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Volumn 71, Issue 6, 2007, Pages 1445-1456

Rimonabant: Just an antiobesity drug? Current evidence on its pleiotropic effects

Author keywords

[No Author keywords available]

Indexed keywords

5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; ANTIOBESITY AGENT; BROMOPRAVADOLINE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR ANTAGONIST; IODOPRAVADOLINE; PLACEBO; RIMONABANT; UNCLASSIFIED DRUG; WIN 56098;

EID: 34347336599     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.033118     Document Type: Short Survey
Times cited : (72)

References (119)
  • 1
    • 0035979606 scopus 로고    scopus 로고
    • Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity
    • Abood ME, Rizvi G, Sallapudi N, McAllister S (2001) Activation of the CB1 cannabinoid receptor protects cultured mouse spinal neurons against excitotoxicity. Neurosci Lett 309:197-201.
    • (2001) Neurosci Lett , vol.309 , pp. 197-201
    • Abood, M.E.1    Rizvi, G.2    Sallapudi, N.3    McAllister, S.4
  • 3
    • 2642559962 scopus 로고    scopus 로고
    • Effect of Rimonabant in the reduction of major cardiovascular risk factors. Results from the STRATUS-US trial (smoking cessation in smokers motivated to quit)
    • Mar 7-10; New Orleans, LA
    • Anthenelli RM and Déspres JP (2004) Effect of Rimonabant in the reduction of major cardiovascular risk factors. Results from the STRATUS-US trial (smoking cessation in smokers motivated to quit). American College of Cardiology 53rd Annual Scientific Session; 2004 Mar 7-10; New Orleans, LA.
    • (2004) American College of Cardiology 53rd Annual Scientific Session
    • Anthenelli, R.M.1    Déspres, J.P.2
  • 4
    • 0030738512 scopus 로고    scopus 로고
    • Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors
    • Arnone M, Maruani J, Chaperon F, Thiebot MH, Poncelet M, Soubrié P, Le Fur G (1997) Selective inhibition of sucrose and ethanol intake by SR 141716, an antagonist of central cannabinoid (CB1) receptors. Pychopharmacology 132:104-106.
    • (1997) Pychopharmacology , vol.132 , pp. 104-106
    • Arnone, M.1    Maruani, J.2    Chaperon, F.3    Thiebot, M.H.4    Poncelet, M.5    Soubrié, P.6    Le Fur, G.7
  • 5
    • 16344376222 scopus 로고    scopus 로고
    • Barrero FJ, Ampuero I, Morales B, Vives F, de Dios Luna Del Castillo J, Hoenicka J, Garcia Yebenes J (2005) Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1). Pharmacogenomics J 5:135-141.
    • Barrero FJ, Ampuero I, Morales B, Vives F, de Dios Luna Del Castillo J, Hoenicka J, Garcia Yebenes J (2005) Depression in Parkinson's disease is related to a genetic polymorphism of the cannabinoid receptor gene (CNR1). Pharmacogenomics J 5:135-141.
  • 7
    • 17144470921 scopus 로고    scopus 로고
    • Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors
    • Bátkai S, Pacher P, Járai Z, Wagner JA, and Kunos G (2004) Cannabinoid antagonist SR-141716 inhibits endotoxic hypotension by a cardiac mechanism not involving CB1 or CB2 receptors. Am J Physiol 287:H595-H600.
    • (2004) Am J Physiol , vol.287
    • Bátkai, S.1    Pacher, P.2    Járai, Z.3    Wagner, J.A.4    Kunos, G.5
  • 8
    • 26044454430 scopus 로고    scopus 로고
    • Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders
    • Beardsley PM and Thomas BF (2005) Current evidence supporting a role of cannabinoid CB1 receptor (CB1R) antagonists as potential pharmacotherapies for drug abuse disorders. Behav Pharmacol 16:275-296.
    • (2005) Behav Pharmacol , vol.16 , pp. 275-296
    • Beardsley, P.M.1    Thomas, B.F.2
  • 11
    • 0036278032 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system in cancer therapy: A call for further research
    • Bifulco M, Di Marzo V (2002) Targeting the endocannabinoid system in cancer therapy: a call for further research. Nat Med 8:547-550.
    • (2002) Nat Med , vol.8 , pp. 547-550
    • Bifulco, M.1    Di Marzo, V.2
  • 12
    • 34249933789 scopus 로고    scopus 로고
    • Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion
    • Bifulco M, Gazzerro P, Laezza C, and Pentimalli F (2007) Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion. Oncol Rep 17:813-816.
    • (2007) Oncol Rep , vol.17 , pp. 813-816
    • Bifulco, M.1    Gazzerro, P.2    Laezza, C.3    Pentimalli, F.4
  • 14
    • 33745013193 scopus 로고    scopus 로고
    • Cannabinoids and cancer: Pros and cons of an antitumour strategy
    • Bifulco M, Laezza C, Pisanti S, and Gazzerro P (2006) Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 148:123-135.
