Actions of cannabinoid receptor ligands on rat cultured sensory neurones: Implications for antinociception

Neuropharmacology

Volumn 40, Issue 2, 2001, Pages 221-232

  Ross, Ruth A ^a   Coutts, Angela A ^a   McFarlane, Shona M ^a   Anavi Goffer, Sharon ^a   Irving, Andrew J ^a   Pertwee, Roger G ^a   MacEwan, David J ^a   Scott, Roderick H ^a  

^a UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

Calcium channels; Cannabinoid receptors; DRG; F 11; Inverse agonism

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ANANDAMIDE; CANNABINOID RECEPTOR; CYCLIC AMP; FORSKOLIN; OMEGA CONOTOXIN GVIA; RECEPTOR SUBTYPE; RIMONABANT;

ANIMAL CELL; ANTINOCICEPTION; ARTICLE; CALCIUM CURRENT; CONTROLLED STUDY; FLUORESCENCE ACTIVATED CELL SORTER; HYBRID CELL; IN VITRO STUDY; NERVE CELL CULTURE; NONHUMAN; PRESYNAPTIC INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SENSORY NERVE CELL; SPINAL GANGLION;

ANIMALS; ANIMALS, NEWBORN; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS; CANNABINOIDS; CELLS, CULTURED; CYCLIC AMP; FLUORESCENCE; FORSKOLIN; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; ION CHANNEL GATING; LIGANDS; MORPHOLINES; NAPHTHALENES; NEURONS, AFFERENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0035218154     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00135-0     Document Type: Article

References (39)

1. Role of endogenous cannabinoid system in the formalin test of persistent pain in the rat
2. Multiple components of both transient and sustained barium currents in rat dorsal root ganglion cell line
3. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions
4. 1 receptor
5. Control of pain initiation by endogenous cannabinoids
6. Cannabinoid receptor agonists inhibit Ca current in NG108-15 neuroblastoma cells via a pertussis toxin-sensitive mechanism
7. Effects of anandamide on cannabinoid receptors in rat brain membranes
8. Comparison of novel cannabinoid partial agonists and SR141716A in the guinea-pig small intestine
9. Direct and indirect modulation of neuronal calcium currents by G-protein activation
10. 1 receptor expression in rat spinal cord
11. Neurchemical characterisation of novel dorsal root ganglion X neuroblastoma hybrid cell line, F-11
12. Improved patch-clamp techniques for high resoluation current recording from cells and cell-free membranne patches
13. The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist, in a rat model of neuropathic pain
14. Cannabinoid receptors undergo axonal flow in sensory nerves
15. 1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridisation study
16. 2 receptor agonist palmitoylethanolamide in visceral and somatic inflammatory pain
17. 1 receptors on rat neuronal cell cultures: binding and functional studies using the selective receptor antagonist SR 141716A
18. 1 receptor knockout mice
19. Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells
20. Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells
21. 2 receptors
22. Cannabinoid transmission and pain perception
23. 1 cannabinoid receptor activity
24. 2 receptors
25. Neuronal traits of clonal cell lines derived by fusion of dorsal root ganglia neurons with neuroblastoma cells
26. 1 receptors
27. Antihyperalgesic effects of spinal cannabinoids
28. 1 cannabinoid receptor functions after a long-term exposure to agonist or inverse agonist in the Chinese hamster ovary cell expression system
29. 2+ currents in neonatal rat cultured DRG neurones
30. Inhibition of neuronal high voltage-activated calcium channels by insect peptides: a comparison with the actions of ω-conotoxin GVIA
31. 35S]thio)triphosphate binding in rat brain membranes
32. The cannabinoid agonist WIN55,212-2 inhibits calcium channels by receptor-mediated and direct pathways in cultured rat hippocampal neurons
33. 1)
34. Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system
35. Cannabinoids inhibit N- and P/Q-type calcium channels in cultured rat hippocampal neurons
36. 1 cannabinoid receptor can sequester G-proteins, making them unavailable to couple to other receptors
37. Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide