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Volumn 111, Issue 12, 2008, Pages 5727-5733

Erythropoietin mediates hepcidin expression in hepatocytes through EPOR signaling and regulation of C/EBPα

Author keywords

[No Author keywords available]

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; ERYTHROPOIETIN RECEPTOR; HEPCIDIN; RECOMBINANT ERYTHROPOIETIN; ANTIBODY; ANTIMICROBIAL CATIONIC PEPTIDE; ERYTHROPOIETIN; HAMP2 PROTEIN, MOUSE; MESSENGER RNA;

EID: 47049116150     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2007-08-106195     Document Type: Article
Times cited : (204)

References (37)
  • 1
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • Nerneth E, Ganz T. Regulation of iron metabolism by hepcidin. Annu Rev Nutr. 2006;26:323-342.
    • (2006) Annu Rev Nutr , vol.26 , pp. 323-342
    • Nerneth, E.1    Ganz, T.2
  • 2
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nerneth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nerneth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 3
    • 0028049495 scopus 로고
    • Regulators of iron balance in humans
    • Finch G. Regulators of iron balance in humans. Blood. 1994;84:1697-1702.
    • (1994) Blood , vol.84 , pp. 1697-1702
    • Finch, G.1
  • 4
    • 28944455407 scopus 로고    scopus 로고
    • Regulation of erythropoietin production
    • Eckardt K-U, Kurtz A. Regulation of erythropoietin production. Eur J Clin Invest. 2005;35(suppl 3): 13-19.
    • (2005) Eur J Clin Invest , vol.35 , Issue.SUPPL. 3 , pp. 13-19
    • Eckardt, K.-U.1    Kurtz, A.2
  • 5
    • 0026768685 scopus 로고
    • Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia
    • Tan CC, Eckardt KU. Firth JD, Ratcliffe PJ. Feedback modulation of renal and hepatic erythropoietin mRNA in response to graded anemia and hypoxia. Am J Physiol. 1992;263:F474-F481.
    • (1992) Am J Physiol , vol.263
    • Tan, C.C.1    Eckardt, K.U.2    Firth, J.D.3    Ratcliffe, P.J.4
  • 8
    • 0037564038 scopus 로고    scopus 로고
    • Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to nontransferrin-bound iron
    • Gehrke SG, Kulaksiz H, Herrmann T, et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to nontransferrin-bound iron. Blood. 2003;102:371-376.
    • (2003) Blood , vol.102 , pp. 371-376
    • Gehrke, S.G.1    Kulaksiz, H.2    Herrmann, T.3
  • 9
    • 0037479926 scopus 로고    scopus 로고
    • Erythropoietin regulates tumour growth of human malignancies
    • YasudaY, FujitaY, MatsuoT, etal. Erythropoietin regulates tumour growth of human malignancies. Carcinogenesis. 2003;24:1021 -1029.
    • (2003) Carcinogenesis , vol.24 , pp. 1021-1029
    • Yasuda, Y.1    Fujita, Y.2    Matsuo, T.3
  • 10
    • 34548825938 scopus 로고    scopus 로고
    • Lin L, Valore EV, Nerneth E, Goodnough JB; Gabayan V. GanzT. Iron-transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007; 110:2182-2189.
    • Lin L, Valore EV, Nerneth E, Goodnough JB; Gabayan V. GanzT. Iron-transferrin regulates hepcidin synthesis in primary hepatocyte culture through hemojuvelin and BMP2/4. Blood. 2007; 110:2182-2189.
  • 12
    • 0034466546 scopus 로고    scopus 로고
    • Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? an in vitro study using freshly isolated mouse hepatocytes
    • Carvalho M, Carvalho F. Bastos ML. Is hyperthermia the triggering factor for hepatotoxicity induced by 3,4-methylenedioxymethamphetamine (ecstasy)? an in vitro study using freshly isolated mouse hepatocytes. Arch Toxicol. 2001 ;74:789-793.
    • (2001) Arch Toxicol , vol.74 , pp. 789-793
    • Carvalho, M.1    Carvalho, F.2    Bastos, M.L.3
  • 13
    • 3042743240 scopus 로고    scopus 로고
    • Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration
    • Grimm C, Wenzel A, Stanescu D, et al. Constitutive overexpression of human erythropoietin protects the mouse retina against induced but not inherited retinal degeneration. J Neurosci. 2004; 24:5651-5658.
    • (2004) J Neurosci , vol.24 , pp. 5651-5658
    • Grimm, C.1    Wenzel, A.2    Stanescu, D.3
  • 14
    • 0025168768 scopus 로고
    • Effects of recombinant human erythropoietin on hemolytic anaemia in mice