    • (2006) Br J Pharmacol , vol.148 , pp. 123-135
    • Bifulco, M.1    Laezza, C.2    Pisanti, S.3    Gazzerro, P.4
  • 15
    • 9444280832 scopus 로고    scopus 로고
    • A new strategy to block tumor growth by inhibiting endocannabinoid inactivation
    • Bifulco M, Laezza C, Valenti M, Ligresti A, Portella G, DI Marzo V (2004) A new strategy to block tumor growth by inhibiting endocannabinoid inactivation. FASEB J 18:1606-1608.
    • (2004) FASEB J , vol.18 , pp. 1606-1608
    • Bifulco, M.1    Laezza, C.2    Valenti, M.3    Ligresti, A.4    Portella, G.5    DI Marzo, V.6
  • 16
    • 19944433322 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis
    • Bost F, Aouadi M, Caron L, Even P, Belmonte N, Prot M, Dani C, Hofman P, Pages G, Pouyssegur J, et al. (2005) The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54:402-411.
    • (2005) Diabetes , vol.54 , pp. 402-411
    • Bost, F.1    Aouadi, M.2    Caron, L.3    Even, P.4    Belmonte, N.5    Prot, M.6    Dani, C.7    Hofman, P.8    Pages, G.9    Pouyssegur, J.10
  • 17
    • 0030826705 scopus 로고    scopus 로고
    • A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions
    • Bouaboula M, Perrachon S, Milligan L, Canat X, Rinaldi-Carmona M, Portier M, Barth F, Calandra B, Pecceu F, Lupker J, et al. (1997) A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1. Evidence for a new model of receptor/ligand interactions. J Biol Chem 272:22330-22339.
    • (1997) J Biol Chem , vol.272 , pp. 22330-22339
    • Bouaboula, M.1    Perrachon, S.2    Milligan, L.3    Canat, X.4    Rinaldi-Carmona, M.5    Portier, M.6    Barth, F.7    Calandra, B.8    Pecceu, F.9    Lupker, J.10
  • 18
    • 0034717595 scopus 로고    scopus 로고
    • Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats
    • Braida D and Sala M (2000) Cannabinoid-induced working memory impairment is reversed by a second generation cholinesterase inhibitor in rats. Neuroreport 11:2025-2029.
    • (2000) Neuroreport , vol.11 , pp. 2025-2029
    • Braida, D.1    Sala, M.2
  • 19
    • 0034254905 scopus 로고    scopus 로고
    • Leptin as a regulator of adipose mass and reproduction
    • Chehab FF (2000) Leptin as a regulator of adipose mass and reproduction. Trends Pharmacol Sci 21:309-313.
    • (2000) Trends Pharmacol Sci , vol.21 , pp. 309-313
    • Chehab, F.F.1
  • 20
    • 20444367602 scopus 로고    scopus 로고
    • Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice
    • Centonze D, Rossi S, Prosperetti C, Tscherter A, Bernardi G, Maccarrone M, and Calabresi P (2005) Abnormal sensitivity to cannabinoid receptor stimulation might contribute to altered gamma-aminobutyric acid transmission in the striatum of R6/2 Huntington's disease mice. Biol Psychiatry 57:1583-1589.
    • (2005) Biol Psychiatry , vol.57 , pp. 1583-1589
    • Centonze, D.1    Rossi, S.2    Prosperetti, C.3    Tscherter, A.4    Bernardi, G.5    Maccarrone, M.6    Calabresi, P.7
  • 24
    • 0031926412 scopus 로고    scopus 로고
    • Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716
    • Colombo G, Agabio R, Fa M, Guano L, Lobina C, Loche A, Reali R, and Gessa GL (1998) Reduction of voluntary ethanol intake in ethanol-preferring sP rats by the cannabinoid antagonist SR-141716. Alcohol 33:126-130.
    • (1998) Alcohol , vol.33 , pp. 126-130
    • Colombo, G.1    Agabio, R.2    Fa, M.3    Guano, L.4    Lobina, C.5    Loche, A.6    Reali, R.7    Gessa, G.L.8
  • 25
    • 0030423694 scopus 로고    scopus 로고
    • In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): Inhibition of Astetrahydrocannabinol-induced responses and apparent agonist activity
    • Compton DR, Aceto MD, Lowe J, and Martin BR (1996) In vivo characterization of a specific cannabinoid receptor antagonist (SR141716A): inhibition of Astetrahydrocannabinol-induced responses and apparent agonist activity. J Pharmacol Exp Ther 277:586-594.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 586-594
    • Compton, D.R.1    Aceto, M.D.2    Lowe, J.3    Martin, B.R.4
  • 27
    • 0141507020 scopus 로고    scopus 로고
    • Role of cannabinoid CB1 receptors and tumor necrosis factor-a in the gut and systemic anti-inflammatory activity of SR141716 (Rimonabant) in rodents
    • Croci T, Landi M, Galzin AM, and Marini P (2003) Role of cannabinoid CB1 receptors and tumor necrosis factor-a in the gut and systemic anti-inflammatory activity of SR141716 (Rimonabant) in rodents. Br J Pharmacol 140:115-122.
