Cannabinoid CB2 receptors: Immunohistochemical localization in rat brain

Brain Research

Volumn 1071, Issue 1, 2006, Pages 10-23

  Gong, Jian Ping ^a   Onaivi, Emmanuel S ^a,b   Ishiguro, Hiroki ^a   Liu, Qing Rong ^a   Tagliaferro, Patricia A ^c   Brusco, Alicia ^c   Uhl, George R ^a  

^a NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^b WILLIAM PATERSON UNIVERSITY   (United States)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

Brain; CB2 blocking peptide; CB2 cannabinoid receptor; CB2 knockout mice; CB2 polyclonal antibody; Hippocampal cultures; Immunohistochemistry; In situ hybridization, mrna; RT PCR

Indexed keywords

ANTIBODY; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR; ENDOCANNABINOID; MESSENGER RNA; POLYCLONAL ANTIBODY;

ARTICLE; BRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; GENE EXPRESSION; HIPPOCAMPUS; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN SITU HYBRIDIZATION; IN VITRO STUDY; PRIORITY JOURNAL; PURKINJE CELL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BRAIN; BRAIN MAPPING; CELL LINE; EMBRYO; GENE EXPRESSION; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; MICE; MICE, KNOCKOUT; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSFECTION;

ORYCTOLAGUS CUNICULUS;

EID: 32844465920     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2005.11.035     Document Type: Article

References (41)

