-
1
-
-
0037082324
-
Target validation of G-protein coupled receptors
-
Wise, A.; Gearing, K.; Rees, S. Target validation of G-protein coupled receptors. Drug Discovery Today 2002, 7, 235-246.
-
(2002)
Drug Discovery Today
, vol.7
, pp. 235-246
-
-
Wise, A.1
Gearing, K.2
Rees, S.3
-
2
-
-
0030611978
-
Pharmacology of cannabinoid CB1 and CB2 receptors
-
Pertwee, R. G. Pharmacology of cannabinoid CB1 and CB2 receptors. Pharmacol. Ther. 1997, 74, 129-180.
-
(1997)
Pharmacol. Ther.
, vol.74
, pp. 129-180
-
-
Pertwee, R.G.1
-
3
-
-
0025325535
-
Structure of a cannabinoid receptor and functional expression of the cloned cDNA
-
Matsuda, L. A.; Lolait, S. J.; Brownstein, M. J.; Young, A. C.; Bonner, T. I. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature 1990, 346, 561-564.
-
(1990)
Nature
, vol.346
, pp. 561-564
-
-
Matsuda, L.A.1
Lolait, S.J.2
Brownstein, M.J.3
Young, A.C.4
Bonner, T.I.5
-
4
-
-
0027515373
-
Molecular characterization of a peripheral receptor for cannabinoids
-
Munro, S.; Thomas, K. L.; Abu-Shaar, M. Molecular characterization of a peripheral receptor for cannabinoids. Nature 1993, 365, 61-65.
-
(1993)
Nature
, vol.365
, pp. 61-65
-
-
Munro, S.1
Thomas, K.L.2
Abu-Shaar, M.3
-
5
-
-
0026715999
-
A novel probe for the cannabinoid receptor
-
Devane, W. A.; Breuer, A.; Sheskin, T.; Jarbe, T. U.; Eisen, M. S.; Mechoulam, R. A novel probe for the cannabinoid receptor. J. Med. Chem. 1992, 35, 2065-2069.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2065-2069
-
-
Devane, W.A.1
Breuer, A.2
Sheskin, T.3
Jarbe, T.U.4
Eisen, M.S.5
Mechoulam, R.6
-
6
-
-
0028970517
-
2-Arachidonoylglycerol: A possible endogenous cannabinoid receptor ligand in brain
-
Sugiura, T.; Kondo, S.; Sukagawa, A.; Nakane, S.; Shinoda, A.; Itoh, K.; Yamashita, A.; Waku, K. 2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain. Biochem. Biophys. Res. Commun. 1995, 215, 89-97.
-
(1995)
Biochem. Biophys. Res. Commun.
, vol.215
, pp. 89-97
-
-
Sugiura, T.1
Kondo, S.2
Sukagawa, A.3
Nakane, S.4
Shinoda, A.5
Itoh, K.6
Yamashita, A.7
Waku, K.8
-
7
-
-
0029012014
-
Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors
-
Mechoulam, R.; Ben-Shabat, S.; Hanus, L.; Ligumsky, M.; Kaminski, N. E.; Schatz, A. R.; Gopher, A.; Almog, S.; Martin, B. R.; Compton, D. R.; Pertwee, R. G.; Griffin, G.; Bayewitch, M.; Barg, J.; Vogel, Z. Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors. Biochem. Pharmacol. 1995, 50, 83-90.
-
(1995)
Biochem. Pharmacol.
, vol.50
, pp. 83-90
-
-
Mechoulam, R.1
Ben-Shabat, S.2
Hanus, L.3
Ligumsky, M.4
Kaminski, N.E.5
Schatz, A.R.6
Gopher, A.7
Almog, S.8
Martin, B.R.9
Compton, D.R.10
Pertwee, R.G.11
Griffin, G.12
Bayewitch, M.13
Barg, J.14
Vogel, Z.15
-
8
-
-
0035957425
-
2-Arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor
-
Hanus, L.; Abu-Lafi, S.; Fride, E.; Breuer, A.; Vogel, Z.; Shalev, D. E. ; Kustanovich, I.; Mechoulam, R. 2-arachidonyl glyceryl ether, an endogenous agonist of the cannabinoid CB1 receptor. Proc. Natl. Acad. Sci. U.S.A. 2001, 98, 3662-3665.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 3662-3665
-
-
Hanus, L.1
Abu-Lafi, S.2
Fride, E.3
Breuer, A.4
Vogel, Z.5
Shalev, D.E.6
Kustanovich, I.7
Mechoulam, R.8
-
9
-
-
0036260823
-
Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor
-
Porter, A. C.; Sauer, J. M.; Knierman, M. D.; Becker, G. W.; Berna, M. J.; Bao, J.; Nomikos, G. G.; Carter, P.; Bymaster, F. P.; Leese, A. B.; Felder, C. C. Characterization of a novel endocannabinoid, virodhamine, with antagonist activity at the CB1 receptor. J. Pharmacol. Exp. Ther. 2002, 301, 1020-1024.
