-
1
-
-
0034284595
-
LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
-
Krause A, Neitz S, Magert HJ, Schulz A, Forssmann WG, Schulz-Knappe P, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett 2000;480:147-50.
-
(2000)
FEBS Lett
, vol.480
, pp. 147-150
-
-
Krause, A.1
Neitz, S.2
Magert, H.J.3
Schulz, A.4
Forssmann, W.G.5
Schulz-Knappe, P.6
-
2
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem 2001;276:7806-10.
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
3
-
-
0037020241
-
The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis
-
Hunter HN, Fulton DB, Ganz T, Vogel HJ. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J Biol Chem 2002;277:37597-603.
-
(2002)
J Biol Chem
, vol.277
, pp. 37597-37603
-
-
Hunter, H.N.1
Fulton, D.B.2
Ganz, T.3
Vogel, H.J.4
-
4
-
-
22144484497
-
Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function
-
Detivaud L, Nemeth E, Boudjema K, Turlin B, Troadec MB, Leroyer P, et al. Hepcidin levels in humans are correlated with hepatic iron stores, hemoglobin levels, and hepatic function. Blood 2005;106:746-8.
-
(2005)
Blood
, vol.106
, pp. 746-748
-
-
Detivaud, L.1
Nemeth, E.2
Boudjema, K.3
Turlin, B.4
Troadec, M.B.5
Leroyer, P.6
-
5
-
-
24744458603
-
Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs
-
Rivera S, Nemeth E, Gabayan V, Lopez MA, Farshidi D, Ganz T. Synthetic hepcidin causes rapid dose-dependent hypoferremia and is concentrated in ferroportin-containing organs. Blood 2005;106:2196-9.
-
(2005)
Blood
, vol.106
, pp. 2196-2199
-
-
Rivera, S.1
Nemeth, E.2
Gabayan, V.3
Lopez, M.A.4
Farshidi, D.5
Ganz, T.6
-
6
-
-
33645525540
-
Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice
-
Viatte L, Nicolas G, Lou DQ, Bennoun M, Lesbordes-Brion JC, Canonne-Hergaux F, et al. Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. Blood 2005;107:2952-8.
-
(2005)
Blood
, vol.107
, pp. 2952-2958
-
-
Viatte, L.1
Nicolas, G.2
Lou, D.Q.3
Bennoun, M.4
Lesbordes-Brion, J.C.5
Canonne-Hergaux, F.6
-
7
-
-
10844258104
-
Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
-
Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-3.
-
(2004)
Science
, vol.306
, pp. 2090-2093
-
-
Nemeth, E.1
Tuttle, M.S.2
Powelson, J.3
Vaughn, M.B.4
Donovan, A.5
Ward, D.M.6
-
8
-
-
20444416123
-
The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis
-
Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, et al. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab 2005;1:191-200.
-
(2005)
Cell Metab
, vol.1
, pp. 191-200
-
-
Donovan, A.1
Lima, C.A.2
Pinkus, J.L.3
Pinkus, G.S.4
Zon, L.I.5
Robine, S.6
-
9
-
-
20244388240
-
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
-
Roetto A, Papanikolaou G, Politou M, Alberti F, Girelli D, Christakis J, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet 2003;33:21-2.
-
(2003)
Nat Genet
, vol.33
, pp. 21-22
-
-
Roetto, A.1
Papanikolaou, G.2
Politou, M.3
Alberti, F.4
Girelli, D.5
Christakis, J.6
-
10
-
-
33745752870
-
Targeted disruption of the hepcidin1 gene results in severe hemochromatosis
-
Mar 30; [Epub ahead of print]
-
Lesbordes-Brion JC, Viatte L, Bennoun M, Lou DQ, Ramey G, Houbron C, et al. Targeted disruption of the hepcidin1 gene results in severe hemochromatosis. Blood 2006 Mar 30; [Epub ahead of print].
-
(2006)
Blood
-
-
Lesbordes-Brion, J.C.1
Viatte, L.2
Bennoun, M.3
Lou, D.Q.4
Ramey, G.5
Houbron, C.6
-
11
-
-
0037007064
-
Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
-
Nicolas G, Bennoun M, Porteu A, Mativet S, Beaumont C, Grandchamp B, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA 2002;99:4596-601.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 4596-4601
-
-
Nicolas, G.1
Bennoun, M.2
Porteu, A.3
Mativet, S.4
Beaumont, C.5
Grandchamp, B.6
-
12
-
-
13544252463
-
Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
-
Rivera S, Liu L, Nemeth E, Gabayan V, Sorensen OE, Ganz T. Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood 2005;105:1797-802.
-
(2005)
Blood
, vol.105
, pp. 1797-1802
-
-
Rivera, S.1
Liu, L.2
Nemeth, E.3
Gabayan, V.4
Sorensen, O.E.5
Ganz, T.6
-
13
-
-
0037111732
-
Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
-
Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood 2002;100:3776-81.
-
(2002)
Blood
, vol.100
, pp. 3776-3781
-
-
Weinstein, D.A.1
Roy, C.N.2
Fleming, M.D.3
Loda, M.F.4
Wolfsdorf, J.I.5
Andrews, N.C.6
-
14
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, Keller C, Taudorf S, Pedersen BK, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest 2004;113:1271-6.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
Keller, C.4
Taudorf, S.5
Pedersen, B.K.6
-
15
-
-
3442875926
-
Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE
-
Frazer DM, Wilkins SJ, Millard KN, McKie AT, Vulpe CD, Anderson GJ. Increased hepcidin expression and hypoferraemia associated with an acute phase response are not affected by inactivation of HFE. Br J Haematol 2004;126:434-6.
-
(2004)
Br J Haematol
, vol.126
, pp. 434-436
-
-
Frazer, D.M.1
Wilkins, S.J.2
Millard, K.N.3
McKie, A.T.4
Vulpe, C.D.5
Anderson, G.J.6
-
16
-
-
0036791486
-
The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation
-
Nicolas G, Chauvet C, Viatte L, Danan JL, Bigard X, Devaux I, et al. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J Clin Invest 2002;110:1037-44.
-
(2002)
J Clin Invest
, vol.110
, pp. 1037-1044
-
-
Nicolas, G.1
Chauvet, C.2
Viatte, L.3
Danan, J.L.4
Bigard, X.5
Devaux, I.6
-
17
-
-
23944502314
-
Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS
-
Kemna E, Pickkers P, Nemeth E, van der HH, Swinkels D. Time-course analysis of hepcidin, serum iron, and plasma cytokine levels in humans injected with LPS. Blood 2005;106:1864-6.
-
(2005)
Blood
, vol.106
, pp. 1864-1866
-
-
Kemna, E.1
Pickkers, P.2
Nemeth, E.3
Van Der, H.H.4
Swinkels, D.5
-
18
-
-
0038662619
-
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
-
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood 2003;101:2461-3.
-
(2003)
Blood
, vol.101
, pp. 2461-2463
-
-
Nemeth, E.1
Valore, E.V.2
Territo, M.3
Schiller, G.4
Lichtenstein, A.5
Ganz, T.6
-
19
-
-
13844307889
-
Regulation of hepcidin transcription by interleukin-1 and interleukin-6
-
Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci USA 2005;102:1906-10.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 1906-1910
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Wang, L.4
Beutler, E.5
-
20
-
-
29144437865
-
Upregulation of hepcidin by interleukin-1β in human hepatoma cell lines
-
Sept. 28
-
Inamura J, Ikuta K, Jimbo J, Shindo M, Sato K, Torimoto Y, et al. Upregulation of hepcidin by interleukin-1β in human hepatoma cell lines. Hepatol Res 2005 Sept. 28.
-
(2005)
Hepatol Res
-
-
Inamura, J.1
Ikuta, K.2
Jimbo, J.3
Shindo, M.4
Sato, K.5
Torimoto, Y.6
-
21
-
-
33645500737
-
In chronic inflammation, there exists an IL-6 independent pathway for the induction of hepcidin
-
11-16-2004
-
Rivera S, Gabayan V, Ganz T. In chronic inflammation, there exists an IL-6 independent pathway for the induction of hepcidin. Blood 2004; 104.11-16-2004.
-
(2004)
Blood
, pp. 104
-
-
Rivera, S.1
Gabayan, V.2
Ganz, T.3
-
22
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, Leroyer P, Turlin B, Brissot P, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem 2001;276:7811-9.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
Leroyer, P.4
Turlin, B.5
Brissot, P.6
-
23
-
-
0037564038
-
Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron
-
Gehrke SG, Kulaksiz H, Herrmann T, Riedel HD, Bents K, Veltkamp C, et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. Blood 2003;102:371-6.
-
(2003)
Blood
, vol.102
, pp. 371-376
-
-
Gehrke, S.G.1
Kulaksiz, H.2
Herrmann, T.3
Riedel, H.D.4
Bents, K.5
Veltkamp, C.6
-
24
-
-
0037509928
-
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
-
Muckenthaler M, Roy CN, Custodio AO, Minana B, deGraaf J, Montross LK, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003;34:102-7.
