methyl-1H-p yrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor. Mol. Pharmacol., 2002, 62, 1274-87.
    • Hurst, D. P.; Lynch, D. L.; Barnett-Norris, J.; Hyatt, S. M.; Seltzman, H. H.; Zhong, M.; Song, Z. H.; Nie, J.; Lewis, D.; Reggio, P. H. N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methyl-1H-p yrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor. Mol. Pharmacol., 2002, 62, 1274-87.
  • 201
    • 18444386531 scopus 로고    scopus 로고
    • Targeting the cannabinoid CB2 receptor: Mutations, modeling and development of CB2 selective ligands
    • Raitio, K. H.; Salo, O. M.; Nevalainen, T.; Poso, A.; Jarvinen, T. Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands. Curr. Med. Chem., 2005, 12, 1217-37.
    • (2005) Curr. Med. Chem , vol.12 , pp. 1217-1237
    • Raitio, K.H.1    Salo, O.M.2    Nevalainen, T.3    Poso, A.4    Jarvinen, T.5
  • 202
    • 49249124000 scopus 로고    scopus 로고
    • Lipid-mediated dimerization of beta(2)-adrenergic receptor reveals important clues for cannabinoid receptors
    • Dainese, E.; Oddi, S.; Maccarrone, M. Lipid-mediated dimerization of beta(2)-adrenergic receptor reveals important clues for cannabinoid receptors. Cell Mol. Life Sci., 2008, 65, 2277-79.
    • (2008) Cell Mol. Life Sci , vol.65 , pp. 2277-2279
    • Dainese, E.1    Oddi, S.2    Maccarrone, M.3
  • 206
    • 0034327611 scopus 로고    scopus 로고
    • Hinges, swivels and switches: The role of prolines in signalling via transmembrane alpha-helices
    • Sansom, M. S.; Weinstein, H. Hinges, swivels and switches: the role of prolines in signalling via transmembrane alpha-helices. Trends Pharmacol. Sci., 2000, 21, 445-51.
    • (2000) Trends Pharmacol. Sci , vol.21 , pp. 445-451
    • Sansom, M.S.1    Weinstein, H.2
  • 207
    • 0036954833 scopus 로고    scopus 로고
    • Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch
    • Singh, R.; Hurst, D. P.; Barnett-Norris, J.; Lynch, D. L.; Reggio, P. H.; Guarnieri, F. Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch. J. Pept. Res., 2002, 60, 357-70.
    • (2002) J. Pept. Res , vol.60 , pp. 357-370
    • Singh, R.1    Hurst, D.P.2    Barnett-Norris, J.3    Lynch, D.L.4    Reggio, P.H.5    Guarnieri, F.6
  • 208
    • 0030611331 scopus 로고    scopus 로고
    • Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment
    • Javitch, J. A.; Fu, D.; Liapakis, G.; Chen, J. Constitutive activation of the beta2 adrenergic receptor alters the orientation of its sixth membrane-spanning segment. J. Biol. Chem., 1997, 272, 18546-49.
    • (1997) J. Biol. Chem , vol.272 , pp. 18546-18549
    • Javitch, J.A.1    Fu, D.2    Liapakis, G.3    Chen, J.4
  • 209
    • 0029866824 scopus 로고    scopus 로고
    • A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
    • Song, Z. H.; Bonner, T. I. A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Mol. Pharmacol., 1996, 49, 891-96.
    • (1996) Mol. Pharmacol , vol.49 , pp. 891-896
    • Song, Z.H.1    Bonner, T.I.2
  • 210
    • 33645774690 scopus 로고    scopus 로고
    • Cannabinoid receptors and their ligands: Ligandligand and ligand-receptor modeling approaches
    • Reggio, P. H. Cannabinoid receptors and their ligands: ligandligand and ligand-receptor modeling approaches. Handb. Exp. Pharmacol., 2005, 247-81.
    • (2005) Handb. Exp. Pharmacol , pp. 247-281
    • Reggio, P.H.1
  • 211
    • 21644450629 scopus 로고    scopus 로고
    • CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches
    • Ortega-Gutierrez, S.; Lopez-Rodriguez, M. L. CB1 and CB2 cannabinoid receptor binding studies based on modeling and mutagenesis approaches. Mini. Rev. Med. Chem., 2005, 5, 651-58.