-
(2002)
J. Pharmacol. Exp. Ther.
, vol.301
, pp. 1020-1024
-
-
Porter, A.C.1
Sauer, J.M.2
Knierman, M.D.3
Becker, G.W.4
Berna, M.J.5
Bao, J.6
Nomikos, G.G.7
Carter, P.8
Bymaster, F.P.9
Leese, A.B.10
Felder, C.C.11
-
10
-
-
0037062411
-
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
-
Huang, S. M.; Bisogno, T.; Trevisani, M.; Al-Hayani, A.; De Petrocellis, L.; Fezza, F.; Tognetto, M.; Petros, T. J.; Krey, J. F.; Chu, C. J.; Miller, J. D.; Davies, S. N.; Geppetti, P.; Walker, J. M.; Di Marzo, V. An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc. Natl. Acad. Sci. U.S.A. 2002, 99, 8400-8405.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 8400-8405
-
-
Huang, S.M.1
Bisogno, T.2
Trevisani, M.3
Al-Hayani, A.4
De Petrocellis, L.5
Fezza, F.6
Tognetto, M.7
Petros, T.J.8
Krey, J.F.9
Chu, C.J.10
Miller, J.D.11
Davies, S.N.12
Geppetti, P.13
Walker, J.M.14
Di Marzo, V.15
-
11
-
-
33947489961
-
Isolation, structure, and partial synthesis of an active constituent of Hashish
-
Gaoni, Y.; Mechoulam, R. Isolation, Structure, and Partial Synthesis of an Active Constituent of Hashish. J. Am. Chem. Soc. 1964, 86, 1646-1647.
-
(1964)
J. Am. Chem. Soc.
, vol.86
, pp. 1646-1647
-
-
Gaoni, Y.1
Mechoulam, R.2
-
12
-
-
0041534429
-
The terapeutic potential of cannabis
-
Baker, D.; Pryce, G.; Giovannoni, G.; Thompson, A. J. The terapeutic potential of cannabis. Lancet Neurol. 2003, 2, 291-298.
-
(2003)
Lancet Neurol.
, vol.2
, pp. 291-298
-
-
Baker, D.1
Pryce, G.2
Giovannoni, G.3
Thompson, A.J.4
-
13
-
-
0029078977
-
Construction of a 3D model of the cannabinoid CB1 receptor: Determination of helix ends and helix orientation
-
Bramblett, R. D.; Panu, A. M.; Ballesteros, J. A.; Reggio, P. H. Construction of a 3D model of the cannabinoid CB1 receptor: determination of helix ends and helix orientation. Life Sci. 1995, 56, 1971-1982.
-
(1995)
Life Sci.
, vol.56
, pp. 1971-1982
-
-
Bramblett, R.D.1
Panu, A.M.2
Ballesteros, J.A.3
Reggio, P.H.4
-
14
-
-
0032860406
-
The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2)
-
Song, Z. H.; Slowey, C. A.; Hurst, D. P.; Reggio, P. H. The difference between the CB(1) and CB(2) cannabinoid receptors at position 5.46 is crucial for the selectivity of WIN55212-2 for CB(2). Mol. Pharmacol. 1999, 56, 834-840.
-
(1999)
Mol. Pharmacol.
, vol.56
, pp. 834-840
-
-
Song, Z.H.1
Slowey, C.A.2
Hurst, D.P.3
Reggio, P.H.4
-
15
-
-
0027190359
-
Projection structure of rhodopsin
-
Schertler, G. F.; Villa, C.; Henderson, R. Projection structure of rhodopsin. Nature 1993, 362, 770-772.
-
(1993)
Nature
, vol.362
, pp. 770-772
-
-
Schertler, G.F.1
Villa, C.2
Henderson, R.3
-
16
-
-
0027506471
-
The probable arrangement of the helices in G protein-coupled receptors
-
Baldwin, J. M. The probable arrangement of the helices in G protein-coupled receptors. EMBO J. 1993, 12, 1693-1703.
-
(1993)
EMBO J.
, vol.12
, pp. 1693-1703
-
-
Baldwin, J.M.1
-
17
-
-
0037098239
-
A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition
-
McAllister, S. D.; Tao, Q.; Barnett-Norris, J.; Buehner, K.; Hurst, D. P.; Guarnieri, F.; Reggio, P. H.; Nowell Harmon, K. W.; Cabral, G. A.; Abood, M. E. A critical role for a tyrosine residue in the cannabinoid receptors for ligand recognition. Biochem. Pharmacol. 2002, 63, 2121-2136.
-
(2002)
Biochem. Pharmacol.
, vol.63
, pp. 2121-2136
-
-
McAllister, S.D.1
Tao, Q.2
Barnett-Norris, J.3
Buehner, K.4
Hurst, D.P.5
Guarnieri, F.6
Reggio, P.H.7
Nowell Harmon, K.W.8
Cabral, G.A.9
Abood, M.E.10
-
18
-
-
0031458958
-
The cannabinoid receptor: Computer-aided molecular modeling and docking of ligand
-
Mahmoudian, M. The cannabinoid receptor: computer-aided molecular modeling and docking of ligand. J. Mol. Graph. Model. 1997, 15, 149-153, 179.
