메뉴 건너뛰기




Volumn 44, Issue 1-2, 2009, Pages 75-82

Cell intrinsic and extrinsic mechanisms of stem cell aging depend on telomere status

Author keywords

Aging; Stem cell; Telomere

Indexed keywords

TELOMERASE;

EID: 57349198857     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.exger.2008.06.009     Document Type: Review
Times cited : (27)

References (134)
  • 2
    • 0037480961 scopus 로고    scopus 로고
    • Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation
    • Allsopp R.C., Morin G.B., DePinho R., Harley C.B., and Weissman I.L. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 102 (2003) 517-520
    • (2003) Blood , vol.102 , pp. 517-520
    • Allsopp, R.C.1    Morin, G.B.2    DePinho, R.3    Harley, C.B.4    Weissman, I.L.5
  • 3
    • 0034958793 scopus 로고    scopus 로고
    • Exo1-dependent mutator mutations: model system for studying functional interactions in mismatch repair
    • Amin N.S., Nguyen M.N., Oh S., and Kolodner R.D. Exo1-dependent mutator mutations: model system for studying functional interactions in mismatch repair. Mol. Cell. Biol. 21 (2001) 5142-5155
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5142-5155
    • Amin, N.S.1    Nguyen, M.N.2    Oh, S.3    Kolodner, R.D.4
  • 5
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi S.E., Chang S., Lee S.L., Alson S., Gottlieb G.J., Chin L., and DePinho R.A. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406 (2000) 641-645
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1    Chang, S.2    Lee, S.L.3    Alson, S.4    Gottlieb, G.J.5    Chin, L.6    DePinho, R.A.7
  • 6
    • 57349094727 scopus 로고    scopus 로고
    • Telomerase as a potential regulator of tissue progenitor cells
    • Rudolph K.L. (Ed), Springer Publishing
    • Artandi S.E. Telomerase as a potential regulator of tissue progenitor cells. In: Rudolph K.L. (Ed). Telomeres and Telomerase in Agieng, Disease, and cancer (2008), Springer Publishing 203-210
    • (2008) Telomeres and Telomerase in Agieng, Disease, and cancer , pp. 203-210
    • Artandi, S.E.1
  • 8
    • 3142616982 scopus 로고    scopus 로고
    • Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice
    • Bagley J., Cortes M.L., Breakefield X.O., and Iacomini J. Bone marrow transplantation restores immune system function and prevents lymphoma in Atm-deficient mice. Blood 104 (2004) 572-578
    • (2004) Blood , vol.104 , pp. 572-578
    • Bagley, J.1    Cortes, M.L.2    Breakefield, X.O.3    Iacomini, J.4
  • 11
    • 1842420441 scopus 로고    scopus 로고
    • Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature
    • Beghe C., Wilson A., and Ershler W.B. Prevalence and outcomes of anemia in geriatrics: a systematic review of the literature. Am. J. Med. 116 Suppl. 7A (2004) 3S-10S
    • (2004) Am. J. Med. , vol.116 , Issue.SUPPL. 7A
    • Beghe, C.1    Wilson, A.2    Ershler, W.B.3
  • 12
    • 2442520305 scopus 로고    scopus 로고
    • EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae
    • Bertuch A.A., and Lundblad V. EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. Genetics 166 (2004) 1651-1659
    • (2004) Genetics , vol.166 , pp. 1651-1659
    • Bertuch, A.A.1    Lundblad, V.2
  • 13
    • 4143075951 scopus 로고    scopus 로고
    • Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance
    • Bi X., Wei S.C., and Rong Y.S. Telomere protection without a telomerase; the role of ATM and Mre11 in Drosophila telomere maintenance. Curr. Biol. 14 (2004) 1348-1353
    • (2004) Curr. Biol. , vol.14 , pp. 1348-1353
    • Bi, X.1    Wei, S.C.2    Rong, Y.S.3
  • 14
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 17
    • 34848836428 scopus 로고    scopus 로고
    • Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis
    • Boyle M., Wong C., Rocha M., and Jones D.L. Decline in self-renewal factors contributes to aging of the stem cell niche in the Drosophila testis. Cell. Stem Cell 1 (2007) 470-478
