1-Alkyl-2-aryl-4-(1-naphthoyl)pyrroles: New high affinity ligands for the cannabinoid CB1 and CB2 receptors

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 20, 2006, Pages 5432-5435

  Huffman, John W ^a   Padgett, Lea W ^a   Isherwood, Matthew L ^a   Wiley, Jenny L ^b   Martin, Billy R ^b  

^a CLEMSON UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cannabimimetic pyrroles; Cannabinoid; CB1 receptor; CB2 receptor

Indexed keywords

1 BUTYL 2 PHENYL 4 (1 NAPHTHOYL)PYRROLE; 1 HEPTYL 2 PHENYL 4 (1 NAPHTHOYL)PYRROLE; 1 HEXYL 2 PHENYL 4 (1 NAPHTHOYL)PYRROLE; 1 PENTYL 2 PHENYL 4 (1 NAPHTHOYL)PYRROLE; 1 PROPYL 2 PHENYL 4 (1 NAPHTHOYL)PYRROLE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1 NAPHTHOYL)PYRROLE DERIVATIVE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; JWH 145; JWH 146; JWH 147; JWH 150; JWH 156; JWH 243; JWH 244; JWH 245; JWH 246; JWH 292; JWH 293; JWH 307; JWH 308; JWH 309; JWH 346; JWH 347; JWH 348; JWH 363; JWH 364; JWH 365; JWH 366; JWH 367; JWH 368; JWH 369; JWH 370; JWH 371; JWH 372; JWH 373; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BRAIN MEMBRANE; BROMINATION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; FRIEDEL CRAFTS REACTION; HYDROLYSIS; NONHUMAN; RAT; RECEPTOR AFFINITY; SUZUKI REACTION;

BINDING, COMPETITIVE; LIGANDS; MOLECULAR STRUCTURE; PYRROLES; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33748305610     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.051     Document Type: Article

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