Hepcidin regulation: Ironing out the details

Journal of Clinical Investigation

Volumn 117, Issue 7, 2007, Pages 1755-1758

  De Domenico, Ivana ^a   Ward, Diane M ^a   Kaplan, Jerry ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; HEMOJUVELIN; HEPCIDIN; INTERLEUKIN 6; IRON; MUTANT PROTEIN; SMAD PROTEIN; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANEMIA; ERYTHROPOIESIS; GENE MUTATION; HEMOCHROMATOSIS; HOMEOSTASIS; HUMAN; IN VITRO STUDY; IN VIVO STUDY; IRON BALANCE; IRON BLOOD LEVEL; IRON OVERLOAD; IRON TRANSPORT; LIVER; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; REVIEW; TRANSCRIPTION REGULATION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BONE MORPHOGENETIC PROTEINS; GENE EXPRESSION REGULATION; HOMEOSTASIS; HUMANS; IRON; MEMBRANE PROTEINS; SIGNAL TRANSDUCTION;

EID: 34447117474     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI32701     Document Type: Review

References (15)

1. Nemeth, E., and Ganz, T. 2006. Regulation of iron metabolism by hepcidin. Annu. Rev. Nutr. 26:323-342.
2. Nemeth, E., et al. 2004. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 306:2090-2093.
3. Babitt, J.L., et al. 2007. Modulation of bone morphogenetic protein signaling in vivo regulates systemic iron balance. J. Clin. Invest. 117:1933-1939. doi:10.1172/JCI31342.
4. Wrighting, D.M., and Andrews, N.C. 2006. Interleukin-6 induces hepcidin expression through STAT3. Blood. 108:3204-3209.
5. Pietrangelo, A., et al. 2007. STAT3 is required for IL-6-gp130-dependent activation of hepcidin in vivo. Gastroenterology. 132:294-300.
6. Verga Falzacappa, M.V., et al. 2007. STAT3 mediates hepatic hepcidin expression and its inflammatory stimulation. Blood. 109:353-358.
7. Massague, J., Seoane, J., and Wotton, D. 2005. Smad transcription factors. Genes Dev. 19:2783-2810.
8. Wang, R.H., et al. 2005. A role of SMAD4 in iron metabolism through the positive regulation of hepcidin expression. Cell Metab. 2:399-409.
9. Babitt, J.L., et al. 2006. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat. Genet. 38:531-539.
10. Papanikolaou, G., et al. 2004. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat. Genet. 36:77-82.
11. Lin, L., Goldberg, Y.P., and Ganz, T. 2005. Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood. 106:2884-2889.
12. Zhang, A.S., et al. 2007. Evidence that inhibition of hemojuvelin shedding in response to iron is mediated through neogenin. J. Biol. Chem. 282:12547-12556.
13. Fukuda, S., et al. 2007. Potentiation of astrogliogenesis by STAT3-mediated activation of BMP-Smad signaling in neural stem cells. Mol. Cell. Biol. doi:10.1128/MCB.02435-06.
14. Truksa, J., Peng, H., Lee, P., and Beutler, E. 2006. Bone morphogenetic proteins 2, 4, and 9 stimulate murine hepcidin 1 expression independently of Hfe, transferrin receptor 2 (Tfr2), and IL-6. Proc. Natl. Acad. Sci. U. S. A. 103:10289-10293.
15. Goswami, T., and Andrews, N.C. 2006. Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. J. Biol. Chem. 281:28494-28498.