-
1
-
-
14744278436
-
Anemia of chronic disease
-
Weiss G, Goodnough LT. Anemia of chronic disease. N Engl J Med. 2005;352:1011-1023.
-
(2005)
N Engl J Med
, vol.352
, pp. 1011-1023
-
-
Weiss, G.1
Goodnough, L.T.2
-
2
-
-
0035146949
-
Iron and its relation to immunity and infectious disease
-
discussion 633S-635S
-
Oppenheimer SJ. Iron and its relation to immunity and infectious disease. J Nutr. 2001;131(suppl):616S-633S; discussion 633S-635S.
-
(2001)
J Nutr
, vol.131
, Issue.SUPPL.
-
-
Oppenheimer, S.J.1
-
3
-
-
0141887122
-
Recent developments in the anemia of chronic disease
-
Means RT Jr. Recent developments in the anemia of chronic disease. Curr Hematol Rep. 2003;2:116-121.
-
(2003)
Curr Hematol Rep
, vol.2
, pp. 116-121
-
-
Means Jr., R.T.1
-
4
-
-
0028908945
-
Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development
-
Wang CQ, Udupa KB, Lipschitz DA. Interferon-gamma exerts its negative regulatory effect primarily on the earliest stages of murine erythroid progenitor cell development. J Cell Physiol. 1995;162:134-138.
-
(1995)
J Cell Physiol
, vol.162
, pp. 134-138
-
-
Wang, C.Q.1
Udupa, K.B.2
Lipschitz, D.A.3
-
5
-
-
0031821059
-
Proinflammatory cytokines lowering erythropoietin production
-
Jelkmann W. Proinflammatory cytokines lowering erythropoietin production. J Interferon Cytokine Res. 1998;18:555-559.
-
(1998)
J Interferon Cytokine Res
, vol.18
, pp. 555-559
-
-
Jelkmann, W.1
-
6
-
-
0025719887
-
Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin
-
Means RT Jr, Krantz SB. Inhibition of human erythroid colony-forming units by gamma interferon can be corrected by recombinant human erythropoietin. Blood. 1991;78:2564-2567.
-
(1991)
Blood
, vol.78
, pp. 2564-2567
-
-
Means Jr, R.T.1
Krantz, S.B.2
-
7
-
-
0027509057
-
Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin
-
Beguin Y, Clemons GK, Pootrakul P, Fillet G. Quantitative assessment of erythropoiesis and functional classification of anemia based on measurements of serum transferrin receptor and erythropoietin. Blood. 1993;81:1067-1076.
-
(1993)
Blood
, vol.81
, pp. 1067-1076
-
-
Beguin, Y.1
Clemons, G.K.2
Pootrakul, P.3
Fillet, G.4
-
8
-
-
0024431912
-
Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor
-
Alvarez-Hernandez X, Liceaga J, McKay IC, Brock JH. Induction of hypoferremia and modulation of macrophage iron metabolism by tumor necrosis factor. Lab Invest. 1989;61:319-322.
-
(1989)
Lab Invest
, vol.61
, pp. 319-322
-
-
Alvarez-Hernandez, X.1
Liceaga, J.2
McKay, I.C.3
Brock, J.H.4
-
9
-
-
0037093202
-
Regulation of ferritin genes and protein
-
Torti FM, Torti SV. Regulation of ferritin genes and protein. Blood. 2002;99:3505-3516.
-
(2002)
Blood
, vol.99
, pp. 3505-3516
-
-
Torti, F.M.1
Torti, S.V.2
-
11
-
-
19044389821
-
Iron and immunity: A double-edged sword
-
Weiss G. Iron and immunity: a double-edged sword. Eur J Clin Invest. 2002;32(Suppl 1):70-78.
-
(2002)
Eur J Clin Invest
, vol.32
, Issue.SUPPL. 1
, pp. 70-78
-
-
Weiss, G.1
-
12
-
-
0030639030
-
Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13
-
Weiss G, Bogdan C, Hentze MW. Pathways for the regulation of macrophage iron metabolism by the anti-inflammatory cytokines IL-4 and IL-13. J Immunol. 1997;158:420-425.
-
(1997)
J Immunol
, vol.158
, pp. 420-425
-
-
Weiss, G.1
Bogdan, C.2
Hentze, M.W.3
-
13
-
-
0033215094
-
Regulation of iron metabolism in murine J774 macrophages: Role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide
-
Mulero V, Brock JH. Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and -independent pathways following activation with gamma interferon and lipopolysaccharide. Blood. 1999;94:2383-2389.