-
(2003)
Nat Genet
, vol.34
, pp. 102-107
-
-
Muckenthaler, M.1
Roy, C.N.2
Custodio, A.O.3
Minana, B.4
DeGraaf, J.5
Montross, L.K.6
-
25
-
-
0038312385
-
Decreased liver hepcidin expression in the hfe knockout mouse
-
Ahmad KA, Ahmann JR, Migas MC, Waheed A, Britton RS, Bacon BR, et al. Decreased liver hepcidin expression in the hfe knockout mouse. Blood Cells Mol Dis 2002;29:361-6.
-
(2002)
Blood Cells Mol Dis
, vol.29
, pp. 361-366
-
-
Ahmad, K.A.1
Ahmann, J.R.2
Migas, M.C.3
Waheed, A.4
Britton, R.S.5
Bacon, B.R.6
-
26
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis
-
Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003;361:669-73.
-
(2003)
Lancet
, vol.361
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
Dixon, J.L.4
Purdie, D.M.5
Crawford, D.H.6
-
27
-
-
13544250486
-
Hepcidin is decreased in TFR2-hemochromatosis
-
Nemeth E, Roetto A, Garozzo G, Ganz T, Camaschella C. Hepcidin is decreased in TFR2-hemochromatosis. Blood 2005;105:1803-6.
-
(2005)
Blood
, vol.105
, pp. 1803-1806
-
-
Nemeth, E.1
Roetto, A.2
Garozzo, G.3
Ganz, T.4
Camaschella, C.5
-
28
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G, Samuels ME, Ludwig EH, MacDonald ML, Franchini PL, Dube MP, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet 2004;36:77-82.
-
(2004)
Nat Genet
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
MacDonald, M.L.4
Franchini, P.L.5
Dube, M.P.6
-
29
-
-
23644460325
-
A mouse model of juvenile hemochromatosis
-
Huang FW, Pinkus JL, Pinkus GS, Fleming MD, Andrews NC. A mouse model of juvenile hemochromatosis. J Clin Invest 2005;115:2187-91.
-
(2005)
J Clin Invest
, vol.115
, pp. 2187-2191
-
-
Huang, F.W.1
Pinkus, J.L.2
Pinkus, G.S.3
Fleming, M.D.4
Andrews, N.C.5
-
30
-
-
23644444316
-
Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
-
Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest 2005;115:2180-6.
-
(2005)
J Clin Invest
, vol.115
, pp. 2180-2186
-
-
Niederkofler, V.1
Salie, R.2
Arber, S.3
-
31
-
-
26644471267
-
Interaction of HJV with neogenin results in iron accumulation in HEK293 cells
-
Zhang AS, West AP Jr, Wyman AE, Bjorkman PJ, Enns CA. Interaction of HJV with neogenin results in iron accumulation in HEK293 cells. J Biol Chem 2005;280:33885-94.
-
(2005)
J Biol Chem
, vol.280
, pp. 33885-33894
-
-
Zhang, A.S.1
West Jr., A.P.2
Wyman, A.E.3
Bjorkman, P.J.4
Enns, C.A.5
-
32
-
-
33646370235
-
Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression
-
Babitt JL, Huang FW, Wrighting DM, Xia Y, Sidis Y, Samad TA, et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006;38:531-9.
-
(2006)
Nat Genet
, vol.38
, pp. 531-539
-
-
Babitt, J.L.1
Huang, F.W.2
Wrighting, D.M.3
Xia, Y.4
Sidis, Y.5
Samad, T.A.6
-
33
-
-
27144459908
-
Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
-
Lin L, Goldberg YP, Ganz T. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood 2005;106:2884-9.
-
(2005)
Blood
, vol.106
, pp. 2884-2889
-
-
Lin, L.1
Goldberg, Y.P.2
Ganz, T.3
-
34
-
-
33644862202
-
Iron imports. IV. Hepcidin and regulation of body iron metabolism
-
Ganz T, Nemeth E. Iron imports. IV. Hepcidin and regulation of body iron metabolism. Am J Physiol Gastrointest Liver Physiol 2006;290:G199-G203.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Ganz, T.1
Nemeth, E.2
-
36
-
-
10244265904
-
Diferric transferrin regulates transferrin receptor 2 protein stability
-
Johnson MB, Enns CA. Diferric transferrin regulates transferrin receptor 2 protein stability. Blood 2004;104:4287-93.
-
(2004)
Blood
, vol.104
, pp. 4287-4293
-
-
Johnson, M.B.1
Enns, C.A.2
-
37
-
-
10244255021
-
Regulation of transferrin receptor 2 protein levels by transferrin
-
Robb A, Wessling-Resnick M. Regulation of transferrin receptor 2 protein levels by transferrin. Blood 2004;104:4294-9.
