The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis

Journal of Biological Chemistry

Volumn 277, Issue 40, 2002, Pages 37597-37603

  Hunter, Howard N ^a   Bruce Fulton, D ^a   Ganz, Tomas ^b   Vogel, Hans J ^a,b,c  

^a UNIVERSITY OF CALGARY   (Canada)

^b IOWA STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ORGANS; DISEASES; HORMONES; IRON; METABOLISM; MONOMERS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE (COMPOSITION);

ANTIMICROBIAL ACTIVITY; HEREDITARY HEMOCHROMATOSIS;

BIOCHEMISTRY;

MONOMER; PEPTIDE HEPCIDIN 20; PEPTIDE HEPCIDIN 25; PEPTIDE HORMONE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIMICROBIAL ACTIVITY; ARTICLE; BETA SHEET; CALCULATION; CARBOXY TERMINAL SEQUENCE; CHEMICAL BOND; DIFFUSION; HEMOCHROMATOSIS; IRON TRANSPORT; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ANALYSIS;

AMINO ACID SEQUENCE; ANTIMICROBIAL CATIONIC PEPTIDES; CYSTEINE; HEMOCHROMATOSIS; HUMANS; IRON; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, SECONDARY;

EID: 0037020241     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M205305200     Document Type: Article

References (32)

1. Park, C. H., Valore, E. V., Waring, A. J., and Ganz, T. (2001) J. Biol. Chem. 276, 7806-7810
2. Krause, A., Neitz, S., Magert, H. J., Schulz, A., Forssmann, W. G., Schulz-Knappe, P., and Adermann, K. (2000) FEBS Lett. 480, 147-150
3. Pigeon, C., Ilyin, G., Courselaud, B., Leroyer, P., Turlin, B., Brissot, P., and Loreal, O. (2001) J. Biol. Chem. 276, 7811-7819
4. Shike, H., Lauth, X., Westerman, M. E., Ostland, V. E., Carlberg, J. M., Van Olst, J. C., Shimizu, C., Bulet, P., and Burns, J. C. (2002) Eur. J. Biochem. 269, 2232-2237
5. Nicolas, G., Bennoun, M., Devaux, I., Beaumont, C., Grandchamp, B., Kahn, A., and Vaulont, S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8780-8785
6. Nicolas, G., Bennoun, M., Porteu, A., Mativet, S., Beaumont, C., Grandchamp, B., Sirito, M., Sawadogo, M., Kahn, A., and Vaulont, S. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 4596-4601
7. Fleming, R. E., and Sly, W. S. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 8160-8162
8. Schibli, D. J., Hunter, H. N., Aseyev, V., Starner, T. D., Wiencek, J. M., McCray, P. B., Jr., Tack, B. F., and Vogel, H. J. (2002) J. Biol. Chem. 277, 8279-8289
9. Matsuzaki, K., Nakayama, M., Fukui, M., Otaka, A., Funakoshi, S., Fujii, N., Bessho, K., and Miyajima, K. (1993) Biochemistry 32, 11704-11710
10. Aumelas, A., Mangoni, M., Roumestand, C., Chiche, L., Despaux, E., Grassy, G., Calas, B., and Chavanieu, A. (1996) Eur. J. Biochem. 237, 575-583
11. Berrocal-Lobo, M., Segura, A., Moreno, M., Lopez, G., Garcia-Olmedo, F., and Molina, A. (2002) Plant Physiol. 128, 951-961
12. Hwang, T. L., and Shaka, A. J. (1995) J. Magn. Reson. A 112, 275-279
13. Johnson, B. A., and Blevins, R. A. (1994) J. Biomol. NMR 4, 603-614
14. Wilkins, D. K., Grimshaw, S. B., Receveur, V., Dobson, C. M., Jones, J. A., and Smith, L. J. (1999) Biochemistry 38, 16424-16431
15. Jones, J. A., Wilkins, D. K., Smith, L. J., and Dobson, C. M. (1997) J. Biomol. NMR 10, 199-203
16. Merrill, M. R. (1993) J. Magn. Reson. 103, 223-225
17. Brunger, A. T., Adams, P. D., Clore, G. M., DeLano, W. L., Gros, P., Grosse-Kunstleve, R. W., Jiang, J. S., Kuszewski, J., Nilges, M., Pannu, N. S., Read, R. J., Rice, L. M., Simonson, T., and Warren, G. L. (1998) Acta Crystallogr. Sect. D Biol. Crystallogr. 54, 905-921
18. Nilges, M., and O'Donoghue, S. I. (1998) Prog. NMR Spect. 32, 107-139
19. Koradi, R., Billeter, M., and Wüthrich, K. (1996) J. Mol. Graphics 14, 51-55
20. Nicholls, A., Sharp, K. A., and Honig, B. (1991) Proteins 11, 281-296
21. Laskowski, R. A., MacArthur, M. W., Moss, D. S., and Thornton, J. M. (1993) J. Appl. Crystallogr. 26, 283-291
22. Wishart, D. S., and Sykes, B. D. (1994) J. Biomol. NMR 4, 171-180
23. Wishart, D. S., Sykes, B. D., and Richards, F. M. (1992) Biochemistry 31, 1647-1651
24. Zahn, R., Damberger, F., Ortenzi, C., Luporini, P., and Wüthrich, K. (2001) J. Mol. Biol. 313, 923-931
25. Kao, P. N., and Karlin, A. (1986) J. Biol. Chem. 261, 8085-8088
26. Kawano, K., Yoneya, T., Miyata, T., Yoshikawa, K., Tokunaga, F., Terada, Y., and Iwanaga, S. (1990) J. Biol. Chem. 265, 15365-15367
27. Hwang, P. M., and Vogel, H. J. (1998) Biochem. Cell Biol. 76, 235-246
28. Blake, C. C., Ghosh, M., Harlos, K., Avezoux, A., and Anthony, C. (1994) Nat. Struct. Biol. 1, 102-105
29. Wang, X., Connor, M., Smith, R., Maciejewski, M. W., Howden, M. E., Nicholson, G. M., Christie, M. J., and King, G. F. (2000) Nat. Struct. Biol. 7, 505-513
30. Moore, M. J., Miller, S. M., and Walsh, C. T. (1992) Biochemistry 31, 1677-1685
31. Morby, A. P., Hobman, J. L., and Brown, N. L. (1995) Mol. Microbiol. 17, 25-35
32. Park, C., and Raines, R. T. (2001) Protein Eng. 14, 939-942