The Hepcidin-Binding Site on Ferroportin Is Evolutionarily Conserved

Cell Metabolism

Volumn 8, Issue 2, 2008, Pages 146-156

  De Domenico, Ivana ^a,c   Nemeth, Elizabeta ^b   Nelson, Jenifer M ^a   Phillips, John D ^c   Ajioka, Richard S ^c   Kay, Michael S ^a   Kushner, James P ^c   Ganz, Tomas ^b   Ward, Diane M ^a   Kaplan, Jerry ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF UTAH   (United States)

Author keywords

EVO_ECOL; HUMDISEASE

Indexed keywords

AMINO ACID; FERROPORTIN; HEPCIDIN; PEPTIDE;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL SURFACE; CONTROLLED STUDY; DISSOCIATION; FISH; FROG; GENETIC CONSERVATION; HORMONE BINDING; HORMONE DETERMINATION; HORMONE RECEPTOR INTERACTION; HORMONE STRUCTURE; HUMAN; HUMAN CELL; IRON BALANCE; IRON TRANSPORT; LOW TEMPERATURE; MAMMAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; REGULATORY MECHANISM; TEMPERATURE DEPENDENCE; VERTEBRATE;

AMINO ACID SEQUENCE; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; ANURA; BINDING SITES; BODY TEMPERATURE; CATION TRANSPORT PROTEINS; CELL LINE; CONSERVED SEQUENCE; EVOLUTION, MOLECULAR; FISHES; HUMANS; IRON; LIVER; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; SPECIES SPECIFICITY;

ANURA; MAMMALIA; VERTEBRATA;

EID: 48149090865     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2008.07.002     Document Type: Article

References (35)

