Mass spectrometry-based hepcidin measurements in serum and urine: Analytical aspects and clinical implications

Clinical Chemistry

Volumn 53, Issue 4, 2007, Pages 620-628

  Kemna, Erwin H J M ^a   Tjalsma, Harold ^a   Podust, Vladimir N ^b   Swinkels, Dorine W ^a  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b CIPHERGEN BIOSYSTEMS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPCIDIN;

ADULT; AMINO ACID SEQUENCE; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; FEMALE; FREEZE THAWING; HEMOCHROMATOSIS; HORMONE BLOOD LEVEL; HORMONE URINE LEVEL; HUMAN; INFLAMMATION; IRON DEFICIENCY ANEMIA; MAJOR CLINICAL STUDY; MALE; PROTEOMICS; REPRODUCIBILITY; SERUM; STORAGE; SURFACE ENHANCED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; THALASSEMIA MAJOR; URINE;

ADULT; AGED; AGED, 80 AND OVER; ANEMIA, IRON-DEFICIENCY; ANTIMICROBIAL CATIONIC PEPTIDES; FEMALE; HEMOCHROMATOSIS; HUMANS; MALE; MIDDLE AGED; PROTEIN ARRAY ANALYSIS; REFERENCE VALUES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; THALASSEMIA;

EID: 34147197662     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1373/clinchem.2006.079186     Document Type: Article

References (28)

1. Krause A, Neitz S, Magert HJ, Schultz A, Forssmann WG, Schultz-Knappe P, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
2. Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001; 276:7806-10.
3. Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-9.
4. Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A 2002;99: 4596-601.
5. Ganz T. Hepcidin in iron metabolism. Curr Opin Hematol 2004; 11:251-4.
6. Swinkels DW, Janssen MCH, Bergmans J, Marx JJM. Hereditary hemochromatosis: genetic complexity and new diagnostic approaches. Clin Chem 2006;52:950-68.
7. Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3.
8. Kemna E, Tjalsma H, Laarakkers C, Nemeth E, Willems H, Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood 2005;106:3268-70.
9. Tomosugi N, Kawabata H, Wakatabe R, Higuchi M, Yamaya H, Umehara H, et al. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip system. Blood 2006;108: 1381-7.
10. Pickkers P, Dorresteijn MJ, Bouw M, van der Hoeven JG, Smits P. In vivo evidence for nitric oxide-mediated calcium-activated potassium-channel activation during human endotoxemia. Circulation 2006;114:414-21.
11. Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2004;36:77-82.
12. Njajou OT, de Jong G, Berghuis B, Vaessen N, Snijders PJLM, Goossens JP, et al. Dominant hemochromatosis due to N144H mutation of SLC11A3: clinical and biological characteristics. Blood Cell Mol Dis 2002;29:439-43.
13. Kemna E, Pickkers P, Nemeth E, van der Hoeven H, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005;106: 1864-8.
14. Ganz T. Hepcidin. A regulator of intestinal iron absorption and iron recycling by macrophages. Best-Pract Res Clin Haematol 2005; 18:171-82.
15. Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002;277:37597-603.
16. Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, et al. Hepcidin in iron overload disorders. Blood 2005;105:4103-5.
17. Waalen J, Nordestgaard BG, Beutler E. The penetrance of hereditary hemochromatosis. Best Pract Res Clin Haematol 2005;18: 203-20.
18. Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, et al. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer 2007;48:57-63.
19. Thongboonkerd V, McLeish KR, Arthur JM, Klein JB. Proteomic analysis of normal urinary proteins isolated by acetone precipitation or ultracentrifugation. Kidney Int 2002;62:1461-9.
20. Kema IP, Meiborg G, Nagel GT, Stob GJ, Muskiet FAJ. Isotope dilution ammonia chemical ionization mass fragmentographic analysis of urinary 3-o-methylated catecholamine metabolites: rapid sample clean up by derivatisation and extraction of lyophilized samples. J Chromatogr B Biomed Appl 1993;617:181-9.
21. Witte DL, Crosby WH, Edwards CQ, Fairbanks VF, Mitros FA. Practice guideline development task force of the College of American Pathologists: hereditary hemochromatosis. Clin Chim Acta 1996;245:139-200.
22. Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cell Mol Dis 2003;30:288-97.
23. Ganz T, Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochim Biophys Acta 2006;1763:690-9.
24. Schaub S, Wilkins J, Weiler T, Sangster K, Rush D, Nickerson P. Urine protein profiling with surface-enhanced laser-desorption/ ionization time-of-flight mass spectrometry. Kidney Int 2004;65: 323-32.
25. Klasen IS, Reichert LJM, de Kat Angelino CM, Wetzels JFM. Quantitative determination of low and high molecular weight proteins in human urine: influence of temperature and storage time. Clin Chem 1999;45:430-2.
26. Detivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, et al. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 2005;106: 746-8.
27. Hortin GL. The MALDI-TOF mass spectrometric view of the plasma proteome and peptidome. Clin Chem 2006;52:1223-37.
28. Vilanueva J, Shaffer DR, Philip J, Chaparro CA, Erdjument-Bromage H, Olshen AB et al. Differential exoprotease activities confer tumor-specific serum peptidome patterns. J Clin Invest 2006; 116:271-84.