    • (2007) Cell. Stem Cell , vol.1 , pp. 470-478
    • Boyle, M.1    Wong, C.2    Rocha, M.3    Jones, D.L.4
  • 18
    • 36248973631 scopus 로고    scopus 로고
    • Intrinsic changes and extrinsic influences of myogenic stem cell function during aging
    • Brack A.S., and Rando T.A. Intrinsic changes and extrinsic influences of myogenic stem cell function during aging. Stem Cell Rev. 3 (2007) 226-237
    • (2007) Stem Cell Rev. , vol.3 , pp. 226-237
    • Brack, A.S.1    Rando, T.A.2
  • 19
    • 0029066169 scopus 로고
    • Telomerase activity in normal and malignant hematopoietic cells
    • Broccoli D., Young J.W., and de Lange T. Telomerase activity in normal and malignant hematopoietic cells. Proc. Natl. Acad. Sci. USA 92 (1995) 9082-9086
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9082-9086
    • Broccoli, D.1    Young, J.W.2    de Lange, T.3
  • 20
    • 0030609861 scopus 로고    scopus 로고
    • Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts
    • Brown J.P., Wei W., and Sedivy J.M. Bypass of senescence after disruption of p21CIP1/WAF1 gene in normal diploid human fibroblasts. Science 277 (1997) 831-834
    • (1997) Science , vol.277 , pp. 831-834
    • Brown, J.P.1    Wei, W.2    Sedivy, J.M.3
  • 22
    • 0037085746 scopus 로고    scopus 로고
    • Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program
    • Castro-Malaspina H., Harris R.E., Gajewski J., Ramsay N., Collins R., Dharan B., King R., and Deeg H.J. Unrelated donor marrow transplantation for myelodysplastic syndromes: outcome analysis in 510 transplants facilitated by the National Marrow Donor Program. Blood 99 (2002) 1943-1951
    • (2002) Blood , vol.99 , pp. 1943-1951
    • Castro-Malaspina, H.1    Harris, R.E.2    Gajewski, J.3    Ramsay, N.4    Collins, R.5    Dharan, B.6    King, R.7    Deeg, H.J.8
  • 23
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length in blood and mortality in people aged 60 years or older
    • Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., and Kerber R.A. Association between telomere length in blood and mortality in people aged 60 years or older. Lancet 361 (2003) 393-395
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 28
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • Chin L., Artandi S.E., Shen Q., Tam A., Lee S.L., Gottlieb G.J., Greider C.W., and DePinho R.A. p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis. Cell 97 (1999) 527-538
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1    Artandi, S.E.2    Shen, Q.3    Tam, A.4    Lee, S.L.5    Gottlieb, G.J.6    Greider, C.W.7    DePinho, R.A.8
  • 31
    • 34147173390 scopus 로고    scopus 로고
    • A population of myogenic stem cells that survives skeletal muscle aging
    • Collins C.A., Zammit P.S., Ruiz A.P., Morgan J.E., and Partridge T.A. A population of myogenic stem cells that survives skeletal muscle aging. Stem Cells 25 (2007) 885-894
    • (2007) Stem Cells , vol.25 , pp. 885-894
    • Collins, C.A.1    Zammit, P.S.2    Ruiz, A.P.3    Morgan, J.E.4    Partridge, T.A.5
  • 32
    • 13944261231 scopus 로고    scopus 로고
    • Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    • Conboy I.M., Conboy M.J., Wagers A.J., Girma E.R., Weissman I.L., and Rando T.A. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433 (2005) 760-764
    • (2005) Nature , vol.433 , pp. 760-764
    • Conboy, I.M.1    Conboy, M.J.2    Wagers, A.J.3    Girma, E.R.4    Weissman, I.L.5    Rando, T.A.6
  • 34
    • 24944460598 scopus 로고    scopus 로고
    • Shelterin: the protein complex that shapes and safeguards human telomeres
    • de Lange T. Shelterin: the protein complex that shapes and safeguards human telomeres. Genes Dev. 19 (2005) 2100-2110
    • (2005) Genes Dev. , vol.19 , pp. 2100-2110
    • de Lange, T.1
  • 37
    • 0036260527 scopus 로고    scopus 로고
    • Does p53 affect organismal aging?