    • (2003) Br J Pharmacol , vol.140 , pp. 115-122
    • Croci, T.1    Landi, M.2    Galzin, A.M.3    Marini, P.4
  • 28
    • 0142106897 scopus 로고    scopus 로고
    • Potentiation of penile erection and yawning responses to apomorphine by cannabinoi receptorantagonist in rats
    • da Silva GE, Fernandes MS, and Takahashi RN (2003) Potentiation of penile erection and yawning responses to apomorphine by cannabinoi receptorantagonist in rats. Neurosci Lett 349:49-52.
    • (2003) Neurosci Lett , vol.349 , pp. 49-52
    • da Silva, G.E.1    Fernandes, M.S.2    Takahashi, R.N.3
  • 30
    • 1842611887 scopus 로고    scopus 로고
    • The cannabinoid system: A general view and la test additions
    • De Petrocellis L, Cascio MG, Di Marzo V (2004) The cannabinoid system: a general view and la test additions. Br J Pharmacol 141:765-774.
    • (2004) Br J Pharmacol , vol.141 , pp. 765-774
    • De Petrocellis, L.1    Cascio, M.G.2    Di Marzo, V.3
  • 31
    • 0032478565 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines
    • Derocq JM, Bouaboula M, Marchand J, Rinaldi-Carmona M, Segui M, and Casellas P (1998) The endogenous cannabinoid anandamide is a lipid messenger activating cell growth via a cannabinoid receptor-independent pathway in hematopoietic cell lines. FEBS Lett 425:419-425.
    • (1998) FEBS Lett , vol.425 , pp. 419-425
    • Derocq, J.M.1    Bouaboula, M.2    Marchand, J.3    Rinaldi-Carmona, M.4    Segui, M.5    Casellas, P.6
  • 32
    • 27844463517 scopus 로고    scopus 로고
    • Déspres JP, Golay A, Sjöström L, Rimonabant in Obesity-Lipids Study Group (2005) Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134.
    • Déspres JP, Golay A, Sjöström L, Rimonabant in Obesity-Lipids Study Group (2005) Effects of rimonabant on metabolic risk factors in overweight patients with dyslipidemia. N Engl J Med 353:2121-2134.
  • 33
    • 19344376599 scopus 로고    scopus 로고
    • Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A
    • De Vries TJ, De Vries W, Janssen MC, and Schoffelmeer AN (2005) Suppression of conditioned nicotine and sucrose seeking by the cannabinoid-1 receptor antagonist SR141716A. Behav Brain Res 161:164-168
    • (2005) Behav Brain Res , vol.161 , pp. 164-168
    • De Vries, T.J.1    De Vries, W.2    Janssen, M.C.3    Schoffelmeer, A.N.4
  • 34
    • 0037825704 scopus 로고    scopus 로고
    • Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats
    • De Vries TJ, Homberg JR, Binnekade R, Raaso H, and Schoffelmeer AN (2003) Cannabinoid modulation of the reinforcing and motivational properties of heroin and heroin-associated cues in rats. Psychopharmacology (Berl) 168:164-169.
    • (2003) Psychopharmacology (Berl) , vol.168 , pp. 164-169
    • De Vries, T.J.1    Homberg, J.R.2    Binnekade, R.3    Raaso, H.4    Schoffelmeer, A.N.5
  • 35
    • 22844434552 scopus 로고    scopus 로고
    • Cannabinoid CB1 receptors control conditioned drug seeking
    • De Vries TJ and Schoffelmeer AN (2005) Cannabinoid CB1 receptors control conditioned drug seeking. Trends Pharmacol Sci 26:420-426.
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 420-426
    • De Vries, T.J.1    Schoffelmeer, A.N.2
  • 37
  • 39
    • 1942452417 scopus 로고    scopus 로고
    • Blockade by the cannabinoid CB1 receptor antagonist, rimonabant (SR14161716), of the potentiation by quinelorane of food primed reinstatement of food-seeking behaviour
    • Duarte C, Alonso R, Bichet N, Cohen C, Soubrié P, and Thiébot ME (2004) Blockade by the cannabinoid CB1 receptor antagonist, rimonabant (SR14161716), of the potentiation by quinelorane of food primed reinstatement of food-seeking behaviour. Neuropsychopharmacology 29:911-920.
    • (2004) Neuropsychopharmacology , vol.29 , pp. 911-920
    • Duarte, C.1    Alonso, R.2    Bichet, N.3    Cohen, C.4    Soubrié, P.5    Thiébot, M.E.6
  • 40
    • 28344434998 scopus 로고    scopus 로고
    • Economidou D, Mattioli l, Cifani C, Perfumi M, Massi M, Cuomo V, Trabace L, and Ciccocioppo R (2006) Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats. Psychopharmacology 183:394-403.
    • Economidou D, Mattioli l, Cifani C, Perfumi M, Massi M, Cuomo V, Trabace L, and Ciccocioppo R (2006) Effect of the cannabinoid CB1 receptor antagonist SR-141716A on ethanol self-administration and ethanol-seeking behaviour in rats. Psychopharmacology 183:394-403.
  • 41
    • 32844465426 scopus 로고    scopus 로고
    • Neuropharmacology and potential efficacy of new treatments for tobacco dependence
    • Fagerstrom K, and Balfour DJ (2006) Neuropharmacology and potential efficacy of new treatments for tobacco dependence. Expert Opin Investig Drugs 15:107-116.