-
(2004)
Blood
, vol.104
, pp. 4294-4299
-
-
Robb, A.1
Wessling-Resnick, M.2
-
38
-
-
25444530350
-
Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload
-
Bondi A, Valentino P, Daraio F, Porporato P, Gramaglia E, Carturan S, et al. Hepatic expression of hemochromatosis genes in two mouse strains after phlebotomy and iron overload. Haematologica 2005;90:1161-7.
-
(2005)
Haematologica
, vol.90
, pp. 1161-1167
-
-
Bondi, A.1
Valentino, P.2
Daraio, F.3
Porporato, P.4
Gramaglia, E.5
Carturan, S.6
-
39
-
-
4644309964
-
Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis
-
Latunde-Dada GO, Vulpe CD, Anderson GJ, Simpson RJ, McKie AT. Tissue-specific changes in iron metabolism genes in mice following phenylhydrazine-induced haemolysis. Biochim Biophys Acta 2004;1690:169-76.
-
(2004)
Biochim Biophys Acta
, vol.1690
, pp. 169-176
-
-
Latunde-Dada, G.O.1
Vulpe, C.D.2
Anderson, G.J.3
Simpson, R.J.4
McKie, A.T.5
-
40
-
-
33745742487
-
Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis
-
Vokurka M, Krijt J, Sulc K, Necas E. Hepcidin mRNA levels in mouse liver respond to inhibition of erythropoiesis. Physiol Res 2006;23[Epub ahead of print].
-
(2006)
Physiol Res
, vol.23
-
-
Vokurka, M.1
Krijt, J.2
Sulc, K.3
Necas, E.4
-
41
-
-
0034254752
-
The molecular defect in hypotransferrinemic mice
-
Trenor CC, III, Campagna DR, Sellers VM, Andrews NC, Fleming MD. The molecular defect in hypotransferrinemic mice. Blood 2000;96:1113-8.
-
(2000)
Blood
, vol.96
, pp. 1113-1118
-
-
Trenor III, C.C.1
Campagna, D.R.2
Sellers, V.M.3
Andrews, N.C.4
Fleming, M.D.5
-
42
-
-
0037369165
-
2002 E. Mead Johnson Award for Research in Pediatrics Lecture: The molecular biology of the anemia of chronic disease: A hypothesis
-
Roy CN, Weinstein DA, Andrews NC. 2002 E. Mead Johnson Award for Research in Pediatrics Lecture: the molecular biology of the anemia of chronic disease: a hypothesis. Pediatr Res 2003;53:507-12.
-
(2003)
Pediatr Res
, vol.53
, pp. 507-512
-
-
Roy, C.N.1
Weinstein, D.A.2
Andrews, N.C.3
-
43
-
-
19544386871
-
Hepcidin in iron overload disorders
-
Papanikolaou G, Tzilianos M, Christakis JI, Bogdanos D, Tsimirika K, MacFarlane J, et al. Hepcidin in iron overload disorders. Blood 2005;105:4103-5.
-
(2005)
Blood
, vol.105
, pp. 4103-4105
-
-
Papanikolaou, G.1
Tzilianos, M.2
Christakis, J.I.3
Bogdanos, D.4
Tsimirika, K.5
MacFarlane, J.6
-
45
-
-
0037362778
-
Soluble transferrin receptor for the evaluation of erythropoiesis and iron status
-
Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003;329:9-22.
-
(2003)
Clin Chim Acta
, vol.329
, pp. 9-22
-
-
Beguin, Y.1
-
46
-
-
33745745320
-
Analysis of the effect of soluble transferrin receptor 1 (sTfR1) on iron metabolism in mice
-
Abstract
-
Flanagan JM, Peng H, Lee PL, Beutler E. Analysis of the effect of soluble transferrin receptor 1 (sTfR1) on iron metabolism in mice. Blood 2006;106[Abstract].
-
(2006)
Blood
, vol.106
-
-
Flanagan, J.M.1
Peng, H.2
Lee, P.L.3
Beutler, E.4
-
47
-
-
33646926831
-
Urinary hepcidin in congenital chronic anemias
-
Epub ahead of print
-
Kearney SL, Nemeth E, Neufeld EJ, Thapa D, Ganz T, Weinstein DA, et al. Urinary hepcidin in congenital chronic anemias. Pediatr Blood Cancer 2005;[Epub ahead of print].
-
(2005)
Pediatr Blood Cancer
-
-
Kearney, S.L.1
Nemeth, E.2
Neufeld, E.J.3
Thapa, D.4
Ganz, T.5
Weinstein, D.A.6
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