메뉴 건너뛰기




Volumn 63, Issue 12, 2006, Pages 1410-1424

Endocannabinoids and β-amyloid-induced neurotoxicity in vivo: Effect of pharmacological elevation of endocannabinoid levels

Author keywords

2 arachidonoyl glycerol; Anandamide; Apoptosis; Cannabinoid; Memory; Neuroprotection; Receptor

Indexed keywords

2 ARACHIDONOYLGLYCEROL; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; AMYLOID BETA PROTEIN[1-42]; ANANDAMIDE; ENDOCANNABINOID; ENDOCANNABINOID REUPTAKE INHIBITOR; N (4 HYDROXY 2 METHYLPHENYL)ARACHIDONAMIDE; UNCLASSIFIED DRUG;

EID: 33745327044     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-006-6037-3     Document Type: Article
Times cited : (200)

References (65)
  • 1
  • 5
    • 0033538441 scopus 로고    scopus 로고
    • Cannabinoids, hippocampal function and memory
    • Hampson, R. E. and Deadwyler, S. A. (1999) Cannabinoids, hippocampal function and memory. Life Sci. 65, 715-723.
    • (1999) Life Sci. , vol.65 , pp. 715-723
    • Hampson, R.E.1    Deadwyler, S.A.2
  • 6
    • 0032589801 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture
    • Shen, M. and Thayer, S. A. (1999) Delta9-tetrahydrocannabinol acts as a partial agonist to modulate glutamatergic synaptic transmission between rat hippocampal neurons in culture. Mol. Pharmacol. 55, 8-13.
    • (1999) Mol. Pharmacol. , vol.55 , pp. 8-13
    • Shen, M.1    Thayer, S.A.2
  • 7
    • 0033561159 scopus 로고    scopus 로고
    • Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures
    • Nagayama, T., Sinor, A. D., Simon, R. P., Chen, J., Graham, S. H., Jin, K. and Greenberg, D. E. (1999) Cannabinoids and neuroprotection in global and focal cerebral ischemia and in neuronal cultures. J. Neurosci. 19, 2987-2995.
    • (1999) J. Neurosci. , vol.19 , pp. 2987-2995
    • Nagayama, T.1    Sinor, A.D.2    Simon, R.P.3    Chen, J.4    Graham, S.H.5    Jin, K.6    Greenberg, D.E.7
  • 13
    • 0141742514 scopus 로고    scopus 로고
    • The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy
    • Wallace, M. J., Blair, R. E., Falenski, K. W., Martin, B. R. and DeLorenzo, R. J. (2003) The endogenous cannabinoid system regulates seizure frequency and duration in a model of temporal lobe epilepsy. J. Pharmacol. Exp. Ther. 307, 129-137.
    • (2003) J. Pharmacol. Exp. Ther. , vol.307 , pp. 129-137
    • Wallace, M.J.1    Blair, R.E.2    Falenski, K.W.3    Martin, B.R.4    DeLorenzo, R.J.5
  • 14
    • 0142184968 scopus 로고    scopus 로고
    • Neurons on cannabinoids: Dead or alive?
    • Guzman, M. (2003) Neurons on cannabinoids: dead or alive? Br. J. Pharmacol. 140, 439-140.
    • (2003) Br. J. Pharmacol. , vol.140 , pp. 439-140
    • Guzman, M.1
  • 15
    • 1842611884 scopus 로고    scopus 로고
    • Cannabinoids and neuroinflammation
    • Walter, L. and Stella, N. (2004) Cannabinoids and neuroinflammation. Br. J. Pharmacol. 141, 775-785.
    • (2004) Br. J. Pharmacol. , vol.141 , pp. 775-785
    • Walter, L.1    Stella, N.2
  • 18
    • 15944389904 scopus 로고    scopus 로고
    • Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils
    • Pegorini, S., Braida, D., Verzoni, C., Guerini-Rocco, C., Consalez, G. G., Croci, L. and Sala, M. (2005) Capsaicin exhibits neuroprotective effects in a model of transient global cerebral ischemia in Mongolian gerbils. Br. J. Pharmacol. 144, 727-735.