    • (2005) Mini. Rev. Med. Chem , vol.5 , pp. 651-658
    • Ortega-Gutierrez, S.1    Lopez-Rodriguez, M.L.2
  • 212
    • 33745897301 scopus 로고    scopus 로고
    • The amyloid code
    • Mandavilli, A. The amyloid code. Nat. Med., 2006, 12, 747-51.
    • (2006) Nat. Med , vol.12 , pp. 747-751
    • Mandavilli, A.1
  • 213
  • 214
    • 33646009985 scopus 로고    scopus 로고
    • Cholinergically mediated augmentation of cerebral perfusion in Alzheimer's disease and related cognitive disorders: The cholinergic-vascular hypothesis
    • Claassen, J. A.; Jansen, R. W. Cholinergically mediated augmentation of cerebral perfusion in Alzheimer's disease and related cognitive disorders: the cholinergic-vascular hypothesis. J. Gerontol. A. Biol. Sci. Med. Sci., 2006, 61, 267-71.
    • (2006) J. Gerontol. A. Biol. Sci. Med. Sci , vol.61 , pp. 267-271
    • Claassen, J.A.1    Jansen, R.W.2
  • 215
    • 33751058040 scopus 로고    scopus 로고
    • Treatment of attention deficits in neurological disorders
    • Coulthard, E.; Singh-Curry, V.; Husain, M. Treatment of attention deficits in neurological disorders. Curr. Opin. Neurol., 2006, 19, 613-18.
    • (2006) Curr. Opin. Neurol , vol.19 , pp. 613-618
    • Coulthard, E.1    Singh-Curry, V.2    Husain, M.3
  • 217
    • 44949096480 scopus 로고    scopus 로고
    • Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis
    • Kamal, M. A.; Qu, X.; Yu, Q. S.; Tweedie, D.; Holloway, H. W.; Li, Y.; Tan, Y.; Greig, N. H. Tetrahydrofurobenzofuran cymserine, a potent butyrylcholinesterase inhibitor and experimental Alzheimer drug candidate, enzyme kinetic analysis. J. Neural. Transm., 2008, 115, 889-98.
    • (2008) J. Neural. Transm , vol.115 , pp. 889-898
    • Kamal, M.A.1    Qu, X.2    Yu, Q.S.3    Tweedie, D.4    Holloway, H.W.5    Li, Y.6    Tan, Y.7    Greig, N.H.8
  • 218
    • 30344485665 scopus 로고    scopus 로고
    • Targeting acetylcholinesterase and butyrylcholinesterase in dementia
    • Lane, R. M.; Potkin, S. G.; Enz, A. Targeting acetylcholinesterase and butyrylcholinesterase in dementia. Int. J. Neuropsychopharmacol., 2006, 9, 101-24.
    • (2006) Int. J. Neuropsychopharmacol , vol.9 , pp. 101-124
    • Lane, R.M.1    Potkin, S.G.2    Enz, A.3
  • 220
    • 34347380706 scopus 로고    scopus 로고
    • Executive dyscontrol in dementia, with emphasis on subcortical pathology and the role of butyrylcholinesterase
    • Bullock, R.; Lane, R. Executive dyscontrol in dementia, with emphasis on subcortical pathology and the role of butyrylcholinesterase. Curr. Alzheimer Res., 2007, 4, 277-93.
    • (2007) Curr. Alzheimer Res , vol.4 , pp. 277-293
    • Bullock, R.1    Lane, R.2
  • 221
    • 33745034018 scopus 로고    scopus 로고
    • The chemical biology of clinically tolerated NMDA receptor antagonists
    • Chen, H. S.; Lipton, S. A. The chemical biology of clinically tolerated NMDA receptor antagonists. J. Neurochem., 2006, 97, 1611-26.
    • (2006) J. Neurochem , vol.97 , pp. 1611-1626
    • Chen, H.S.1    Lipton, S.A.2
  • 222
    • 33750379305 scopus 로고    scopus 로고
    • Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor
    • Goto, Y.; Niidome, T.; Akaike, A.; Kihara, T.; Sugimoto, H. Amyloid beta-peptide preconditioning reduces glutamate-induced neurotoxicity by promoting endocytosis of NMDA receptor. Biochem. Biophys. Res. Commun., 2006, 351, 259-65.
