The hereditary hemochromatosis protein, HFE, inhibits iron uptake via down-regulation of Zip14 in HepG2 Cells

Journal of Biological Chemistry

Volumn 283, Issue 31, 2008, Pages 21462-21468

  Gao, Junwei ^a   Zhao, Ningning ^b   Knutson, Mitchell D ^b   Enns, Caroline A ^a,c  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

^c NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE;

CELL LINES; HEPATOCYTES; HEPG2 CELLS; HUMAN HEPATOMA CELL LINES; IN CELLS; IRON LOADINGS; IRON UPTAKES; METAL TRANSPORTERS; PROTEIN LEVELS;

CELL CULTURE;

HFE PROTEIN; IRON; MESSENGER RNA; PROTEIN; SMALL INTERFERING RNA; TETRACYCLINE; TRANSFERRIN; UNCLASSIFIED DRUG; ZRT AND IRT LIKE PROTEIN 14; CATION TRANSPORT PROTEIN; HFE PROTEIN, HUMAN; HLA ANTIGEN CLASS 1; MEMBRANE PROTEIN; SLC39A14 PROTEIN, HUMAN;

ARTICLE; CELL STRAIN HEPG2; CONCENTRATION (PARAMETERS); DOWN REGULATION; HALF LIFE TIME; HELA CELL; HUMAN; INHIBITION KINETICS; IRON TRANSPORT; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN METABOLISM; PROTEIN TRANSPORT; REGULATORY MECHANISM; CELL LINE; CHEMISTRY; GENE EXPRESSION REGULATION; HEMOCHROMATOSIS; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROMOTER REGION; TIME; TUMOR CELL LINE;

CATION TRANSPORT PROTEINS; CELL LINE; CELL LINE, TUMOR; DOWN-REGULATION; GENE EXPRESSION REGULATION; HELA CELLS; HEMOCHROMATOSIS; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; IRON; MEMBRANE PROTEINS; PROMOTER REGIONS (GENETICS); RNA, SMALL INTERFERING; TIME FACTORS; TRANSFERRIN;

EID: 52049125740     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803150200     Document Type: Article

References (41)