    • Donehower L.A. Does p53 affect organismal aging?. J. Cell Physiol. 192 (2002) 23-33
    • (2002) J. Cell Physiol. , vol.192 , pp. 23-33
    • Donehower, L.A.1
  • 40
    • 0142123580 scopus 로고    scopus 로고
    • Late degeneration of nigro-striatal neurons in ATM-/- mice
    • Eilam R., Peter Y., Groner Y., and Segal M. Late degeneration of nigro-striatal neurons in ATM-/- mice. Neuroscience 121 (2003) 83-98
    • (2003) Neuroscience , vol.121 , pp. 83-98
    • Eilam, R.1    Peter, Y.2    Groner, Y.3    Segal, M.4
  • 43
    • 3342929538 scopus 로고    scopus 로고
    • DNA damage checkpoint kinase Chk2 triggers replicative senescence
    • Gire V., Roux P., Wynford-Thomas D., Brondello J.M., and Dulic V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J. 23 (2004) 2554-2563
    • (2004) EMBO J. , vol.23 , pp. 2554-2563
    • Gire, V.1    Roux, P.2    Wynford-Thomas, D.3    Brondello, J.M.4    Dulic, V.5
  • 44
    • 33845239216 scopus 로고    scopus 로고
    • Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    • Gray D.H., Seach N., Ueno T., Milton M.K., Liston A., Lew A.M., Goodnow C.C., and Boyd R.L. Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood 108 (2006) 3777-3785
    • (2006) Blood , vol.108 , pp. 3777-3785
    • Gray, D.H.1    Seach, N.2    Ueno, T.3    Milton, M.K.4    Liston, A.5    Lew, A.M.6    Goodnow, C.C.7    Boyd, R.L.8
  • 45
    • 0242721689 scopus 로고    scopus 로고
    • End resection initiates genomic instability in the absence of telomerase
    • Hackett J.A., and Greider C.W. End resection initiates genomic instability in the absence of telomerase. Mol. Cell. Biol. 23 (2003) 8450-8461
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8450-8461
    • Hackett, J.A.1    Greider, C.W.2
  • 46
    • 28944455294 scopus 로고    scopus 로고
    • Short telomeres, even in the presence of telomerase, limit tissue renewal capacity
    • Hao L.Y., Armanios M., Strong M.A., Karim B., Feldser D.M., Huso D., and Greider C.W. Short telomeres, even in the presence of telomerase, limit tissue renewal capacity. Cell 123 (2005) 1121-1131
    • (2005) Cell , vol.123 , pp. 1121-1131
    • Hao, L.Y.1    Armanios, M.2    Strong, M.A.3    Karim, B.4    Feldser, D.M.5    Huso, D.6    Greider, C.W.7
  • 47
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell. Res. 37 (1965) 614-636
    • (1965) Exp. Cell. Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 48
    • 3142521394 scopus 로고    scopus 로고
    • Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice
    • Henckaerts E., Langer J.C., and Snoeck H.W. Quantitative genetic variation in the hematopoietic stem cell and progenitor cell compartment and in lifespan are closely linked at multiple loci in BXD recombinant inbred mice. Blood 104 (2004) 374-379
    • (2004) Blood , vol.104 , pp. 374-379
    • Henckaerts, E.1    Langer, J.C.2    Snoeck, H.W.3
  • 49
    • 24944532151 scopus 로고    scopus 로고
    • Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation
    • Hishiya A., Ito M., Aburatani H., Motoyama N., Ikeda K., and Watanabe K. Ataxia telangiectasia mutated (Atm) knockout mice as a model of osteopenia due to impaired bone formation. Bone 37 (2005) 497-503
    • (2005) Bone , vol.37 , pp. 497-503
    • Hishiya, A.1    Ito, M.2    Aburatani, H.3    Motoyama, N.4    Ikeda, K.5    Watanabe, K.6
  • 51
    • 5144231886 scopus 로고    scopus 로고
    • Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation
    • Hong Y., and Stambrook P.J. Restoration of an absent G1 arrest and protection from apoptosis in embryonic stem cells after ionizing radiation. Proc. Natl. Acad. Sci. USA 101 (2004) 14443-14448
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 14443-14448
    • Hong, Y.1    Stambrook, P.J.2
  • 52
    • 34547194433 scopus 로고    scopus 로고
    • Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells
    • Hosen N., Yamane T., Muijtjens M., Pham K., Clarke M.F., and Weissman I.L. Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells 25 (2007) 1635-1644
    • (2007) Stem Cells , vol.25 , pp. 1635-1644
    • Hosen, N.1    Yamane, T.2    Muijtjens, M.3    Pham, K.4    Clarke, M.F.5    Weissman, I.L.6
  • 57
    • 57349097147 scopus 로고    scopus 로고
    • Jiang, H., Schiffer, E., Song, Z., Wang, J., Zürbig, P., Thedieck, K., Moes, S., Bantel, H., Saal, N., Jantos, J., Brecht, M., Jenö, P., Hall, MN., Hager, K., Manns, M.P., Hecker, H., Ganser, A., Doehner, K., Bartke, A., Meissner, C., Mischak, H., Ju, Z., Rudolph, K.L., in press. Proteins induced by telomere dysfunction and DNA damage represent bio-markers of human aging and disease. PNAS.
