메뉴 건너뛰기




Volumn 107, Issue 9, 2006, Pages 3727-3732

TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens

Author keywords

[No Author keywords available]

Indexed keywords

FERROPORTIN 1; HEPCIDIN; MESSENGER RNA; TOLL LIKE RECEPTOR 4;

EID: 33646427702     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2005-06-2259     Document Type: Article
Times cited : (304)

References (41)
  • 1
    • 14544298717 scopus 로고    scopus 로고
    • Hepcidin - A regulator of intestinal iron absorption and iron recycling by macrophages
    • Ganz T. Hepcidin - a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol. 2005;18:171-182.
    • (2005) Best Pract Res Clin Haematol , vol.18 , pp. 171-182
    • Ganz, T.1
  • 2
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ, et al. LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett. 2000;480:147-150.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    Magert, H.J.3
  • 3
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, a urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 4
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • U S A
    • Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A. 2001;98:8780-8785.
    • (2001) Proc Natl Acad Sci , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 5
    • 0037007064 scopus 로고    scopus 로고
    • Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    • U S A
    • Nicolas G, Bennoun M, Porteu A, et al. Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci U S A. 2002;99:4596-4601.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 4596-4601
    • Nicolas, G.1    Bennoun, M.2    Porteu, A.3
  • 6
    • 1642315903 scopus 로고    scopus 로고
    • Functional differences between hepcidin 1 and 2 in transgenic mice
    • Lou DQ, Nicolas G, Lesbordes JC, et al. Functional differences between hepcidin 1 and 2 in transgenic mice. Blood. 2004;103:2816-2821.
    • (2004) Blood , vol.103 , pp. 2816-2821
    • Lou, D.Q.1    Nicolas, G.2    Lesbordes, J.C.3
  • 7
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J, et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science. 2004;306:2090-2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 8
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996;13:399-408.
    • (1996) Nat Genet , vol.13 , pp. 399-408
    • Feder, J.N.1    Gnirke, A.2    Thomas, W.3
  • 9
    • 0037509928 scopus 로고    scopus 로고
    • Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
    • Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet. 2003;34:102-107.
    • (2003) Nat Genet , vol.34 , pp. 102-107
    • Muckenthaler, M.1    Roy, C.N.2    Custodio, A.O.3
  • 11
    • 0034022636 scopus 로고    scopus 로고
    • The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
    • Camaschella C, Roetto A, Cali A, et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 2000;25:14-15.
    • (2000) Nat Genet , vol.25 , pp. 14-15
    • Camaschella, C.1    Roetto, A.2    Cali, A.3
  • 12
    • 0033539556 scopus 로고    scopus 로고
    • Experimental hemochromatosis due to MHC class I HFE deficiency: Immune status and iron metabolism
    • U S A
    • Bahram S, Gilfillan S, Kuhn LC, et al. Experimental hemochromatosis due to MHC class I HFE deficiency: immune status and iron metabolism. Proc Natl Acad Sci U S A. 1999;96:13312-13317.
    • (1999) Proc Natl Acad Sci , vol.96 , pp. 13312-13317
    • Bahram, S.1    Gilfillan, S.2    Kuhn, L.C.3
  • 13
    • 0001376313 scopus 로고    scopus 로고
    • HFE gene knockout produces mouse model of hereditary hemochromatosis
    • U S A
    • Zhou XY, Tomatsu S, Fleming RE, et al. HFE gene knockout produces mouse model of hereditary hemochromatosis. Proc Natl Acad Sci U S A. 1998;95:2492-2497.
    • (1998) Proc Natl Acad Sci , vol.95 , pp. 2492-2497
    • Zhou, X.Y.1    Tomatsu, S.2    Fleming, R.E.3
  • 14
    • 0036678091 scopus 로고    scopus 로고
    • Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
    • U S A
    • Fleming RE, Ahmann JR, Migas MC, et al. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A. 2002;99:10653-10658.
    • (2002) Proc Natl Acad Sci , vol.99 , pp. 10653-10658
    • Fleming, R.E.1    Ahmann, J.R.2    Migas, M.C.3
  • 15
    • 19944427107 scopus 로고    scopus 로고
    • Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis
    • Kawabata H, Fleming RE, Gui D, et al. Expression of hepcidin is down-regulated in TfR2 mutant mice manifesting a phenotype of hereditary hemochromatosis. Blood. 2005;105:376-381.