    • (2005) Br. J. Pharmacol. , vol.144 , pp. 727-735
    • Pegorini, S.1    Braida, D.2    Verzoni, C.3    Guerini-Rocco, C.4    Consalez, G.G.5    Croci, L.6    Sala, M.7
  • 20
    • 0037396888 scopus 로고    scopus 로고
    • The therapeutic potential of cannabis in multiple sclerosis
    • Baker, D. and Pryce, G. (2003) The therapeutic potential of cannabis in multiple sclerosis. Expert Opin. Invest. Drugs 12, 561-567.
    • (2003) Expert Opin. Invest. Drugs , vol.12 , pp. 561-567
    • Baker, D.1    Pryce, G.2
  • 21
    • 0348010292 scopus 로고    scopus 로고
    • Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains
    • Benito, C., Nunez, E., Tolon, R. M., Carrier, E. J., Rabano, A., Hillard, C. J. and Romero, J. (2003) Cannabinoid CB2 receptors and fatty acid amide hydrolase are selectively overexpressed in neuritic plaque-associated glia in Alzheimer's disease brains. J. Neurosci. 23, 11136-11141.
    • (2003) J. Neurosci. , vol.23 , pp. 11136-11141
    • Benito, C.1    Nunez, E.2    Tolon, R.M.3    Carrier, E.J.4    Rabano, A.5    Hillard, C.J.6    Romero, J.7
  • 22
    • 0037206662 scopus 로고    scopus 로고
    • Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide
    • Milton, N. G. (2002) Anandamide and noladin ether prevent neurotoxicity of the human amyloid-beta peptide. Neurosci. Lett. 332, 127-130.
    • (2002) Neurosci. Lett. , vol.332 , pp. 127-130
    • Milton, N.G.1
  • 23
    • 14244264502 scopus 로고    scopus 로고
    • Prevention of Alzheimer's disease pathology by cannabinoids: Neuroprotection mediated by blockade of microglial activation
    • Ramirez, B. G., Blazquez, C., Gomez del Pulgar, T., Guzman, M. and de Ceballos, M. L. (2005) Prevention of Alzheimer's disease pathology by cannabinoids: neuroprotection mediated by blockade of microglial activation. J. Neurosci. 25, 1904-1913.
    • (2005) J. Neurosci. , vol.25 , pp. 1904-1913
    • Ramirez, B.G.1    Blazquez, C.2    Gomez Del Pulgar, T.3    Guzman, M.4    De Ceballos, M.L.5
  • 25
    • 0036068317 scopus 로고    scopus 로고
    • Functions of cannabinoid receptors in the hippocampus
    • Davies, S. N., Pertwee, R. G. and Riedel, G. (2002) Functions of cannabinoid receptors in the hippocampus. Neuropharmacology 42, 993-1007.
    • (2002) Neuropharmacology , vol.42 , pp. 993-1007
    • Davies, S.N.1    Pertwee, R.G.2    Riedel, G.3
  • 26
    • 0031459576 scopus 로고    scopus 로고
    • The effects of anandamide on memory consolidation in mice involve both D1 and D2 dopamine receptors
    • Castellano, C., Cabib, S., Palmisano, A., Di Marzo, V. and Puglisi-Allegra, S. (1997) The effects of anandamide on memory consolidation in mice involve both D1 and D2 dopamine receptors. Behav. Pharmacol. 8, 707-712.
    • (1997) Behav. Pharmacol. , vol.8 , pp. 707-712
    • Castellano, C.1    Cabib, S.2    Palmisano, A.3    Di Marzo, V.4    Puglisi-Allegra, S.5
  • 27
    • 0342696154 scopus 로고    scopus 로고
    • The effects of acute treatment with delta9-THC on exploratory behaviour and memory in the rat
    • Hernandez-Tristan, R., Arevalo, C., Canals, S. and Leret, M. L. (2000) The effects of acute treatment with delta9-THC on exploratory behaviour and memory in the rat. J. Physiol. Biochem. 56, 17-24.
    • (2000) J. Physiol. Biochem. , vol.56 , pp. 17-24
    • Hernandez-Tristan, R.1    Arevalo, C.2    Canals, S.3    Leret, M.L.4
  • 29
    • 0034666557 scopus 로고    scopus 로고
    • SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats
    • Lichtman, A. H. (2000) SR 141716A enhances spatial memory as assessed in a radial-arm maze task in rats. Eur. J. Pharmacol. 404, 175-179.
