-
1
-
-
9344224529
-
A novel MHC class I - Like gene is mutated in patients with hereditary haemochromatosis
-
Feder JN, Gnirke A, Thomas W, et al. A novel MHC class I - like gene is mutated in patients with hereditary haemochromatosis. Nat Genet. 1996; 13:399-408.
-
(1996)
Nat Genet
, vol.13
, pp. 399-408
-
-
Feder, J.N.1
Gnirke, A.2
Thomas, W.3
-
2
-
-
0037164344
-
Genetics of haemochromatosis
-
Bomford A. Genetics of haemochromatosis. Lancet. 2002;360:1673-1681.
-
(2002)
Lancet
, vol.360
, pp. 1673-1681
-
-
Bomford, A.1
-
3
-
-
0037132786
-
Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA
-
Beutler E, Felitti VJ, Koziol JA, Ho NJ, Gelbart T. Penetrance of 845G → A (C282Y) HFE hereditary haemochromatosis mutation in the USA. Lancet. 2002;359:211-218.
-
(2002)
Lancet
, vol.359
, pp. 211-218
-
-
Beutler, E.1
Felitti, V.J.2
Koziol, J.A.3
Ho, N.J.4
Gelbart, T.5
-
4
-
-
9144252017
-
Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis
-
Papanikolaou G, Samuels ME, Ludwig EH, et al. Mutations in HFE2 cause iron overload in chromosome 1q-linked juvenile hemochromatosis. Nat Genet. 2004;36:77-82.
-
(2004)
Nat Genet
, vol.36
, pp. 77-82
-
-
Papanikolaou, G.1
Samuels, M.E.2
Ludwig, E.H.3
-
5
-
-
20244388240
-
Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
-
Roetto A, Papanikolaou G, Politou M, et al. Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet. 2003;33:21-22.
-
(2003)
Nat Genet
, vol.33
, pp. 21-22
-
-
Roetto, A.1
Papanikolaou, G.2
Politou, M.3
-
6
-
-
0034022636
-
The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22
-
Camaschella C, Roetto A, Cali A, et al. The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22. Nat Genet. 2000;25:14-15.
-
(2000)
Nat Genet
, vol.25
, pp. 14-15
-
-
Camaschella, C.1
Roetto, A.2
Cali, A.3
-
7
-
-
0033597780
-
Molecular cloning of transferrin receptor 2: A new member of the transferrin receptor-like family
-
Kawabata H, Yang R, Hirama T, et al. Molecular cloning of transferrin receptor 2: a new member of the transferrin receptor-like family. J Biol Chem. 1999;274:20826-20832.
-
(1999)
J Biol Chem
, vol.274
, pp. 20826-20832
-
-
Kawabata, H.1
Yang, R.2
Hirama, T.3
-
8
-
-
0034595856
-
Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo
-
Kawabata H, Germain RS, Vuong PT, Nakamaki T, Said JW, Koeffler HP. Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo. J Biol Chem. 2000;275: 16618-16625.
-
(2000)
J Biol Chem
, vol.275
, pp. 16618-16625
-
-
Kawabata, H.1
Germain, R.S.2
Vuong, P.T.3
Nakamaki, T.4
Said, J.W.5
Koeffler, H.P.6
-
9
-
-
0035525741
-
Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells
-
Kawabata H, Nakamaki T, Ikonomi P, Smith RD, Germain RS, Koeffler HP. Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells. Blood. 2001;98:2714-2719.
-
(2001)
Blood
, vol.98
, pp. 2714-2719
-
-
Kawabata, H.1
Nakamaki, T.2
Ikonomi, P.3
Smith, R.D.4
Germain, R.S.5
Koeffler, H.P.6
-
10
-
-
0036678091
-
Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis
-
Fleming RE, Ahmann JR, Migas MC, et al. Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis. Proc Natl Acad Sci U S A. 2002;99:10653-10658.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 10653-10658
-
-
Fleming, R.E.1
Ahmann, J.R.2
Migas, M.C.3
-
11
-
-
0017101039
-
Preparation of isolated rat liver cells
-
Seglen PO. Preparation of isolated rat liver cells. Methods Cell Biol. 1976;13:29-83.
