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Volumn 15, Issue 5, 2009, Pages 538-551

Hepcidin modulation in human diseases: From research to clinic

Author keywords

Anemia; Erythropoiesis; Hemochromatosis; Hepcidin; Iron homeostasis; Liver diseases

Indexed keywords

CYTOKINE; GROWTH DIFFERENTIATION FACTOR 15; HEMOJUVELIN; HEPCIDIN; HYPOXIA INDUCIBLE FACTOR; INTERLEUKIN 6; OXYGENASE; REACTIVE OXYGEN METABOLITE; SERINE PROTEINASE; TRANSFERRIN RECEPTOR 2; TRANSMEMBRANE SERINE PROTEINASE 6; UNCLASSIFIED DRUG;

EID: 63749113268     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.15.538     Document Type: Review
Times cited : (89)

References (117)
  • 3
    • 30144432585 scopus 로고    scopus 로고
    • The N-terminus of hepcidin is essential for its interaction with ferroportin: Structure-function study
    • Nemeth E, Preza GC, Jung CL, Kaplan J, Waring AJ, Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 2006; 107: 328-333
    • (2006) Blood , vol.107 , pp. 328-333
    • Nemeth, E.1    Preza, G.C.2    Jung, C.L.3    Kaplan, J.4    Waring, A.J.5    Ganz, T.6
  • 4
    • 26944441309 scopus 로고    scopus 로고
    • Cellular iron: Ferroportin is the only way out
    • Ganz T. Cellular iron: ferroportin is the only way out. Cell Metab 2005; 1: 155-157
    • (2005) Cell Metab , vol.1 , pp. 155-157
    • Ganz, T.1
  • 6
    • 47649126246 scopus 로고    scopus 로고
    • Forging a field: The golden age of iron biology
    • Andrews NC. Forging a field: the golden age of iron biology. Blood 2008; 112: 219-230
    • (2008) Blood , vol.112 , pp. 219-230
    • Andrews, N.C.1
  • 7
    • 37549059612 scopus 로고    scopus 로고
    • Regulation of iron acquisition and storage: Consequences for iron-linked disorders
    • De Domenico I, McVey Ward D, Kaplan J. Regulation of iron acquisition and storage: consequences for iron-linked disorders. Nat Rev Mol Cell Biol 2008; 9: 72-81
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 72-81
    • De Domenico, I.1    McVey Ward, D.2    Kaplan, J.3
  • 9
    • 46749158788 scopus 로고    scopus 로고
    • Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin
    • Xia Y, Babitt JL, Sidis Y, Chung RT, Lin HY. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood 2008; 111: 5195-5204
    • (2008) Blood , vol.111 , pp. 5195-5204
    • Xia, Y.1    Babitt, J.L.2    Sidis, Y.3    Chung, R.T.4    Lin, H.Y.5
  • 11
    • 41549127253 scopus 로고    scopus 로고
    • Iron homeostasis: Fitting the puzzle pieces together
    • Ganz T. Iron homeostasis: fitting the puzzle pieces together. Cell Metab 2008; 7: 288-290
    • (2008) Cell Metab , vol.7 , pp. 288-290
    • Ganz, T.1
  • 13
    • 2942554825 scopus 로고    scopus 로고
    • HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface
    • Giannetti AM, Björkman PJ. HFE and transferrin directly compete for transferrin receptor in solution and at the cell surface. J Biol Chem 2004; 279: 25866-25875
    • (2004) J Biol Chem , vol.279 , pp. 25866-25875
    • Giannetti, A.M.1    Björkman, P.J.2
  • 14
    • 0033585129 scopus 로고    scopus 로고
    • The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor
    • Lebrón JA, West AP Jr, Bjorkman PJ. The hemochromatosis protein HFE competes with transferrin for binding to the transferrin receptor. J Mol Biol 1999; 294: 239-245
    • (1999) J Mol Biol , vol.294 , pp. 239-245
    • Lebrón, J.A.1    West Jr, A.P.2    Bjorkman, P.J.3
  • 15
    • 33749393565 scopus 로고    scopus 로고
    • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing
    • Goswami T, Andrews NC. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J Biol Chem 2006; 281: 28494-28498