    • Cynshi O, ShimonakaY, Higuchi M, etal. Effects of recombinant human erythropoietin on hemolytic anaemia in mice. Br J Haematol. 1990;76: 414-419.
    • (1990) Br J Haematol , vol.76 , pp. 414-419
    • Cynshi, O.1    Shimonaka, Y.2    Higuchi, M.3
  • 16
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nerneth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nerneth, E.1    Rivera, S.2    Gabayan, V.3
  • 18
    • 0032540934 scopus 로고    scopus 로고
    • Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells
    • Jover R, Bort R, Gómez-Lechón MJ, Castell JV. Re-expression of C/EBP alpha induces CYP2B6, CYP2C9 and CYP2D6 genes in HepG2 cells. FEBS Lett. 1998;431:227-230.
    • (1998) FEBS Lett , vol.431 , pp. 227-230
    • Jover, R.1    Bort, R.2    Gómez-Lechón, M.J.3    Castell, J.V.4
  • 19
    • 34548509194 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines
    • TomizawaM, SaishoH. Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines. J Cell Biochem. 2007;102:161-170.
    • (2007) J Cell Biochem , vol.102 , pp. 161-170
    • TomizawaM1    SaishoH2
  • 20
    • 34548363843 scopus 로고    scopus 로고
    • lnterleukin-6 inhibits human peroxisome proliferator activated receptor alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes
    • Chew CH; Chew GS, Najimudin N, Tengku-Muhammad TS. lnterleukin-6 inhibits human peroxisome proliferator activated receptor alpha gene expression via CCAAT/enhancer-binding proteins in hepatocytes. Int J Biochem Cell Biol. 2007;39:1975-1986.
    • (2007) Int J Biochem Cell Biol , vol.39 , pp. 1975-1986
    • Chew, C.H.1    Chew, G.S.2    Najimudin, N.3    Tengku-Muhammad, T.S.4
  • 21
    • 10044222111 scopus 로고    scopus 로고
    • C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes
    • Yoon K, Smart RC. C/EBPalpha is a DNA damage-inducible p53-regulated mediator of the G1 checkpoint in keratinocytes. Mol Cell Biol. 2004; 24:10650-10660.
    • (2004) Mol Cell Biol , vol.24 , pp. 10650-10660
    • Yoon, K.1    Smart, R.C.2
  • 22
    • 33947095427 scopus 로고    scopus 로고
    • ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3
    • Choi SO, Cho YS, Kim HL, Park JW. ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochem Biophys Res Commun. 2007;356:312-317.
    • (2007) Biochem Biophys Res Commun , vol.356 , pp. 312-317
    • Choi, S.O.1    Cho, Y.S.2    Kim, H.L.3    Park, J.W.4
  • 23
    • 34548509194 scopus 로고    scopus 로고
    • Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines
    • Tomizawa M, Saisho H. Insulin-like growth factor (IGF)-II regulates CCAAT/enhancer binding protein alpha expression via phosphatidyl-inositol 3 kinase in human hepatoblastoma cell lines. J Cell Biochem. 2007;102:161-170.
    • (2007) J Cell Biochem , vol.102 , pp. 161-170
    • Tomizawa, M.1    Saisho, H.2
  • 24
    • 0038482148 scopus 로고    scopus 로고
    • Lithium stabilizes the CCAAT/ enhancer-binding protein alpha (G/EBPalpha) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibition of proteasomal activity
    • Shim M, Smart RC. Lithium stabilizes the CCAAT/ enhancer-binding protein alpha (G/EBPalpha) through a glycogen synthase kinase 3 (GSK3)-independent pathway involving direct inhibition of proteasomal activity. J Biol Ghem. 2003;278: 19674-19681.
    • (2003) J Biol Ghem , vol.278 , pp. 19674-19681
    • Shim, M.1    Smart, R.C.2
  • 25
    • 33748370295 scopus 로고    scopus 로고
    • Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera
    • Weizer-Stern O, Adamsky K. Amariglio N. et al. Downregulation of hepcidin and haemojuvelin expression in the hepatocyte cell-line HepG2 induced by thalassaemic sera. Br J Haematol. 2006;135:129-138.
    • (2006) Br J Haematol , vol.135 , pp. 129-138
    • Weizer-Stern, O.1    Adamsky, K.2    Amariglio, N.3
  • 26
    • 33845245942 scopus 로고    scopus 로고
    • Suppression of hepcidin during anemia requires erythropoietic activity
    • Pak M, Lopez MA, Gabayan V, Ganz T, Rivera S. Suppression of hepcidin during anemia requires erythropoietic activity. Blood. 2006;108:3730-3735.
    • (2006) Blood , vol.108 , pp. 3730-3735
    • Pak, M.1    Lopez, M.A.2    Gabayan, V.3    Ganz, T.4    Rivera, S.5