-
(1999)
Blood
, vol.94
, pp. 2383-2389
-
-
Mulero, V.1
Brock, J.H.2
-
14
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
15
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
-
16
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-4601.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
-
17
-
-
0037111732
-
Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
-
Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100:3776-3781.
-
(2002)
Blood
, vol.100
, pp. 3776-3781
-
-
Weinstein, D.A.1
Roy, C.N.2
Fleming, M.D.3
Loda, M.F.4
Wolfsdorf, J.I.5
Andrews, N.C.6
-
18
-
-
20244388240
-
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
-
Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33:21-22.
-
(2003)
Nat Genet
, vol.33
, pp. 21-22
-
-
Roetto, A.1
Papanikolaou, G.2
Politou, M.3
-
19
-
-
36349028180
-
Hemochromatosis: An endocrine liver disease
-
Pietrangelo A. Hemochromatosis: An endocrine liver disease. Hepatology. 2007;46:1291-1301.
-
(2007)
Hepatology
, vol.46
, pp. 1291-1301
-
-
Pietrangelo, A.1
-
20
-
-
0033861745
-
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
-
McKie AT, Marciani P, Rolfs A, et al. A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell. 2000;5:299-309.
-
(2000)
Mol Cell
, vol.5
, pp. 299-309
-
-
McKie, A.T.1
Marciani, P.2
Rolfs, A.3
-
21
-
-
0034677467
-
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
-
Donovan A, Brownlie A, Zhou Y, et al. Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature. 2000;403:776-781.
-
(2000)
Nature
, vol.403
, pp. 776-781
-
-
Donovan, A.1
Brownlie, A.2
Zhou, Y.3
-
22
-
-
0034733635
-
A novel mammalian iron-regulated protein involved in intracellular iron metabolism
-
Abboud S, Haile DJ. A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem. 2000;275:19906-19912.
-
(2000)
J Biol Chem
, vol.275
, pp. 19906-19912
-
-
Abboud, S.1
Haile, D.J.2
-
23
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-2093.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
-
24
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
-
25
-
-
13844307889
-
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
-
Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci U S A. 2005;102:1906-1910.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 1906-1910
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Wang, L.4
Beutler, E.5
-
26
-
-
3042636759
-
The IL-6-and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes
-
Lee P, Peng H, Gelbart T, Beutler E. The IL-6-and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A. 2004;101:9263-9265.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9263-9265
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Beutler, E.4
-
27
-
-
0038662619
-
Hepcidin, a putative mediator of anemia of inflammation, is a type II acutephase protein
-
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acutephase protein. Blood. 2003;101:2461-2463.
-
(2003)
Blood
, vol.101
, pp. 2461-2463
-
-
Nemeth, E.1
Valore, E.V.2
Territo, M.3
Schiller, G.4
Lichtenstein, A.5
Ganz, T.6
-
28
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest. 2002;110:1037-1044.
-
(2002)
J Clin Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
-
29
-
-
23944502314
-
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
-
Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood. 2005;106:1864-1866.
-
(2005)
Blood
, vol.106
, pp. 1864-1866
-
-
Kemna, E.1
Pickkers, P.2
Nemeth, E.3
van der Hoeven, H.4
Swinkels, D.5
-
30
-
-
33646577477
-
Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease
-
Theurl I, Mattle V, Seifert M, Mariani M, Marth C, Weiss G. Dysregulated monocyte iron homeostasis and erythropoietin formation in patients with anemia of chronic disease. Blood. 2006;107:4142-4148.
-
(2006)
Blood
, vol.107
, pp. 4142-4148
-
-
Theurl, I.1
Mattle, V.2
Seifert, M.3
Mariani, M.4
Marth, C.5
Weiss, G.6
-
31
-
-
85047693999
-
Anemia of inflammation: The cytokine-hepcidin link
-
Andrews NC. Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest. 2004;113:1251-1253.
-
(2004)
J Clin Invest
, vol.113
, pp. 1251-1253
-
-
Andrews, N.C.1
-
32
-
-
0037131264
-
Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
-
Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277:39786-39791.