    • (2006) J Biol Chem , vol.281 , pp. 28494-28498
    • Goswami, T.1    Andrews, N.C.2
  • 17
    • 43949135168 scopus 로고    scopus 로고
    • HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron
    • Waheed A, Britton RS, Grubb JH, Sly WS, Fleming RE. HFE association with transferrin receptor 2 increases cellular uptake of transferrin-bound iron. Arch Biochem Biophys 2008; 474: 193-197
    • (2008) Arch Biochem Biophys , vol.474 , pp. 193-197
    • Waheed, A.1    Britton, R.S.2    Grubb, J.H.3    Sly, W.S.4    Fleming, R.E.5
  • 22
    • 52049125740 scopus 로고    scopus 로고
    • The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells
    • Gao J, Zhao N, Knutson MD, Enns CA. The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 cells. J Biol Chem 2008; 283: 21462-21468
    • (2008) J Biol Chem , vol.283 , pp. 21462-21468
    • Gao, J.1    Zhao, N.2    Knutson, M.D.3    Enns, C.A.4
  • 25
    • 21044434748 scopus 로고    scopus 로고
    • First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin
    • Wallace DF, Summerville L, Lusby PE, Subramaniam VN. First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin. Gut 2005; 54: 980-986
    • (2005) Gut , vol.54 , pp. 980-986
    • Wallace, D.F.1    Summerville, L.2    Lusby, P.E.3    Subramaniam, V.N.4
  • 26
    • 33846225653 scopus 로고    scopus 로고
    • Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload
    • Wallace DF, Summerville L, Subramaniam VN. Targeted disruption of the hepatic transferrin receptor 2 gene in mice leads to iron overload. Gastroenterology 2007; 132: 301-310
    • (2007) Gastroenterology , vol.132 , pp. 301-310
    • Wallace, D.F.1    Summerville, L.2    Subramaniam, V.N.3
  • 27
    • 10244265904 scopus 로고    scopus 로고
    • Diferric transferrin regulates transferrin receptor 2 protein stability
    • Johnson MB, Enns CA. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004; 104: 4287-4293
    • (2004) Blood , vol.104 , pp. 4287-4293
    • Johnson, M.B.1    Enns, C.A.2
  • 28
    • 10244255021 scopus 로고    scopus 로고
    • Regulation of transferrin receptor 2 protein levels by transferrin
    • Robb A, Wessling-Resnick M. Regulation of transferrin receptor 2 protein levels by transferrin. Blood 2004; 104: 4294-4299
    • (2004) Blood , vol.104 , pp. 4294-4299
    • Robb, A.1    Wessling-Resnick, M.2
  • 30
    • 34447117474 scopus 로고    scopus 로고
    • Hepcidin regulation: Ironing out the details
    • De Domenico I, Ward DM, Kaplan J. Hepcidin regulation: ironing out the details. J Clin Invest 2007; 117: 1755-1758
    • (2007) J Clin Invest , vol.117 , pp. 1755-1758
    • De Domenico, I.1    Ward, D.M.2    Kaplan, J.3
  • 31
    • 43049132128 scopus 로고    scopus 로고
    • A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells
    • Verga Falzacappa MV, Casanovas G, Hentze MW, Muckenthaler MU. A bone morphogenetic protein (BMP)-responsive element in the hepcidin promoter controls HFE2-mediated hepatic hepcidin expression and its response to IL-6 in cultured cells. J Mol Med 2008; 86: 531-540
    • (2008) J Mol Med , vol.86 , pp. 531-540
    • Verga Falzacappa, M.V.1    Casanovas, G.2    Hentze, M.W.3    Muckenthaler, M.U.4
  • 32
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 2005; 115: 2180-2186
    • (2005) J Clin Invest , vol.115 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 33
    • 27144459908 scopus 로고    scopus 로고
    • Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
    • Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005; 106: 2884-2889
    • (2005) Blood , vol.106 , pp. 2884-2889