1. C. Benito, E. Nunez, R.M. Tolon, E.J. Carrier, A. Rabano, C.J. Hillard, and J. Romero Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains J. Neurosci. 23 2003 11136 11141
2. C. Benito, W.K. Kim, I. Chavarria, C.J. Hillard, K. Mackie, R.M. Tolon, K. Williams, and J. Romero A glial endogenous cannabinoid system is upregulated in the brains of macaques with simian immunodeficiency virus-induced encephalitis J. Neurosci. 25 2005 2530 2536
3. S. Ben-Shabat, E. Fride, T. Sheskin, T. Tsippy, M.-H. Rhee, Z. Vogel, T. Bisogno, L. De Petrocellis, V. Di Marzo, and R. Mechoulam An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonyl-glycerol cannabinoid activity Eur. J. Pharmacol. 353 1998 23 31
4. E.V. Berdyshev Cannabinoid receptors and the regulation of immune response Chem. Phys. Lipids 108 2000 169 190
5. N.E. Buckley, K.L. McCoy, E. Mezey, T. Bonner, A. Zimmer, C.C. Felder, M. Glass, and A. Zimmer Immunomodulation by cannabinoids is absent in mice deficient for the cannabinoid CB(2) receptor Eur. J. Pharmacol. 396 2-3 2000 (May 19) 141 149
6. S.J. Carlisle, F. Marciano-Cabral, A. Staab, C. Ludwick, and G.A. Cabral Differential expression of the CB2 cannabinoid receptor by rodent macrophages and macrophage-like cells in relation to cell activation Int. J. Immunopharmacol. 2 2002 69 82
7. A. Chakrabarti, E.S. Onaivi, and G. Chaudhuri Cloning and sequencing of a cDNA encoding the mouse brain-type cannabinoid receptor protein DNA Sequence 5 1995 385 388
8. J.M. Derocq, M. Segui, J. Marchand, G. Le Fur, and P. Casellas Cannabinoids enhance human B-cell growth at low nanomolar concentrations FEBS Lett. 369 1995 177 182
9. W.A. Devane, L. Hanus, A. Breuer, R.G. Pertwee, L.A. Stevenson, G. Griffin, D. Gibson, A. Mandel-baum, A. Etinger, and R. Mechoulam Isolation and structure of a brain constituent that binds to the cannabinoid receptor Science 258 1992 1946 1949
10. L. Facci, R. Dal Toso, S. Romanello, A. Buriani, S.D. Skaper, and A. Leona Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide and palmitoylethanolamide Proc. Natl. Acad. Sci. 92 1995 3376 3380
11. S. Galiegue, S. Mary, J. Marchand, D. Dussossoy, D. Carriere, P. Carayon, M. Bouaboula, D. Shire, G. Le Fur, and P. Casellas Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations Eur. J. Biochem 232 1995 54 61
12. S.A. Golech, R.M. McCarron, Y. Chen, J. Bembry, F. Lenz, R. Mechoulam, E. Shohami, and M. Spatz Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors Mol. Brain Res. 132 2004 87 92
13. J.P. Gong, E. Onaivi, and G.R. Uhl Cannabinoid CB2 receptors: immunohistochemical localization in rat brain Symposium on Cannabinoids, Burlington Vermont, ICRS 91 2005
14. G. Griffin, E.J. Wray, Q. Tao, S.D. McAllister, W.K. Rorrer, M. Aung, B.R. Martin, and M.E. Abood Evaluation of the cannabinoid CB2 receptor-selective antagonist, SR144528, further evidence for CB2 receptor absence in the rat central nervous system Eur. J. Pharmacol. 377 1999 117 125
15. G. Griffin, Q. Tao, and M.E. Abood Cloning and pharmacological characterization of the rat CB2 cannabinoid receptor J. Pharmacol. Exp. Ther. 292 2000 886 894
16. L. Hanus, S. Abu-Lafi, E. Fride, A. Breuer, Z. Vogel, D.E. Shalev, I. Kustanovich, and R. Mechoulam 2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor Proc. Natl. Acad. Sci. U.S.A. 98 2001 3662 3665
17. S.M. Hsu, L. Raine, and H. Fanger A comparative study of the peroxidase-antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies Am. J. Clin. Pathol. 75 1981 734 738
18. C.S. Kearn, and C.J. Hilliard Rat microglial cell express the peripheral-type cannabinoid receptor (CB2), which is negatively coupled to adenyly cyclase ICRS 1997 Symposium on Cannabinoids 1997 61
19. Q. Lu, A. Straiker, Q. Lu, and G. Maguire Expression of CB2 cannabinoid receptor mRNA in adult rat retina Vis. Neurosci. 17 2000 91 95
20. L.A. Matsuda, T.I. Lolait, M.J. Brownstein, A.C. Young, and T.I. Bonner Structure of a cannabinoid receptor and functional expression of the cloned cDNA Nature 346 1990 561 564
21. R. Mechoulam, and L. Parker Cannabis and alcohol-A close friendship Trends Pharmacol. Sci. 24 2003 266 268
22. S. Munro, K.L. Thomas, and M. Abu-Shaar Molecular characterization of a peripheral cannabinoid receptor Nature 365 1993 61 65
