Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction

Biopolymers - Peptide Science Section

Volumn 71, Issue 2, 2003, Pages 169-189

  Shim, Joong Youn ^a   Welsh, William J ^b   Howlett, Allyn C ^c  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c NORTH CAROLINA CENTRAL UNIVERSITY   (United States)

Author keywords

Bovine rhodopsin; Cannabinoid agonist interaction; Cannabinoid receptor; G protein coupled receptors; G proteins; Homology; Molecular docking; Neuronal functions

Indexed keywords

BINDING ENERGY; BRAIN; COMPUTER SIMULATION; CONFORMATIONS; CRYSTAL STRUCTURE; HYDROGEN BONDS; MATHEMATICAL MODELS; MOLECULAR DYNAMICS; PROTEINS; X RAY ANALYSIS;

HOMOLOGY MODELS;

NEUROLOGY;

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 3 [2 HYDROXY 4 (1,1 DIMETHYLHEPTYL)PHENYL]CYCLOHEXANOL; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (1,1 DIMETHYLHEPTYL) 2 (3 HYDROXY 7 HYDROXYMETHYLDECAHYDRO 1 NAPHTHYL)PHENOL; ANANDAMIDE; CANNABINOID; CANNABINOID 1 RECEPTOR; CANNABINOID RECEPTOR AGONIST; DRONABINOL; G PROTEIN COUPLED RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; INDOLE DERIVATIVE; LIGAND; LYSINE; RHODOPSIN; UNCLASSIFIED DRUG; CANNABINOID RECEPTOR;

ARTICLE; BINDING AFFINITY; BRAIN; CALCULATION; CATTLE; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; DRUG RECEPTOR BINDING; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DYNAMICS; MONTE CARLO METHOD; NERVE FUNCTION; NONHUMAN; PHARMACOPHORE; PREDICTION; PROTEIN INTERACTION; RAT; RECEPTOR AFFINITY; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SIMULATION; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG POTENTIATION; KINETICS; METABOLISM; MOLECULAR GENETICS; PROTEIN CONFORMATION; STRUCTURE ACTIVITY RELATION; THERMODYNAMICS;

BOVINAE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CANNABINOIDS; CATTLE; HUMANS; HYDROGEN BONDING; KINETICS; LIGANDS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN CONFORMATION; RATS; RECEPTORS, CANNABINOID; SEQUENCE HOMOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP; THERMODYNAMICS;

EID: 0038119607     PISSN: 00063525     EISSN: None     Source Type: Journal    
DOI: 10.1002/bip.10424     Document Type: Article

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