    • Lin, L.1    Goldberg, Y.P.2    Ganz, T.3
  • 34
    • 43049124745 scopus 로고    scopus 로고
    • Iron and inflammation: Cross-talk between pathways regulating hepcidin
    • Fleming RE. Iron and inflammation: cross-talk between pathways regulating hepcidin. J Mol Med 2008; 86: 491-494
    • (2008) J Mol Med , vol.86 , pp. 491-494
    • Fleming, R.E.1
  • 36
    • 0028049495 scopus 로고
    • Regulators of iron balance in humans
    • Finch C. Regulators of iron balance in humans. Blood 1994; 84: 1697-1702
    • (1994) Blood , vol.84 , pp. 1697-1702
    • Finch, C.1
  • 37
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • Semenza GL. Life with oxygen. Science 2007; 318: 62-64
    • (2007) Science , vol.318 , pp. 62-64
    • Semenza, G.L.1
  • 38
    • 41949133287 scopus 로고    scopus 로고
    • Iron regulation and erythropoiesis
    • Nemeth E. Iron regulation and erythropoiesis. Curr Opin Hematol 2008; 15: 169-175
    • (2008) Curr Opin Hematol , vol.15 , pp. 169-175
    • Nemeth, E.1
  • 39
    • 47049116150 scopus 로고    scopus 로고
    • Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha
    • Pinto JP, Ribeiro S, Pontes H, Thowfeequ S, Tosh D, Carvalho F, Porto G. Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPalpha. Blood 2008; 111: 5727-5733
    • (2008) Blood , vol.111 , pp. 5727-5733
    • Pinto, J.P.1    Ribeiro, S.2    Pontes, H.3    Thowfeequ, S.4    Tosh, D.5    Carvalho, F.6    Porto, G.7
  • 40
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood 2006; 108: 3730-3735
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 43
    • 33947095427 scopus 로고    scopus 로고
    • ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3
    • Choi SO, Cho YS, Kim HL, Park JW. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochem Biophys Res Commun 2007; 356: 312-317
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 312-317
    • Choi, S.O.1    Cho, Y.S.2    Kim, H.L.3    Park, J.W.4
  • 46
    • 34848886872 scopus 로고    scopus 로고
    • Role of alcohol in the regulation of iron metabolism
    • Harrison-Findik DD. Role of alcohol in the regulation of iron metabolism. World J Gastroenterol 2007; 13: 4925-4930
    • (2007) World J Gastroenterol , vol.13 , pp. 4925-4930
    • Harrison-Findik, D.D.1
  • 47
    • 34848838993 scopus 로고    scopus 로고
    • Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol
    • Harrison-Findik DD, Klein E, Crist C, Evans J, Timchenko N, Gollan J. Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol. Hepatology 2007; 46: 1979-1985
    • (2007) Hepatology , vol.46 , pp. 1979-1985
    • Harrison-Findik, D.D.1    Klein, E.2    Crist, C.3    Evans, J.4    Timchenko, N.5    Gollan, J.6
  • 48
    • 33845864447 scopus 로고    scopus 로고
    • Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations
    • Flanagan JM, Peng H, Beutler E. Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations. Alcohol Clin Exp Res 2007; 31: 138-143
    • (2007) Alcohol Clin Exp Res , vol.31 , pp. 138-143
    • Flanagan, J.M.1    Peng, H.2    Beutler, E.3
  • 49
    • 0029039555 scopus 로고
    • A long-term study of the interaction between iron and alcohol in an animal model of iron overload
    • Olynyk J, Hall P, Reed W, Williams P, Kerr R, Mackinnon M. A long-term study of the interaction between iron and alcohol in an animal model of iron overload. J Hepatol 1995; 22: 671-676
    • (1995) J Hepatol , vol.22 , pp. 671-676
    • Olynyk, J.1    Hall, P.2    Reed, W.3    Williams, P.4    Kerr, R.5    Mackinnon, M.6
  • 50
    • 0029927660 scopus 로고    scopus 로고