-
(1997)
J. Mol. Graph. Model.
, vol.15
, pp. 149-153
-
-
Mahmoudian, M.1
-
19
-
-
0028082050
-
Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin
-
Zhang, D.; Weinstein, H. Polarity conserved positions in transmembrane domains of G-protein coupled receptors and bacteriorhodopsin. FEBS Lett. 1994, 337, 207-212.
-
(1994)
FEBS Lett.
, vol.337
, pp. 207-212
-
-
Zhang, D.1
Weinstein, H.2
-
20
-
-
0034604451
-
Crystal structure of rhodopsin: A G protein-coupled receptor
-
Palczewski, K.; Kumasaka, T.; Hori, T.; Behnke, C. A.; Motoshima, H.; Fox, B. A.; Le Trong, I.; Teller, D. C.; Okada, T.; Stenkamp, R. E.; Yamamoto, M.; Miyano, M. Crystal structure of rhodopsin: A G protein-coupled receptor. Science 2000, 289, 739-745.
-
(2000)
Science
, vol.289
, pp. 739-745
-
-
Palczewski, K.1
Kumasaka, T.2
Hori, T.3
Behnke, C.A.4
Motoshima, H.5
Fox, B.A.6
Le Trong, I.7
Teller, D.C.8
Okada, T.9
Stenkamp, R.E.10
Yamamoto, M.11
Miyano, M.12
-
21
-
-
0034801665
-
G protein-coupled receptor drug discovery: Implications from the crystal structure of rhodopsin
-
Ballesteros, J.; Palczewski, K. G protein-coupled receptor drug discovery: implications from the crystal structure of rhodopsin. Curr. Opin. Drug Discovery Dev. 2001, 4, 561-574.
-
(2001)
Curr. Opin. Drug Discovery Dev.
, vol.4
, pp. 561-574
-
-
Ballesteros, J.1
Palczewski, K.2
-
22
-
-
0034948696
-
Structural mimicry in G protein-coupled receptors: Implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors
-
Ballesteros, J. A.; Shi, L.; Javitch, J. A. Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors. Mol. Pharmacol. 2001, 60, 1-19.
-
(2001)
Mol. Pharmacol.
, vol.60
, pp. 1-19
-
-
Ballesteros, J.A.1
Shi, L.2
Javitch, J.A.3
-
23
-
-
0037235663
-
Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets?
-
Bissantz, C.; Bernard, P.; Hibert, M.; Rognan, D. Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets? Proteins 2003, 50, 5-25.
-
(2003)
Proteins
, vol.50
, pp. 5-25
-
-
Bissantz, C.1
Bernard, P.2
Hibert, M.3
Rognan, D.4
-
24
-
-
0037103265
-
Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor
-
Barnett-Norris, J.; Hurst, D. P.; Lynch, D. L.; Guarnieri, F.; Makriyannis, A.; Reggio, P. H. Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor. J. Med. Chem. 2002, 45, 3649-3659.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3649-3659
-
-
Barnett-Norris, J.1
Hurst, D.P.2
Lynch, D.L.3
Guarnieri, F.4
Makriyannis, A.5
Reggio, P.H.6
-
25
-
-
0038119607
-
Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction
-
Shim, J. Y.; Welsh, W. J.; Howlett, A. C. Homology model of the CB1 cannabinoid receptor: Sites critical for nonclassical cannabinoid agonist interaction. Biopolymers 2003, 71, 169-189.
-
(2003)
Biopolymers
, vol.71
, pp. 169-189
-
-
Shim, J.Y.1
Welsh, W.J.2
Howlett, A.C.3
-
26
-
-
0031565726
-
An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors
-
Baldwin, J. M.; Schertler, G. F.; Unger, V. M. An alpha-carbon template for the transmembrane helices in the rhodopsin family of G-protein-coupled receptors. J. Mol. Biol. 1997, 272, 144-164.
-
(1997)
J. Mol. Biol.
, vol.272
, pp. 144-164
-
-
Baldwin, J.M.1
Schertler, G.F.2
Unger, V.M.3
-
27
-
-
0037452868
-
Sequence analyses of G-protein-coupled receptors: Similarities to rhodopsin
-
Mirzadegan, T.; Benko, G.; Filipek, S.; Palczewski, K. Sequence analyses of G-protein-coupled receptors: similarities to rhodopsin. Biochemistry 2003, 42, 2759-2767.
-
(2003)
Biochemistry
, vol.42
, pp. 2759-2767
-
-
Mirzadegan, T.1
Benko, G.2
Filipek, S.3
Palczewski, K.4
-
28
-
-
0034726036
-
Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor
-
Gouldson, P.; Calandra, B.; Legoux, P.; Kerneis, A.; Rinaldi-Carmona, M. ; Barth, F.; Le Fur, G.; Ferrara, P.; Shire, D. Mutational analysis and molecular modelling of the antagonist SR 144528 binding site on the human cannabinoid CB(2) receptor. Eur. J. Pharmacol. 2000, 401, 17-25.
