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Volumn 30, Issue 1, 2006, Pages 106-112

Hepcidin is down-regulated in alcoholic liver injury: Implications for the pathogenesis of alcoholic liver disease

Author keywords

C EBP ; Ethanol; Hepcidin; IL 6; Iron

Indexed keywords

ACETALDEHYDE; ALCOHOL; CCAAT ENHANCER BINDING PROTEIN ALPHA; HEPCIDIN; MESSENGER RNA; RECOMBINANT INTERLEUKIN 6;

EID: 33644773569     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2006.00002.x     Document Type: Article
Times cited : (139)

References (42)
  • 1
    • 0031432550 scopus 로고    scopus 로고
    • IL-6-regulated transcription factors
    • Akira S 1997 IL-6-regulated transcription factors Int J Biochem Cell Biol 29 1401 1418
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 1401-1418
    • Akira, S.1
  • 2
    • 0037371816 scopus 로고    scopus 로고
    • Oxidants and antioxidants in alcohol-induced liver disease
    • Arteel GE 2003 Oxidants and antioxidants in alcohol-induced liver disease Gastroenterology 24 778 790
    • (2003) Gastroenterology , vol.24 , pp. 778-790
    • Arteel, G.E.1
  • 3
    • 0028133060 scopus 로고
    • Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases
    • Bell H Skinningsrud A Raknerud N 1994 Serum ferritin and transferrin saturation in patients with chronic alcoholic and non-alcoholic liver diseases J Intern Med 236 315 322
    • (1994) J Intern Med , vol.236 , pp. 315-322
    • Bell, H.1    Skinningsrud, A.2    Raknerud, N.3
  • 4
    • 0034807728 scopus 로고    scopus 로고
    • Synergystic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1
    • Caro AA Cederbaum AI 2001 Synergystic toxicity of iron and arachidonic acid in HepG2 cells overexpressing CYP2E1 Mol Pharmacol 60 742 752
    • (2001) Mol Pharmacol , vol.60 , pp. 742-752
    • Caro, A.A.1    Cederbaum, A.I.2
  • 5
    • 0032792685 scopus 로고    scopus 로고
    • Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes
    • Chen J Kunos G Gao B 1999 Ethanol rapidly inhibits IL-6-activated STAT3 and C/EBP mRNA expression in freshly isolated rat hepatocytes FEBS Lett 457 162 168
    • (1999) FEBS Lett , vol.457 , pp. 162-168
    • Chen, J.1    Kunos, G.2    Gao, B.3
  • 8
    • 0034051068 scopus 로고    scopus 로고
    • Age-associated increased interleukin-6 gene expression, late-life diseases and frailty
    • Ershler WB Keller ET 2000 Age-associated increased interleukin-6 gene expression, late-life diseases and frailty Annu Rev Med 51 245 270
    • (2000) Annu Rev Med , vol.51 , pp. 245-270
    • Ershler, W.B.1    Keller, E.T.2
  • 10
  • 11
    • 4344600507 scopus 로고    scopus 로고
    • Hepcidin in iron metabolism
    • Gantz T 2004 Hepcidin in iron metabolism Curr Opin Hematol 11 251 254
    • (2004) Curr Opin Hematol , vol.11 , pp. 251-254
    • Gantz, T.1
  • 12
    • 0037564038 scopus 로고    scopus 로고
    • Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
    • Gehrke SG Kulaksiz H Herrmann T Riedel HD Bents K Veltkamp C Stremmel W 2003 Expression of hepcidin in hereditary hemochromatosis evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron Blood 102 371 376
    • (2003) Blood , vol.102 , pp. 371-376
    • Gehrke, S.G.1    Kulaksiz, H.2    Herrmann, T.3    Riedel, H.D.4    Bents, K.5    Veltkamp, C.6    Stremmel, W.7
  • 14
    • 4644237206 scopus 로고    scopus 로고
    • Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease
    • Hong F Radaeva S Pan HN Tian Z Veech R Gao B 2004 Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease Hepatology 40 933 941
    • (2004) Hepatology , vol.40 , pp. 933-941
    • Hong, F.1    Radaeva, S.2    Pan, H.N.3    Tian, Z.4    Veech, R.5    Gao, B.6
  • 17
    • 0742306111 scopus 로고    scopus 로고
    • CYP2E1: From ASH to NASH
    • Lieber CS 2004 CYP2E1 from ASH to NASH Hepatol Res 28 1 11
    • (2004) Hepatol Res , vol.28 , pp. 1-11