    • Alcoholism inhereditary hemochromatosis revisited: Prevalence and clinical consequences among homozygous siblings
    • Adams PC, Agnew S, Alcoholism inhereditary hemochromatosis revisited: prevalence and clinical consequences among homozygous siblings. Hepatology 1996; 23: 724-727
    • (1996) Hepatology , vol.23 , pp. 724-727
    • Adams, P.C.1    Agnew, S.2
  • 52
    • 0019985082 scopus 로고
    • Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis
    • Chapman RW, Morgan MY, Laulicht M, Hoffbrand AV, Sherlock S. Hepatic iron stores and markers of iron overload in alcoholics and patients with idiopathic hemochromatosis. Dig Dis Sci 1982; 27: 909-916
    • (1982) Dig Dis Sci , vol.27 , pp. 909-916
    • Chapman, R.W.1    Morgan, M.Y.2    Laulicht, M.3    Hoffbrand, A.V.4    Sherlock, S.5
  • 55
    • 58149399349 scopus 로고    scopus 로고
    • Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I
    • Tamary H, Shalev H, Perez-Avraham G, Zoldan M, Levi I, Swinkels DW, Tanno T, Miller JL. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood 2008; 112: 5241-5244
    • (2008) Blood , vol.112 , pp. 5241-5244
    • Tamary, H.1    Shalev, H.2    Perez-Avraham, G.3    Zoldan, M.4    Levi, I.5    Swinkels, D.W.6    Tanno, T.7    Miller, J.L.8
  • 56
    • 34447137331 scopus 로고    scopus 로고
    • Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance
    • Babitt JL, Huang FW, Xia Y, Sidis Y, Andrews NC, Lin HY. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J Clin Invest 2007; 117: 1933-1939
    • (2007) J Clin Invest , vol.117 , pp. 1933-1939
    • Babitt, J.L.1    Huang, F.W.2    Xia, Y.3    Sidis, Y.4    Andrews, N.C.5    Lin, H.Y.6
  • 57
    • 38349194098 scopus 로고    scopus 로고
    • Furin-mediated release of soluble hemojuvelin: A new link between hypoxia and iron homeostasis
    • Silvestri L, Pagani A, Camaschella C. Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis. Blood 2008; 111: 924-931
    • (2008) Blood , vol.111 , pp. 924-931
    • Silvestri, L.1    Pagani, A.2    Camaschella, C.3
  • 59
    • 56449096622 scopus 로고    scopus 로고
    • The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin
    • Silvestri L, Pagani A, Nai A, De Domenico I, Kaplan J, Camaschella C. The serine protease matriptase-2 (TMPRSS6) inhibits hepcidin activation by cleaving membrane hemojuvelin. Cell Metab 2008; 8: 502-511
    • (2008) Cell Metab , vol.8 , pp. 502-511
    • Silvestri, L.1    Pagani, A.2    Nai, A.3    De Domenico, I.4    Kaplan, J.5    Camaschella, C.6
  • 60
    • 33644862202 scopus 로고    scopus 로고
    • Iron imports. IV. Hepcidin and regulation of body iron metabolism
    • Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006; 290: G199-G203
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Ganz, T.1    Nemeth, E.2
  • 61
    • 0037020241 scopus 로고    scopus 로고
    • The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis
    • Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002; 277: 37597-37603
    • (2002) J Biol Chem , vol.277 , pp. 37597-37603
    • Hunter, H.N.1    Fulton, D.B.2    Ganz, T.3    Vogel, H.J.4
  • 62
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276: 7806-7810
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 63
    • 2342422913 scopus 로고    scopus 로고
    • Pro-hepcidin: Expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia
    • Kulaksiz H, Gehrke SG, Janetzko A, Rost D, Bruckner T, Kallinowski B, Stremmel W. Pro-hepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut 2004; 53: 735-743
    • (2004) Gut , vol.53 , pp. 735-743
