메뉴 건너뛰기




Volumn 54, Issue 7, 2005, Pages 980-986

First phenotypic description of transferrin receptor 2 knockout mouse, and the role of hepcidin

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN; MESSENGER RNA; TRANSFERRIN RECEPTOR; TRANSFERRIN RECEPTOR 2; UNCLASSIFIED DRUG;

EID: 21044434748     PISSN: 00175749     EISSN: None     Source Type: Journal    
DOI: 10.1136/gut.2004.062018     Document Type: Article
Times cited : (131)

References (30)
  • 1
    • 0033597780 scopus 로고    scopus 로고
    • Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family
    • Kawabata H, Yang R, Hirama T, et al. Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem 1999;274:20826-32.
    • (1999) J Biol Chem , vol.274 , pp. 20826-20832
    • Kawabata, H.1    Yang, R.2    Hirama, T.3
  • 2
    • 0034007995 scopus 로고    scopus 로고
    • Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
    • Fleming RE, Migas MC, Holden CC, et al. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci U S A 2000;97:2214-19.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 2214-2219
    • Fleming, R.E.1    Migas, M.C.2    Holden, C.C.3
  • 3
    • 0034595856 scopus 로고    scopus 로고
    • Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo
    • Kawabata H, Germain RS, Vuong PT, et al. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem 2000;275:16618-25.
    • (2000) J Biol Chem , vol.275 , pp. 16618-16625
    • Kawabata, H.1    Germain, R.S.2    Vuong, P.T.3
  • 4
    • 0034623930 scopus 로고    scopus 로고
    • Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
    • West AP Jr, Bennett MJ, Sellers VM, et al. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem 2000;275:38135-8.
    • (2000) J Biol Chem , vol.275 , pp. 38135-38138
    • West Jr., A.P.1    Bennett, M.J.2    Sellers, V.M.3
  • 5
    • 0034022636 scopus 로고    scopus 로고
    • The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
    • Camaschella C, Roetto A, Cali A, et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet 2000;25:14-15.
    • (2000) Nat Genet , vol.25 , pp. 14-15
    • Camaschella, C.1    Roetto, A.2    Cali, A.3
  • 6
    • 0141607526 scopus 로고    scopus 로고
    • Hemochromatosis due to mutations in transferrin receptor 2
    • Roetto A, Daraio F, Alberti F, et al. Hemochromatosis due to mutations in transferrin receptor 2. Blood Cells Mol Dis 2002;29:465-70.
    • (2002) Blood Cells Mol Dis , vol.29 , pp. 465-470
    • Roetto, A.1    Daraio, F.2    Alberti, F.3
  • 7
    • 0036678091 scopus 로고    scopus 로고
    • Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
    • Fleming RE, Ahmann JR, Migas MC, et al. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A 2002;99:10653-8.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 10653-10658
    • Fleming, R.E.1    Ahmann, J.R.2    Migas, M.C.3
  • 8
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3
  • 9
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, et al. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3
  • 10
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-19.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 11
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 12
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001;98:8780-5.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 13
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2.
    • (2003) Nat Genet , vol.33 , pp. 21-22
    • Roetto, A.1    Papanikolaou, G.2    Politou, M.3
  • 14
    • 0037460697 scopus 로고    scopus 로고
    • Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
    • Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003;361:669-73.
    • (2003) Lancet , vol.361 , pp. 669-673
    • Bridle, K.R.1    Frazer, D.M.2    Wilkins, S.J.3
  • 15
    • 0038312385 scopus 로고    scopus 로고
    • Decreased liver hepcidin expression in the Hfe knockout mouse
    • Ahmad KA, Ahmann JR, Migas MC, et al. Decreased liver hepcidin expression in the Hfe knockout mouse. Blood Cell Mol Dis 2002;29:361-6.
    • (2002) Blood Cell Mol Dis , vol.29 , pp. 361-366
    • Ahmad, K.A.1    Ahmann, J.R.2    Migas, M.C.3
  • 16
    • 2442426523 scopus 로고    scopus 로고
    • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
    • Roy CN, Custodio AO, de Graaf J, et al. An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet 2004;36:481-5.
    • (2004) Nat Genet , vol.36 , pp. 481-485
    • Roy, C.N.1    Custodio, A.O.2    De Graaf, J.3
  • 17
    • 3442875926 scopus 로고    scopus 로고
    • Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE
    • Frazer DM, Wilkins SJ, Millard KN, et al. Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol 2004;126:434-6.
    • (2004) Br J Haematol , vol.126 , pp. 434-436
    • Frazer, D.M.1    Wilkins, S.J.2    Millard, K.N.3
  • 18
    • 3042636759 scopus 로고    scopus 로고
    • The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepotocytes
    • Lee P, Peng H, Gelbart T, et al. The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepotocytes. Proc Natl Acad Sci U S A 2004;101:9203-5.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9203-9205
    • Lee, P.1    Peng, H.2    Gelbart, T.3
  • 19
    • 9144252017 scopus 로고    scopus 로고
    • Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
    • Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2004;36:77-82.
    • (2004) Nat Genet , vol.36 , pp. 77-82
    • Papanikolaou, G.1    Samuels, M.E.2    Ludwig, E.H.3
  • 20
    • 0033168767 scopus 로고    scopus 로고
    • The C282Y mutation causing hereditary hemochromatosis does not produce a null allele
    • Levy JE, Montross LK, Cohen DE, et al. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 1999;94:9-11.
    • (1999) Blood , vol.94 , pp. 9-11
    • Levy, J.E.1    Montross, L.K.2    Cohen, D.E.3
  • 21
    • 2942608896 scopus 로고    scopus 로고
    • Inactivation of the murine transferrin receptor 2 gene using the Cre recombinase:loxP system
    • Wallace DF, Tonks ID, Zournazi A, et al. Inactivation of the murine transferrin receptor 2 gene using the Cre recombinase:loxP system. Genesis 2004;39:38-41.
    • (2004) Genesis , vol.39 , pp. 38-41
    • Wallace, D.F.1    Tonks, I.D.2    Zournazi, A.3
  • 22
    • 21044450599 scopus 로고    scopus 로고
    • Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
    • in press
    • Wallace DF, Summerville L, Lusby PE, et al. Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes. J Hepatol 2005 (in press).
    • (2005) J Hepatol
    • Wallace, D.F.1    Summerville, L.2    Lusby, P.E.3
  • 23
    • 0014267781 scopus 로고
    • A simple technique for measuring storage iron concentrations in formalinised liver samples
    • Torrance JD, Bothwell TH. A simple technique for measuring storage iron concentrations in formalinised liver samples. S Afr J Med Sci 1968;33:9-11.
    • (1968) S Afr J Med Sci , vol.33 , pp. 9-11
    • Torrance, J.D.1    Bothwell, T.H.2
  • 24
    • 0036838570 scopus 로고    scopus 로고
    • Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice
    • Dupic F, Fruchon S, Bensaid M, et al. Duodenal mRNA expression of iron related genes in response to iron loading and iron deficiency in four strains of mice. Gut 2002;51:648-53.
    • (2002) Gut , vol.51 , pp. 648-653
    • Dupic, F.1    Fruchon, S.2    Bensaid, M.3
  • 25
    • 1442306702 scopus 로고    scopus 로고
    • Non-HFE hemochromatosis
    • Pietrangelo A. Non-HFE hemochromatosis. Hepatology 2004;39:21-9.
    • (2004) Hepatology , vol.39 , pp. 21-29
    • Pietrangelo, A.1
  • 26
    • 10744226568 scopus 로고    scopus 로고
    • Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice
    • Courselaud B, Troadec MB, Fruchon S, et al. Strain and gender modulate hepatic hepcidin 1 and 2 mRNA expression in mice. Blood Cells Mol Dis 2004;32:283-9.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 283-289
    • Courselaud, B.1    Troadec, M.B.2    Fruchon, S.3
  • 27
    • 13544250486 scopus 로고    scopus 로고
    • Hepcidin is decreased in TFR2 hemochromatosis
    • Nemeth E, Roetto A, Garozzo G, et al. Hepcidin is decreased in TFR2 hemochromatosis. Blood 2005;105:1803-6.
    • (2005) Blood , vol.105 , pp. 1803-1806
    • Nemeth, E.1    Roetto, A.2    Garozzo, G.3
  • 28
    • 19944427107 scopus 로고    scopus 로고
    • Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
    • Kawabata H, Fleming RE, Gui D, et al. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood 2005;105:376-81.
    • (2005) Blood , vol.105 , pp. 376-381
    • Kawabata, H.1    Fleming, R.E.2    Gui, D.3
  • 29
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 30
    • 1642315903 scopus 로고    scopus 로고
    • Functional differences between hepcidin 1 and 2 in transgenic mice
    • Lou DQ, Nicolas G, Lesbordes JC, et al. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood 2004;103:2816-21.
    • (2004) Blood , vol.103 , pp. 2816-2821
    • Lou, D.Q.1    Nicolas, G.2    Lesbordes, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.