Iron-mediated regulation of liver hepcidin expression in rats and mice is abolished by alcohol

Hepatology

Volumn 46, Issue 6, 2007, Pages 1979-1985

  Harrison Findik, Duygu Dee ^a   Klein, Elizabeth ^a   Crist, Callie ^a   Evans, John ^a   Timchenko, Nikolai ^b   Gollan, John ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CARBONYL IRON; CCAAT ENHANCER BINDING PROTEIN ALPHA; DNA; FERRITIN; HEPCIDIN; IRON; MESSENGER RNA;

ALCOHOL LIVER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DUODENUM; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; IRON OVERLOAD; KNOCKOUT MOUSE; LIVER; LIVER INJURY; LIVER LEVEL; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; UPREGULATION;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; DISEASE MODELS, ANIMAL; ETHANOL; IRON COMPOUNDS; IRON OVERLOAD; LIVER; MALE; MICE; RATS; RATS, WISTAR;

EID: 34848838993     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.21895     Document Type: Article

References (20)

1. Nicolas G, Bennoun M, Devaux I, Beaumont C, Grandchamp B, Kahn A, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A 2001;98:8780-8785.
2. Ganz T. Hepcidin in iron metabolism. Curr Opin Hematol 2004;11:251-254.
3. Harrison-Findik DD, Schafer D, Klein E, Timchenko NA, Kulaksiz H, Clemens D, et al. Alcohol metabolism-mediated oxidative stress downregulates hepcidin transcription and leads to increased duodenal iron transporter expression. J Biol Chem 2006;281:22974-22982.
4. Bridle K, Cheung TK, Murphy T, Walters M, Anderson G, Crawford DG, et al. Hepcidin is down-regulated in alcoholic liver injury: Implications for the pathogenesis of alcoholic liver disease. Alcohol Clin Exp Res 2006;30:106-112.
5. Bridle KR, Frazer DM, Wilkins SJ, Dixon JL, Purdie DM, Crawford DH, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homoeostasis. Lancet 2003;361:669-673.
6. Muckenthaler M, Roy CN, Custodio AO, Minana B, deGraaf J, Montross LK, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet 2003;34:102-107.
7. Fletcher LM, Dixon JL, Purdie DM, Powell LW, Crawford DH. Excess alcohol greatly increases the prevalence of cirrhosis in hereditary hemochromatosis. Gastroenterology 2002;122:281-289.
8. Tsukamoto H, Lin M, Ohata M, Giulivi C, French SW, Brittenham G. Iron primes hepatic macrophages for NF-kappaB activation in alcoholic liver injury. Am J Physiol 1999;277:G1240-G1250.
9. Coyle P, Philcox JC, Rofe AM. Metallothionein-null mice absorb less Zn from an egg-white diet, but a similar amount from solutions, although with altered intertissue Zn distribution. J Nutr 1999;129:372-379.
10. Levy JE, Montross LK, Cohen DE, Fleming MD, Andrews NC. The C282Y mutation causing hereditary hemochromatosis does not produce a null allele. Blood 1999;94:9-11.
11. Lieber CS, DeCarli LM. Liquid diet technique of ethanol administration: 1989 update. Alcohol 1989;24:197-211.
12. Timchenko NA, Wilde M, Darlington GJ. C/EBPalpha regulates formation of S-phase-specific E2F-p107 complexes in livers of newborn mice. Mol Cell Biol 1999;19:2936-2945.
13. Wang GL, Iakova P, Wilde M, Awad S, Timchenko NA. Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev 2004;18:912-925.
14. Dahlquist RL, Knoll JW. Inductively coupled plasma atomic emission spectrometry: analysis of biological materials and soils for major, trace and ultra-trace elements. Applied Spectroscopy 1978;32:1-30.
15. Courselaud B, Pigeon C, Inoue Y, Inoue J, Gonzalez FJ, Leroyer P, et al. C/EBPalpha regulates hepatic transcription of hepcidin, an antimicrobial peptide and regulator of iron metabolism. Cross-talk between C/EBP pathway and iron metabolism. J Biol Chem 2002;277:41163-41170.
16. Tsukamoto H, Lu SC. Current concepts in the pathogenesis of alcoholic liver injury. FASEB J 2001;15:1335-1349.
17. Pietrangelo A. Iron, oxidative stress and liver fibrogenesis. J Hepatol 1998;(28 Suppl 1):8-13.
18. Kaufman N, Klavins JV, Kinney TD. Iron content of liver in relation to age. J Nutr 1962;78:338-340.
19. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, et al. Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization. Science 2004;306:2090-2093.
20. Flanagan JM, Peng H, Beutler E. Effects of alcohol consumption on iron metabolism in mice with hemochromatosis mutations. Alcohol Clin Exp Res 2007;31:138-143.