    • Jiang, H., Schiffer, E., Song, Z., Wang, J., Zürbig, P., Thedieck, K., Moes, S., Bantel, H., Saal, N., Jantos, J., Brecht, M., Jenö, P., Hall, MN., Hager, K., Manns, M.P., Hecker, H., Ganser, A., Doehner, K., Bartke, A., Meissner, C., Mischak, H., Ju, Z., Rudolph, K.L., in press. Proteins induced by telomere dysfunction and DNA damage represent bio-markers of human aging and disease. PNAS.
  • 58
    • 34250017413 scopus 로고    scopus 로고
    • Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment
    • Ju Z., Jiang H., Jaworski M., Rathinam C., Gompf A., Klein C., Trumpp A., and Rudolph K.L. Telomere dysfunction induces environmental alterations limiting hematopoietic stem cell function and engraftment. Nat. Med. 13 (2007) 742-747
    • (2007) Nat. Med. , vol.13 , pp. 742-747
    • Ju, Z.1    Jiang, H.2    Jaworski, M.3    Rathinam, C.4    Gompf, A.5    Klein, C.6    Trumpp, A.7    Rudolph, K.L.8
  • 60
    • 36749006617 scopus 로고    scopus 로고
    • Telomere dysfunction and stem cell ageing
    • Ju Z., and Rudolph L. Telomere dysfunction and stem cell ageing. Biochimie 90 (2008) 24-32
    • (2008) Biochimie , vol.90 , pp. 24-32
    • Ju, Z.1    Rudolph, L.2
  • 61
    • 33644521267 scopus 로고    scopus 로고
    • Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome
    • Kantarjian H., O'Brien S., Cortes J., Giles F., Faderl S., Jabbour E., Garcia-Manero G., Wierda W., Pierce S., Shan J., and Estey E. Results of intensive chemotherapy in 998 patients age 65 years or older with acute myeloid leukemia or high-risk myelodysplastic syndrome: predictive prognostic models for outcome. Cancer 106 (2006) 1090-1098
    • (2006) Cancer , vol.106 , pp. 1090-1098
    • Kantarjian, H.1    O'Brien, S.2    Cortes, J.3    Giles, F.4    Faderl, S.5    Jabbour, E.6    Garcia-Manero, G.7    Wierda, W.8    Pierce, S.9    Shan, J.10    Estey, E.11
  • 62
    • 0036325981 scopus 로고    scopus 로고
    • Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment
    • Kempermann G., Gast D., and Gage F.H. Neuroplasticity in old age: sustained fivefold induction of hippocampal neurogenesis by long-term environmental enrichment. Ann. Neurol. 52 (2002) 135-143
    • (2002) Ann. Neurol. , vol.52 , pp. 135-143
    • Kempermann, G.1    Gast, D.2    Gage, F.H.3
  • 63
    • 34247225987 scopus 로고    scopus 로고
    • Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse
    • Khoo C.M., Carrasco D.R., Bosenberg M.W., Paik J.H., and Depinho R.A. Ink4a/Arf tumor suppressor does not modulate the degenerative conditions or tumor spectrum of the telomerase-deficient mouse. Proc. Natl. Acad. Sci. USA 104 (2007) 3931-3936
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 3931-3936
    • Khoo, C.M.1    Carrasco, D.R.2    Bosenberg, M.W.3    Paik, J.H.4    Depinho, R.A.5
  • 64
    • 0038806560 scopus 로고    scopus 로고
    • Major age-related changes of mouse hematopoietic stem/progenitor cells
    • Kim M., Moon H.B., and Spangrude G.J. Major age-related changes of mouse hematopoietic stem/progenitor cells. Ann. N.Y. Acad. Sci. 996 (2003) 195-208
    • (2003) Ann. N.Y. Acad. Sci. , vol.996 , pp. 195-208
    • Kim, M.1    Moon, H.B.2    Spangrude, G.J.3
  • 65
    • 15444377643 scopus 로고    scopus 로고
    • p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity
    • Kippin T.E., Martens D.J., and van der Kooy D. p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity. Genes Dev. 19 (2005) 756-767
    • (2005) Genes Dev. , vol.19 , pp. 756-767
    • Kippin, T.E.1    Martens, D.J.2    van der Kooy, D.3
  • 66
    • 0035496909 scopus 로고    scopus 로고
    • Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age