    • (2006) Expert Opin Investig Drugs , vol.15 , pp. 107-116
    • Fagerstrom, K.1    Balfour, D.J.2
  • 42
    • 19444364776 scopus 로고    scopus 로고
    • Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats
    • Fattore L, Spano S, Cossu G, Deiana S, Fadda P, and Fratta W (2005) Cannabinoid CB(1) antagonist SR 141716A attenuates reinstatement of heroin self-administration in heroin-abstinent rats. Neuropharmacology 48:1097-1104.
    • (2005) Neuropharmacology , vol.48 , pp. 1097-1104
    • Fattore, L.1    Spano, S.2    Cossu, G.3    Deiana, S.4    Fadda, P.5    Fratta, W.6
  • 44
    • 21544456623 scopus 로고    scopus 로고
    • Cannabinoid control of motor function at the basal ganglia
    • Fernandez-Ruiz J and Gonzales S (2005) Cannabinoid control of motor function at the basal ganglia. Handb Exp Pharmacol (168):479-507.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 479-507
    • Fernandez-Ruiz, J.1    Gonzales, S.2
  • 45
    • 28844473489 scopus 로고    scopus 로고
    • Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma
    • Flygare J, Gustafsson K, Kimby E, Christensson B, and Sander B (2005) Cannabinoid receptor ligands mediate growth inhibition and cell death in mantle cell lymphoma. FEBS Lett 579:6885-6889.
    • (2005) FEBS Lett , vol.579 , pp. 6885-6889
    • Flygare, J.1    Gustafsson, K.2    Kimby, E.3    Christensson, B.4    Sander, B.5
  • 46
    • 0037661996 scopus 로고    scopus 로고
    • Role of endogenous cannabinoids in synaptic signaling
    • Freund TF, Katona I, and Piomelli D (2003) Role of endogenous cannabinoids in synaptic signaling. Physiol Rev 83:1017-1066.
    • (2003) Physiol Rev , vol.83 , pp. 1017-1066
    • Freund, T.F.1    Katona, I.2    Piomelli, D.3
  • 47
    • 33748086764 scopus 로고    scopus 로고
    • Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease
    • Gable DR, Hurel SJ, and Humphries SE (2006) Adiponectin and its gene variants as risk factors for insulin resistance, the metabolic syndrome and cardiovascular disease. Atherosclerosis 188:231-244.
    • (2006) Atherosclerosis , vol.188 , pp. 231-244
    • Gable, D.R.1    Hurel, S.J.2    Humphries, S.E.3
  • 48
    • 31044456243 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes
    • Gary-Bobo M, Elachouri G, Scatton B, Le Fur G, Oury-Donat F, and Bensaid M (2006) The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits cell proliferation and increases markers of adipocyte maturation in cultured mouse 3T3 F442A preadipocytes. Mol Pharmacol 69:471-478.
    • (2006) Mol Pharmacol , vol.69 , pp. 471-478
    • Gary-Bobo, M.1    Elachouri, G.2    Scatton, B.3    Le Fur, G.4    Oury-Donat, F.5    Bensaid, M.6
  • 49
    • 34249671248 scopus 로고    scopus 로고
    • Association between Cannabinoid type-1 receptor polymorphism and body mass index in a Southern Italian population
    • in press
    • Gazzerro P, Caruso MG, Notarnicola M, Misciagna G, Guerra V, Laezza C, Bifulco M (2007) Association between Cannabinoid type-1 receptor polymorphism and body mass index in a Southern Italian population. Int J Obes, in press.
    • (2007) Int J Obes
    • Gazzerro, P.1    Caruso, M.G.2    Notarnicola, M.3    Misciagna, G.4    Guerra, V.5    Laezza, C.6    Bifulco, M.7
  • 50
    • 0030441132 scopus 로고    scopus 로고
    • Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A
    • Gifford AN and Ashby CR (1996) Electrically evoked acetylcholine release from hippocampal slices is inhibited by the cannabinoid receptor agonist, WIN 55212-2, and is potentiated by the cannabinoid antagonist, SR 141716A. J Pharmacol Exp Ther 277:1431-1436.
    • (1996) J Pharmacol Exp Ther , vol.277 , pp. 1431-1436
    • Gifford, A.N.1    Ashby, C.R.2
  • 55
    • 0025802871 scopus 로고
    • Neuronal localization of cannabinoid receptors in basal ganglia of the rat
    • Herkenham M, Lynn AB, de Costa BR, and Richfield EK (1991a) Neuronal localization of cannabinoid receptors in basal ganglia of the rat. Brain Res 547:267-274.
    • (1991) Brain Res , vol.547 , pp. 267-274
    • Herkenham, M.1    Lynn, A.B.2    de Costa, B.R.3    Richfield, E.K.4
  • 56
    • 0025954862 scopus 로고
    • Characterization and localization of cannabinoid receptors in rat brain: A quantitative in vitro autoradiographic study
    • Herkenham M, Lynn AB, Johnson MR, Melvin LS, de Costa BR, and Rice KC (1991b) Characterization and localization of cannabinoid receptors in rat brain: a quantitative in vitro autoradiographic study. J Neurosci 11:563-583.
