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Volumn 111, Issue 4, 2008, Pages 2392-2399

Autocrine formation of hepcidin induces iron retention in human monocytes

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN; HEPCIDIN; INTERLEUKIN 6; IRON; LIPOPOLYSACCHARIDE; MESSENGER RNA; SMALL INTERFERING RNA;

EID: 41349106987     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2007-05-090019     Document Type: Article
Times cited : (244)

References (52)
  • 1
    • 14744278436 scopus 로고    scopus 로고
    • Anemia of chronic disease
    • Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.
    • (2005) N Engl J Med , vol.352 , pp. 1011-1023
    • Weiss, G.1    Goodnough, L.T.2
  • 2
    • 0035146949 scopus 로고    scopus 로고
    • Iron and its relation to immunity and infectious disease
    • discussion 633S-635S
    • Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr. 2001;131(suppl):616S-633S; discussion 633S-635S.
    • (2001) J Nutr , vol.131 , Issue.SUPPL.
    • Oppenheimer, S.J.1
  • 3
    • 0141887122 scopus 로고    scopus 로고
    • Recent developments in the anemia of chronic disease
    • Means RT Jr. Recent developments in the anemia of chronic disease. Curr Hematol Rep. 2003;2:116-121.
    • (2003) Curr Hematol Rep , vol.2 , pp. 116-121
    • Means Jr., R.T.1
  • 4
    • 0028908945 scopus 로고
    • Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development
    • Wang CQ, Udupa KB, Lipschitz DA. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol. 1995;162:134-138.
    • (1995) J Cell Physiol , vol.162 , pp. 134-138
    • Wang, C.Q.1    Udupa, K.B.2    Lipschitz, D.A.3
  • 5
    • 0031821059 scopus 로고    scopus 로고
    • Proinflammatory cytokines lowering erythropoietin production
    • Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res. 1998;18:555-559.
    • (1998) J Interferon Cytokine Res , vol.18 , pp. 555-559
    • Jelkmann, W.1
  • 6
    • 0025719887 scopus 로고
    • Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin
    • Means RT Jr, Krantz SB. Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin. Blood. 1991;78:2564-2567.
    • (1991) Blood , vol.78 , pp. 2564-2567
    • Means Jr, R.T.1    Krantz, S.B.2
  • 7
    • 0027509057 scopus 로고
    • Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin
    • Beguin Y, Clemons GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood. 1993;81:1067-1076.
    • (1993) Blood , vol.81 , pp. 1067-1076
    • Beguin, Y.1    Clemons, G.K.2    Pootrakul, P.3    Fillet, G.4
  • 8
    • 0024431912 scopus 로고
    • Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor
    • Alvarez-Hernandez X, Liceaga J, McKay IC, Brock JH. Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor. Lab Invest. 1989;61:319-322.
    • (1989) Lab Invest , vol.61 , pp. 319-322
    • Alvarez-Hernandez, X.1    Liceaga, J.2    McKay, I.C.3    Brock, J.H.4
  • 9
    • 0037093202 scopus 로고    scopus 로고
    • Regulation of ferritin genes and protein
    • Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood. 2002;99:3505-3516.
    • (2002) Blood , vol.99 , pp. 3505-3516
    • Torti, F.M.1    Torti, S.V.2
  • 11
    • 19044389821 scopus 로고    scopus 로고
    • Iron and immunity: A double-edged sword
    • Weiss G. Iron and immunity: a double-edged sword. Eur J Clin Invest. 2002;32(Suppl 1):70-78.
    • (2002) Eur J Clin Invest , vol.32 , Issue.SUPPL. 1 , pp. 70-78
    • Weiss, G.1
  • 12
    • 0030639030 scopus 로고    scopus 로고
    • Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13
    • Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. J Immunol. 1997;158:420-425.
    • (1997) J Immunol , vol.158 , pp. 420-425
    • Weiss, G.1    Bogdan, C.2    Hentze, M.W.3
  • 13
    • 0033215094 scopus 로고    scopus 로고
    • Regulation of iron metabolism in murine J774 macrophages: Role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide
    • Mulero V, Brock JH. Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide. Blood. 1999;94:2383-2389.
    • (1999) Blood , vol.94 , pp. 2383-2389
    • Mulero, V.1    Brock, J.H.2
  • 14
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 15
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 16
    • 0037007064 scopus 로고    scopus 로고
    • Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    • Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-4601.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 4596-4601
    • Nicolas, G.1    Bennoun, M.2    Porteu, A.3
  • 17
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100:3776-3781.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 18