    • (2000) Eur. J. Pharmacol. , vol.404 , pp. 175-179
    • Lichtman, A.H.1
  • 30
    • 1642331623 scopus 로고    scopus 로고
    • SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task
    • Wolff, M. C. and Leander, J. D. (2003) SR141716A, a cannabinoid CB1 receptor antagonist, improves memory in a delayed radial maze task. Eur. J. Pharmacol. 477, 213-217.
    • (2003) Eur. J. Pharmacol. , vol.477 , pp. 213-217
    • Wolff, M.C.1    Leander, J.D.2
  • 31
    • 0042591496 scopus 로고    scopus 로고
    • Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons
    • Hampson, R. E., Simeral, J. D., Kelly, E. J. and Deadwyler, S. A. (2003) Tolerance to the memory disruptive effects of cannabinoids involves adaptation by hippocampal neurons. Hippocampus 13, 543-556.
    • (2003) Hippocampus , vol.13 , pp. 543-556
    • Hampson, R.E.1    Simeral, J.D.2    Kelly, E.J.3    Deadwyler, S.A.4
  • 32
    • 1642320366 scopus 로고    scopus 로고
    • Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade
    • Mazzola, C., Micale, V. and Drago, F. (2003) Amnesia induced by beta-amyloid fragments is counteracted by cannabinoid CB1 receptor blockade. Eur. J. Pharmacol. 477, 219-225.
    • (2003) Eur. J. Pharmacol. , vol.477 , pp. 219-225
    • Mazzola, C.1    Micale, V.2    Drago, F.3
  • 33
    • 0026353502 scopus 로고
    • Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease
    • USA
    • Flood, J. F., Morley, J. E. and Roberts, E. (1991) Amnestic effects in mice of four synthetic peptides homologous to amyloid beta protein from patients with Alzheimer disease. Proc. Natl. Acad. Sci. USA 88, 3363-3366.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 3363-3366
    • Flood, J.F.1    Morley, J.E.2    Roberts, E.3
  • 34
    • 0026702704 scopus 로고
    • The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain
    • Emre, M., Geula, C., Ransil, B. J. and Mesulam, M. M. (1992) The acute neurotoxicity and effects upon cholinergic axons of intracerebrally injected beta-amyloid in the rat brain. Neurobiol. Aging 13, 553-559.
    • (1992) Neurobiol. Aging , vol.13 , pp. 553-559
    • Emre, M.1    Geula, C.2    Ransil, B.J.3    Mesulam, M.M.4
  • 36
    • 0034751335 scopus 로고    scopus 로고
    • Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
    • Bisogno, T., Hanus, L., De Petrocellis, L., Tchilibon, S., Ponde, D. E., Brandi, I., Moriello, A. S., Davis, J. B., Mechoulam, R. and Di Marzo, V. (2001) Molecular targets for cannabidiol and its synthetic analogues: effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br. J. Pharmacol. 134, 845-852.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 845-852
    • Bisogno, T.1    Hanus, L.2    De Petrocellis, L.3    Tchilibon, S.4    Ponde, D.E.5    Brandi, I.6    Moriello, A.S.7    Davis, J.B.8    Mechoulam, R.9    Di Marzo, V.10
  • 37
    • 1842510018 scopus 로고    scopus 로고
    • Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa on β-amyloid-induced toxicity in PC12 cells
    • Iuvone, T., Esposito, G., Esposito, R., Santamaria, R., Di Rosa, M. and Izzo, A. A. (2004) Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa on β-amyloid-induced toxicity in PC12 cells. J. Neurochem. 89. 134-141.
    • (2004) J. Neurochem. , vol.89 , pp. 134-141
    • Iuvone, T.1    Esposito, G.2    Esposito, R.3    Santamaria, R.4    Di Rosa, M.5    Izzo, A.A.6
  • 38
    • 33344456093 scopus 로고    scopus 로고
    • The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    • Esposito, G., De Filippis, D., Carnuccio, R., Izzo, A. A. and Iuvone, T. (2005) The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells. J. Mol. Med. 84, 253-258.