    • Lieber, C.S.1
  • 18
    • 0020395484 scopus 로고
    • The feeding of alcohol in liquid diets: Two decades of applications and 1982 update
    • Lieber CS DeCarli LM 1982 The feeding of alcohol in liquid diets two decades of applications and 1982 update Alcohol Clin Exp Res 6 523 531
    • (1982) Alcohol Clin Exp Res , vol.6 , pp. 523-531
    • Lieber, C.S.1    Decarli, L.M.2
  • 21
    • 0033037150 scopus 로고    scopus 로고
    • Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity: Down-regulation with essential fatty acids, ethanol and pentoxifylline
    • McCarty MF 1999 Interleukin-6 as a central mediator of cardiovascular risk associated with chronic inflammation, smoking, diabetes, and visceral obesity down-regulation with essential fatty acids, ethanol and pentoxifylline Med Hypotheses 52 465 477
    • (1999) Med Hypotheses , vol.52 , pp. 465-477
    • McCarty, M.F.1
  • 22
    • 3142759942 scopus 로고    scopus 로고
    • Molecular aspects of alcohol metabolism: Transcription factors involved in early ethanol-induced liver injury
    • Nagy LE 2004 Molecular aspects of alcohol metabolism transcription factors involved in early ethanol-induced liver injury Annu Rev Nutr 24 55 78
    • (2004) Annu Rev Nutr , vol.24 , pp. 55-78
    • Nagy, L.E.1
  • 23
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E Rivera S Gabayan V Keller C Taudorf S Pedersen BK Ganz T 2004 IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J Clin Invest 113 1271 1276
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3    Keller, C.4    Taudorf, S.5    Pedersen, B.K.6    Ganz, T.7
  • 24
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E Valore EV Territo M Schiller G Lichtenstein A Ganz T 2003 Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 2461 2463
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 25
    • 0027771951 scopus 로고
    • In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line
    • Neuman MG Koren G Terribelli C 1993 In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line Biochem Biophys Res Commun 197 932 941
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 932-941
    • Neuman, M.G.1    Koren, G.2    Terribelli, C.3
  • 26
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G Bennoun M Devaux I Beaumont C Grandchamp B Kahn A Vaulont S 2001 Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proc Natl Acad Sci USA 98 8780 8785
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3    Beaumont, C.4    Grandchamp, B.5    Kahn, A.6    Vaulont, S.7
  • 28
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H Ohishi N Yagi K 1979 Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction Anal Biochem 95 351 358
    • (1979) Anal Biochem , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 29
    • 0029039555 scopus 로고
    • A long-term study of the interaction between iron and alcohol in an animal model of iron overload
    • Olynyk J Hall P Reed W Williams P Kerr R MacKinnon M 1995 A long-term study of the interaction between iron and alcohol in an animal model of iron overload J Hepatol 22 671 676
    • (1995) J Hepatol , vol.22 , pp. 671-676
    • Olynyk, J.1    Hall, P.2    Reed, W.3    Williams, P.4    Kerr, R.5    MacKinnon, M.6
  • 30
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C Ilyin G Courselaud B Leroyer P Turlin B Brissot P Loreal O 2001 A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J Biol Chem 276 7811 7819
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3    Leroyer, P.4    Turlin, B.5    Brissot, P.6    Loreal, O.7
  • 31
    • 0013911977 scopus 로고
    • Normal human iron storage and its relation to ethanol consumption
    • Powell LW 1966 Normal human iron storage and its relation to ethanol consumption Aust Ann Med 15 110 115
    • (1966) Aust Ann Med , vol.15 , pp. 110-115