-
(2000)
Eur. J. Pharmacol.
, vol.401
, pp. 17-25
-
-
Gouldson, P.1
Calandra, B.2
Legoux, P.3
Kerneis, A.4
Rinaldi-Carmona, M.5
Barth, F.6
Le Fur, G.7
Ferrara, P.8
Shire, D.9
-
29
-
-
0033538481
-
Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528
-
Shire, D.; Calandra, B.; Bouaboula, M.; Barth, F.; Rinaldi-Carmona, M.; Casellas, P.; Ferrara, P. Cannabinoid receptor interactions with the antagonists SR 141716A and SR 144528. Life Sci. 1999, 65, 627-635.
-
(1999)
Life Sci.
, vol.65
, pp. 627-635
-
-
Shire, D.1
Calandra, B.2
Bouaboula, M.3
Barth, F.4
Rinaldi-Carmona, M.5
Casellas, P.6
Ferrara, P.7
-
30
-
-
0029965292
-
Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A
-
Shire, D.; Calandra, B.; Delpech, M.; Dumont, X.; Kaghad, M.; Le Fur, G. ; Caput, D.; Ferrara, P. Structural features of the central cannabinoid CB1 receptor involved in the binding of the specific CB1 antagonist SR 141716A. J. Biol. Chem. 1996, 271, 6941-6946.
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6941-6946
-
-
Shire, D.1
Calandra, B.2
Delpech, M.3
Dumont, X.4
Kaghad, M.5
Le Fur, G.6
Caput, D.7
Ferrara, P.8
-
31
-
-
0030589514
-
Phi/Psi-chology: Ramachandran revisited
-
Kleywegt, G. J.; Jones, T. A. Phi/Psi-chology: Ramachandran revisited. Structure 1996, 4, 1395-1400.
-
(1996)
Structure
, vol.4
, pp. 1395-1400
-
-
Kleywegt, G.J.1
Jones, T.A.2
-
32
-
-
0042991377
-
Pharmacophores for ligand recognition and activation/inactivation of the cannabinoid receptors
-
Reggio, P. H. Pharmacophores for ligand recognition and activation/inactivation of the cannabinoid receptors. Curr. Pharm. Des. 2003, 9, 1607-1633.
-
(2003)
Curr. Pharm. Des.
, vol.9
, pp. 1607-1633
-
-
Reggio, P.H.1
-
33
-
-
0035937786
-
Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta(2) adrenergic receptor mapped by site-selective fluorescent labeling
-
Jensen, A. D.; Guarnieri, F.; Rasmussen, S. G. F.; Asmar, F.; Ballesteros, J. A.; Gether, U. Agonist-induced conformational changes at the cytoplasmic side of transmembrane segment 6 in the beta(2) adrenergic receptor mapped by site-selective fluorescent labeling. J. Biol. Chem. 2001, 276, 9279-9290.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 9279-9290
-
-
Jensen, A.D.1
Guarnieri, F.2
Rasmussen, S.G.F.3
Asmar, F.4
Ballesteros, J.A.5
Gether, U.6
-
34
-
-
0037066183
-
Agonist alkyl tail interaction with cannabinoid CB1 receptor V6.43/I6.46 groove induces a helix 6 active conformation
-
Barnett-Norris, J.; Hurst, D. P.; Buehner, K.; Ballesteros, J. A.; Guarnieri, F.; Reggio, P. H. Agonist alkyl tail interaction with cannabinoid CB1 receptor V6.43/I6.46 groove induces a helix 6 active conformation. Int. J. Quantum Chem. 2002, 88, 76-86.
-
(2002)
Int. J. Quantum Chem.
, vol.88
, pp. 76-86
-
-
Barnett-Norris, J.1
Hurst, D.P.2
Buehner, K.3
Ballesteros, J.A.4
Guarnieri, F.5
Reggio, P.H.6
-
35
-
-
0036954833
-
Activation of the cannabinoid CB1 receptor may involve a W6.48/F3.36 rotamer toggle switch
-
Singh, R.; Hurst, D. P.; Barnett-Norris, J.; Lynch, D. L.; Reggio, P. H. ; Guarnieri, F. Activation of the cannabinoid CB1 receptor may involve a W6.48/F3.36 rotamer toggle switch. J. Pept. Res. 2002, 60, 357-370.
-
(2002)
J. Pept. Res.
, vol.60
, pp. 357-370
-
-
Singh, R.1
Hurst, D.P.2
Barnett-Norris, J.3
Lynch, D.L.4
Reggio, P.H.5
Guarnieri, F.6
-
36
-
-
0029866824
-
A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2
-
Song, Z. H.; Bonner, T. I. A lysine residue of the cannabinoid receptor is critical for receptor recognition by several agonists but not WIN55212-2. Mol. Pharmacol. 1996, 49, 891-896.