    • (2005) J. Mol. Med. , vol.84 , pp. 253-258
    • Esposito, G.1    De Filippis, D.2    Carnuccio, R.3    Izzo, A.A.4    Iuvone, T.5
  • 39
    • 0025879957 scopus 로고
    • An in vivo model for neurodegenerative effects of β-amyloid and protection by substance, P
    • USA
    • Kowall, N. W., Beal, M. F., Busciglio, J., Duffy, L. K. and Yankner, B. A. (1991) An in vivo model for neurodegenerative effects of β-amyloid and protection by substance, P. Proc. Natl. Acad. Sci. USA 88,7247-7251.
    • (1991) Proc. Natl. Acad. Sci. , vol.88 , pp. 7247-7251
    • Kowall, N.W.1    Beal, M.F.2    Busciglio, J.3    Duffy, L.K.4    Yankner, B.A.5
  • 40
    • 0034644842 scopus 로고    scopus 로고
    • Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: Inhibitors of anandamide uptake with negligible capsaicin-like activity
    • De Petrocellis, L., Bisogno, T., Davis, J. B., Pertwee, R. G. and Di Marzo, V. (2000) Overlap between the ligand recognition properties of the anandamide transporter and the VR1 vanilloid receptor: inhibitors of anandamide uptake with negligible capsaicin-like activity. FEBS Lett. 483, 52-56.
    • (2000) FEBS Lett. , vol.483 , pp. 52-56
    • De Petrocellis, L.1    Bisogno, T.2    Davis, J.B.3    Pertwee, R.G.4    Di Marzo, V.5
  • 41
    • 0032531916 scopus 로고    scopus 로고
    • Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion
    • Chan, P. H., Kawase, M., Murakami, K., Chen, S. F., Li, Y., Calagui, B., Reola, L., Carlson, E. and Epstein, C. J. (1998) Overexpression of SOD1 in transgenic rats protects vulnerable neurons against ischemic damage after global cerebral ischemia and reperfusion. J. Neurosci. 18, 8292-9299.
    • (1998) J. Neurosci. , vol.18 , pp. 8292-9299
    • Chan, P.H.1    Kawase, M.2    Murakami, K.3    Chen, S.F.4    Li, Y.5    Calagui, B.6    Reola, L.7    Carlson, E.8    Epstein, C.J.9
  • 42
    • 0030048606 scopus 로고    scopus 로고
    • Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction
    • Maurice, T., Lockhart, B. P. and Privat, A. (1996) Amnesia induced in mice by centrally administered beta-amyloid peptides involves cholinergic dysfunction. Brain Res. 706, 181-193.
    • (1996) Brain Res. , vol.706 , pp. 181-193
    • Maurice, T.1    Lockhart, B.P.2    Privat, A.3
  • 44
    • 0022647809 scopus 로고
    • Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks
    • Venault, P., Chapouthier, G., de Carvalho, L. P., Simiand, J., Morre, M., Dodd, R. H. and Rossier, J. (1986) Benzodiazepine impairs and beta-carboline enhances performance in learning and memory tasks. Nature 321, 864-866.
    • (1986) Nature , vol.321 , pp. 864-866
    • Venault, P.1    Chapouthier, G.2    De Carvalho, L.P.3    Simiand, J.4    Morre, M.5    Dodd, R.H.6    Rossier, J.7
  • 46
    • 0018965414 scopus 로고
    • A rapid method for the regional dissection of the rat brain
    • Heffner, T. G., Hartman, J. A. and Seiden, L. S. (1980) A rapid method for the regional dissection of the rat brain. Pharmacol. Biochem. Behav. 13, 453-456.
    • (1980) Pharmacol. Biochem. Behav. , vol.13 , pp. 453-456
    • Heffner, T.G.1    Hartman, J.A.2    Seiden, L.S.3
  • 47
    • 0028837562 scopus 로고
    • Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain
    • Schmid, P. C., Krebsbach, R. J., Perry, S. R., Dettmer, T. M., Maasson, J. L. and Schmid, H. H. (1995) Occurrence and postmortem generation of anandamide and other long-chain N-acylethanolamines in mammalian brain. FEBS Lett. 375, 117-120.