    • (2006) Biochem. Biophys. Res. Commun , vol.351 , pp. 259-265
    • Goto, Y.1    Niidome, T.2    Akaike, A.3    Kihara, T.4    Sugimoto, H.5
  • 224
    • 52949112654 scopus 로고    scopus 로고
    • The role of the endocannabinoid system in Alzheimer's disease: Facts and hypotheses
    • Bisogno, T.; Di Marzo, V. The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses. Curr. Pharm. Des., 2008, 14, 2299-3305.
    • (2008) Curr. Pharm. Des , vol.14 , pp. 2299-3305
    • Bisogno, T.1    Di Marzo, V.2
  • 226
    • 0037206662 scopus 로고    scopus 로고
    • Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide
    • Milton, N. G. Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. Neurosci. Lett., 2002, 332, 127-30.
    • (2002) Neurosci. Lett , vol.332 , pp. 127-130
    • Milton, N.G.1
  • 227
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • Ramirez, B. G.; Blazquez, C.; Gomez del Pulgar, T.; Guzman, M.; de Ceballos, M. L. Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci., 2005, 25, 1904-13.
    • (2005) J. Neurosci , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez del Pulgar, T.3    Guzman, M.4    de Ceballos, M.L.5
  • 230
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    • Iuvone, T.; Esposito, G.; Esposito, R.; Santamaria, R.; Di Rosa, M.; Izzo, A.A. Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells. J. Neurochem., 2004, 89, 134-41.
    • (2004) J. Neurochem , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 231
    • 33746296471 scopus 로고    scopus 로고
    • CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons
    • Esposito, G.; De Filippis, D.; Steardo, L.; Scuderi, C.; Savani, C.; Cuomo, V.; Iuvone, T. CB1 receptor selective activation inhibits beta-amyloid-induced iNOS protein expression in C6 cells and subsequently blunts tau protein hyperphosphorylation in co-cultured neurons. Neurosci. Lett., 2006, 404, 342-46.
    • (2006) Neurosci. Lett , vol.404 , pp. 342-346
    • Esposito, G.1    De Filippis, D.2    Steardo, L.3    Scuderi, C.4    Savani, C.5    Cuomo, V.6    Iuvone, T.7
  • 232
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • Esposito, G.; De Filippis, D.; Carnuccio, R.; Izzo, A. A.; Iuvone, T. The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J. Mol. Med., 2006, 84, 253-58.
    • (2006) J. Mol. Med , vol.84 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 233
    • 33646078800 scopus 로고    scopus 로고
    • Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in betaamyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement
    • Esposito, G.; De Filippis, D.; Maiuri, M. C.; De Stefano, D.; Carnuccio, R.; Iuvone, T. Cannabidiol inhibits inducible nitric oxide synthase protein expression and nitric oxide production in betaamyloid stimulated PC12 neurons through p38 MAP kinase and NF-kappaB involvement. Neurosci. Lett., 2006, 399, 91-95.
    • (2006) Neurosci. Lett , vol.399 , pp. 91-95
    • Esposito, G.1    De Filippis, D.2    Maiuri, M.C.3    De Stefano, D.4    Carnuccio, R.5    Iuvone, T.6
  • 237
    • 33846335526 scopus 로고    scopus 로고
    • Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation
    • Marchalant, Y.; Rosi, S.; Wenk, G. L. Anti-inflammatory property of the cannabinoid agonist WIN-55212-2 in a rodent model of chronic brain inflammation. Neuroscience, 2007, 144, 1516-22.
    • (2007) Neuroscience , vol.144 , pp. 1516-1522
    • Marchalant, Y.1    Rosi, S.2    Wenk, G.L.3
  • 238
    • 0030886734 scopus 로고    scopus 로고
    • Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease
    • Volicer, L.; Stelly, M.; Morris, J.; McLaughlin, J.; Volicer, B. J. Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease. Int. J. Geriatr. Psychiatry, 1997, 12, 913-19.