  • 27
    • 0037174609 scopus 로고    scopus 로고
    • C/EBPalpha regulates hepatic transcription of hepcidin. an antimicrobial peptide and regulator of iron metabolism: Cross-talk between C/EBP pathway and iron metabolism
    • Courselaud B, Pigeon C, Inoue Y, et al. C/EBPalpha regulates hepatic transcription of hepcidin. an antimicrobial peptide and regulator of iron metabolism: cross-talk between C/EBP pathway and iron metabolism. J Biol Chem. 2002;277:41163-41170.
    • (2002) J Biol Chem , vol.277 , pp. 41163-41170
    • Courselaud, B.1    Pigeon, C.2    Inoue, Y.3
  • 28
    • 33747359666 scopus 로고    scopus 로고
    • Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression
    • Harrison-Findik DD, Schafer D, Klein E, et al. Alcohol metabolism-mediated oxidative stress down-regulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem. 2006;281:22974-22982.
    • (2006) J Biol Chem , vol.281 , pp. 22974-22982
    • Harrison-Findik, D.D.1    Schafer, D.2    Klein, E.3
  • 29
    • 37349065804 scopus 로고    scopus 로고
    • Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription
    • Nishina S, Hino K, Korenaga M, et al. Hepatitis C virus-induced reactive oxygen species raise hepatic iron level in mice by reducing hepcidin transcription. Gastroenterology. 2008;134:226-238.
    • (2008) Gastroenterology , vol.134 , pp. 226-238
    • Nishina, S.1    Hino, K.2    Korenaga, M.3
  • 30
    • 0026546365 scopus 로고    scopus 로고
    • Ron D. Habener JF. CHOP, a novel developmen-tally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6:439-453.
    • Ron D. Habener JF. CHOP, a novel developmen-tally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6:439-453.
  • 31
    • 61949307102 scopus 로고    scopus 로고
    • Coutts M, Cui K, Davis KL Keutzer JC, Sytkowski AJ. Regulated expression and functional role of
    • Coutts M, Cui K, Davis KL Keutzer JC, Sytkowski AJ. Regulated expression and functional role of
  • 32
    • 85087577685 scopus 로고    scopus 로고
    • the transcription factor CHOP (GADD153) in ery- throid growth and differentiation
    • the transcription factor CHOP (GADD153) in ery- throid growth and differentiation. Blood. 1999;93: 3369-3378.
    • (1999) Blood , vol.93 , pp. 3369-3378
  • 33
    • 0025768277 scopus 로고
    • Organ distribution of erythropoietin messenger RNAin normal and uremic rats
    • Tan CC; Eckardt KU, Ratcliffe PJ. Organ distribution of erythropoietin messenger RNAin normal and uremic rats. Kidney Int. 1991 ;40:69-76.
    • (1991) Kidney Int , vol.40 , pp. 69-76
    • Tan, C.C.1    Eckardt, K.U.2    Ratcliffe, P.J.3
  • 34
    • 10644267714 scopus 로고    scopus 로고
    • The erythropoietin receptor and its expression in tumor cells and other tissues
    • Farrell F, Lee A. The erythropoietin receptor and its expression in tumor cells and other tissues. Oncologist. 2004;9(suppl 5): 18-30.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 18-30
    • Farrell, F.1    Lee, A.2
  • 35
    • 3242677738 scopus 로고    scopus 로고
    • PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors
    • Schmidt EK. Fichelson S, Feller SM. PI3 kinase is important for Ras, MEK and Erk activation of Epo-stimulated human erythroid progenitors. BMC Biol (http://www.biomedcentral.com/ bmcbiol/). 2004;2:7.
    • BMC Biol
    • Schmidt, E.K.1    Fichelson, S.2    Feller, S.M.3
  • 36
    • 33750957845 scopus 로고    scopus 로고
    • Erythropoietin and the cardiorenal syndrome: Cellular mechanisms on the cardiorenal connectors
    • Jie KE, Verhaar MC, Cramer MJ, et al. Erythropoietin and the cardiorenal syndrome: cellular mechanisms on the cardiorenal connectors. Am J Physiol Renal Physiol. 2006;291 :F932-F944.
    • (2006) Am J Physiol Renal Physiol , vol.291
    • Jie, K.E.1    Verhaar, M.C.2    Cramer, M.J.3
  • 37
    • 34948904750 scopus 로고    scopus 로고
    • High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin
    • Tanno T, Bhanu NV, Oneal PA, et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med. 2007;13:1096-1101.
    • (2007) Nat Med , vol.13 , pp. 1096-1101
    • Tanno, T.1    Bhanu, N.V.2    Oneal, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.