    • (1995) FEBS Lett. , vol.375 , pp. 117-120
    • Schmid, P.C.1    Krebsbach, R.J.2    Perry, S.R.3    Dettmer, T.M.4    Maasson, J.L.5    Schmid, H.H.6
  • 49
    • 0033549259 scopus 로고    scopus 로고
    • Beta(1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo
    • Scali, C., Prosperi, C., Giovannelli, L., Bianchi, L., Pepeu, G. and Casamenti, F. (1999) Beta(1-40) amyloid peptide injection into the nucleus basalis of rats induces microglia reaction and enhances cortical gamma-aminobutyric acid release in vivo. Brain Res. 831, 319-321.
    • (1999) Brain Res. , vol.831 , pp. 319-321
    • Scali, C.1    Prosperi, C.2    Giovannelli, L.3    Bianchi, L.4    Pepeu, G.5    Casamenti, F.6
  • 50
    • 0036827728 scopus 로고    scopus 로고
    • Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Abeta(1-42) injections in the rat
    • Richardson, R. L., Kim, E. M., Shephard, R. A., Gardiner, T., Cleary, J. and O'Hare, E. (2002) Behavioural and histopathological analyses of ibuprofen treatment on the effect of aggregated Abeta(1-42) injections in the rat. Brain Res. 954, 1-10.
    • (2002) Brain Res. , vol.954 , pp. 1-10
    • Richardson, R.L.1    Kim, E.M.2    Shephard, R.A.3    Gardiner, T.4    Cleary, J.5    O'Hare, E.6
  • 51
    • 29344438047 scopus 로고    scopus 로고
    • UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders
    • de Lago, E., Fernandez-Ruiz, J., Ortega-Gutierrez, S., Cabranes, A., Pryce, G., Baker, D., Lopez-Rodriguez, M. and Ramos, J. A.(2006) UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders. Eur. Neuropsychopharmacol. 16, 7-18.
    • (2006) Eur. Neuropsychopharmacol. , vol.16 , pp. 7-18
    • De Lago, E.1    Fernandez-Ruiz, J.2    Ortega-Gutierrez, S.3    Cabranes, A.4    Pryce, G.5    Baker, D.6    Lopez-Rodriguez, M.7    Ramos, J.A.8
  • 52
    • 17444387480 scopus 로고    scopus 로고
    • Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes
    • Ramirez, G., Toro, R., Dobeli, H. and von Bernhardi, R. (2005) Protection of rat primary hippocampal cultures from A beta cytotoxicity by pro-inflammatory molecules is mediated by astrocytes. Neurobiol. Dis. 19, 243-254.
    • (2005) Neurobiol. Dis. , vol.19 , pp. 243-254
    • Ramirez, G.1    Toro, R.2    Dobeli, H.3    Von Bernhardi, R.4
  • 54
    • 9444277292 scopus 로고    scopus 로고
    • Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis
    • Patel, S., Roelke, C. T., Rademacher, D. J., Cullinan, W. E. and Hillard, C. J. (2004) Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 145, 5431-5438.
    • (2004) Endocrinology , vol.145 , pp. 5431-5438
    • Patel, S.1    Roelke, C.T.2    Rademacher, D.J.3    Cullinan, W.E.4    Hillard, C.J.5
  • 56
    • 0023824378 scopus 로고
    • Neurochemical aspects of Alzheimer's disease: Involvement of membrane phospholipids
    • Farooqui, A. A., Liss, L. and Horrocks, L. A. (1988) Neurochemical aspects of Alzheimer's disease: involvement of membrane phospholipids. Metab. Brain Dis. 3, 19-35.
    • (1988) Metab. Brain Dis. , vol.3 , pp. 19-35
    • Farooqui, A.A.1    Liss, L.2    Horrocks, L.A.3
  • 57
    • 0035662685 scopus 로고    scopus 로고
    • The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice
    • Al-Hayani, A., Wease, K. N., Ross, R. A., Pertwee, R. G. and Davies, S. N. (2001) The endogenous cannabinoid anandamide activates vanilloid receptors in the rat hippocampal slice. Neuropharmacology 41, 1000-1005.