-
(1996)
Mol. Pharmacol.
, vol.49
, pp. 891-896
-
-
Song, Z.H.1
Bonner, T.I.2
-
37
-
-
2542644214
-
Aromatic residues in helixes 3-5-6 of CB1 provide specific interaction sites for WIN55,212-2 and SR141716A
-
Burlington, VT
-
McAllister, S. D.; Hurst, D.; Buehner, K.; Norris, J. B.; Reggio, P. H.; Abood, M. E. Aromatic residues in helixes 3-5-6 of CB1 provide specific interaction sites for WIN55,212-2 and SR141716A. 2002 Symposium on the Cannabinoids; International Cannabinoid Research Society, Burlington, VT, 2002; p 76.
-
(2002)
2002 Symposium on the Cannabinoids; International Cannabinoid Research Society
, pp. 76
-
-
McAllister, S.D.1
Hurst, D.2
Buehner, K.3
Norris, J.B.4
Reggio, P.H.5
Abood, M.E.6
-
38
-
-
0242522905
-
An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region
-
McAllister, S. D.; Rizvi, G.; Anavi-Goffer, S.; Hurst, D. P.; Barnett-Norris, J.; Lynch, D. L.; Reggio, P. H.; Abood, M. E. An aromatic microdomain at the cannabinoid CB(1) receptor constitutes an agonist/inverse agonist binding region. J. Med. Chem. 2003, 46, 5139-5152.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 5139-5152
-
-
McAllister, S.D.1
Rizvi, G.2
Anavi-Goffer, S.3
Hurst, D.P.4
Barnett-Norris, J.5
Lynch, D.L.6
Reggio, P.H.7
Abood, M.E.8
-
39
-
-
0029846519
-
Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor
-
Huffman, J. W.; Yu, S.; Showalter, V.; Abood, M. E.; Wiley: J. L.; Compton, D. R.; Martin, B. R.; Bramblett, R. D.; Reggio, P. H. Synthesis and pharmacology of a very potent cannabinoid lacking a phenolic hydroxyl with high affinity for the CB2 receptor. J. Med. Chem. 1996, 39, 3875-3877.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 3875-3877
-
-
Huffman, J.W.1
Yu, S.2
Showalter, V.3
Abood, M.E.4
Wiley, J.L.5
Compton, D.R.6
Martin, B.R.7
Bramblett, R.D.8
Reggio, P.H.9
-
40
-
-
2542577354
-
The CB1 TMH 2-3 region forms the binding site for (+)-7-OH-CBD-DMH
-
International Cannabinoid Research Society, Burlington, VT
-
Hart, R.; Hurst, D. P.; Reggio, P. The CB1 TMH 2-3 region forms the binding site for (+)-7-OH-CBD-DMH. 2003 Symposium on the Cannabinoids; International Cannabinoid Research Society, Burlington, VT, 2003; p 76.
-
(2003)
2003 Symposium on the Cannabinoids
, pp. 76
-
-
Hart, R.1
Hurst, D.P.2
Reggio, P.3
-
41
-
-
0037248374
-
3-Indolyl-1-naphthylmethanes: New cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor
-
Huffman, J. W.; Mabon, R.; Wu, M. J.; Lu, J.; Hart, R.; Hurst, D. P.; Reggio, P. H.; Wiley, J. L.; Martin, B. R. 3-Indolyl-1-naphthylmethanes: new cannabimimetic indoles provide evidence for aromatic stacking interactions with the CB(1) cannabinoid receptor. Bioorg. Med. Chem. 2003, 11, 539-549.
-
(2003)
Bioorg. Med. Chem.
, vol.11
, pp. 539-549
-
-
Huffman, J.W.1
Mabon, R.2
Wu, M.J.3
Lu, J.4
Hart, R.5
Hurst, D.P.6
Reggio, P.H.7
Wiley, J.L.8
Martin, B.R.9
-
42
-
-
2542530276
-
Prediction of the CB1 cannabinoid receptor region critical for the binding of aminoalkylindole (AAI) WIN55212-2
-
International Cannabinoid Research Society, Burlington, VT
-
Shim, J. Y.; Howlett, A. Prediction of the CB1 cannabinoid receptor region critical for the binding of aminoalkylindole (AAI) WIN55212-2. 2003 Symposium on the Cannabinoids; International Cannabinoid Research Society, Burlington, VT, 2003; p 9.
-
(2003)
2003 Symposium on the Cannabinoids
, pp. 9
-
-
Shim, J.Y.1
Howlett, A.2
-
43
-
-
0031972779
-
Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1
-
Chin, C. N., Lucas-Lenard, J.; Abadji, V.; Kendall, D. A. Ligand binding and modulation of cyclic AMP levels depend on the chemical nature of residue 192 of the human cannabinoid receptor 1. J. Neurochem. 1998, 70, 366-373.
