Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing

Journal of Biological Chemistry

Volumn 281, Issue 39, 2006, Pages 28494-28498

  Goswami, Tapasree ^a   Andrews, Nancy C ^a,b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEREDITARY HEMOCHROMATOSIS PROTEINS; IRON SENSING; MOLECULAR MECHANISM; TRANSFERRIN RECEPTORS;

CELL CULTURE; DISEASES; IRON COMPOUNDS; MATHEMATICAL MODELS; PROTEINS;

MOLECULAR DYNAMICS;

CD71 ANTIGEN; HFE PROTEIN; IRON; TRANSFERRIN; TRANSFERRIN RECEPTOR 2;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IRON BLOOD LEVEL; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; RECEPTOR BINDING; WESTERN BLOTTING;

ANIMALS; ANTIGENS, CD; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HOMEOSTASIS; HUMANS; IRON; MEMBRANE PROTEINS; MICE; MODELS, BIOLOGICAL; MUTATION; RECEPTORS, TRANSFERRIN;

MAMMALIA;

EID: 33749393565     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.C600197200     Document Type: Article

References (20)

1. Hentze, M. W., Muckenthaler, M. U. & Andrews, N. C. (2004) Cell 117, 285-297
2. Nemeth, E., Tuttle, M. S., Powelson, J., Vaughn, M. B., Donovan, A., Ward, D. M., Ganz, T. & Kaplan, J. (2006) Science 306, 2090-2093
3. Nicolas, G., Chauvet, C., Viatte, L., Danan, J. L., Bigard, X., Devaux, I., Beaumont, C., Kahn, A. & Vaulont, S. (2002) J. Clin. Investig. 110, 1037-1044
4. Le Gac, G. & Férec, C. (2005) Eur. J. Hum. Genet. 13, 1172-1185
5. Bennett, M. J., Lebrón, J. A. & Bjorkman, P. J. (2000) Nature 403, 46-53
6. Kawabata, H., Yang, R., Hirama, T., Vuong, P. T., Kawano, S., Gombart, A. F. & Koeffler, H. P. (1999) J. Biol. Chem. 274, 20826-20832
7. Griffiths, W. J. H. & Cox, T. M. (2003) J. Histochem. Cytochem. 51, 613-623
8. Weinstein, D. A., Roy, C. N., Fleming, M. D., Loda, M. F., Wolfsdorf, J. I. & Andrews, N. C. (2002) Blood 100, 3776-3781
9. Robb, A. & Wessling-Resnick, M. (2004) Blood 104, 4294-4299
10. Johnson, M. B. & Enns, C. A. (2004) Blood 104, 4287-4291
11. West, A. P., Bennett, M. J., Sellers, V. M., Andrews, N. C., Enns, C. A. & Bjorkman, P. J. (2000) J. Biol. Chem. 275, 38135-38138
12. Wu, J. C., Merlino, G.&Fausto, N. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 674-678
13. McGraw, T. E., Greenfield, L. & Maxfield, F. R. (1987) J. Cell Biol. 105, 207-214
14. Ausubel, F. M., Brent, R., Kingston, R. E., Moore, D. D., Seidman, J. G., Smith, J. A. & Struhl, K. (eds) Current Protocols in Molecular Biology, pp. 9.1.1-9.1.11 and 12.1.1-12.1.6, Wiley-Interscience, New York
15. Sidis, Y., Mukherjee, A., Keutmann, H., Delbaere, A., Sadatsuki, M., Schneyer, A. (2006) Endocrinology 147, 3586-3597
16. West, A. P., Giannetti, A. M., Herr, A. B., Bennett, M. J., Nangiana, J. S., Pierce, J. R., Weiner, L. P., Snow, P. M.&Bjorkman, P. J. (2001) J. Mol. Biol. 313, 385-397
17. Roetto, A., Daraio, F., Alberti, F., Porporato, P., Cali, A., De Gobbi, M. & Camaschella, C. (2002) Blood Cells Mol. Dis. 29, 465-470
18. Hubert, N., Lescoat, G., Sciot, R., Moirand, R., Jego, P., Leroyer, P. & Brissot, P. (1993) J. Hepatol. 18, 301-312
19. Wilkins, S. J., Frazer, D. M., Millard, K. N., McLaren, G. D. & Anderson, G. J. (2006) Blood 107, 1659-1664
20. Levy, J. E., Montross, L. K., Cohen, D. E., Fleming, M. D. & Andrews, N. C. (1999) Blood 94, 9-11