    • Kollman C., Howe C.W., Anasetti C., Antin J.H., Davies S.M., Filipovich A.H., Hegland J., Kamani N., Kernan N.A., King R., et al. Donor characteristics as risk factors in recipients after transplantation of bone marrow from unrelated donors: the effect of donor age. Blood 98 (2001) 2043-2051
    • (2001) Blood , vol.98 , pp. 2043-2051
    • Kollman, C.1    Howe, C.W.2    Anasetti, C.3    Antin, J.H.4    Davies, S.M.5    Filipovich, A.H.6    Hegland, J.7    Kamani, N.8    Kernan, N.A.9    King, R.10
  • 68
    • 4344599559 scopus 로고    scopus 로고
    • Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice
    • Labrie III J.E., Sah A.P., Allman D.M., Cancro M.P., and Gerstein R.M. Bone marrow microenvironmental changes underlie reduced RAG-mediated recombination and B cell generation in aged mice. J. Exp. Med. 200 (2004) 411-423
    • (2004) J. Exp. Med. , vol.200 , pp. 411-423
    • Labrie III, J.E.1    Sah, A.P.2    Allman, D.M.3    Cancro, M.P.4    Gerstein, R.M.5
  • 69
    • 39149137857 scopus 로고    scopus 로고
    • Stem cell trafficking in tissue development, growth, and disease
    • Laird D.J., von Andrian U.H., and Wagers A.J. Stem cell trafficking in tissue development, growth, and disease. Cell 132 (2008) 612-630
    • (2008) Cell , vol.132 , pp. 612-630
    • Laird, D.J.1    von Andrian, U.H.2    Wagers, A.J.3
  • 72
    • 23744439044 scopus 로고    scopus 로고
    • Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells
    • Liang Y., Van Zant G., and Szilvassy S.J. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 106 (2005) 1479-1487
    • (2005) Blood , vol.106 , pp. 1479-1487
    • Liang, Y.1    Van Zant, G.2    Szilvassy, S.J.3
  • 73
    • 0029945231 scopus 로고    scopus 로고
    • Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations
    • Liu P.K., Kraus E., Wu T.A., Strong L.C., and Tainsky M.A. Analysis of genomic instability in Li-Fraumeni fibroblasts with germline p53 mutations. Oncogene 12 (1996) 2267-2278
    • (1996) Oncogene , vol.12 , pp. 2267-2278
    • Liu, P.K.1    Kraus, E.2    Wu, T.A.3    Strong, L.C.4    Tainsky, M.A.5
  • 75
    • 23844527874 scopus 로고    scopus 로고
    • What the physician needs to know about Lynch syndrome: an update
    • Lynch H.T., and Lynch J.F. What the physician needs to know about Lynch syndrome: an update. Oncology 19 (2005) 455-463; discussion 463-454, 466, 469
    • (2005) Oncology , vol.19
    • Lynch, H.T.1    Lynch, J.F.2
  • 76
    • 0031466825 scopus 로고    scopus 로고
    • Thymic aging and T-cell regeneration
    • Mackall C.L., and Gress R.E. Thymic aging and T-cell regeneration. Immunol. Rev. 160 (1997) 91-102
    • (1997) Immunol. Rev. , vol.160 , pp. 91-102
    • Mackall, C.L.1    Gress, R.E.2
  • 77
    • 7544247595 scopus 로고    scopus 로고
    • Telomerase- and recombination-independent immortalization of budding yeast
    • Maringele L., and Lydall D. Telomerase- and recombination-independent immortalization of budding yeast. Genes Dev. 18 (2004) 2663-2675
    • (2004) Genes Dev. , vol.18 , pp. 2663-2675
    • Maringele, L.1    Lydall, D.2
  • 78
    • 0031715965 scopus 로고    scopus 로고
    • Altered stem cell regeneration in irradiated intestinal crypts of senescent mice
    • Martin K., Potten C.S., Roberts S.A., and Kirkwood T.B. Altered stem cell regeneration in irradiated intestinal crypts of senescent mice. J. Cell Sci. 111 Pt. 16 (1998) 2297-2303
    • (1998) J. Cell Sci. , vol.111 , Issue.PART 16 , pp. 2297-2303
    • Martin, K.1    Potten, C.S.2    Roberts, S.A.3    Kirkwood, T.B.4
  • 81
    • 0028047723 scopus 로고
    • The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice
    • Merritt A.J., Potten C.S., Kemp C.J., Hickman J.A., Balmain A., Lane D.P., and Hall P.A. The role of p53 in spontaneous and radiation-induced apoptosis in the gastrointestinal tract of normal and p53-deficient mice. Cancer Res. 54 (1994) 614-617