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33:21-22.
    • (2003) Nat Genet , vol.33 , pp. 21-22
    • Roetto, A.1    Papanikolaou, G.2    Politou, M.3
  • 19
    • 36349028180 scopus 로고    scopus 로고
    • Hemochromatosis: An endocrine liver disease
    • Pietrangelo A. Hemochromatosis: An endocrine liver disease. Hepatology. 2007;46:1291-1301.
    • (2007) Hepatology , vol.46 , pp. 1291-1301
    • Pietrangelo, A.1
  • 20
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309.
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3
  • 21
    • 0034677467 scopus 로고    scopus 로고
    • Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
    • Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-781.
    • (2000) Nature , vol.403 , pp. 776-781
    • Donovan, A.1    Brownlie, A.2    Zhou, Y.3
  • 22
    • 0034733635 scopus 로고    scopus 로고
    • A novel mammalian iron-regulated protein involved in intracellular iron metabolism
    • Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906-19912.
    • (2000) J Biol Chem , vol.275 , pp. 19906-19912
    • Abboud, S.1    Haile, D.J.2
  • 23
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 24
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 25
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci U S A. 2005;102:1906-1910.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 26
    • 3042636759 scopus 로고    scopus 로고
    • The IL-6-and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes
    • Lee P, Peng H, Gelbart T, Beutler E. The IL-6-and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A. 2004;101:9263-9265.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 9263-9265
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Beutler, E.4
  • 27
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acutephase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acutephase protein. Blood. 2003;101:2461-2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 28
    • 0036791486 scopus 로고    scopus 로고
    • The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
    • Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037-1044.
    • (2002) J Clin Invest , vol.110 , pp. 1037-1044
    • Nicolas, G.1    Chauvet, C.2    Viatte, L.3
  • 29
    • 23944502314 scopus 로고    scopus 로고
    • Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
    • Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005;106:1864-1866.
    • (2005) Blood , vol.106 , pp. 1864-1866
    • Kemna, E.1    Pickkers, P.2    Nemeth, E.3    van der Hoeven, H.4    Swinkels, D.5
  • 30
    • 33646577477 scopus 로고    scopus 로고
    • Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
    • Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood. 2006;107:4142-4148.
    • (2006) Blood , vol.107 , pp. 4142-4148
    • Theurl, I.1    Mattle, V.2    Seifert, M.3    Mariani, M.4    Marth, C.5    Weiss, G.6
  • 31
    • 85047693999 scopus 로고    scopus 로고
    • Anemia of inflammation: The cytokine-hepcidin link
    • Andrews NC. Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest. 2004;113:1251-1253.
    • (2004) J Clin Invest , vol.113 , pp. 1251-1253
    • Andrews, N.C.1
  • 32
    • 0037131264 scopus 로고    scopus 로고
    • Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
    • Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277:39786-39791.
    • (2002) J Biol Chem , vol.277 , pp. 39786-39791
    • Yang, F.1    Liu, X.B.2    Quinones, M.3    Melby, P.C.4    Ghio, A.5    Haile, D.J.6
  • 33
    • 0037926880 scopus 로고    scopus 로고
    • Cytokine-mediated regulation of iron transport in human monocytic cells
    • Ludwiczek S, Aigner E, Theurl I, Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood. 2003;101:4148-4154.
    • (2003) Blood , vol.101 , pp. 4148-4154
    • Ludwiczek, S.1    Aigner, E.2    Theurl, I.3    Weiss, G.4
  • 34
    • 14844291392 scopus 로고    scopus 로고
    • The iron-regulatory peptide hormone hepcidin: Expression and cellular localization in the mammalian kidney
    • Kulaksiz H, Theilig F, Bachmann S, et al. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinol. 2005;184:361-370.
    • (2005) J Endocrinol , vol.184 , pp. 361-370
    • Kulaksiz, H.1    Theilig, F.2    Bachmann, S.3
  • 35
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • Liu XB, Nguyen NB, Marquess KD, Yang F, Haile DJ. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis. 2005;35:47-56.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 47-56
    • Liu, X.B.1    Nguyen, N.B.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 36
    • 33646427702 scopus 로고    scopus 로고
    • TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
    • Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood. 2006;107:3727-3732.
    • (2006) Blood , vol.107 , pp. 3727-3732
    • Peyssonnaux, C.1    Zinkernagel, A.S.2    Datta, V.3    Lauth, X.4    Johnson, R.S.5    Nizet, V.6
  • 38
    • 0036728509 scopus 로고    scopus 로고
    • Iron and the anemia of chronic disease
    • Spivak JL. Iron and the anemia of chronic disease. Oncology (Williston Park). 2002;16:25-33.
    • (2002) Oncology (Williston Park) , vol.16 , pp. 25-33
    • Spivak, J.L.1
  • 39
    • 0033066772 scopus 로고    scopus 로고
    • Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells
    • Weiss G, Murr C, Zoller H, et al. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin Exp Immunol. 1999;116:435-440.
    • (1999) Clin Exp Immunol , vol.116 , pp. 435-440
    • Weiss, G.1    Murr, C.2    Zoller, H.3
  • 40
    • 3042745199 scopus 로고    scopus 로고
    • Duodenal HFE expression and hepcidin levels determine body iron homeostasis: Modulation by genetic diversity and dietary iron availability
    • Ludwiczek S, Theurl I, Artner-Dworzak E, Chorney M, Weiss G. Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability. J Mol Med. 2004;82:373-382.
    • (2004) J Mol Med , vol.82 , pp. 373-382
    • Ludwiczek, S.1    Theurl, I.2    Artner-Dworzak, E.3    Chorney, M.4    Weiss, G.5
  • 41
    • 24344434227 scopus 로고    scopus 로고
    • Pathways for the regulation of body iron homeostasis in response to experimental iron overload
    • Theurl I, Ludwiczek S, Eller P, et al. Pathways for the regulation of body iron homeostasis in response to experimental iron overload. J Hepatol. 2005;43:711-719.
    • (2005) J Hepatol , vol.43 , pp. 711-719
    • Theurl, I.1    Ludwiczek, S.2    Eller, P.3
  • 42
    • 20844462571 scopus 로고    scopus 로고
    • In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations
    • Schimanski LM, Drakesmith H, Merryweather-Clarke AT, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. Blood. 2005;105:4096-4102.
    • (2005) Blood , vol.105 , pp. 4096-4102
    • Schimanski, L.M.1    Drakesmith, H.2    Merryweather-Clarke, A.T.3
  • 43
    • 3943098598 scopus 로고    scopus 로고
    • Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3
    • Theurl I, Zoller H, Obrist P, et al. Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3. J Infect Dis. 2004;190:819-825.
    • (2004) J Infect Dis , vol.190 , pp. 819-825
    • Theurl, I.1    Zoller, H.2    Obrist, P.3
  • 44
    • 34250865977 scopus 로고    scopus 로고
    • The molecular mechanism of hepcidin-mediated ferroportin down-regulation
    • De Domenico I, Ward DM, Langelier C, et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007;18:2569-2578.
    • (2007) Mol Biol Cell , vol.18 , pp. 2569-2578
    • De Domenico, I.1    Ward, D.M.2    Langelier, C.3
  • 45
    • 23044508432 scopus 로고    scopus 로고
    • Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
    • Drakesmith H, Schimanski LM, Ormerod E, et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood. 2005;106:1092-1097.
    • (2005) Blood , vol.106 , pp. 1092-1097
    • Drakesmith, H.1    Schimanski, L.M.2    Ormerod, E.3
  • 47
    • 33846212344 scopus 로고    scopus 로고
    • STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
    • Pietrangelo A, Dierssen U, Valli L, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132:294-300.
    • (2007) Gastroenterology , vol.132 , pp. 294-300
    • Pietrangelo, A.1    Dierssen, U.2    Valli, L.3
  • 48
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAT3
    • Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204-3209.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 49
    • 1342322891 scopus 로고    scopus 로고
    • Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
    • Yeh KY, Yeh M, Glass J. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol. 2004;286:G385-G394.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Yeh, K.Y.1    Yeh, M.2    Glass, J.3
  • 51
    • 0032997261 scopus 로고    scopus 로고
    • Iron loading and disease surveillance
    • Weinberg ED. Iron loading and disease surveillance. Emerg Infect Dis. 1999;5:346-352.
    • (1999) Emerg Infect Dis , vol.5 , pp. 346-352
    • Weinberg, E.D.1
  • 52
    • 33748764432 scopus 로고    scopus 로고
    • Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis
    • Nairz M, Weiss G. Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis. Wien Klin Wochenschr. 2006;118:442-462.
    • (2006) Wien Klin Wochenschr , vol.118 , pp. 442-462
    • Nairz, M.1    Weiss, G.2


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