-
(1998)
J. Neurochem.
, vol.70
, pp. 366-373
-
-
Chin, C.N.1
Lucas-Lenard, J.2
Abadji, V.3
Kendall, D.A.4
-
44
-
-
0031861372
-
Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors
-
MacLennan, S. J.; Reynen, P. H.; Kwan, J.; Bonhaus, D. W. Evidence for inverse agonism of SR141716A at human recombinant cannabinoid CB1 and CB2 receptors. Br. J. Pharmacol. 1998, 124, 619-622.
-
(1998)
Br. J. Pharmacol.
, vol.124
, pp. 619-622
-
-
MacLennan, S.J.1
Reynen, P.H.2
Kwan, J.3
Bonhaus, D.W.4
-
45
-
-
0037187367
-
Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor
-
Shim, J. Y.; Welsh, W. J.; Cartier, E.; Edwards, J. L.; Howlett, A. C. Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. J. Med. Chem. 2002, 45, 1447-1459.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 1447-1459
-
-
Shim, J.Y.1
Welsh, W.J.2
Cartier, E.3
Edwards, J.L.4
Howlett, A.C.5
-
46
-
-
0036892304
-
N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor
-
Hurst, D. P.; Lynch, D. L.; Barnett-Norris, J.; Hyatt, S. M.; Seltzman, H. H.; Zhong, M.; Song, Z. H.; Nie, J.; Lewis, D.; Reggio, P. H. N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl) -4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor. Mol. Pharmacol. 2002, 62, 1274-1287.
-
(2002)
Mol. Pharmacol.
, vol.62
, pp. 1274-1287
-
-
Hurst, D.P.1
Lynch, D.L.2
Barnett-Norris, J.3
Hyatt, S.M.4
Seltzman, H.H.5
Zhong, M.6
Song, Z.H.7
Nie, J.8
Lewis, D.9
Reggio, P.H.10
-
47
-
-
0033957834
-
The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000
-
Bairoch, A.; Apweiler, R. The SWISS-PROT protein sequence database and its supplement TrEMBL in 2000. Nucleic Acids Res. 2000, 28, 45-48.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 45-48
-
-
Bairoch, A.1
Apweiler, R.2
-
48
-
-
0036616218
-
The Protein Data Bank
-
Berman, H. M.; Battistuz, T.; Bhat, T. N.; Bluhm, W. F.; Bourne, P. E.; Burkhardt, K.; Feng, Z.; Gilliland, G. L.; Iype, L.; Jain, S.; Fagan, P.; Marvin, J.; Padilla, D.; Ravichandran, V.; Schneider, B.; Thanki, N.; Weissig, H.; Westbrook, J. D.; Zardecki, C. The Protein Data Bank. Acta Crystallogr. D Biol. Crystallogr. 2002, 58, 899-907.
-
(2002)
Acta Crystallogr. D Biol. Crystallogr.
, vol.58
, pp. 899-907
-
-
Berman, H.M.1
Battistuz, T.2
Bhat, T.N.3
Bluhm, W.F.4
Bourne, P.E.5
Burkhardt, K.6
Feng, Z.7
Gilliland, G.L.8
Iype, L.9
Jain, S.10
Fagan, P.11
Marvin, J.12
Padilla, D.13
Ravichandran, V.14
Schneider, B.15
Thanki, N.16
Weissig, H.17
Westbrook, J.D.18
Zardecki, C.19
-
49
-
-
0027968068
-
CLUSTAL W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
-
Thompson, J. D.; Higgins, D. G.; Gibson, T. J. CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 1994, 22, 4673-4680.
-
(1994)
Nucleic Acids Res.
, vol.22
, pp. 4673-4680
-
-
Thompson, J.D.1
Higgins, D.G.2
Gibson, T.J.3
-
50
-
-
2542546893
-
-
default settings: matrix, Blosum series; gap opening penalty, 10; gap extension penalty, 0.05
-
CLUSTAL W (version 1.82): http://www.ebi.ac.uk/clustalw/ (default settings: matrix, Blosum series; gap opening penalty, 10; gap extension penalty, 0.05).
-
CLUSTAL W (Version 1.82)
-
-
-
51
-
-
2542556194
-
-
Tripos Associates, Inc.: St, Louis, MO
-
Sybyl v. 6.9; Tripos Associates, Inc.: St, Louis, MO.
-
Sybyl V. 6.9
-
-
-
52
-
-
0346449590
-
-
Accelrys, Inc.: San Diego, CA
-
InsightII v. 2000; Accelrys, Inc.: San Diego, CA.
-
InsightII V. 2000
-
-
-
53
-
-
0021757436
-
A new force field for molecular mechanical simulation of nucleic acids and proteins
-
Weiner, S. J.; Kollman, P. A.; Case, D. A.; Singh, U. C.; Ghio, C.; Alagona, G.; Profeta, S.; Weiner, J. P. A new force field for molecular mechanical simulation of nucleic acids and proteins. J. Am. Chem. Soc. 1984, 106, 765-784.