-
(1976)
Methods Cell Biol
, vol.13
, pp. 29-83
-
-
Seglen, P.O.1
-
12
-
-
0031027611
-
Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines
-
Yang R, Morosetti R, Koeffler HP. Characterization of a second human cyclin A that is highly expressed in testis and in several leukemic cell lines. Cancer Res. 1997;57:913-920.
-
(1997)
Cancer Res
, vol.57
, pp. 913-920
-
-
Yang, R.1
Morosetti, R.2
Koeffler, H.P.3
-
13
-
-
0037126002
-
Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function
-
Hubert N, Hentze MW. Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: implications for regulation and cellular function. Proc Natl Acad Sci U S A. 2002;99: 12345-12350.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 12345-12350
-
-
Hubert, N.1
Hentze, M.W.2
-
14
-
-
0038460956
-
Duodenal expression of iron transport molecules in untreated haemochromatosis subjects
-
Stuart KA, Anderson GJ, Frazer DM, et al. Duodenal expression of iron transport molecules in untreated haemochromatosis subjects. Gut. 2003;52:953-959.
-
(2003)
Gut
, vol.52
, pp. 953-959
-
-
Stuart, K.A.1
Anderson, G.J.2
Frazer, D.M.3
-
15
-
-
0036566143
-
Expression of the two mRNA isoforms of the iron transporter Nrmap2/DMTI in mice and function of the iron responsive element
-
Tchernitchko D, Bourgeois M, Martin ME, Beaumont C. Expression of the two mRNA isoforms of the iron transporter Nrmap2/DMTI in mice and function of the iron responsive element. Biochem J. 2002;363:449-455.
-
(2002)
Biochem J
, vol.363
, pp. 449-455
-
-
Tchernitchko, D.1
Bourgeois, M.2
Martin, M.E.3
Beaumont, C.4
-
16
-
-
0041672570
-
Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
-
Ganz T. Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood. 2003;102:783-788.
-
(2003)
Blood
, vol.102
, pp. 783-788
-
-
Ganz, T.1
-
17
-
-
0035896581
-
A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload
-
Pigeon C, Ilyin G, Courselaud B, et al A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. J Biol Chem. 2001;276:7811-7819.
-
(2001)
J Biol Chem
, vol.276
, pp. 7811-7819
-
-
Pigeon, C.1
Ilyin, G.2
Courselaud, B.3
-
18
-
-
0036727925
-
Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats
-
Frazer DM, Wilkins SJ, Becker EM, et al. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology. 2002;123: 835-844.
-
(2002)
Gastroenterology
, vol.123
, pp. 835-844
-
-
Frazer, D.M.1
Wilkins, S.J.2
Becker, E.M.3
-
19
-
-
0037847496
-
Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis
-
Nicolas G, Viatte L, Lou DQ, et al. Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. Nat Genet. 2003;34:97-101.
-
(2003)
Nat Genet
, vol.34
, pp. 97-101
-
-
Nicolas, G.1
Viatte, L.2
Lou, D.Q.3
-
20
-
-
0037111732
-
Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
-
Weinstein DA, Roy CN, Fleming MD, Loda MF, Wolfsdorf JI, Andrews NC. Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood. 2002;100:3776-3781.
-
(2002)
Blood
, vol.100
, pp. 3776-3781
-
-
Weinstein, D.A.1
Roy, C.N.2
Fleming, M.D.3
Loda, M.F.4
Wolfsdorf, J.I.5
Andrews, N.C.6
-
21
-
-
1342322891
-
Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat
-
Yeh KY, Yeh M, Glass J. Hepcidin regulation of ferroportin 1 expression in the liver and intestine of the rat. Am J Physiol Gastrointest Liver Physiol. 2004;286:G385-G394.