    • (1991) J Neurosci , vol.11 , pp. 563-583
    • Herkenham, M.1    Lynn, A.B.2    Johnson, M.R.3    Melvin, L.S.4    de Costa, B.R.5    Rice, K.C.6
  • 58
    • 21644457753 scopus 로고    scopus 로고
    • Ferulic acid inhibits endothelial cell proliferation through NO down-regulating ERK1/2 pathway
    • Hou Y, Yang J, Zhao G, and Yuan Y (2004) Ferulic acid inhibits endothelial cell proliferation through NO down-regulating ERK1/2 pathway. J Cell Biochem 93:1203-1209.
    • (2004) J Cell Biochem , vol.93 , pp. 1203-1209
    • Hou, Y.1    Yang, J.2    Zhao, G.3    Yuan, Y.4
  • 59
    • 0033393956 scopus 로고    scopus 로고
    • The role of TNFalfa in human adipose tissue: Prevention of weight gain at the expense of insulin resistance?
    • Hube F and Hauner H (1999) The role of TNFalfa in human adipose tissue: prevention of weight gain at the expense of insulin resistance? Hormone Metab Res 31:626-631.
    • (1999) Hormone Metab Res , vol.31 , pp. 626-631
    • Hube, F.1    Hauner, H.2
  • 60
    • 0035200613 scopus 로고    scopus 로고
    • Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors
    • Jacobsson SO, Wallin T, and Fowler CJ (2001) Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J Pharmacol Exp Ther 299:951-959.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 951-959
    • Jacobsson, S.O.1    Wallin, T.2    Fowler, C.J.3
  • 61
    • 0026511304 scopus 로고
    • Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles
    • Jansen EM, Haycock DA, Ward SJ, and Seybold VS (1992) Distribution of cannabinoid receptors in rat brain determined with aminoalkylindoles. Brain Res 575:93-102.
    • (1992) Brain Res , vol.575 , pp. 93-102
    • Jansen, E.M.1    Haycock, D.A.2    Ward, S.J.3    Seybold, V.S.4
  • 64
    • 19444368081 scopus 로고    scopus 로고
    • Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists
    • Lange JHM and Kruse CG (2005) Medicinal chemistry strategies to CB1 cannabinoid receptor antagonists. Drug Discov Today 10:693-702.
    • (2005) Drug Discov Today , vol.10 , pp. 693-702
    • Lange, J.H.M.1    Kruse, C.G.2
  • 65
    • 0038201773 scopus 로고    scopus 로고
    • Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate
    • Lastres-Becker I, Bizat N, Boyer F, Hantraye P, Brouillet E, and Fernandez-Ruiz J (2003) Effects of cannabinoids in the rat model of Huntington's disease generated by an intrastriatal injection of malonate. Neuroreport 14:813-816.
    • (2003) Neuroreport , vol.14 , pp. 813-816
    • Lastres-Becker, I.1    Bizat, N.2    Boyer, F.3    Hantraye, P.4    Brouillet, E.5    Fernandez-Ruiz, J.6
  • 66
    • 0037162960 scopus 로고    scopus 로고
    • Effect of anandamide on embryo implantation in the mouse
    • Liu WM, Duan EK, and Cao YJ (2002) Effect of anandamide on embryo implantation in the mouse. Life Sci 71:1623-1632.
    • (2002) Life Sci , vol.71 , pp. 1623-1632
    • Liu, W.M.1    Duan, E.K.2    Cao, Y.J.3
  • 67
    • 0034644769 scopus 로고    scopus 로고
    • Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors
    • Maccarrone M, Lorenzon T, Bari M, Melino G, Finazzi-Agrò A (2000a) Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem 275:31938-31945.
    • (2000) J Biol Chem , vol.275 , pp. 31938-31945
    • Maccarrone, M.1    Lorenzon, T.2    Bari, M.3    Melino, G.4    Finazzi-Agrò, A.5
  • 68
    • 0034655926 scopus 로고    scopus 로고
    • Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage
    • Maccarrone M, Valensise H, Bari M, Lazzarin N, Romanini C, Finazzi-Agrò A (2000b) Relation between decreased anandamide hydrolase concentrations in human lymphocytes and miscarriage. Lancet 355:1326-1329.
    • (2000) Lancet , vol.355 , pp. 1326-1329
    • Maccarrone, M.1    Valensise, H.2    Bari, M.3    Lazzarin, N.4    Romanini, C.5    Finazzi-Agrò, A.6
  • 69
    • 3042569771 scopus 로고    scopus 로고
    • Anandamide hydrolase: A guardian angel of human reproduction?
    • Maccarrone M, Finazzi-Agrò A (2004) Anandamide hydrolase: a guardian angel of human reproduction? Trends Pharmacol Sci 25:353-357.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 353-357
    • Maccarrone, M.1    Finazzi-Agrò, A.2
  • 70
    • 33645982868 scopus 로고    scopus 로고
    • Involvement of the endocannabinoid system in drug addiction
    • Maldonado R, Valverde O, and Berrendero F (2006) Involvement of the endocannabinoid system in drug addiction. Trends Neurosci 29:225-232.