    • (2005) Blood , vol.105 , pp. 376-381
    • Kawabata, H.1    Fleming, R.E.2    Gui, D.3
  • 18
    • 23644444316 scopus 로고    scopus 로고
    • Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload
    • Niederkofler V, Salie R, Arber S. Hemojuvelin is essential for dietary iron sensing, and its mutation leads to severe iron overload. J Clin Invest. 2005;115:2180-2186.
    • (2005) J Clin Invest , vol.115 , pp. 2180-2186
    • Niederkofler, V.1    Salie, R.2    Arber, S.3
  • 19
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100:3776-3781.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.D.3    Loda, M.F.4    Wolfsdorf, J.I.5    Andrews, N.C.6
  • 20
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidin transcription by interleukin-1 and interleukin-6
    • U S A
    • Lee P, Peng H, Gelbart T, Wang L, Beutler E. Regulation of hepcidin transcription by interleukin-1 and interleukin-6. Proc Natl Acad Sci U S A. 2005;102:1906-1910.
    • (2005) Proc Natl Acad Sci , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Wang, L.4    Beutler, E.5
  • 21
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 22
    • 4444367679 scopus 로고    scopus 로고
    • Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment
    • Motley ST, Morrow BJ, Liu X, et al. Simultaneous analysis of host and pathogen interactions during an in vivo infection reveals local induction of host acute phase response proteins, a novel bacterial stress response, and evidence of a host-imposed metal ion limited environment. Cell Microbiol. 2004;6:849-865.
    • (2004) Cell Microbiol , vol.6 , pp. 849-865
    • Motley, S.T.1    Morrow, B.J.2    Liu, X.3
  • 23
    • 0033791996 scopus 로고    scopus 로고
    • Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group a streptococcal infection cases
    • Kansal RG, McGeer A, Low DE, Norrby-Teglund A, Kotb M. Inverse relation between disease severity and expression of the streptococcal cysteine protease, SpeB, among clonal M1T1 isolates recovered from invasive group A streptococcal infection cases. Infect Immun. 2000;68:6362-6369.
    • (2000) Infect Immun , vol.68 , pp. 6362-6369
    • Kansal, R.G.1    McGeer, A.2    Low, D.E.3    Norrby-Teglund, A.4    Kotb, M.5
  • 24
    • 22144492953 scopus 로고    scopus 로고
    • HIF-1α expression regulates the bactericidal capacity of phagocytes
    • Peyssonnaux C, Datta V, Cramer T, et al. HIF-1α expression regulates the bactericidal capacity of phagocytes. J Clin Invest. 2005;115:1806-1815.
    • (2005) J Clin Invest , vol.115 , pp. 1806-1815
    • Peyssonnaux, C.1    Datta, V.2    Cramer, T.3
  • 25
    • 17644385827 scopus 로고    scopus 로고
    • Mutational analysis of the group a streptococcal operon encoding streptolysin S and its virulence role in invasive infection
    • Datta V, Myskowski SM, Kwinn LA, et al. Mutational analysis of the group A streptococcal operon encoding streptolysin S and its virulence role in invasive infection. Mol Microbiol. 2005;56:681-695.
    • (2005) Mol Microbiol , vol.56 , pp. 681-695
    • Datta, V.1    Myskowski, S.M.2    Kwinn, L.A.3
  • 26
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1α is essential for myeloid cell-mediated inflammation
    • Cramer T, Yamanishi Y, Clausen BE, et al. HIF-1α is essential for myeloid cell-mediated inflammation. Cell. 2003;112:645-657.
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1    Yamanishi, Y.2    Clausen, B.E.3
  • 27
    • 0038025679 scopus 로고    scopus 로고
    • Comparative analysis of mouse hepcidin 1 and 2 genes: Evidence for different patterns of expression and co-inducibility during iron overload
    • Ilyin G, Courselaud B, Troadec MB, et al. Comparative analysis of mouse hepcidin 1 and 2 genes: evidence for different patterns of expression and co-inducibility during iron overload. FEBS Lett. 2003;542:22-26.
    • (2003) FEBS Lett , vol.542 , pp. 22-26
    • Ilyin, G.1    Courselaud, B.2    Troadec, M.B.3
  • 28
    • 2342422913 scopus 로고    scopus 로고
    • Prohepcidin: Expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia
    • Kulaksiz H, Gehrke SG, Janetzko A, et al. Prohepcidin: expression and cell specific localisation in the liver and its regulation in hereditary haemochromatosis, chronic renal insufficiency, and renal anaemia. Gut. 2004;53:735-743.
    • (2004) Gut , vol.53 , pp. 735-743
    • Kulaksiz, H.1    Gehrke, S.G.2    Janetzko, A.3
  • 29
    • 21044450599 scopus 로고    scopus 로고
    • Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes
    • Wallace DF, Summerville L, Lusby PE, Subramaniam VN. Prohepcidin localises to the Golgi compartment and secretory pathway in hepatocytes. J Hepatol. 2005;43:720-728.
    • (2005) J Hepatol , vol.43 , pp. 720-728
    • Wallace, D.F.1    Summerville, L.2    Lusby, P.E.3    Subramaniam, V.N.4
  • 30
    • 0032509295 scopus 로고    scopus 로고
    • Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in Tlr4 gene
    • Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085-2088.
    • (1998) Science , vol.282 , pp. 2085-2088
    • Poltorak, A.1    He, X.2    Smirnova, I.3
  • 31
    • 0037452778 scopus 로고    scopus 로고
    • Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection
    • U S A
    • Malley R, Henneke P, Morse SC, et al. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc Natl Acad Sci U S A. 2003;100:1966-1971.
    • (2003) Proc Natl Acad Sci , vol.100 , pp. 1966-1971
    • Malley, R.1    Henneke, P.2    Morse, S.C.3
  • 32
    • 11844262784 scopus 로고    scopus 로고
    • Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists
    • Park JM, Ng VH, Maeda S, Rest RF, Karin M. Anthrolysin O and other gram-positive cytolysins are toll-like receptor 4 agonists. J Exp Med. 2004;200:1647-1655.
    • (2004) J Exp Med , vol.200 , pp. 1647-1655
    • Park, J.M.1    Ng, V.H.2    Maeda, S.3    Rest, R.F.4    Karin, M.5
  • 33
    • 19644362276 scopus 로고    scopus 로고
    • Tissue-specific mRNA expression profiles of human toll-like receptors and related genes
    • Nishimura M, Naito S. Tissue-specific mRNA expression profiles of human toll-like receptors and related genes. Biol Pharm Bull. 2005;28:886-892.
    • (2005) Biol Pharm Bull , vol.28 , pp. 886-892
    • Nishimura, M.1    Naito, S.2
  • 34
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B, et al. A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 35
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461-2463.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3    Schiller, G.4    Lichtenstein, A.5    Ganz, T.6
  • 36
    • 2442426523 scopus 로고    scopus 로고
    • An Hfedependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice
    • Roy CN, Custodio AO, de Graaf J, et al. An Hfedependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. Nat Genet. 2004;36:481-485.
    • (2004) Nat Genet , vol.36 , pp. 481-485
    • Roy, C.N.1    Custodio, A.O.2    De Graaf, J.3
  • 37
    • 3042636759 scopus 로고    scopus 로고
    • The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes
    • U S A
    • Lee P, Peng H, Gelbart T, Beutler E. The IL-6- and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta 2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A. 2004;101:9263-9265.
    • (2004) Proc Natl Acad Sci , vol.101 , pp. 9263-9265
    • Lee, P.1    Peng, H.2    Gelbart, T.3    Beutler, E.4
  • 38
    • 21544449756 scopus 로고    scopus 로고
    • Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages
    • Liu XB, Nguyen NB, Marquess KD, Yang F, Haile DJ. Regulation of hepcidin and ferroportin expression by lipopolysaccharide in splenic macrophages. Blood Cells Mol Dis. 2005;35:47-56.
    • (2005) Blood Cells Mol Dis , vol.35 , pp. 47-56
    • Liu, X.B.1    Nguyen, N.B.2    Marquess, K.D.3    Yang, F.4    Haile, D.J.5
  • 39
    • 0037131264 scopus 로고    scopus 로고
    • Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
    • Yang F, Liu XB, Quinones M, Melby PC, Ghio A, Haile DJ. Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem. 2002;277:39786-39791.
    • (2002) J Biol Chem , vol.277 , pp. 39786-39791
    • Yang, F.1    Liu, X.B.2    Quinones, M.3    Melby, P.C.4    Ghio, A.5    Haile, D.J.6
  • 40
    • 20044366342 scopus 로고    scopus 로고
    • Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload
    • Montosi G, Corradini E, Garuti C, et al. Kupffer cells and macrophages are not required for hepatic hepcidin activation during iron overload. Hepatology. 2005;41:545-552.
    • (2005) Hepatology , vol.41 , pp. 545-552
    • Montosi, G.1    Corradini, E.2    Garuti, C.3
  • 41
    • 17844362181 scopus 로고    scopus 로고
    • Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo
    • Lou DQ, Lesbordes JC, Nicolas G, et al. Iron- and inflammation-induced hepcidin gene expression in mice is not mediated by Kupffer cells in vivo. Hepatology. 2005;41:1056-1064.
    • (2005) Hepatology , vol.41 , pp. 1056-1064
    • Lou, D.Q.1    Lesbordes, J.C.2    Nicolas, G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.