Enantioselective synthesis of 1-methoxy- and 1-deoxy-2′-methyl- Δ8-tetrahydrocannabinols: New selective ligands for the CB 2 receptor

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 1, 2006, Pages 247-262

  Huffman, John W ^a   Bushell, Simon M ^a   Joshi, Sudhir N ^a   Wiley, Jenny L ^b   Martin, Billy R ^b  

^a CLEMSON UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Cannabinoid receptors; Cannabinoids; Enantioselective synthesis; Structure activity relationships

Indexed keywords

1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 1 DEOXY 3 (2 METHYLPROPYL) DELTA 8 TETRAHYDROCANNABINOL; 1 DEOXY 3 (2' METHYLBUTYL) DELTA 8 TETRAHYDROCANNABINOL; 1 DEOXY 3 (2' METHYLHEPTYL) DELTA 8 TETRAHYDROCANNABINOL; 1 DEOXY 3 (2' METHYLHEXYL) DELTA 8 TETRAHYDROCANNABINOL; 1 DEOXY 3 (2' METHYLPENTYL) DELTA 8 TETRAHYDROCANNABINOL; 1 METHOXY 3 (2 METHYLPROPYL) DELTA 8 TETRAHYDROCANNABINOL; 1 METHOXY 3 (2' METHYLBUTYL) DELTA 8 TETRAHYDROCANNABINOL; 1 METHOXY 3 (2' METHYLHEPTYL) DELTA 8 TETRAHYDROCANNABINOL; 1 METHOXY 3 (2' METHYLHEXYL) DELTA 8 TETRAHYDROCANNABINOL; 1 METHOXY 3 (2' METHYLPENTYL) DELTA 8 TETRAHYDROCANNABINOL; 3 (2 METHYLPROPYL) DELTA 8 TETRAHYDROCANNABINOL; 3 (2' METHYLBUTYL) DELTA 8 TETRAHYDROCANNABINOL; 3 (2' METHYLHEPTYL) DELTA 8 TETRAHYDROCANNABINOL; 3 (2' METHYLHEXYL) DELTA 8 TETRAHYDROCANNABINOL; 3 (2' METHYLPENTYL) DELTA 8 TETRAHYDROCANNABINOL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 2 RECEPTOR; JWH 247; JWH 254; JWH 255; JWH 256; JWH 257; JWH 264; JWH 338; JWH 339; JWH 351; JWH 352; JWH 353; JWH 354; JWH 355; JWH 356; JWH 357; JWH 358; JWH 359; JWH 360; TETRAHYDROCANNABINOL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; ATOM; BINDING AFFINITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; EMBRYO; ENANTIOSELECTIVITY; HUMAN; HUMAN CELL; ISOMER;

LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; RECEPTOR, CANNABINOID, CB2; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM; TETRAHYDROCANNABINOL;

EID: 27744550205     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.08.013     Document Type: Article

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