    • Powell, L.W.1
  • 32
    • 0025351674 scopus 로고
    • Sensitive and rapid colorimetric immunoenzymometric assay of ferritin in biological samples
    • Ramm GA Duplock LR Powell LW Halliday JW 1990 Sensitive and rapid colorimetric immunoenzymometric assay of ferritin in biological samples Clin Chem 36 837 840
    • (1990) Clin Chem , vol.36 , pp. 837-840
    • Ramm, G.A.1    Duplock, L.R.2    Powell, L.W.3    Halliday, J.W.4
  • 33
    • 0026526023 scopus 로고
    • Ferritin as a source of iron for oxidative damage
    • Reif DW 1982 Ferritin as a source of iron for oxidative damage Free Radic Biol Med. 12 417 427
    • (1982) Free Radic Biol Med. , vol.12 , pp. 417-427
    • Reif, D.W.1
  • 34
    • 0031744631 scopus 로고    scopus 로고
    • The labile iron pool in hepatocytes: Prooxidant-induced increase in free iron precedes oxidative cell injury
    • Staubli A Boelsterli UA 1998 The labile iron pool in hepatocytes Prooxidant-induced increase in free iron precedes oxidative cell injury Am J Physiol 274 G1031 G1037
    • (1998) Am J Physiol , vol.274
    • Staubli, A.1    Boelsterli, U.A.2
  • 35
    • 0033652582 scopus 로고    scopus 로고
    • Increased hepatic iron and cirrhosis: No evidence for an adverse effect on patient outcome following liver transplantation
    • Stuart KA Fletcher LM Clouston AD Lynch SV Purdie DM Kerlin P Crawford DHG 2000 Increased hepatic iron and cirrhosis No evidence for an adverse effect on patient outcome following liver transplantation Hepatology 32 1200 1207
    • (2000) Hepatology , vol.32 , pp. 1200-1207
    • Stuart, K.A.1    Fletcher, L.M.2    Clouston, A.D.3    Lynch, S.V.4    Purdie, D.M.5    Kerlin, P.6    Crawford, D.H.G.7
  • 38
    • 1042263379 scopus 로고    scopus 로고
    • Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults: The health, aging, and body composition study
    • Volpato S Pahor M Ferrucci L Simonsick EM Guralnik JM Kritchevsky SB Fellin R Harris TB 2004 Relationship of alcohol intake with inflammatory markers and plasminogen activator inhibitor-1 in well-functioning older adults the health, aging, and body composition study Circulation 109 607 612
    • (2004) Circulation , vol.109 , pp. 607-612
    • Volpato, S.1    Pahor, M.2    Ferrucci, L.3    Simonsick, E.M.4    Guralnik, J.M.5    Kritchevsky, S.B.6    Fellin, R.7    Harris, T.B.8
  • 39
    • 8844250922 scopus 로고    scopus 로고
    • Lipopolysaccharide suppresses albumin expression by activating NF-kappaB in rat hepatocytes
    • Wang X Li W Lu J Li N Li J 2004 Lipopolysaccharide suppresses albumin expression by activating NF-kappaB in rat hepatocytes J Surg Res 122 274 279
    • (2004) J Surg Res , vol.122 , pp. 274-279
    • Wang, X.1    Li, W.2    Lu, J.3    Li, N.4    Li, J.5
  • 40
    • 0023920996 scopus 로고
    • Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone
    • Wolfla CE Ross RA Crabb DW 1988 Induction of alcohol dehydrogenase activity and mRNA in hepatoma cells by dexamethasone Arch Biochem Biophys 263 69 76
    • (1988) Arch Biochem Biophys , vol.263 , pp. 69-76
    • Wolfla, C.E.1    Ross, R.A.2    Crabb, D.W.3
  • 41
    • 0000405470 scopus 로고    scopus 로고
    • Epidemiology of alcohol-induced liver disease
    • Younossi ZM 1998 Epidemiology of alcohol-induced liver disease Clin Liv Dis 2 661 671
    • (1998) Clin Liv Dis , vol.2 , pp. 661-671
    • Younossi, Z.M.1
  • 42
    • 1642524196 scopus 로고    scopus 로고
    • Toxicology investigations with cell culture systems: 20 years after
    • Zucco F De Angelis I Testai E Stammati A 2004 Toxicology investigations with cell culture systems 20 years after Toxicol in Vitro 18 153 163
    • (2004) Toxicol in Vitro , vol.18 , pp. 153-163
    • Zucco, F.1    De Angelis, I.2    Testai, E.3    Stammati, A.4


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