    • Kulaksiz, H.1    Gehrke, S.G.2    Janetzko, A.3    Rost, D.4    Bruckner, T.5    Kallinowski, B.6    Stremmel, W.7
  • 64
    • 33747406251 scopus 로고    scopus 로고
    • Iron absorption by healthy women is not associated with either serum or urinary prohepcidin
    • Hadley KB, Johnson LK, Hunt JR. Iron absorption by healthy women is not associated with either serum or urinary prohepcidin. Am J Clin Nutr 2006; 84: 150-155
    • (2006) Am J Clin Nutr , vol.84 , pp. 150-155
    • Hadley, K.B.1    Johnson, L.K.2    Hunt, J.R.3
  • 65
    • 34047261779 scopus 로고    scopus 로고
    • Serum prohepcidin concentration: No association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women
    • Roe MA, Spinks C, Heath AL, Harvey LJ, Foxall R, Wimperis J, Wolf C, Fairweather-Tait SJ. Serum prohepcidin concentration: no association with iron absorption in healthy men; and no relationship with iron status in men carrying HFE mutations, hereditary haemochromatosis patients undergoing phlebotomy treatment, or pregnant women. Br J Nutr 2007; 97: 544-549
    • (2007) Br J Nutr , vol.97 , pp. 544-549
    • Roe, M.A.1    Spinks, C.2    Heath, A.L.3    Harvey, L.J.4    Foxall, R.5    Wimperis, J.6    Wolf, C.7    Fairweather-Tait, S.J.8
  • 66
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, Ganz T. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004; 113: 1271-1276
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 69
    • 2342541676 scopus 로고    scopus 로고
    • Proteomics techniques and their application to hematology
    • Cristea IM, Gaskell SJ, Whetton AD. Proteomics techniques and their application to hematology. Blood 2004; 103: 3624-3634
    • (2004) Blood , vol.103 , pp. 3624-3634
    • Cristea, I.M.1    Gaskell, S.J.2    Whetton, A.D.3
  • 72
    • 34147197662 scopus 로고    scopus 로고
    • Mass spectrometry-based hepcidin measurements in serum and urine: Analytical aspects and clinical implications
    • Kemna EH, Tjalsma H, Podust VN, Swinkels DW. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin Chem 2007; 53: 620-628
    • (2007) Clin Chem , vol.53 , pp. 620-628
    • Kemna, E.H.1    Tjalsma, H.2    Podust, V.N.3    Swinkels, D.W.4
  • 73
    • 33747167627 scopus 로고    scopus 로고
    • Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System
    • Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, Ishikawa I. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System. Blood 2006; 108: 1381-1387
    • (2006) Blood , vol.108 , pp. 1381-1387
    • Tomosugi, N.1    Kawabata, H.2    Wakatabe, R.3    Higuchi, M.4    Yamaya, H.5    Umehara, H.6    Ishikawa, I.7
  • 74
    • 34547940326 scopus 로고    scopus 로고
    • Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry
    • Murphy AT, Witcher DR, Luan P, Wroblewski VJ. Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 2007; 110: 1048-1054
    • (2007) Blood , vol.110 , pp. 1048-1054
    • Murphy, A.T.1    Witcher, D.R.2    Luan, P.3    Wroblewski, V.J.4
  • 78
    • 51349114252 scopus 로고    scopus 로고
    • Quantification of hepcidin-25 in human serum by isotope dilution micro-HPLC-tandem mass spectrometry
    • Kobold U, Dülffer T, Dangl M, Escherich A, Kubbies M, Röddiger R, Wright JA. Quantification of hepcidin-25 in human serum by isotope dilution micro-HPLC-tandem mass spectrometry. Clin Chem 2008; 54: 1584-1586
    • (2008) Clin Chem , vol.54 , pp. 1584-1586
    • Kobold, U.1    Dülffer, T.2    Dangl, M.3    Escherich, A.4    Kubbies, M.5    Röddiger, R.6    Wright, J.A.7
  • 81
    • 36349028180 scopus 로고    scopus 로고
    • Hemochromatosis: An endocrine liver disease
