Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 18, 2003, Pages 10529-10533

  Ibrahim, Mohab M ^a   Deng, Hongfeng ^b   Zvonok, Alexander ^b   Cockayne, Debra A ^c   Kwan, Joyce ^c   Mata, Heriberto P ^d   Vanderah, Todd W ^d   Lai, Josephine ^d   Porreca, Frank ^d   Makriyannis, Alexandros ^b   Malan Jr , T Philip ^a,d  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF CONNECTICUT   (United States)

^c ROCHE BIOSCIENCE   (United States)

^d UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (2 IODO 5 NITROBENZOYL) 1 (1 METHYL 2 PIPERIDINYLMETHYL)INDOLE; CANNABINOID 1 RECEPTOR; CANNABINOID 2 RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; ANALGESIC AGENT; CANNABINOID; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR CB2, RAT; DRUG RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; HYPOTHESIS; IN VIVO STUDY; MALE; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TARGETING; RAT; SENSORY NERVE; SPINAL NERVE; ANIMAL; BRAIN; C57BL MOUSE; DOSE RESPONSE; DRUG EFFECT; MOUSE; PAIN; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANALGESICS; ANIMALS; BRAIN; CANNABINOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MICE; MICE, INBRED C57BL; PAIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, CANNABINOID, CB2; RECEPTORS, CANNABINOID; RECEPTORS, DRUG;

EID: 0041836218     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.1834309100     Document Type: Article

References (34)

1. Merskey, H. & Bogduk, N. (1994) Classification of Chronic Pain: Descriptions of Chronic Pain Syndromes and Definitions of Pain Terms (IASP Press, Seattle).
2. Bowsher, D. (1991) Br. Med. Bull. 47, 644-646.
3. Kingery, W. S. (1997) Pain 73, 123-139.
4. Jensen, T. S., Gottrup, H., Sindrup, S. H. & Bach, F. W. (2001) Eur. J. Pharmacol. 429, 1-11.
5. Sindrup, S. H. & Jensen, T. S. (1999) Pain 83, 389-400.
6. Munro, S., Thomas, K. L. & Abu-Shaar, M. (1993) Nature 365, 3842-3851.
7. Griffin, G., Wray, E. J., Tao, Q., McAllister, S. D., Rorrer, W. K., Aung, M. M., Martin, B. R. & Abood, M. E. (1999) Eur. J. Pharmacol. 377, 117-125.
8. Zimmer, A., Zimmer, A. M., Hohmann, A. G., Herkenham, M. & Bonner, T. I. (1999) Proc. Natl. Acad. Sci. USA 96, 5780-5785.
9. Buckley, N. E., McCoy, K. L., Mezey, E., Bonner, T. Zimmer, A., Felder, C. C., Glass, M. & Zimmer, A. (2000) Eur. J. Pharmacol. 396, 141-149.
10. Malan, T. P., Jr., Ibrahim, M. M., Deng, H., Liu, Q., Mata, H. P., Vanderah, T., Porreca, F. & Makriyannis, A. (2001) Pain 93, 239-245.
11. Hanus, L., Breuer, A., Tchilibon, S., Shiloah, S., Goldenberg, D., Horowitz, M., Pertwee, R. G., Ross, R. A., Mechoulam, R. & Fride, E. (1999) Proc. Natl. Acad. Sci. USA 96, 14228-14233.
12. Galiegue, S., Mary, S., Marchand, J., Dussossoy, D., Carriere, D., Carayon, P., Bouaboula, M., Shire, D., Le Fur, G. & Casellas, P. (1995) Eur. J. Biochem. 232, 54-61.
13. Facci, L., Dal Toso, R., Romanello, S., Buriani, A., Skaper, S. D. & Leon, A. (1995) Proc. Natl. Acad. Sci. USA 92, 3376-3380.
14. Schatz, A. R., Lee, M., Condie, R. B., Pulaski, J. T. & Kaminski, N. E. (1997) Toxicol. Appl. Pharmacol. 142, 278-287.
15. Lan, R., Liu, Q., Fan, P., Lin, S., Fernando, S. R., McCallion, D., Pertwee, R. & Makriyannis, A. (1999) J. Med. Chem. 42, 769-776.
16. Cheng, Y. C. & Prusoff, W. H. (1973) Biochem. Pharmacol. 22, 3099-3102.
17. Herkenham, M., Lynn, A. B., Johnson, M. R., Melvin, L. S., de Costa, B. R. & Rice, K. C. (1991) J. Neurosci. 11, 563-583.
18. Ross, R. A., Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, F., Makriyannis, A. & Pertwee, R. G. (1999) Br. J. Pharmacol. 126, 665-672.
19. Hosohata, Y., Quock, R. M., Hosohata, K., Makriyannis, A., Consroe, P., Roeske, W. R. & Yamamura, H. I. (1997) Eur. J. Pharmacol. 321, R1-R3.
20. Gatley, S. J., Gifford, A. N., Volkow, N. D., Lan, R. & Makriyannis, A. (1996) Eur. J. Pharmacol. 307, 331-338.
21. Gatley, S. J., Lan, R., Pyatt, B., Gifford, A. N., Volkow, N. D. & Makriyannis, A. (1997) Life Sci. 61, PL191-PL197.
22. Kim, S. H. & Chung, J. M. (1992) Pain 50, 355-363.
23. Chaplan, S. R., Bach, F. W., Pogrel, J. W., Chung, J. M. & Yaksh, T. L. (1994) J. Neurosci. Methods 53, 55-63.
24. Dixon, W. J. (1980) Annu. Rev. Pharmacol. Toxicol. 20, 441-462.
25. Hargreaves, K. M., Dubner, R., Brown, F., Flores, C. & Joris, J. (1988) Pain 32, 77-88.
26. Rowbotham, M. C. (1995) Neurology 45, S5-S10.
27. Ossipov, M. H., Bian, D., Malan, T. P., Lai, J. & Porreca, F. (1999) Pain 79, 127-133.
28. Hohmann, A. G. & Herkenham, M. (1999) Neuroscience 90, 923-931.
29. Quartilho, A., Mata, H. P., Ibrahim, M. M., Vanderah, T. W., Porreca, F., Makriyannis, A. & Malan, T. P., Jr. (2003) Anesthesiology, in press.
30. Dray, A. (1995) Br. J. Anaesthesiol., 75, 125-131.
31. Ma, W. & Eisenach, J. C. (2002) Eur. J. Neurosci. 15, 1037-1047.
32. Daemen, M. A., Kurvers, H. A., Kitslaar, P. J., Slaaf, D. W., Bullens, P. H. & Van den Wildenberg, F. A. (1998) Neurol. Res. 26, 41-45.
33. Daemen, M., Kurvers, H., Bullens, P., Barendse, G., Van Kleef, M. & Van den Wildenberg, F. (1998) Acta Orthop. Belg. 64, 441-447.
34. Hajos, N. & Freund, T. F. (2002) Neuropharmacology 43, 503-510.