Comparison of cannabinoid ligands affinities and efficacies in murine tissues and in transfected cells expressing human recombinant cannabinoid receptors

European Journal of Pharmaceutical Sciences

Volumn 23, Issue 3, 2004, Pages 233-243

  Govaerts, Sophie J ^a   Hermans, Emmanuel ^a   Lambert, Didier M ^a  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

Author keywords

35S GTP S; Aminoalkylindoles; Bicyclic cannabinoids; Cannabinoid CB 1 and CB 2 receptors; Inverse agonism; Tetrahydrocannabinol

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3 [2 HYDROXY 4 (1,1 DIMETHYLHEPTYL)PHENYL]CYCLOHEXANOL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (1,1 DIMETHYLHEPTYL) 2 (3 HYDROXY 7 HYDROXYMETHYLDECAHYDRO 1 NAPHTHYL)PHENOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; CANNABINOID DERIVATIVE; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; CP 47947; DELTA8 TETRAHYDROCANNABINOL; DEXANABINOL; DRONABINOL; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); PROTEIN G; RIMONABANT; SULFUR 35; TERPENE DERIVATIVE; TETRAHYDROCANNABINOL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING ASSAY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG EFFICACY; DRUG RECEPTOR BINDING; HUMAN; MALE; MOUSE; NONHUMAN; NUCLEOTIDE BINDING SITE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ANIMALS; BINDING, COMPETITIVE; BRAIN; CANNABINOIDS; CELLS, CULTURED; CHO CELLS; CRICETINAE; CRICETULUS; HUMANS; INDOLES; LIGANDS; MALE; MICE; PYRAZOLES; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTOR, CANNABINOID, CB1; RECEPTOR, CANNABINOID, CB2; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; TERPENES; TRANSFECTION;

EID: 5644244290     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2004.07.013     Document Type: Article

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