High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin

Nature Medicine

Volumn 13, Issue 9, 2007, Pages 1096-1101

  Tanno, Toshihiko ^a   Bhanu, Natarajan V ^a   Oneal, Patricia A ^a   Goh, Sung Ho ^a   Staker, Pamela ^a   Lee, Y Terry ^a   Moroney, John W ^b   Reed, Christopher H ^b   Luban, Naomi L C ^c   Wang, Rui Hong ^a   Eling, Thomas E ^d   Childs, Richard ^e   Ganz, Tomas ^f   Leitman, Susan F ^g   Fucharoen, Suthat ^h   Miller, Jeffery L ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^b WALTER REED ARMY MEDICAL CENTER   (United States)

^c CHILDREN'S NATIONAL MEDICAL CENTER   (United States)

^d NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^e NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g NATIONAL INSTITUTES OF HEALTH   (United States)

^h MAHIDOL UNIVERSITY   (Thailand)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 15; ERYTHROPOIETIN; FERRITIN; HEPCIDIN; IRON REGULATORY FACTOR; MESSENGER RNA; TRANSCRIPTOME; TRANSFERRIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BETA THALASSEMIA; CELL MATURATION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORRELATION ANALYSIS; ERYTHROBLAST; HUMAN; HUMAN CELL; HYPOTHESIS; IRON OVERLOAD; LIVER CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN SECRETION; THALASSEMIA;

ANTIMICROBIAL CATIONIC PEPTIDES; CYTOKINES; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; POLYMERASE CHAIN REACTION; REFERENCE VALUES; RNA, MESSENGER; THALASSEMIA; TRANSCRIPTION, GENETIC;

EID: 34948904750     PISSN: 10788956     EISSN: 1546170X     Source Type: Journal    
DOI: 10.1038/nm1629     Document Type: Article

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