-
(1984)
J. Am. Chem. Soc.
, vol.106
, pp. 765-784
-
-
Weiner, S.J.1
Kollman, P.A.2
Case, D.A.3
Singh, U.C.4
Ghio, C.5
Alagona, G.6
Profeta, S.7
Weiner, J.P.8
-
54
-
-
84988053694
-
An all atom force field for simulations of proteins and nucleic acids
-
Weiner, S. J.; Kollman, P. A.; Nguyen, D. T.; Case, D. A. An all atom force field for simulations of proteins and nucleic acids. J. Comput. Chem. 1986, 7, 230-252.
-
(1986)
J. Comput. Chem.
, vol.7
, pp. 230-252
-
-
Weiner, S.J.1
Kollman, P.A.2
Nguyen, D.T.3
Case, D.A.4
-
55
-
-
84986492477
-
Atomic charges derived from semiempirical methods
-
Besler, B. H.; Merz, K. M.; Kollman, P. A. Atomic charges derived from semiempirical methods. J. Comput. Chem. 1990, 11, 431-439.
-
(1990)
J. Comput. Chem.
, vol.11
, pp. 431-439
-
-
Besler, B.H.1
Merz, K.M.2
Kollman, P.A.3
-
56
-
-
2542615531
-
-
Department of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
-
GROMACS, v. 3.1.4; Department of Biophysical Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands (http://www.gromacs.org/).
-
GROMACS, V. 3.1.4
-
-
-
57
-
-
0035789518
-
GROMACS 3.0: A package for molecular simulation and trajectory analysis
-
Lindahl, E.; Hess, B.; van der Spoel, D. GROMACS 3.0: A package for molecular simulation and trajectory analysis. J. Mol. Mod. 2001, 7, 306-317.
-
(2001)
J. Mol. Mod.
, vol.7
, pp. 306-317
-
-
Lindahl, E.1
Hess, B.2
Van Der Spoel, D.3
-
58
-
-
2542604914
-
-
Cambridge Crystallographic Data Centre: Cambridge, U.K.
-
GOLD v. 2.0; Cambridge Crystallographic Data Centre: Cambridge, U.K.
-
GOLD V. 2.0
-
-
-
59
-
-
2542618684
-
-
CScore: http://www.tripos.com/sciTech/inSilicoDisc/virtualScreening/cscore. html#references.
-
CScore
-
-
-
60
-
-
0000243829
-
PROCHECK: A program to check the stereochemical quality of protein structures
-
Laskowski, R. A.; MacArthur, M. W.; Moss, D. S.; Thornton, J. M. PROCHECK: a program to check the stereochemical quality of protein structures. J. Appl. Crystallogr. 1993, 26, 283-291.
-
(1993)
J. Appl. Crystallogr.
, vol.26
, pp. 283-291
-
-
Laskowski, R.A.1
MacArthur, M.W.2
Moss, D.S.3
Thornton, J.M.4
-
61
-
-
77957055780
-
Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors
-
Sealfon, S. C., Ed.; Academic Press: San Diego
-
Ballesteros, J. A.; Weinstein, H. W. Integrated methods for the construction of three-dimensional models and computational probing of structure-function relations in G-protein coupled receptors. In Methods in Neuroscience; Sealfon, S. C., Ed.; Academic Press: San Diego, 1995; pp 366-428.
-
(1995)
Methods in Neuroscience
, pp. 366-428
-
-
Ballesteros, J.A.1
Weinstein, H.W.2
-
62
-
-
0035800032
-
Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs)
-
Teller, D. C.; Okada, T.; Behnke, C. A.; Palezewski, K.; Stenkamp, R. E. Advances in determination of a high-resolution three-dimensional structure of rhodopsin, a model of G-protein-coupled receptors (GPCRs). Biochemistry 2001, 40, 7761-7772.
-
(2001)
Biochemistry
, vol.40
, pp. 7761-7772
-
-
Teller, D.C.1
Okada, T.2
Behnke, C.A.3
Palezewski, K.4
Stenkamp, R.E.5
-
63
-
-
0030801002
-
Gapped BLAST PSI-BLAST: A new generation of protein database search programs
-
Altschul, S. F.; Madden, T. L.; Schaffer, A. A.; Zhang, J.; Zhang, Z.; Miller, W.; Lipman, D. J. Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res. 1997, 25, 3389-3402.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
Lipman, D.J.7
-
64
-
-
2542514966
-
-
default settings; matrix, Blosum62
-
PSI-BLAST: http://www.ncbi.nlm.nih.gov/BLAST/(default settings; matrix, Blosum62).
-
PSI-BLAST
-
-
-
65
-
-
2542522631
-
-
SWISS-PROT: CB1R_HUMAN (P21554), CB1R_RAT (P20272), CB1R_FELCA (O02777), CB1R_POEGU (P56971), CB1R_TARGR (Q9PUI7), CB1A_FUGRU (Q98894), CB1B_FUGRU (Q98895), CB2R_RAT (Q9QZN9), CB2R_MOUSE (P47936), CB2R_HUMAN (P34972), HH1R_BOVIN (P30546), EDG1_RAT (P48303), MC5R_RAT (P35345), OPSD_BOVIN (P02699)
-
SWISS-PROT: CB1R_HUMAN (P21554), CB1R_RAT (P20272), CB1R_FELCA (O02777), CB1R_POEGU (P56971), CB1R_TARGR (Q9PUI7), CB1A_FUGRU (Q98894), CB1B_FUGRU (Q98895), CB2R_RAT (Q9QZN9), CB2R_MOUSE (P47936), CB2R_HUMAN (P34972), HH1R_BOVIN (P30546), EDG1_RAT (P48303), MC5R_RAT (P35345), OPSD_BOVIN (P02699).