    • (1994) Cancer Res. , vol.54 , pp. 614-617
    • Merritt, A.J.1    Potten, C.S.2    Kemp, C.J.3    Hickman, J.A.4    Balmain, A.5    Lane, D.P.6    Hall, P.A.7
  • 82
    • 2942700206 scopus 로고    scopus 로고
    • Reduction in the developmental potential of intrathymic T cell progenitors with age
    • Min H., Montecino-Rodriguez E., and Dorshkind K. Reduction in the developmental potential of intrathymic T cell progenitors with age. J. Immunol. 173 (2004) 245-250
    • (2004) J. Immunol. , vol.173 , pp. 245-250
    • Min, H.1    Montecino-Rodriguez, E.2    Dorshkind, K.3
  • 85
    • 13244287677 scopus 로고    scopus 로고
    • Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche
    • Nishimura E.K., Granter S.R., and Fisher D.E. Mechanisms of hair graying: incomplete melanocyte stem cell maintenance in the niche. Science 307 (2005) 720-724
    • (2005) Science , vol.307 , pp. 720-724
    • Nishimura, E.K.1    Granter, S.R.2    Fisher, D.E.3
  • 86
    • 34848891273 scopus 로고    scopus 로고
    • Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary
    • Pan L., Chen S., Weng C., Call G., Zhu D., Tang H., Zhang N., and Xie T. Stem cell aging is controlled both intrinsically and extrinsically in the Drosophila ovary. Cell. Stem Cell 1 (2007) 458-469
    • (2007) Cell. Stem Cell , vol.1 , pp. 458-469
    • Pan, L.1    Chen, S.2    Weng, C.3    Call, G.4    Zhu, D.5    Tang, H.6    Zhang, N.7    Xie, T.8
  • 87
    • 39549096892 scopus 로고    scopus 로고
    • p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus
    • Pechnick R.N., Zonis S., Wawrowsky K., Pourmorady J., and Chesnokova V. p21Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus. Proc. Natl. Acad. Sci. USA 105 (2008) 1358-1363
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 1358-1363
    • Pechnick, R.N.1    Zonis, S.2    Wawrowsky, K.3    Pourmorady, J.4    Chesnokova, V.5
  • 88
    • 0035794540 scopus 로고    scopus 로고
    • Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice
    • Peter Y., Rotman G., Lotem J., Elson A., Shiloh Y., and Groner Y. Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice. EMBO J. 20 (2001) 1538-1546
    • (2001) EMBO J. , vol.20 , pp. 1538-1546
    • Peter, Y.1    Rotman, G.2    Lotem, J.3    Elson, A.4    Shiloh, Y.5    Groner, Y.6
  • 89
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse K.R., and Greider C.W. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc. Natl. Acad. Sci. USA 92 (1995) 4818-4822
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 91
    • 33745618456 scopus 로고    scopus 로고
    • Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis
    • Rasheed N., Wang X., Niu Q.T., Yeh J., and Li B. Atm-deficient mice: an osteoporosis model with defective osteoblast differentiation and increased osteoclastogenesis. Hum. Mol. Genet. 15 (2006) 1938-1948
    • (2006) Hum. Mol. Genet. , vol.15 , pp. 1938-1948
    • Rasheed, N.1    Wang, X.2    Niu, Q.T.3    Yeh, J.4    Li, B.5
  • 92
    • 0041440074 scopus 로고    scopus 로고
    • Repopulating defect of mismatch repair-deficient hematopoietic stem cells
    • Reese J.S., Liu L., and Gerson S.L. Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood 102 (2003) 1626-1633
    • (2003) Blood , vol.102 , pp. 1626-1633
    • Reese, J.S.1    Liu, L.2    Gerson, S.L.3
  • 95
    • 33747595402 scopus 로고    scopus 로고
    • Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal
    • Ryu B.Y., Orwig K.E., Oatley J.M., Avarbock M.R., and Brinster R.L. Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Stem Cells 24 (2006) 1505-1511
    • (2006) Stem Cells , vol.24 , pp. 1505-1511