    • (2006) Trends Neurosci , vol.29 , pp. 225-232
    • Maldonado, R.1    Valverde, O.2    Berrendero, F.3
  • 71
    • 33745493475 scopus 로고    scopus 로고
    • Endocannabinoids as novel mediators of liver diseases
    • Mallat A and Lotersztajn S (2006) Endocannabinoids as novel mediators of liver diseases. J Endocrinol Investig 29:58-65.
    • (2006) J Endocrinol Investig , vol.29 , pp. 58-65
    • Mallat, A.1    Lotersztajn, S.2
  • 72
    • 0031593783 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9- tetrahydrocannabinol or anandamide
    • Mallet PE and Beninger RJ (1998) The cannabinoid CB1 receptor antagonist SR141716A attenuates the memory impairment produced by delta9- tetrahydrocannabinol or anandamide. Psychopharmacology 140:11-19.
    • (1998) Psychopharmacology , vol.140 , pp. 11-19
    • Mallet, P.E.1    Beninger, R.J.2
  • 73
    • 0141892161 scopus 로고    scopus 로고
    • Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions
    • Manabe Y, Toda S, Miyazaki K, and Sugihara H (2003) Mature adipocytes, but not preadipocytes, promote the growth of breast carcinoma cells in collagen gel matrix culture through cancer-stromal cell interactions. J Pathol 201:221-228.
    • (2003) J Pathol , vol.201 , pp. 221-228
    • Manabe, Y.1    Toda, S.2    Miyazaki, K.3    Sugihara, H.4
  • 74
    • 1642320366 scopus 로고    scopus 로고
    • Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade
    • Mazzola C, Micale V, and Drago F (2003) Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade. Eur J Pharmacol 477:219-225.
    • (2003) Eur J Pharmacol , vol.477 , pp. 219-225
    • Mazzola, C.1    Micale, V.2    Drago, F.3
  • 76
    • 30744455029 scopus 로고    scopus 로고
    • The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: Involvement of paraventricular glutamic acid and nitric oxide
    • Melis MR, Succu S, Mascia MS, Sanna F, Melis T, Castelli MP, and Argiolas A (2006) The cannabinoid receptor antagonist SR-141716A induces penile erection in male rats: involvement of paraventricular glutamic acid and nitric oxide. Neuropharmacology 50:219-228.
    • (2006) Neuropharmacology , vol.50 , pp. 219-228
    • Melis, M.R.1    Succu, S.2    Mascia, M.S.3    Sanna, F.4    Melis, T.5    Castelli, M.P.6    Argiolas, A.7
  • 80
    • 32144462629 scopus 로고    scopus 로고
    • Managing cardiovascular risk in patients with metabolic syndrome
    • Nesto RW (2005) Managing cardiovascular risk in patients with metabolic syndrome. Clin Cornerstone 7:46-51.
    • (2005) Clin Cornerstone , vol.7 , pp. 46-51
    • Nesto, R.W.1
  • 83
    • 12744258029 scopus 로고    scopus 로고
    • Inverse agonism and neutral antagonism at cannabinoid CB1 receptors
    • Pertwee RG (2005) Inverse agonism and neutral antagonism at cannabinoid CB1 receptors. Life Sci 76:1307-1324.
    • (2005) Life Sci , vol.76 , pp. 1307-1324
    • Pertwee, R.G.1
  • 84
    • 33645502759 scopus 로고    scopus 로고
    • The pharmacology of cannabinoid receptors and their ligands: An overview
    • Pertwee RG (2006) The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (London) 1:S13-S18.
    • (2006) Int J Obes (London) , vol.1
    • Pertwee, R.G.1
  • 85
    • 0029786781 scopus 로고    scopus 로고
    • Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine
    • Pertwee RG, Fernando SR, Nash JE, and Coutts AA (1996) Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine. Br J Pharmacol 118:2199-2205.
    • (1996) Br J Pharmacol , vol.118 , pp. 2199-2205
    • Pertwee, R.G.1    Fernando, S.R.2    Nash, J.E.3    Coutts, A.A.4
  • 87
    • 85136405873 scopus 로고    scopus 로고
    • Pi-Sunyer XF, Aronne LJ, Heshmati HM, Devin J, Rosenstock J, RIO-North America Study Group (2006) Effect of Rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: a randomized controlled trial. J Am Med Assoc 295:761-775.
    • Pi-Sunyer XF, Aronne LJ, Heshmati HM, Devin J, Rosenstock J, RIO-North America Study Group (2006) Effect of Rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: a randomized controlled trial. J Am Med Assoc 295:761-775.
  • 88
    • 0141594998 scopus 로고    scopus 로고
    • Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: Actions on signals involved in angiogenesis and metastasis
    • Portella G, Laezza C, Laccetti P, De Petrocellis L, Di Marzo V, and Bifulco M (2003) Inhibitory effects of cannabinoid CB1 receptor stimulation on tumor growth and metastatic spreading: actions on signals involved in angiogenesis and metastasis. FASEB J 17:1771-1773.