-
(2002)
J Biol Chem
, vol.277
, pp. 39786-39791
-
-
Yang, F.1
Liu, X.B.2
Quinones, M.3
Melby, P.C.4
Ghio, A.5
Haile, D.J.6
-
33
-
-
0037926880
-
Cytokine-mediated regulation of iron transport in human monocytic cells
-
Ludwiczek S, Aigner E, Theurl I, Weiss G. Cytokine-mediated regulation of iron transport in human monocytic cells. Blood. 2003;101:4148-4154.
-
(2003)
Blood
, vol.101
, pp. 4148-4154
-
-
Ludwiczek, S.1
Aigner, E.2
Theurl, I.3
Weiss, G.4
-
34
-
-
14844291392
-
The iron-regulatory peptide hormone hepcidin: Expression and cellular localization in the mammalian kidney
-
Kulaksiz H, Theilig F, Bachmann S, et al. The iron-regulatory peptide hormone hepcidin: expression and cellular localization in the mammalian kidney. J Endocrinol. 2005;184:361-370.
-
(2005)
J Endocrinol
, vol.184
, pp. 361-370
-
-
Kulaksiz, H.1
Theilig, F.2
Bachmann, S.3
-
35
-
-
21544449756
-
Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
-
Liu XB, Nguyen NB, Marquess KD, Yang F, Haile DJ. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis. 2005;35:47-56.
-
(2005)
Blood Cells Mol Dis
, vol.35
, pp. 47-56
-
-
Liu, X.B.1
Nguyen, N.B.2
Marquess, K.D.3
Yang, F.4
Haile, D.J.5
-
36
-
-
33646427702
-
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
-
Peyssonnaux C, Zinkernagel AS, Datta V, Lauth X, Johnson RS, Nizet V. TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens. Blood. 2006;107:3727-3732.
-
(2006)
Blood
, vol.107
, pp. 3727-3732
-
-
Peyssonnaux, C.1
Zinkernagel, A.S.2
Datta, V.3
Lauth, X.4
Johnson, R.S.5
Nizet, V.6
-
37
-
-
33748412748
-
Hepcidin expression and iron transport in alveolar macrophages
-
Nguyen NB, Callaghan KD, Ghio AJ, Haile DJ, Yang F. Hepcidin expression and iron transport in alveolar macrophages. Am J Physiol Lung Cell Mol Physiol. 2006;291:L417-L425.
-
(2006)
Am J Physiol Lung Cell Mol Physiol
, vol.291
-
-
Nguyen, N.B.1
Callaghan, K.D.2
Ghio, A.J.3
Haile, D.J.4
Yang, F.5
-
38
-
-
0036728509
-
Iron and the anemia of chronic disease
-
Spivak JL. Iron and the anemia of chronic disease. Oncology (Williston Park). 2002;16:25-33.
-
(2002)
Oncology (Williston Park)
, vol.16
, pp. 25-33
-
-
Spivak, J.L.1
-
39
-
-
0033066772
-
Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells
-
Weiss G, Murr C, Zoller H, et al. Modulation of neopterin formation and tryptophan degradation by Th1- and Th2-derived cytokines in human monocytic cells. Clin Exp Immunol. 1999;116:435-440.
-
(1999)
Clin Exp Immunol
, vol.116
, pp. 435-440
-
-
Weiss, G.1
Murr, C.2
Zoller, H.3
-
40
-
-
3042745199
-
Duodenal HFE expression and hepcidin levels determine body iron homeostasis: Modulation by genetic diversity and dietary iron availability
-
Ludwiczek S, Theurl I, Artner-Dworzak E, Chorney M, Weiss G. Duodenal HFE expression and hepcidin levels determine body iron homeostasis: modulation by genetic diversity and dietary iron availability. J Mol Med. 2004;82:373-382.
-
(2004)
J Mol Med
, vol.82
, pp. 373-382
-
-
Ludwiczek, S.1
Theurl, I.2
Artner-Dworzak, E.3
Chorney, M.4
Weiss, G.5
-
41
-
-
24344434227
-
Pathways for the regulation of body iron homeostasis in response to experimental iron overload
-
Theurl I, Ludwiczek S, Eller P, et al. Pathways for the regulation of body iron homeostasis in response to experimental iron overload. J Hepatol. 2005;43:711-719.