1. Ohgami, R. S., Campagna, D. R., Greer, E. L., Antiochos, B., McDonald, A., Chen, J., Sharp, J. J., Fujiwara, Y., Barker, J. E., and Fleming, M. D. (2005) Nat. Genet. 37, 1264-1269
2. Knutson, M. D. (2007) Nutr. Rev. 65, 335-340
3. Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., and Hediger, M. A. (1997) Nature 388, 482-488
4. Graham, R. M., Chua, A. C., Herbison, C. E., Olynyk, J. K., and Trinder, D. (2007) World J. Gastroenterol. 13, 4725-4736
5. Taylor, K. M., Morgan, H. E., Johnson, A., and Nicholson, R. I. (2005) FEBS Lett. 579, 427-432
6. Eide, D. J. (2004) Pflugers Arch. 447, 796-800
7. Liuzzi, J. P., Aydemir, F., Nam, H., Knutson, M. D., and Cousins, R. J. (2006) Proc. Natl. Acad. Sci. U. S. A. 103, 13612-13617
8. Sarkar, B. (1970) Can. J. Biochem. 48, 1339-1350
9. Chua, A. C., Olynyk, J. K., Leedman, P. J., and Trinder, D. (2004) Blood 104, 1519-1525
10. Fletcher, L. M., and Halliday, J. W. (2002) J. Intern. Med. 251, 181-192
11. Hentze, M. W., Muckenthaler, M. U., and Andrews, N. C. (2004) Cell 117, 285-297
12. Feder, J. N., Tsuchihashi, Z., Irrinki, A., Lee, V. K., Mapa, F. A., Morikang, E., Prass, C. E., Starnes, S. M., Wolff, R. K., Parkkila, S., Sly, W. S., and Schatzman, R. C. (1997) J. Biol. Chem. 272, 14025-14028
13. Zhou, X. Y., Tomatsu, S., Fleming, R. E., Parkkila, S., Waheed, A., Jiang, J., Fei, Y., Brunt, E. M., Ruddy, D. A., Prass, C. E., Schatzman, R. C., O'Neill, R., Britton, R. S., Bacon, B. R., and Sly, W. S. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2492-2497
14. Lebron, J. A., Bennett, M. J., Vaughn, D. E., Chirino, A. J., Snow, P. M., Mintier, G. A., Feder, J. N., and Bjorkman, P. J. (1998) Cell 93, 111-123
15. Feder, J. N., Penny, D. M., Irrinki, A., Lee, V. K., Lebron, J. A., Watson, N., Tsuchihashi, Z., Sigal, E., Bjorkman, P. J., and Schatzman, R. C. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 1472-1477
16. Giannetti, A. M., and Bjorkman, P. J. (2004) J. Biol. Chem. 279, 25866-25875
17. Andrews, N. C., and Schmidt, P. J. (2007) Annu. Rev. Physiol. 69, 69-85
18. Carlson, H., Zhang, A. S., Fleming, W. H., and Enns, C. A. (2005) Blood 105, 2564-2570
19. Gross, C. N., Irrinki, A., Feder, J. N., and Enns, C. A. (1998) J. Biol. Chem. 273, 22068-22074
20. Davies, P. S., and Enns, C. A. (2004) J. Biol. Chem. 279, 25085-25092
21. Roy, C. N., Penny, D. M., Feder, J. N., and Enns, C. A. (1999) J. Biol. Chem. 274, 9022-9028
22. Zhang, A. S., Xiong, S., Tsukamoto, H., and Enns, C. A. (2004) Blood 103, 1509-1514
23. Zhang, A. S., Anderson, S. A., Meyers, K. R., Hernandez, C., Eisenstein, R. S., and Enns, C. A. (2007) J. Biol. Chem. 282, 12547-12556
24. Laemmli, U. K. (1970) Nature 227, 680-685
25. Hentze, M. W., Caughman, S. W., Rouault, T. A., Barriocanal, J. G., Dancis, A., Harford, J. B., and Klausner, R. D. (1987) Science 238, 1570-1573
26. Leibold, E. A., and Munro, H. N. (1988) Proc. Natl. Acad. Sci. U. S. A. 85, 2171-2175
27. Haile, D. J., Rouault, T. A., Harford, J. B., Kennedy, M. C., Blondin, G. A., Beinert, H., and Klausner, R. D. (1992) Proc. Natl. Acad. Sci. U. S. A. 89, 11735-11739
28. Owen, D., and Kuhn, L. C. (1987) EMBO J. 6, 1287-1293
29. Schmidt, P. J., Toran, P. T., Giannetti, A. M., Bjorkman, P. J., and Andrews, N. C. (2008) Cell Metab. 7, 205-214
30. Vujic Spasic, M., Kiss, J., Herrmann, T., Galy, B., Martinache, S., Stolte, J., Grone, H. J., Stremmel, W., Hentze, M. W., and Muckenthaler, M. U. (2008) Cell Metab. 7, 173-178
31. Enns, C. A. (2006) Biol. Res. 39, 105-111
32. Bokhari, M., Carnachan, R. J., Cameron, N. R., and Przyborski, S. A. (2007) J. Anat. 211, 567-576
33. Gruenheid, S., Cellier, M., Vidal, S., and Gros, P. (1995) Genomics 25, 514-525
34. Liuzzi, J. P., Lichten, L. A., Rivera, S., Blanchard, R. K., Aydemir, T. B., Knutson, M. D., Ganz, T., and Cousins, R. J. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 6843-6848
35. Garrick, M. D., Kuo, H. C., Vargas, F., Singleton, S., Zhao, L., Smith, J. J., Paradkar, P., Roth, J. A., and Garrick, L. M. (2006) Biochem. J. 398, 539-546
36. Shindo, M., Torimoto, Y., Saito, H., Motomura, W., Ikuta, K., Sato, K., Fujimoto, Y., and Kohgo, Y. (2006) Hepatol. Res. 35, 152-162
37. Gouya, L., Muzeau, F., Robreau, A. M., Letteron, P., Couchi, E., Lyoumi, S., Deybach, J. C., Puy, H., Fleming, R., Demant, P., Beaumont, C., and Grandchamp, B. (2007) Gastroenterology 132, 679-686
38. Cruz, E., Melo, G., Lacerda, R., Almeida, S., and Porto, G. (2006) Blood Cells Mol. Dis. 37, 33-39
39. Jacolot, S., Le Gac, G., Scotet, V., Quere, I., Mura, C., and Ferec, C. (2004) Blood 103, 2835-2840
40. Gunshin, H., Fujiwara, Y., Custodio, A. O., Direnzo, C., Robine, S., and Andrews, N. C. (2005) J. Clin. Invest. 115, 1258-1266
41. Coppin, H., Darnaud, V., Kautz, L., Meynard, D., Aubry, M., Mosser, J., Martinez, M., and Roth, M. P. (2007) Genome Biol. 8, R221.1-R221.16