    • (2003) FASEB J , vol.17 , pp. 1771-1773
    • Portella, G.1    Laezza, C.2    Laccetti, P.3    De Petrocellis, L.4    Di Marzo, V.5    Bifulco, M.6
  • 89
    • 12844255714 scopus 로고    scopus 로고
    • Cannabis-induced cytotoxicity in leukemic cell lines: The role of the cannabinoid receptors and the MAPK pathway
    • Powles T, Poele R, Shamash J, Chaplin T, Propper D, Joel S, Oliver T, and Liu WM (2005) Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway. Blood 105:1214-1221.
    • (2005) Blood , vol.105 , pp. 1214-1221
    • Powles, T.1    Poele, R.2    Shamash, J.3    Chaplin, T.4    Propper, D.5    Joel, S.6    Oliver, T.7    Liu, W.M.8
  • 92
    • 33645786113 scopus 로고    scopus 로고
    • Human studies of cannabinoids and medicinal cannabis
    • Robson P (2005) Human studies of cannabinoids and medicinal cannabis. Handb Exp Pharmacol 168:719-756.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 719-756
    • Robson, P.1
  • 94
    • 0035422139 scopus 로고    scopus 로고
    • Sanchez C, de Ceballos ML, del Pulgar TG, Rueda D, Corbacho C, Velasco G, Galve-Roperh I, Huffman JW, Ramon y Cajal S, and Guzman M (2001) Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61:5784-5789.
    • Sanchez C, de Ceballos ML, del Pulgar TG, Rueda D, Corbacho C, Velasco G, Galve-Roperh I, Huffman JW, Ramon y Cajal S, and Guzman M (2001) Inhibition of glioma growth in vivo by selective activation of the CB(2) cannabinoid receptor. Cancer Res 61:5784-5789.
  • 95
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz S, Afaq F, Adhami VM, and Mukhtar H (2005) Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 65:1635-1641.
    • (2005) Cancer Res , vol.65 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 96
    • 33748933891 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism
    • Sarnataro D, Pisanti S, Santoro A, Gazzerro P, Malfitano AM, Laezza C, and Bifulco M (2006) The cannabinoid CB1 receptor antagonist rimonabant (SR141716) inhibits human breast cancer cell proliferation through a lipid raft-mediated mechanism. Mol Pharmacol 70:1298-1306.
    • (2006) Mol Pharmacol , vol.70 , pp. 1298-1306
    • Sarnataro, D.1    Pisanti, S.2    Santoro, A.3    Gazzerro, P.4    Malfitano, A.M.5    Laezza, C.6    Bifulco, M.7
  • 97
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomized controlled study
    • RIO-Diabetes Study Group
    • Scheen AJ, Finer N, Hollander P, Jensen MD, Van Gaal LF, RIO-Diabetes Study Group (2006) Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomized controlled study. Lancet 368:1660-1672.
    • (2006) Lancet , vol.368 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 99
    • 0344406282 scopus 로고    scopus 로고
    • Effects of CB1 cannabinoid receptor modulating compounds on the hiperkinesia induced by high-dose Levodopa in the reserpine-treated rat model of Parkinson's disease
    • Segovia G, Mora F, Crossman AR, and Brotchie JM (2003) Effects of CB1 cannabinoid receptor modulating compounds on the hiperkinesia induced by high-dose Levodopa in the reserpine-treated rat model of Parkinson's disease. Mov Disord 18:138-149.
    • (2003) Mov Disord , vol.18 , pp. 138-149
    • Segovia, G.1    Mora, F.2    Crossman, A.R.3    Brotchie, J.M.4
  • 100
    • 0029965292 scopus 로고    scopus 로고
    • Shire D, Calandra B, Delpech M, Dumont X, Kagha M, Le Fur G, Caput D, Ferrara P. (1996) Structural features of the central cannabinoid CB, receptor involved in the binding of the specific CB1 antagonist SR 141716A. J Biol Chem 271:69414946.
    • Shire D, Calandra B, Delpech M, Dumont X, Kagha M, Le Fur G, Caput D, Ferrara P. (1996) Structural features of the central cannabinoid CB, receptor involved in the binding of the specific CB1 antagonist SR 141716A. J Biol Chem 271:69414946.
  • 101
    • 22044455129 scopus 로고    scopus 로고
    • A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena
    • Solbrig MV, Adrian R, Baratta J, Piomelli D, and Giuffrida A (2005) A role for endocannabinoids in viral-induced dyskinetic and convulsive phenomena. Exp Neurol 194:355-362.
    • (2005) Exp Neurol , vol.194 , pp. 355-362
    • Solbrig, M.V.1    Adrian, R.2    Baratta, J.3    Piomelli, D.4    Giuffrida, A.5
  • 102
    • 0033231660 scopus 로고    scopus 로고
    • The dopamine hypothesis of reward: Past and current status
    • Spanagel R, Weiss F (1999) The dopamine hypothesis of reward: past and current status. Trends Neurosci 22:521-527.
    • (1999) Trends Neurosci , vol.22 , pp. 521-527
    • Spanagel, R.1    Weiss, F.2
  • 103
    • 7044234515 scopus 로고    scopus 로고
    • CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat
    • Spano MS, Fattore L, Cossu G, Deiana S, Fadda P, and Fratta W (2004) CB1 receptor agonist and heroin, but not cocaine, reinstate cannabinoid-seeking behaviour in the rat. Br J Pharmacol 143:343-350.