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
-
-
Yeh, K.Y.1
Yeh, M.2
Glass, J.3
-
22
-
-
0038662619
-
Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
-
Nemeth E, Valore EV, Territo M, Schiller G, Lichtenstein A, Ganz T. Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood. 2003;101:2461-2463.
-
(2003)
Blood
, vol.101
, pp. 2461-2463
-
-
Nemeth, E.1
Valore, E.V.2
Territo, M.3
Schiller, G.4
Lichtenstein, A.5
Ganz, T.6
-
23
-
-
0037509928
-
Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis
-
Muckenthaler M, Roy CN, Custodio AO, et al. Regulatory defects in liver and intestine implicate abnormal hepcidin and Cybrd1 expression in mouse hemochromatosis. Nat Genet. 2003;34: 102-107.
-
(2003)
Nat Genet
, vol.34
, pp. 102-107
-
-
Muckenthaler, M.1
Roy, C.N.2
Custodio, A.O.3
-
24
-
-
0037460697
-
Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis
-
Bridle KR, Frazer DM, Wilkins SJ, et al. Disrupted hepcidin regulation in HFE-associated haemochromatosis and the liver as a regulator of body iron homeostasis. Lancet. 2003;361:669-673.
-
(2003)
Lancet
, vol.361
, pp. 669-673
-
-
Bridle, K.R.1
Frazer, D.M.2
Wilkins, S.J.3
-
25
-
-
0035902605
-
Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
-
Nicolas G, Bennoun M, Devaux I, et al. Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci U S A. 2001; 98:8780-8785.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 8780-8785
-
-
Nicolas, G.1
Bennoun, M.2
Devaux, I.3
-
26
-
-
2342510407
-
IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin
-
Nemeth E, Rivera S, Gabayan V, et al. IL-6 mediates hypoferremia of inflammation by inducing the synthesis of the iron regulatory hormone hepcidin. J Clin Invest. 2004;113:1271-1276.
-
(2004)
J Clin Invest
, vol.113
, pp. 1271-1276
-
-
Nemeth, E.1
Rivera, S.2
Gabayan, V.3
-
27
-
-
0035896642
-
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
-
Park CH, Valore EV, Waring AJ, Ganz T. Hepcidin, a urinary antimicrobial peptide synthesized in the liver. J Biol Chem. 2001;276:7806-7810.
-
(2001)
J Biol Chem
, vol.276
, pp. 7806-7810
-
-
Park, C.H.1
Valore, E.V.2
Waring, A.J.3
Ganz, T.4
-
28
-
-
0034007995
-
Transferrin receptor 2: Continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis
-
Fleming RE, Migas MC, Holden CC, et al. Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci U S A. 2000;97:2214-2219.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 2214-2219
-
-
Fleming, R.E.1
Migas, M.C.2
Holden, C.C.3
-
29
-
-
0035885970
-
Regulation of expression of murine transferrin receptor 2
-
Kawabata H, Germain RS, Ikezoe T, et al. Regulation of expression of murine transferrin receptor 2. Blood. 2001;98:1949-1954.
-
(2001)
Blood
, vol.98
, pp. 1949-1954
-
-
Kawabata, H.1
Germain, R.S.2
Ikezoe, T.3
-
30
-
-
0037564038
-
Expression of hepcidin in hereditary hemochromatosis: Evidence for a regulation in response to serum transferrin saturation and non-transferrin-bound iron
-
Gehrke SG, Kulaksiz H, Herrmann T, et al. Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to serum transferrin saturation and non-transferrin-bound iron. Blood. 2003;102:371-376.
-
(2003)
Blood
, vol.102
, pp. 371-376
-
-
Gehrke, S.G.1
Kulaksiz, H.2
Herrmann, T.3
-
31
-
-
0037111572
-
Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum
-
Deaglio S, Capobianco A, Cali A, et al. Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood. 2002;100:3782-3789.
