Agonist selective regulation of G proteins by cannabinoid CB1 and CB2 receptors

Molecular Pharmacology

Volumn 56, Issue 6, 1999, Pages 1362-1369

  Glass, Michelle ^a   Northup, John K ^a  

^a NATIONAL INSTITUTE ON DEAFNESS AND OTHER COMMUNICATION DISORDERS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; ANANDAMIDE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; DEXANABINOL; DRONABINOL; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE DIPHOSPHATE; GUANOSINE TRIPHOSPHATE; N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 5 (4 CHLORO 3 METHYL PHENYL) 1 (4 METHYLBENZYL)PYRAZOLE 3 CARBOXAMIDE; RIMONABANT; SR 155528; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CATALYSIS; CATTLE; LEPIDOPTERA; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RECEPTOR BINDING; SIGNAL TRANSDUCTION;

EID: 0032756226     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.56.6.1362     Document Type: Article

References (36)

1. Bayewitch M, Avidor-Reiss T, Levy R, Barg J, Mechoulam R and Vogel Z (1995) The peripheral cannabinoid receptor - adenylate-cyclase inhibition and G-protein coupling. FEBS Lett 375:143-147.
2. 9-tetrahydrocannabinol antagonizes the peripheral cannabinoid receptor-mediated inhibition of adenylate cyclase. J Biol Chem 271:9902-9905.
3. Bonhaus DW, Chang LK, Kwan J and Martin GR (1998) Dual activation and inhibition of adenylyl cyclase by cannabinoid receptor agonists: Evidence for agonist specific trafficking of intracellular responses. J Pharmacol Exp Ther 287:884-888.
4. Bouaboula M, Perrachon S, Milligan L, Canat X, Rinaldi-Carmona M, Portier M, Barth F, Clandra B, Pecceu F, Lupker J, Maffrand J-P and Le Fur G (1997) A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor 1 - Evidence for a new model of receptor/ligand interactions. J Biol Chem 272:22330-22339.
5. 35S]GTPγS binding to rat cerebellar membranes correlates with agonist-induced decreases in GDP affinity. J Biol Chem 273:16865-16873.
6. Burkey TH, Quock RM, Consroe P, Ehlert FJ, Hosohata Y, Roeske WR and Yamamura HI (1997a) Relative efficacies of cannabinoid CB1 receptor agonists in the mouse brain. Eur J Pharmacol 336:295-298.
7. Burkey TH, Quock RM, Consroe P, Roeske WR and Yamamura HI (1997b) Δ-9-Tetrahydrocannabinol is a partial agonist of cannabinoid receptors in the mouse brain. Eur J Pharmacol 323:R3-R4.
8. 2+ current in NG108-15 neuroblastoma cells via a pertussis toxin sensitive mechanism. Br J Pharmacol 106:231-232.
9. Chin CN, Lucas-Lenard J, Abadji V and Kendall DA (1998) Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1. J Neurochem 70:366-373.
10. Fawzi AB and Northup JK (1990) Guanine-nucleotide binding characteristics of transducin - Essential role of rhodopsin for rapid exchange of guanine-nucleotides. Biochemistry 29:3804.
11. Felder CC, Joyce KE, Briley EM, Mansouri J, Mackie K, Blond O, Lia Y, Ma A and Mitchell RL (1995) Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors. Mol Pharmacol 48:443-450.
12. Glass M and Felder CC (1997) Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors augments cAMP accumulation in striatal neurons: Evidence for a Gs-linkage to the CB1 receptor. J Neurosci 17:5327-5333.
13. 35S]thio]-triphosphate binding assay in rat cerebellar membranes. J Pharmacol Exp Ther 285:553-560.
14. Gudermann T, Schöneberg T and Schultz G (1997) Functional and structural complexity of signal transduction via G-protein coupled receptors. Annu Rev Neurosci 20:399-427.
15. 2C receptor antagonists. J Biol Chem 271:22591-22597.
16. Houston DB and Hewlett AC (1998) Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists. Cell Signal 10:667-674.
17. Howlett AC (1998) The CB1 cannabinoid receptor in the brain. Neurobiol Dis 5:405-416.
18. Jian X, Sainz E, Clark WA, Jensen RT, Battey JF and Northup JK (1999) The bombesin receptor subtypes have distinct G-protein specificity. J Biol Chem 274: 11573-11581.
19. Kearn CS, Greenberg MJ, DiCamelli R, Kurzawak K and Hillard CJ (1999) Relationship between ligand affinities for the cerebellar cannabinoid receptor CB1 and the induction of GDP/GTP exchange. J Neurochem 72:2379-2387.
20. Landsman RS, Burkey TH, Consroe P, Roeske WR and Yamamura HI (1997) SR141716A is an inverse agonist at the human cannabinoid CB1 receptor. Eur J Pharmacol 334:R1-R2.
21. Mackie K, Devane WA and Hille B (1993) Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol Pharmacol 44:498-503.
22. Mackie K and Hille B (1992) Cannabinoids inhibit N-type calcium channels in neuroblastoma-glioma cells. Proc Natl Acad Sci USA 89:3825-3829.
23. Mackie K, Lai Y, Westenbroek R and Mitchell R (1995) Cannabinoids activate an inwardly rectifying potassium conductance and inhibit Q-type calcium currents in ATT20 cells transfected with rat brain cannabinoid receptors. J Neurosci 15:6552-6561.
24. MacLennan SJ, Reynen PH, Kwan J and Bonhaus DW (1998) Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors. Br J Pharmacol 124:619-622.
25. Matsuda LA, Lolait SJ, Brownstein MJ, Young AC and Bonner TI (1990) Structure of cannabinoid receptor and functional expression of the cloned cDNA. Nature (Lond) 346:561-564.
26. Mumby S, Pang IH, Gilman AG and Sternweis PC (1988) Chromatographic resolution and immunological identification of the alpha-40 and alpha-41 subunits of guanine nucleotide binding regulatory proteins. J Biol Chem 263:2020-2026.
27. Munro S, Thomas KL and Abu-Shaar M (1993) Molecular characterization of a peripheral receptor for cannabinoids. Nature (Lond) 365:61-65.
28. Northup JK, Smigel MD and Gilman AG (1982) The guanine nucleotide activating site of. the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem 257:11416-11423.
29. 2+ channels in a neuronal expression system. Mol Pharmacol 49:707-714.
30. 2+ currents by reversal of tonic CB1 cannabinoid receptor activity. Mol Pharmacol 54:1064-1072.
31. Pertwee RG (1997) Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol Ther 74:129-180.
32. 35S]thiotriphosphate binding. Proc Natl Acad Sci USA 92:7242-7246.
33. Slipetz DM, O'Neill GP, Favreau L, Dufresne C, Gallant M, Gareau Y, Guay D, Labelle M and Metters KM (1995) Activation of the human peripheral cannabinoid receptor results in inhibition of adenylyl cyclase. Mol Pharmacol 48:352-361.
34. Song ZH and Bonner TI (1996) A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Mol Pharmacol 49:891-896.
35. Sternweis PC and Robinshaw JD (1984) Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain. J Biol Chem 259:13806-13813.
36. Tucek S (1997) Is the R and R* dichotomy real? Trends Pharmacol Sci 18:414-416