    • Pietrangelo A. Hemochromatosis: an endocrine liver disease. Hepatology 2007; 46: 1291-1301
    • (2007) Hepatology , vol.46 , pp. 1291-1301
    • Pietrangelo, A.1
  • 84
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003; 101: 2461-2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 86
    • 0037564038 scopus 로고    scopus 로고
    • Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
    • Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, Stremmel W. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003; 102: 371-376
    • (2003) Blood , vol.102 , pp. 371-376
    • Gehrke, S.G.1    Kulaksiz, H.2    Herrmann, T.3    Riedel, H.D.4    Bents, K.5    Veltkamp, C.6    Stremmel, W.7
  • 87
    • 50049109451 scopus 로고    scopus 로고
    • Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels
    • van Dijk BA, Laarakkers CM, Klaver SM, Jacobs EM, van Tits LJ, Janssen MC, Swinkels DW. Serum hepcidin levels are innately low in HFE-related haemochromatosis but differ between C282Y-homozygotes with elevated and normal ferritin levels. Br J Haematol 2008; 142: 979-985
    • (2008) Br J Haematol , vol.142 , pp. 979-985
    • van Dijk, B.A.1    Laarakkers, C.M.2    Klaver, S.M.3    Jacobs, E.M.4    van Tits, L.J.5    Janssen, M.C.6    Swinkels, D.W.7
  • 89
    • 40849097485 scopus 로고    scopus 로고
    • Iron and the liver: Update 2008
    • Deugnier Y, Brissot P, Loreal O. Iron and the liver: update 2008. J Hepatol 2008; 48 Suppl 1: S113-S123
    • (2008) J Hepatol , vol.48 , Issue.SUPPL. 1
    • Deugnier, Y.1    Brissot, P.2    Loreal, O.3
  • 94
    • 5044239523 scopus 로고    scopus 로고
    • Sickle-cell disease
    • Stuart MJ, Nagel RL. Sickle-cell disease. Lancet 2004; 364: 1343-1360
    • (2004) Lancet , vol.364 , pp. 1343-1360
    • Stuart, M.J.1    Nagel, R.L.2
  • 95
    • 33745743014 scopus 로고    scopus 로고
    • Hepcidin and iron-loading anemias
    • Nemeth E, Ganz T. Hepcidin and iron-loading anemias. Haematologica 2006; 91: 727-732
    • (2006) Haematologica , vol.91 , pp. 727-732
    • Nemeth, E.1    Ganz, T.2
  • 96
    • 36348972935 scopus 로고    scopus 로고
    • Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia
    • Trombini P, Coliva T, Nemeth E, Mariani R, Ganz T, Biondi A, Piperno A. Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia. Haematologica 2007; 92: 1407-1410
    • (2007) Haematologica , vol.92 , pp. 1407-1410
    • Trombini, P.1    Coliva, T.2    Nemeth, E.3    Mariani, R.4    Ganz, T.5    Biondi, A.6    Piperno, A.7
  • 98
    • 55949091434 scopus 로고    scopus 로고
    • Reduced expression of hepcidin in patients with myelodysplastic syndrome and myelofibrosis: The causes might be more heterogeneous than in thalassaemia
    • Mariani R, Pelucchi S, Pozzi M, Paolini V, Piperno A. Reduced expression of hepcidin in patients with myelodysplastic syndrome and myelofibrosis: the causes might be more heterogeneous than in thalassaemia. Br J Haematol 2008; 143: 746-747
    • (2008) Br J Haematol , vol.143 , pp. 746-747
    • Mariani, R.1    Pelucchi, S.2    Pozzi, M.3    Paolini, V.4    Piperno, A.5
  • 99
  • 100
    • 53249142510 scopus 로고    scopus 로고
    • Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion
    • Fujita N, Sugimoto R, Motonishi S, Tomosugi N, Tanaka H, Takeo M, Iwasa M, Kobayashi Y, Hayashi H, Kaito M, Takei Y. Patients with chronic hepatitis C achieving a sustained virological response to peginterferon and ribavirin therapy recover from impaired hepcidin secretion. J Hepatol 2008; 49: 702-710
    • (2008) J Hepatol , vol.49 , pp. 702-710