-
(2002)
Blood
, vol.100
, pp. 3782-3789
-
-
Deaglio, S.1
Capobianco, A.2
Cali, A.3
-
32
-
-
0031915456
-
Epidermal growth factor upregulates the expression of its own intestinal receptor after small bowel resection
-
Helmrath MA, Shin CE, Erwin CR, Warner BW. Epidermal growth factor upregulates the expression of its own intestinal receptor after small bowel resection. J Pediatr Surg. 1998;33:229-234.
-
(1998)
J Pediatr Surg
, vol.33
, pp. 229-234
-
-
Helmrath, M.A.1
Shin, C.E.2
Erwin, C.R.3
Warner, B.W.4
-
33
-
-
0032007185
-
Erythropoietin upregulates the expression of its own receptor in TF-1 cell line
-
Grossi A, Vannucchi AM, Bacci P, et al. Erythropoietin upregulates the expression of its own receptor in TF-1 cell line. Leuk Res. 1998;22:145-151.
-
(1998)
Leuk Res
, vol.22
, pp. 145-151
-
-
Grossi, A.1
Vannucchi, A.M.2
Bacci, P.3
-
34
-
-
0028047591
-
Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells
-
Steinman RA, Tweardy DJ. Granulocyte colony-stimulating factor receptor mRNA upregulation is an immediate early marker of myeloid differentiation and exhibits dysfunctional regulation in leukemic cells. Blood. 1994;83:119-127.
-
(1994)
Blood
, vol.83
, pp. 119-127
-
-
Steinman, R.A.1
Tweardy, D.J.2
-
35
-
-
3042636759
-
The IL-6- and lipopolysaccharide-induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta2-microglobulin-deficient hepatocytes
-
Lee P, Peng H, Gelbart T, Beutler E. The IL-6- and lipopolysaccharide- induced transcription of hepcidin in HFE-, transferrin receptor 2-, and beta2-microglobulin-deficient hepatocytes. Proc Natl Acad Sci U S A. 2004;101:9263-9265.
-
(2004)
Proc Natl Acad Sci U S A
, vol.101
, pp. 9263-9265
-
-
Lee, P.1
Peng, H.2
Gelbart, T.3
Beutler, E.4
-
36
-
-
4644320292
-
Inhibition of iron transport across human intestinal epithelial cells by hepcidin
-
Yamaji S, Sharp P, Ramesh B, Srai SK. Inhibition of iron transport across human intestinal epithelial cells by hepcidin. Blood. 2004;104:2178-2180.
-
(2004)
Blood
, vol.104
, pp. 2178-2180
-
-
Yamaji, S.1
Sharp, P.2
Ramesh, B.3
Srai, S.K.4
-
37
-
-
0037117603
-
Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse
-
Trinder D, Olynyk JK, Sly WS, Morgan EH. Iron uptake from plasma transferrin by the duodenum is impaired in the Hfe knockout mouse. Proc Natl Acad Sci U S A. 2002;99:5622-5626.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 5622-5626
-
-
Trinder, D.1
Olynyk, J.K.2
Sly, W.S.3
Morgan, E.H.4
-
38
-
-
0034623930
-
Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE
-
West AP Jr, Bennett MJ, Sellers VM, Andrews NC, Enns CA, Bjorkman PJ. Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE. J Biol Chem. 2000;275:38135-38138.
-
(2000)
J Biol Chem
, vol.275
, pp. 38135-38138
-
-
West Jr., A.P.1
Bennett, M.J.2
Sellers, V.M.3
Andrews, N.C.4
Enns, C.A.5
Bjorkman, P.J.6
-
39
-
-
0037406254
-
Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells
-
Griffiths WJ, Cox TM. Co-localization of the mammalian hemochromatosis gene product (HFE) and a newly identified transferrin receptor (TfR2) in intestinal tissue and cells. J Histochem Cytochem. 2003;51:613-624.
-
(2003)
J Histochem Cytochem
, vol.51
, pp. 613-624
-
-
Griffiths, W.J.1
Cox, T.M.2
|