2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 1: Discovery of CB2 receptor selective compounds

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 14, 2007, Pages 4030-4034

  Kai, Hiroyuki ^a   Morioka, Yasuhide ^a   Murashi, Takami ^a   Morita, Koichi ^a   Shinonome, Satomi ^a   Nakazato, Hitoshi ^a   Kawamoto, Keiko ^a   Hanasaki, Kohji ^a   Takahashi, Fumiyo ^a   Mihara, Shin ichi ^a   Arai, Tohko ^a   Abe, Kohji ^a   Okabe, Hiroshi ^a   Baba, Takahiko ^a   Yoshikawa, Takayoshi ^a   Takenaka, Hideyuki ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

1,3 Thiazine; Cannabinoid receptor agonist; CB1; CB2; CB2 receptor selective; Pain; Structure activity relationship

Indexed keywords

1,3 THIAZINE DERIVATIVE; 2 PHENYLIMINO 5,6 DIHYDRO 4H 1,3 THIAZINE DERIVATIVE; ANALGESIC AGENT; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; FUNCTIONAL GROUP; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; HIGH THROUGHPUT SCREENING; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; RATS; RECEPTORS, CANNABINOID; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZINES;

EID: 34250322008     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.04.093     Document Type: Article

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