    • Fujita, N.1    Sugimoto, R.2    Motonishi, S.3    Tomosugi, N.4    Tanaka, H.5    Takeo, M.6    Iwasa, M.7    Kobayashi, Y.8    Hayashi, H.9    Kaito, M.10    Takei, Y.11
  • 101
    • 56149115918 scopus 로고    scopus 로고
    • Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity
    • Miura K, Taura K, Kodama Y, Schnabl B, Brenner DA. Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity. Hepatology 2008; 48: 1420-1429
    • (2008) Hepatology , vol.48 , pp. 1420-1429
    • Miura, K.1    Taura, K.2    Kodama, Y.3    Schnabl, B.4    Brenner, D.A.5
  • 104
    • 45549096257 scopus 로고    scopus 로고
    • Fine tuning of hepcidin expression by positive and negative regulators
    • Muckenthaler MU. Fine tuning of hepcidin expression by positive and negative regulators. Cell Metab 2008; 8: 1-3
    • (2008) Cell Metab , vol.8 , pp. 1-3
    • Muckenthaler, M.U.1
  • 105
    • 54349094273 scopus 로고    scopus 로고
    • A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron
    • Melis MA, Cau M, Congiu R, Sole G, Barella S, Cao A, Westerman M, Cazzola M, Galanello R. A mutation in the TMPRSS6 gene, encoding a transmembrane serine protease that suppresses hepcidin production, in familial iron deficiency anemia refractory to oral iron. Haematologica 2008; 93: 1473-1479
    • (2008) Haematologica , vol.93 , pp. 1473-1479
    • Melis, M.A.1    Cau, M.2    Congiu, R.3    Sole, G.4    Barella, S.5    Cao, A.6    Westerman, M.7    Cazzola, M.8    Galanello, R.9
  • 107
    • 41649120714 scopus 로고    scopus 로고
    • Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe
    • Gnana-Prakasam JP, Martin PM, Mysona BA, Roon P, Smith SB, Ganapathy V. Hepcidin expression in mouse retina and its regulation via lipopolysaccharide/Toll-like receptor-4 pathway independent of Hfe. Biochem J 2008; 411: 79-88
    • (2008) Biochem J , vol.411 , pp. 79-88
    • Gnana-Prakasam, J.P.1    Martin, P.M.2    Mysona, B.A.3    Roon, P.4    Smith, S.B.5    Ganapathy, V.6
  • 110
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • Liu XB, Nguyen NB, Marquess KD, Yang F, Haile DJ. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis 2005; 35: 47-56
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 47-56
    • Liu, X.B.1    Nguyen, N.B.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 111
    • 34250850987 scopus 로고    scopus 로고
    • The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation
    • Merle U, Fein E, Gehrke SG, Stremmel W, Kulaksiz H. The iron regulatory peptide hepcidin is expressed in the heart and regulated by hypoxia and inflammation. Endocrinology 2007; 148: 2663-2668
    • (2007) Endocrinology , vol.148 , pp. 2663-2668
    • Merle, U.1    Fein, E.2    Gehrke, S.G.3    Stremmel, W.4    Kulaksiz, H.5
  • 112
    • 33646427702 scopus 로고    scopus 로고
    • TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
    • Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood 2006; 107: 3727-3732
    • (2006) Blood , vol.107 , pp. 3727-3732
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Datta, V.3    Lauth, X.4    Johnson, R.S.5    Nizet, V.6
  • 115
    • 53149093558 scopus 로고    scopus 로고
    • Serum prohepcidin is associated with soluble transferrin receptor-1 but not ferritin in healthy post-menopausal women
    • Huang X, Fung ET, Yip C, Zeleniuch-Jacquotte A. Serum prohepcidin is associated with soluble transferrin receptor-1 but not ferritin in healthy post-menopausal women. Blood Cells Mol Dis 2008; 41: 265-269
    • (2008) Blood Cells Mol Dis , vol.41 , pp. 265-269
    • Huang, X.1    Fung, E.T.2    Yip, C.3    Zeleniuch-Jacquotte, A.4


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