    • (2001) Neuropharmacology , vol.41 , pp. 1000-1005
    • Al-Hayani, A.1    Wease, K.N.2    Ross, R.A.3    Pertwee, R.G.4    Davies, S.N.5
  • 58
    • 0031706164 scopus 로고    scopus 로고
    • Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity
    • Shen, M. and Thayer, S. A. (1999) Cannabinoid receptor agonists protect cultured rat hippocampal neurons from excitotoxicity. Mol. Pharmacol. 54, 459-462.
    • (1999) Mol. Pharmacol. , vol.54 , pp. 459-462
    • Shen, M.1    Thayer, S.A.2
  • 59
    • 19444373244 scopus 로고    scopus 로고
    • Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores
    • Zhuang, S. Y., Bridges, D., Grigorenko, E., McCloud, S., Boon, A., Hampson, R. E. and Deadwyler, S. A. (2005) Cannabinoids produce neuroprotection by reducing intracellular calcium release from ryanodine-sensitive stores. Neuropharmacology 48, 1086-1096.
    • (2005) Neuropharmacology , vol.48 , pp. 1086-1096
    • Zhuang, S.Y.1    Bridges, D.2    Grigorenko, E.3    McCloud, S.4    Boon, A.5    Hampson, R.E.6    Deadwyler, S.A.7
  • 60
    • 27844499204 scopus 로고    scopus 로고
    • + current in hippocampal CA1 pyramidal neurons
    • + current in hippocampal CA1 pyramidal neurons. Biochem. Biophys. Res. Commun. 338, 1913-1919.
    • (2005) Biochem. Biophys. Res. Commun. , vol.338 , pp. 1913-1919
    • Chen, C.1
  • 62
    • 0033936028 scopus 로고    scopus 로고
    • Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease
    • Di Marzo, V., Hill, M. P., Bisogno, T., Crossman, A. R. and Brotchie, J. M. (2000) Enhanced levels of endogenous cannabinoids in the globus pallidus are associated with a reduction in movement in an animal model of Parkinson's disease. FASEB J. 14, 1432-1438.
    • (2000) FASEB J. , vol.14 , pp. 1432-1438
    • Di Marzo, V.1    Hill, M.P.2    Bisogno, T.3    Crossman, A.R.4    Brotchie, J.M.5
  • 63
    • 14744301757 scopus 로고    scopus 로고
    • Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism
    • Fernandez-Espejo, E., Caraballo, I., de Fonseca, F. R., El Banoua, F., Ferrer, B., Flores, J. A. and Galan-Rodriguez, B. (2005) Cannabinoid CB1 antagonists possess antiparkinsonian efficacy only in rats with very severe nigral lesion in experimental parkinsonism. Neurobiol. Dis. 18, 591-601.
    • (2005) Neurobiol. Dis. , vol.18 , pp. 591-601
    • Fernandez-Espejo, E.1    Caraballo, I.2    De Fonseca, F.R.3    El Banoua, F.4    Ferrer, B.5    Flores, J.A.6    Galan-Rodriguez, B.7
  • 64
    • 21744461614 scopus 로고    scopus 로고
    • A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease
    • van der Stelt, M., Fox, S. H., Hill, M., Crossman, A. R., Petrosino, S., Di Marzo, V. and Brotchie, J. (2005) A role for endocannabinoids in the generation of parkinsonism and levodopa-induced dyskinesia in MPTP-lesioned non-human primate models of Parkinson's disease. FASEB J. 19, 1140-1142.
    • (2005) FASEB J. , vol.19 , pp. 1140-1142
    • Van Der Stelt, M.1    Fox, S.H.2    Hill, M.3    Crossman, A.R.4    Petrosino, S.5    Di Marzo, V.6    Brotchie, J.7
  • 65
    • 33745189940 scopus 로고    scopus 로고
    • Non-CB1, non-CB2 receptors for endocannabinodis
    • Onaivi E., Sugiura T. and Di Marzo V., Eds., CRC-Press/Taylor & Francis, Boca Raton
    • Di Marzo, V. and De Petrocellis, L. (2006) Non-CB1, non-CB2 receptors for endocannabinodis. In: Endocannabinoids (Onaivi E., Sugiura T. and Di Marzo V., Eds.), pp. 151-174. CRC-Press/Taylor & Francis, Boca Raton.
    • (2006) Endocannabinoids , pp. 151-174
    • Di Marzo, V.1    De Petrocellis, L.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.