    • (1997) Int. J. Geriatr. Psychiatry , vol.12 , pp. 913-919
    • Volicer, L.1    Stelly, M.2    Morris, J.3    McLaughlin, J.4    Volicer, B.J.5
  • 239
    • 33645453054 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia
    • Walther, S.; Mahlberg, R.; Eichmann, U.; Kunz, D. Delta-9-tetrahydrocannabinol for nighttime agitation in severe dementia. Psychopharmacology (Berl.), 2006, 185, 524-28.
    • (2006) Psychopharmacology (Berl.) , vol.185 , pp. 524-528
    • Walther, S.1    Mahlberg, R.2    Eichmann, U.3    Kunz, D.4
  • 240
    • 33846401540 scopus 로고    scopus 로고
    • Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: Importance of antioxidant and cannabinoid receptor-independent properties
    • Garcia-Arencibia, M.; Gonzalez, S.; de Lago, E.; Ramos, J. A.; Mechoulam, R.; Fernandez-Ruiz, J. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties. Brain Res., 2007, 1134, 162-70.
    • (2007) Brain Res , vol.1134 , pp. 162-170
    • Garcia-Arencibia, M.1    Gonzalez, S.2    de Lago, E.3    Ramos, J.A.4    Mechoulam, R.5    Fernandez-Ruiz, J.6
  • 241
  • 242
    • 33748038473 scopus 로고    scopus 로고
    • Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats
    • Fernandez-Lopez, D.; Martinez-Orgado, J.; Nunez, E.; Romero, J.; Lorenzo, P.; Moro, M. A.; Lizasoain, I. Characterization of the neuroprotective effect of the cannabinoid agonist WIN-55212 in an in vitro model of hypoxic-ischemic brain damage in newborn rats. Pediatr. Res., 2006, 60, 169-73.
    • (2006) Pediatr. Res , vol.60 , pp. 169-173
    • Fernandez-Lopez, D.1    Martinez-Orgado, J.2    Nunez, E.3    Romero, J.4    Lorenzo, P.5    Moro, M.A.6    Lizasoain, I.7
  • 243
    • 33746261289 scopus 로고    scopus 로고
    • AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis
    • Kim, K.; Moore, D. H.; Makriyannis, A.; Abood, M. E. AM1241, a cannabinoid CB2 receptor selective compound, delays disease progression in a mouse model of amyotrophic lateral sclerosis. Eur. J. Pharmacol., 2006, 542, 100-05.
    • (2006) Eur. J. Pharmacol , vol.542 , pp. 100-105
    • Kim, K.1    Moore, D.H.2    Makriyannis, A.3    Abood, M.E.4
  • 244
    • 34250717998 scopus 로고    scopus 로고
    • Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model
    • Zhang, M.; Martin, B. R.; Adler, M. W.; Razdan, R. K.; Jallo, J. I.; Tuma, R. F. Cannabinoid CB(2) receptor activation decreases cerebral infarction in a mouse focal ischemia/reperfusion model. J. Cereb. Blood Flow Metab., 2007, 27, 1387-96.
    • (2007) J. Cereb. Blood Flow Metab , vol.27 , pp. 1387-1396
    • Zhang, M.1    Martin, B.R.2    Adler, M.W.3    Razdan, R.K.4    Jallo, J.I.5    Tuma, R.F.6
  • 245
    • 17444370570 scopus 로고    scopus 로고
    • Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: Relevance to Parkinson's disease
    • Lastres-Becker, I.; Molina-Holgado, F.; Ramos, J. A.; Mechoulam, R.; Fernandez-Ruiz, J. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease. Neurobiol. Dis. 2005, 19, 96-107.
    • (2005) Neurobiol. Dis , vol.19 , pp. 96-107
    • Lastres-Becker, I.1    Molina-Holgado, F.2    Ramos, J.A.3    Mechoulam, R.4    Fernandez-Ruiz, J.5
  • 248
    • 0028323255 scopus 로고
    • Dong Design, synthesis and pharmacology of cannabimimetic indoles
    • Huffmann, J. W. D. Dong Design, synthesis and pharmacology of cannabimimetic indoles. Bioorg. Med. Chem. Lett. 1994, 4, 563-66.
    • (1994) Bioorg. Med. Chem. Lett , vol.4 , pp. 563-566
    • Huffmann, J.W.D.1


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