Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages

Blood Cells, Molecules, and Diseases

Volumn 35, Issue 1, 2005, Pages 47-56

  Liu, Xiao Bing ^a,b   Nguyen, Ngoc Bich H ^b   Marquess, Kimberly D ^b   Yang, Funmei ^b   Haile, David J ^a,b  

^a SOUTH TEXAS VETERANS HEALTH CARE SYSTEM   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Ferroportin; Hepcidin; Lipopolysaccharide; Splenic macrophage

Indexed keywords

FERROPORTIN 1; HEPCIDIN; INTERLEUKIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; DOWN REGULATION; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RNA ANALYSIS; SPLEEN;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATION TRANSPORT PROTEINS; CELLS, CULTURED; DOWN-REGULATION; GENE EXPRESSION REGULATION; INFLAMMATION; INTERLEUKIN-6; IRON; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED STRAINS; RNA, MESSENGER; SPLEEN; TRANSCRIPTION, GENETIC;

ANIMALIA; RODENTIA;

EID: 21544449756     PISSN: 10799796     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcmd.2005.04.006     Document Type: Article

References (19)

1. E. Nemeth, S. Rivera, V. Gabayan, C. Keller, S. Taudorf, B.K. Pedersen, and T. Ganz IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin J. Clin. Invest. 113 9 2004 1271 1276
2. E. Nemeth, E.V. Valore, M. Territo, G. Schiller, A. Lichtenstein, and T. Ganz Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein Blood 101 7 2003 2461 2463
3. F. Yang, X.B. Liu, M. Quinones, P.C. Melby, A. Ghio, and D.J. Haile Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation J. Biol. Chem. 277 42 2002 39786 39791
4. A. Roetto, G. Papanikolaou, M. Politou, F. Alberti, D. Girelli, J. Christakis, D. Loukopoulos, and C. Camaschella Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis Nat. Genet. 33 1 2003 21 22
5. G. Nicolas, M. Bennoun, I. Devaux, C. Beaumont, B. Grandchamp, A. Kahn, and S. Vaulont Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice Proc. Natl. Acad. Sci. U. S. A. 98 15 2001 8780 8785
6. G. Nicolas, M. Bennoun, A. Porteu, S. Mativet, C. Beaumont, B. Grandchamp, M. Sirito, M. Sawadogo, A. Kahn, and S. Vaulont Severe iron deficiency anemia in transgenic mice expressing liver hepcidin Proc. Natl. Acad. Sci. U. S. A. 99 7 2002 4596 4601
7. N.C. Andrews Anemia of inflammation: the cytokine-hepcidin link J. Clin. Invest. 113 9 2004 1251 1253
8. S. Abboud, and D.J. Haile A novel mammalian iron-regulated protein involved in intracellular iron metabolism J. Biol. Chem. 275 26 2000 19906 19912
9. K.Y. Yeh, M. Yeh, and J. Glass Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat Am. J. Physiol.: Gastrointest. Liver Physiol. 286 3 2004
10. C.N. Roy, A.O. Custodio, J. de Graaf, S. Schneider, I. Akpan, L.K. Montross, M. Sanchez, A. Gaudino, M.W. Hentze, N.C. Andrews, and M.U. Muckenthaler An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice Nat. Genet. 36 5 2004 481 485
11. C. Pigeon, G. Ilyin, B. Courselaud, P. Leroyer, B. Turlin, P. Brissot, and O. Loreal A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload J. Biol. Chem. 276 11 2001 7811 7819
12. A. Mazur, C. Feillet-Coudray, B. Romier, D. Bayle, E. Gueux, M. Ruivard, C. Coudray, and Y. Rayssiguier Dietary iron regulates hepatic hepcidin 1 and 2 mRNAs in mice Metabolism 52 10 2003 1229 1231
13. M.D. Knutson, M.R. Vafa, D.J. Haile, and M. Wessling-Resnick Iron loading and erythrophagocytosis increase ferroportin 1 (FPN1) expression in J774 macrophages Blood 102 12 2003 4191 4197
14. E. Nemeth, M.S. Tuttle, J. Powelson, M.B. Vaughn, A. Donovan, D.M. Ward, T. Ganz, and J. Kaplan Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization Science 306 5704 2004 2090 2093
15. M.D. Knutson, M. Oukka, L.M. Koss, F. Aydemir, and M. Wessling-Resnick Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin Proc. Natl. Acad. Sci. U. S. A. 102 5 2005 1324 1328
16. D.A. Weinstein, C.N. Roy, M.D. Fleming, M.F. Loda, J.I. Wolfsdorf, and N.C. Andrews Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease Blood 100 10 2002 3776 3781
17. G. Nicolas, C. Chauvet, L. Viatte, J.L. Danan, X. Bigard, I. Devaux, C. Beaumont, A. Kahn, and S. Vaulont The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation J. Clin. Invest. 110 7 2002 1037 1044
18. P. Lee, H. Peng, T. Gelbart, L. Wang, and E. Beutler Regulation of hepcidin transcription by interleukin-1 and interleukin-6 Proc. Natl. Acad. Sci. U. S. A. 102 6 2005 1906 1910
19. P. Lee, H. Peng, T. Gelbart, and E. Beutler The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes Proc. Natl. Acad. Sci. U. S. A. 101 25 2004 9263 9265