1. Casale G., Bonora C., Migliavacca A., Zurita I.E., and de Nicola P. Serum ferritin and ageing. Age Ageing 10 (1981) 119-122
2. De Domenico I., Ward D.M., Nemeth E., Vaughn M.B., Musci G., Ganz T., and Kaplan J. The molecular basis of ferroportin-linked hemochromatosis. Proc. Natl. Acad. Sci. USA 102 (2005) 8955-8960
3. De Domenico I., McVey Ward D., Nemeth E., Ganz T., Corradini E., Ferrara F., Musci G., Pietrangelo A., and Kaplan J. Molecular and clinical correlates in iron overload associated with mutations in ferroportin. Haematologica 91 (2006) 1092-1095
4. De Domenico I., Ward D.M., Musci G., and Kaplan J. Iron overload due to mutations in ferroportin. Haematologica 91 (2006) 92-95
5. De Domenico I., Ward D.M., and Kaplan J. Hepcidin regulation: ironing out the details. J. Clin. Invest. 117 (2007) 1755-1758
6. De Domenico I., Ward D.M., Langelier C., Vaughn M.B., Nemeth E., Sundquist W.I., Ganz T., Musci G., and Kaplan J. The molecular mechanism of hepcidin-mediated ferroportin down-regulation. Mol. Biol. Cell 18 (2007) 2569-2578
7. Donovan A., Lima C.A., Pinkus J.L., Pinkus G.S., Zon L.I., Robine S., and Andrews N.C. The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis. Cell Metab. 1 (2005) 191-200
8. Drakesmith H., Schimanski L.M., Ormerod E., Merryweather-Clarke A.T., Viprakasit V., Edwards J.P., Sweetland E., Bastin J.M., Cowley D., Chinthammitr Y., et al. Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin. Blood 106 (2005) 1092-1097
9. Enoch H.G., Fleming P.J., and Strittmatter P. Cytochrome b5 and cytochrome b5 reductase-phospholipid vesicles. Intervesicle protein transfer and oreintation factors in protein-protein interactions. J. Biol. Chem. 252 (1977) 5656-5660
10. Ganz T., and Nemeth E. Regulation of iron acquisition and iron distribution in mammals. Biochim. Biophys. Acta 1763 (2006) 690-699
11. Hetet G., Devaux I., Soufir N., Grandchamp B., and Beaumont C. Molecular analyses of patients with hyperferritinemia and normal serum iron values reveal both L ferritin IRE and 3 new ferroportin (slc11A3) mutations. Blood 102 (2003) 1904-1910
12. Huang F.W., Rubio-Aliaga I., Kushner J.P., Andrews N.C., and Fleming M.D. Identification of a novel mutation (C321X) in HJV. Blood 104 (2004) 2176-2177
13. Huang P.H., Chen J.Y., and Kuo C.M. Three different hepcidins from tilapia, Oreochromis mossambicus: analysis of their expressions and biological functions. Mol. Immunol. 44 (2007) 1922-1934
14. Hunter H.N., Fulton D.B., Ganz T., and Vogel H.J. The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. J. Biol. Chem. 277 (2002) 37597-37603
15. Ilyin G., Courselaud B., Troadec M.B., Pigeon C., Alizadeh M., Leroyer P., Brissot P., and Loreal O. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. FEBS Lett. 542 (2003) 22-26
16. Kemna E., Tjalsma H., Laarakkers C., Nemeth E., Willems H., and Swinkels D. Novel urine hepcidin assay by mass spectrometry. Blood 106 (2005) 3268-3270
17. Kemna E.H., Tjalsma H., Podust V.N., and Swinkels D.W. Mass spectrometry-based hepcidin measurements in serum and urine: analytical aspects and clinical implications. Clin. Chem. 53 (2007) 620-628
18. Lauth X., Babon J.J., Stannard J.A., Singh S., Nizet V., Carlberg J.M., Ostland V.E., Pennington M.W., Norton R.S., and Westerman M.E. Bass hepcidin synthesis, solution structure, antimicrobial activities and synergism, and in vivo hepatic response to bacterial infections. J. Biol. Chem. 280 (2005) 9272-9282
19. Lesbordes-Brion J.C., Viatte L., Bennoun M., Lou D.Q., Ramey G., Houbron C., Hamard G., Kahn A., and Vaulont S. Targeted disruption of the hepcidin 1 gene results in severe hemochromatosis. Blood 108 (2006) 1402-1405
20. Levy J.E., Montross L.K., Cohen D.E., Fleming M.D., and Andrews N.C. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 94 (1999) 9-11
21. Liu X.B., Yang F., and Haile D.J. Functional consequences of ferroportin 1 mutations. Blood Cells Mol. Dis. 35 (2005) 33-46
22. Lou D.Q., Nicolas G., Lesbordes J.C., Viatte L., Grimber G., Szajnert M.F., Kahn A., and Vaulont S. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood 103 (2004) 2816-2821
23. Murphy A.T., Witcher D.R., Luan P., and Wroblewski V.J. Quantitation of hepcidin from human and mouse serum using liquid chromatography tandem mass spectrometry. Blood 110 (2007) 1048-1054
24. Nemeth E., Tuttle M.S., Powelson J., Vaughn M.B., Donovan A., Ward D.M., Ganz T., and Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306 (2004) 2090-2093
25. Nemeth E., Preza G.C., Jung C.L., Kaplan J., Waring A.J., and Ganz T. The N-terminus of hepcidin is essential for its interaction with ferroportin: structure-function study. Blood 107 (2006) 328-333
26. Nicolas G., Chauvet C., Viatte L., Danan J.L., Bigard X., Devaux I., Beaumont C., Kahn A., and Vaulont S. The gene encoding the iron regulatory peptide hepcidin is regulated by anemia, hypoxia, and inflammation. J. Clin. Invest. 110 (2002) 1037-1044
27. Njajou O.T., de Jong G., Berghuis B., Vaessen N., Snijders P.J., Goossens J.P., Wilson J.H., Breuning M.H., Oostra B.A., Heutink P., et al. Dominant hemochromatosis due to N144H mutation of SLC11A3: clinical and biological characteristics. Blood Cells Mol. Dis. 29 (2002) 439-443
28. Padhi A., and Verghese B. Evidence for positive Darwinian selection on the hepcidin gene of Perciform and Pleuronectiform fishes. Mol. Divers. 11 (2007) 119-130
29. Park C.H., Valore E.V., Waring A.J., and Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J. Biol. Chem. 276 (2001) 7806-7810
30. Pigeon C., Ilyin G., Courselaud B., Leroyer P., Turlin B., Brissot P., and Loreal O. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J. Biol. Chem. 276 (2001) 7811-7819
31. Sham R.L., Phatak P.D., West C., Lee P., Andrews C., and Beutler E. Autosomal dominant hereditary hemochromatosis associated with a novel ferroportin mutation and unique clinical features. Blood Cells Mol. Dis. 34 (2005) 157-161
32. Shi J., and Camus A.C. Hepcidins in amphibians and fishes: Antimicrobial peptides or iron-regulatory hormones?. Dev. Comp. Immunol. 30 (2006) 746-755
33. Shike H., Lauth X., Westerman M.E., Ostland V.E., Carlberg J.M., Van Olst J.C., Shimizu C., Bulet P., and Burns J.C. Bass hepcidin is a novel antimicrobial peptide induced by bacterial challenge. Eur. J. Biochem. 269 (2002) 2232-2237
34. Tomosugi N., Kawabata H., Wakatabe R., Higuchi M., Yamaya H., Umehara H., and Ishikawa I. Detection of serum hepcidin in renal failure and inflammation by using ProteinChip System. Blood 108 (2006) 1381-1387
35. Wallace D.F., Dixon J.L., Ramm G.A., Anderson G.J., Powell L.W., and Subramaniam V.N. A novel mutation in ferroportin implicated in iron overload. J. Hepatol. 46 (2007) 921-926