-
-
-
-
66
-
-
33645961739
-
A smooth particle mesh Ewald method
-
Essman, U.; Perela, L.; Berkowitz, M. L.; Darden, T.; Lee, H.; Pedersen, L. G. A smooth particle mesh Ewald method. J. Chem. Phys. 1995, 103, 8577-8592.
-
(1995)
J. Chem. Phys.
, vol.103
, pp. 8577-8592
-
-
Essman, U.1
Perela, L.2
Berkowitz, M.L.3
Darden, T.4
Lee, H.5
Pedersen, L.G.6
-
67
-
-
33750587438
-
Molecular dynamics with coupling to an external bath
-
Berendsen, H. J. C.; Postma, J. P. M.; DiNola, A.; Haak, J. R. Molecular dynamics with coupling to an external bath. J. Chem. Phys. 1984, 81, 3684-3690.
-
(1984)
J. Chem. Phys.
, vol.81
, pp. 3684-3690
-
-
Berendsen, H.J.C.1
Postma, J.P.M.2
DiNola, A.3
Haak, J.R.4
-
68
-
-
0004016501
-
Comparison of simple potential functions for simulating liquid water
-
Jorgensen, W. L.; Chandrasekhar, J.; Madura, J. D.; Impey, R. W.; Klein, M. L. Comparison of simple potential functions for simulating liquid water. J. Chem. Phys. 1983, 79, 926-935.
-
(1983)
J. Chem. Phys.
, vol.79
, pp. 926-935
-
-
Jorgensen, W.L.1
Chandrasekhar, J.2
Madura, J.D.3
Impey, R.W.4
Klein, M.L.5
-
69
-
-
0029912748
-
Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids
-
Jorgensen, W. L.; Maxwell, D. S.; Tirado-Rives, J. Development and testing of the OPLS all-atom force field on conformational energetics and properties of organic liquids. J. Am. Chem. Soc. 1996, 118, 11225-11236.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 11225-11236
-
-
Jorgensen, W.L.1
Maxwell, D.S.2
Tirado-Rives, J.3
-
70
-
-
0037202434
-
An improved OPLS-AA force field for carbohydrates
-
Kony, D.; Damm, W.; Stoll, S.; Van Gunsteren, W. F. An improved OPLS-AA force field for carbohydrates. J. Comput. Chem. 2002, 23, 1416-1429.
-
(2002)
J. Comput. Chem.
, vol.23
, pp. 1416-1429
-
-
Kony, D.1
Damm, W.2
Stoll, S.3
Van Gunsteren, W.F.4
-
72
-
-
2542525702
-
-
Visipoint Oy, Kuopio, Finland
-
Visual Data; Visipoint Oy, Kuopio, Finland (http://www.visi-point.fi).
-
Visual Data
-
-
-
74
-
-
0028304962
-
Satisfying hydrogen bonding potential in proteins
-
McDonald, I. K.; Thornton, J. M. Satisfying hydrogen bonding potential in proteins. J. Mol. Biol. 1994, 238, 777-793.
-
(1994)
J. Mol. Biol.
, vol.238
, pp. 777-793
-
-
McDonald, I.K.1
Thornton, J.M.2
-
75
-
-
0022419375
-
Aromatic-aromatic interaction: A mechanism of protein structure stabilization
-
Burley, S. K.; Petsko, G. A. Aromatic-aromatic interaction: a mechanism of protein structure stabilization. Science 1985, 229, 23-28.
-
(1985)
Science
, vol.229
, pp. 23-28
-
-
Burley, S.K.1
Petsko, G.A.2
-
76
-
-
0025878347
-
Pi-pi interactions: The geometry and energetics of phenylalanine-phenylalanine interactions in proteins
-
Hunter, C. A.; Singh, J.; Thornton, J. M. Pi-pi interactions: the geometry and energetics of phenylalanine-phenylalanine interactions in proteins. J. Mol. Biol. 1991, 218, 837-846.
-
(1991)
J. Mol. Biol.
, vol.218
, pp. 837-846
-
-
Hunter, C.A.1
Singh, J.2
Thornton, J.M.3
-
77
-
-
0021107965
-
Solvent-accessible surfaces of proteins and nucleic acids
-
Connolly, M. L. Solvent-accessible surfaces of proteins and nucleic acids. Science 1983, 221, 709-713.
-
(1983)
Science
, vol.221
, pp. 709-713
-
-
Connolly, M.L.1
|