Tricyclic pyrazoles. Part 1: Synthesis and biological evaluation of novel 1,4-Dihydroindeno[1,2-c]pyrazol-based ligands for CB1 and CB2 cannabinoid receptors

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 2, 2003, Pages 251-263

  Mussinu, Jean Mario ^a   Ruiu, Stefania ^b   Mulè, Antonio C ^a   Pau, Amedeo ^a   Carai, Mauro A M ^b   Loriga, Giovanni ^a,b   Murineddu, Gabriele ^a,b   Pinna, Gérard A ^a  

^a UNIVERSITY OF SASSARI   (Italy)

^b Neuroscienze PharmaNess Scarl   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; AMINE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CARBOXYLIC ACID DERIVATIVE; LIGAND; PYRAZOLE DERIVATIVE; RIMONABANT; BENZENE DERIVATIVE; CANNABINOID RECEPTOR; DRUG RECEPTOR; ENDOCANNABINOID; PIPERIDINE DERIVATIVE; TRITIUM;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; IN VITRO STUDY; SUBSTITUTION REACTION; ANIMAL; CELL MEMBRANE; CEREBELLUM; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; MALE; METABOLISM; MOUSE; RADIOASSAY; SPLEEN; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

HUMAN ECHOVIRUS 1;

AMINES; ANIMALS; BENZENE DERIVATIVES; CELL MEMBRANE; CEREBELLUM; ENDOCANNABINOIDS; LIGANDS; MALE; MICE; PIPERIDINES; PYRAZOLES; RADIOLIGAND ASSAY; RECEPTORS, CANNABINOID; RECEPTORS, DRUG; SPLEEN; STRUCTURE-ACTIVITY RELATIONSHIP; TRITIUM;

EID: 1842832439     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00319-X     Document Type: Article

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