23. E. Nunez, C. Benito, M.R. Pazos, A. Barbachano, O. Fajardo, S. Gonzalez, R.M. Tolon, and J. Romero Cannabinoid CB2 receptors are expressed by perivascular microglia cells in the human brain: an immunohistochemical study Synapse 53 2004 208 213
24. E.S. Onaivi, C.M. Leonard, H. Ishiguro, P.W. Zhang, Z. Lin, B.E. Akinshola, and G.R. Uhl Endocannabinoids and cannabinoid receptor genetics Prog. Neurobiol. 66 2002 307 344
25. Onaivi, E.S., Ishiguro, H., Sejal, P., Meozzi, P.A., Myers, L., Tagliaferro, P., Hope, B., Leonard, C.M., Uhl, G.R., Brusco, A., Gardner, E., in press. Methods to study the behavioral effects and expression of CB2 cannabinoid receptors and its gene transcripts in chronic mild stress model of depression. In: E.S. Onaivi (Ed.), Marijuana and Cannabinoid Research: Methods and Protocols. The Humana press Inc.
26. G. Paxinos, and C. Watson The Rat Brain in Stereotaxic Coordinates 1982 Academic Press
27. M.R. Pazos, E. Nunez, C. Benito, R.M. Tolon, and J. Romero Role of the endocannabinoid system in Alzheimer's disease: new perspectives Life Sci. 75 2004 1907 1915
28. D.A. Pettit, M.P. Harrison, J.M. Olson, R.F. Spencer, and G.A. Cabral Immunohistochemical localization of the neural cannabinoid receptor in rat brain Neurosci Res. 51 1998 342 391
29. A.C. Porter, J.M. Sauer, M.D. Knierman, G.W. Becker, M.J. Berna, J. Bao, G.G. Nomikos, P. Carter, F.P. Bymaster, A.B. Leese, and C.C. Felder Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor J. Pharmacol. Exp. Ther. 301 2002 1020 1024
30. M.-T. Samson, A. Small-Howard, L.M.N. Shimoda, M. Koblan-Huberson, A.J. Stokes, and H. Turner Differential roles of CB1 and CB2 cannabinoid receptors in mast cells J. Immunol. 170 2003 4953 4962
31. A.R. Shatz, M. Lee, R.B. Condie, J.T. Pulaski, and N.E. Kaminski Cannabinoid receptors CB1 and CB2, a characterization of expression and adenylate cyclase modulation within the immune system Toxicol. Appl. Pharmacol. 142 1997 278 287
32. W.S. Sheng, S. Hu, X. Min, G.Y. Cabral, J.R. Lokensgard, and P.K. Peterson Synthetic cannabinoid WIN55212-2 inhibits generation of inflammatory mediators by IL-IB-stimulated human astrocytes Glia 49 2005 211 219
33. S.D. Skaper, A. Buriani, R. Dal Toso, L. Petrelli, S. Romanello, L. Facci, and A. Leon The ALIAmide palmitoylethanolamide and cannabinoids, but not anandamide, are protective in a delayed postglutamate paradigm of excitotoxic death in cerebral granule neurons Proc. Natl. Acad. Sci. 93 1996 3984 3989
34. S. Steffens, N.R. Veillard, C. Arnaud, G. Pelli, F. Burger, C. Staub, A. Zimmer, J.-L. Frossard, and F. Mach Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice Nature 434 2005 782 786
35. T. Suigiura, and K. Waku 2-Arachidonoylglycerol and cannabinoid receptors Chem. Phys. Lipids 108 2000 89 106
36. T. Sugiura, S. Kondo, A. Sukagawa, A. Nakane, A. Shinoda, K. Itoh, A. Yamashita, and K. Waku 2-Arachidonoylglycerol: a possible endogenous cannabinoid ligand in brain Biochem. Biophys. Res. Commun. 215 1995 89 97
37. T. Sugiura, S. Kondo, S. Kishimoto, T. Miyashita, S. Nakane, T. Kodata, Y. Suhara, and K. Waku Evidence that 2-arachidonylglycerol but not N-palmitoylethanolamine or anandamide is the physiological ligand for the cannabinoid CB2 receptor J. Biol. Chem. 275 2000 605 612
38. K. Tsou, S. Brown, M.C. Sanudo-Pena, K. Mackie, and J.M. Walker Immunohistochemical distribution of cannabinoid CB1 receptors in the rat central nervous system Neuroscience 83 1998 393 411
39. R.I. Wilson, and R. Nicoll Endogenous cannabinoids mediate retrograde signaling at hippocampal synapses Nature 410 2001 588 592
40. M.D. Van Sickle, M. Duncan, P.J. Kingsley, A. Mouihate, P. Urbani, K. Mackie, N. Stella, A. Makriyannis, D. Piomelli, J.S. Davison, L.J. Marnet, V. Di Marzo, Q.J. Pittman, D.P. Patel, and KA. Sharkey Identification and functional characterization of brainstem cannabinoid CB2 receptors Science 310 2005 329 332
41. J. Zhang, C. Hoffert, H.K. Vu, T. Groblewski, S. Ahmad, and D. O'Donnell Induction of CB2 receptor expression in the rat spinal cord of neuropathic but not inflammatory chronic pain models Eur. J. Neurosci. 17 2003 2750 2754