    • (2004) Br J Pharmacol , vol.143 , pp. 343-350
    • Spano, M.S.1    Fattore, L.2    Cossu, G.3    Deiana, S.4    Fadda, P.5    Fratta, W.6
  • 105
    • 33645063448 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor antagonist SR141716 induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats
    • Succu S, Mascia MS, Sanna F, Melis T, Argiolas A, and Melis MR (2006) The cannabinoid CB1 receptor antagonist SR141716 induces penile erection by increasing extra-cellular glutamic acid in the paraventricular nucleus of male rats. Behav Brain Res 169:274-281.
    • (2006) Behav Brain Res , vol.169 , pp. 274-281
    • Succu, S.1    Mascia, M.S.2    Sanna, F.3    Melis, T.4    Argiolas, A.5    Melis, M.R.6
  • 106
    • 0032495836 scopus 로고    scopus 로고
    • Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum
    • Szabo B, Dörner L, Pfreundtner C, Nörenberg W, and Starke K (1998) Inhibition of GABAergic inhibitory postsynaptic currents by cannabinoids in rat corpus striatum. Neuroscience 85:395-403.
    • (1998) Neuroscience , vol.85 , pp. 395-403
    • Szabo, B.1    Dörner, L.2    Pfreundtner, C.3    Nörenberg, W.4    Starke, K.5
  • 107
    • 18144391976 scopus 로고    scopus 로고
    • The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze
    • Takahashi RN, Pampona FA, and Fernandes MS (2005) The cannabinoid antagonist SR141716A facilitates memory acquisition and consolidation in the mouse elevated T-maze. Neurosci Lett 380:270-275.
    • (2005) Neurosci Lett , vol.380 , pp. 270-275
    • Takahashi, R.N.1    Pampona, F.A.2    Fernandes, M.S.3
  • 108
    • 0030761521 scopus 로고    scopus 로고
    • Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism
    • Tanda G, Pontieri FE, Di Chiara G (1997) Cannabinoid and heroin activation of mesolimbic dopamine transmission by a common mu1 opioid receptor mechanism. Science (Wash DC) 276:2048-2050.
    • (1997) Science (Wash DC) , vol.276 , pp. 2048-2050
    • Tanda, G.1    Pontieri, F.E.2    Di Chiara, G.3
  • 112
    • 33645784201 scopus 로고    scopus 로고
    • Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice
    • Valverde O, Karsak M, and Zimmer A (2005) Analysis of the endocannabinoid system by using CB1 cannabinoid receptor knockout mice. Handb Exp Pharmacol 168:117-145.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 117-145
    • Valverde, O.1    Karsak, M.2    Zimmer, A.3
  • 113
    • 17144382751 scopus 로고    scopus 로고
    • Van Gaal LF, Rissanen AM, Scheen A, Ziegler O, Rössner S, RIO-Europe Study Group (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365:1389-1397.
    • Van Gaal LF, Rissanen AM, Scheen A, Ziegler O, Rössner S, RIO-Europe Study Group (2005) Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Lancet 365:1389-1397.
  • 114
    • 0031823187 scopus 로고    scopus 로고
    • Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension
    • Varga K, Wagner JA, Bridgen DT, and Kunos G (1998) Platelet- and macrophage-derived endogenous cannabinoids are involved in endotoxin-induced hypotension. FASEB J 12:1035-1044.
    • (1998) FASEB J , vol.12 , pp. 1035-1044
    • Varga, K.1    Wagner, J.A.2    Bridgen, D.T.3    Kunos, G.4
  • 115
    • 27644578059 scopus 로고    scopus 로고
    • Cannabinoid mechanisms of pain suppression
    • Walker JM, Hohmann AG (2005) Cannabinoid mechanisms of pain suppression. Handb Exp Pharmacol 168:509-554.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 509-554
    • Walker, J.M.1    Hohmann, A.G.2
  • 116
    • 0037417989 scopus 로고    scopus 로고
    • Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice
    • Wang L, Liu J, Harvey-White J, Zimmer A, and Kunos G (2003) Endocannabinoid signaling via cannabinoid receptor 1 is involved in ethanol preference and its age-dependent decline in mice. Prot Natl Acad Sci USA 100:1393-1398.
    • (2003) Prot Natl Acad Sci USA , vol.100 , pp. 1393-1398
    • Wang, L.1    Liu, J.2    Harvey-White, J.3    Zimmer, A.4    Kunos, G.5
  • 117
    • 0037177601 scopus 로고    scopus 로고
    • Endocannabinoids signaling in the brain
    • Wilson RI, Nicoll RA (2002) Endocannabinoids signaling in the brain. Science (Wash DC) 296:678-682.
    • (2002) Science (Wash DC) , vol.296 , pp. 678-682
    • Wilson, R.I.1    Nicoll, R.A.2
  • 119
    • 30944447568 scopus 로고    scopus 로고
    • The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions
    • Yoon S, and Seger R (2006) The extracellular signal-regulated kinase: multiple substrates regulate diverse cellular functions. Growth Factors 24:21-44.
    • (2006) Growth Factors , vol.24 , pp. 21-44
    • Yoon, S.1    Seger, R.2


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