-
(2005)
J Hepatol
, vol.43
, pp. 711-719
-
-
Theurl, I.1
Ludwiczek, S.2
Eller, P.3
-
42
-
-
20844462571
-
In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations
-
Schimanski LM, Drakesmith H, Merryweather-Clarke AT, et al. In vitro functional analysis of human ferroportin (FPN) and hemochromatosis-associated FPN mutations. Blood. 2005;105:4096-4102.
-
(2005)
Blood
, vol.105
, pp. 4096-4102
-
-
Schimanski, L.M.1
Drakesmith, H.2
Merryweather-Clarke, A.T.3
-
43
-
-
3943098598
-
Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3
-
Theurl I, Zoller H, Obrist P, et al. Iron regulates hepatitis C virus translation via stimulation of expression of translation initiation factor 3. J Infect Dis. 2004;190:819-825.
-
(2004)
J Infect Dis
, vol.190
, pp. 819-825
-
-
Theurl, I.1
Zoller, H.2
Obrist, P.3
-
44
-
-
34250865977
-
The molecular mechanism of hepcidin-mediated ferroportin down-regulation
-
De Domenico I, Ward DM, Langelier C, et al. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol Biol Cell. 2007;18:2569-2578.
-
(2007)
Mol Biol Cell
, vol.18
, pp. 2569-2578
-
-
De Domenico, I.1
Ward, D.M.2
Langelier, C.3
-
45
-
-
23044508432
-
Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin
-
Drakesmith H, Schimanski LM, Ormerod E, et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood. 2005;106:1092-1097.
-
(2005)
Blood
, vol.106
, pp. 1092-1097
-
-
Drakesmith, H.1
Schimanski, L.M.2
Ormerod, E.3
-
46
-
-
33845985236
-
STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation
-
Verga Falzacappa MV, Vujic Spasic M, Kessler R, Stolte J, Hentze MW, Muckenthaler MU. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 2007;109:353-358.
-
(2007)
Blood
, vol.109
, pp. 353-358
-
-
Verga Falzacappa, M.V.1
Vujic Spasic, M.2
Kessler, R.3
Stolte, J.4
Hentze, M.W.5
Muckenthaler, M.U.6
-
47
-
-
33846212344
-
STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo
-
Pietrangelo A, Dierssen U, Valli L, et al. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 2007;132:294-300.
-
(2007)
Gastroenterology
, vol.132
, pp. 294-300
-
-
Pietrangelo, A.1
Dierssen, U.2
Valli, L.3
-
48
-
-
33751175421
-
Interleukin-6 induces hepcidin expression through STAT3
-
Wrighting DM, Andrews NC. Interleukin-6 induces hepcidin expression through STAT3. Blood. 2006;108:3204-3209.
-
(2006)
Blood
, vol.108
, pp. 3204-3209
-
-
Wrighting, D.M.1
Andrews, N.C.2
-
49
-
-
1342322891
-
Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
-
Yeh KY, Yeh M, Glass J. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol. 2004;286:G385-G394.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
-
-
Yeh, K.Y.1
Yeh, M.2
Glass, J.3
-
50
-
-
34848888911
-
Expression and localization of hepcidin in macrophages: A role in host defense against tuberculosis
-
Sow FB, Florence WC, Satoskar AR, Schlesinger LS, Zwilling BS, Lafuse WP. Expression and localization of hepcidin in macrophages: a role in host defense against tuberculosis. J Leukoc Biol. 2007;82:934-945.
-
(2007)
J Leukoc Biol
, vol.82
, pp. 934-945
-
-
Sow, F.B.1
Florence, W.C.2
Satoskar, A.R.3
Schlesinger, L.S.4
Zwilling, B.S.5
Lafuse, W.P.6
-
51
-
-
0032997261
-
Iron loading and disease surveillance
-
Weinberg ED. Iron loading and disease surveillance. Emerg Infect Dis. 1999;5:346-352.
-
(1999)
Emerg Infect Dis
, vol.5
, pp. 346-352
-
-
Weinberg, E.D.1
-
52
-
-
33748764432
-
Molecular and clinical aspects of iron homeostasis: From anemia to hemochromatosis
-
Nairz M, Weiss G. Molecular and clinical aspects of iron homeostasis: from anemia to hemochromatosis. Wien Klin Wochenschr. 2006;118:442-462.
-
(2006)
Wien Klin Wochenschr
, vol.118
, pp. 442-462
-
-
Nairz, M.1
Weiss, G.2
|