    • Ryu, B.Y.1    Orwig, K.E.2    Oatley, J.M.3    Avarbock, M.R.4    Brinster, R.L.5
  • 100
    • 15944368044 scopus 로고    scopus 로고
    • Telomere-end processing the terminal nucleotides of human chromosomes
    • Sfeir A.J., Chai W., Shay J.W., and Wright W.E. Telomere-end processing the terminal nucleotides of human chromosomes. Mol. Cell 18 (2005) 131-138
    • (2005) Mol. Cell , vol.18 , pp. 131-138
    • Sfeir, A.J.1    Chai, W.2    Shay, J.W.3    Wright, W.E.4
  • 101
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: safeguarding genome integrity. Nat. Rev. Cancer 3 (2003) 155-168
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 102
    • 34447533257 scopus 로고    scopus 로고
    • Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres
    • Siegl-Cachedenier I., Munoz P., Flores J.M., Klatt P., and Blasco M.A. Deficient mismatch repair improves organismal fitness and survival of mice with dysfunctional telomeres. Genes Dev. 21 (2007) 2234-2247
    • (2007) Genes Dev. , vol.21 , pp. 2234-2247
    • Siegl-Cachedenier, I.1    Munoz, P.2    Flores, J.M.3    Klatt, P.4    Blasco, M.A.5
  • 104
    • 35148826938 scopus 로고    scopus 로고
    • Shaping genetic alterations in human cancer: the p53 mutation paradigm
    • Soussi T., and Wiman K.G. Shaping genetic alterations in human cancer: the p53 mutation paradigm. Cancer Cell 12 (2007) 303-312
    • (2007) Cancer Cell , vol.12 , pp. 303-312
    • Soussi, T.1    Wiman, K.G.2
  • 105
    • 0029826927 scopus 로고    scopus 로고
    • Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation
    • Sproston A.R., Boyle J.M., Heighway J., Birch J.M., and Scott D. Fibroblasts from Li-Fraumeni patients are resistant to low dose-rate irradiation. Int. J. Radiat. Biol. 70 (1996) 145-150
    • (1996) Int. J. Radiat. Biol. , vol.70 , pp. 145-150
    • Sproston, A.R.1    Boyle, J.M.2    Heighway, J.3    Birch, J.M.4    Scott, D.5
  • 106
    • 23044461852 scopus 로고    scopus 로고
    • A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress
    • Stepanova L., and Sorrentino B.P. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood 106 (2005) 827-832
    • (2005) Blood , vol.106 , pp. 827-832
    • Stepanova, L.1    Sorrentino, B.P.2
  • 107
    • 0031985281 scopus 로고    scopus 로고
    • Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age
    • Stephan R.P., Reilly C.R., and Witte P.L. Impaired ability of bone marrow stromal cells to support B-lymphopoiesis with age. Blood 91 (1998) 75-88
    • (1998) Blood , vol.91 , pp. 75-88
    • Stephan, R.P.1    Reilly, C.R.2    Witte, P.L.3
  • 108
    • 0028072523 scopus 로고
    • DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2
    • Strasser A., Harris A.W., Jacks T., and Cory S. DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2. Cell 79 (1994) 329-339
    • (1994) Cell , vol.79 , pp. 329-339
    • Strasser, A.1    Harris, A.W.2    Jacks, T.3    Cory, S.4
  • 109
    • 0034613690 scopus 로고    scopus 로고
    • Age-associated characteristics of murine hematopoietic stem cells
    • Sudo K., Ema H., Morita Y., and Nakauchi H. Age-associated characteristics of murine hematopoietic stem cells. J. Exp. Med. 192 (2000) 1273-1280
    • (2000) J. Exp. Med. , vol.192 , pp. 1273-1280
    • Sudo, K.1    Ema, H.2    Morita, Y.3    Nakauchi, H.4
  • 111
    • 0042420304 scopus 로고    scopus 로고
    • DNA damage foci at dysfunctional telomeres
    • Takai H., Smogorzewska A., and de Lange T. DNA damage foci at dysfunctional telomeres. Curr. Biol. 13 (2003) 1549-1556
    • (2003) Curr. Biol. , vol.13 , pp. 1549-1556
    • Takai, H.1    Smogorzewska, A.2    de Lange, T.3
  • 112
    • 0037711685 scopus 로고    scopus 로고
    • Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice
    • TeKippe M., Harrison D.E., and Chen J. Expansion of hematopoietic stem cell phenotype and activity in Trp53-null mice. Exp. Hematol. 31 (2003) 521-527
    • (2003) Exp. Hematol. , vol.31 , pp. 521-527
    • TeKippe, M.1    Harrison, D.E.2    Chen, J.3
  • 116
    • 0025281056 scopus 로고
    • Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice
    • Van Zant G., Holland B.P., Eldridge P.W., and Chen J.J. Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice. J. Exp. Med. 171 (1990) 1547-1565
    • (1990) J. Exp. Med. , vol.171 , pp. 1547-1565
    • Van Zant, G.1    Holland, B.P.2    Eldridge, P.W.3    Chen, J.J.4
  • 118
    • 2442617343 scopus 로고    scopus 로고
    • Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC
    • Vulliamy T., Marrone A., Szydlo R., Walne A., Mason P.J., and Dokal I. Disease anticipation is associated with progressive telomere shortening in families with dyskeratosis congenita due to mutations in TERC. Nat. Genet. 36 (2004) 447-449
    • (2004) Nat. Genet. , vol.36 , pp. 447-449
    • Vulliamy, T.1    Marrone, A.2    Szydlo, R.3    Walne, A.4    Mason, P.J.5    Dokal, I.6
  • 120
    • 0037364995 scopus 로고    scopus 로고
    • Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility
    • Wei K., Clark A.B., Wong E., Kane M.F., Mazur D.J., Parris T., Kolas N.K., Russell R., Hou Jr. H., Kneitz B., et al. Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev. 17 (2003) 603-614
    • (2003) Genes Dev. , vol.17 , pp. 603-614
    • Wei, K.1    Clark, A.B.2    Wong, E.3    Kane, M.F.4    Mazur, D.J.5    Parris, T.6    Kolas, N.K.7    Russell, R.8    Hou Jr., H.9    Kneitz, B.10
  • 121
    • 37249078012 scopus 로고    scopus 로고
    • Sustained telomere erosion due to increased stem cell turnover during triple autologous hematopoietic stem cell transplantation
    • Widmann T., Kneer H., Konig J., Herrmann M., and Pfreundschuh M. Sustained telomere erosion due to increased stem cell turnover during triple autologous hematopoietic stem cell transplantation. Exp. Hematol. 36 (2008) 104-110
    • (2008) Exp. Hematol. , vol.36 , pp. 104-110
    • Widmann, T.1    Kneer, H.2    Konig, J.3    Herrmann, M.4    Pfreundschuh, M.5
  • 123
  • 124
    • 0029872174 scopus 로고    scopus 로고
    • Telomerase activity in human germline and embryonic tissues and cells
    • Wright W.E., Piatyszek M.A., Rainey W.E., Byrd W., and Shay J.W. Telomerase activity in human germline and embryonic tissues and cells. Dev. Genet. 18 (1996) 173-179
    • (1996) Dev. Genet. , vol.18 , pp. 173-179
    • Wright, W.E.1    Piatyszek, M.A.2    Rainey, W.E.3    Byrd, W.4    Shay, J.W.5
  • 125
    • 0026680249 scopus 로고
    • The two-stage mechanism controlling cellular senescence and immortalization
    • Wright W.E., and Shay J.W. The two-stage mechanism controlling cellular senescence and immortalization. Exp. Gerontol. 27 (1992) 383-389
    • (1992) Exp. Gerontol. , vol.27 , pp. 383-389
    • Wright, W.E.1    Shay, J.W.2
  • 127
    • 0029844048 scopus 로고    scopus 로고
    • Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma
    • Xu Y., Ashley T., Brainerd E.E., Bronson R.T., Meyn M.S., and Baltimore D. Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev. 10 (1996) 2411-2422
    • (1996) Genes Dev. , vol.10 , pp. 2411-2422
    • Xu, Y.1    Ashley, T.2    Brainerd, E.E.3    Bronson, R.T.4    Meyn, M.S.5    Baltimore, D.6
  • 128
    • 34247621290 scopus 로고    scopus 로고
    • Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow
    • Yang L., Wang L., Geiger H., Cancelas J.A., Mo J., and Zheng Y. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc. Natl. Acad. Sci. USA 104 (2007) 5091-5096
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 5091-5096
    • Yang, L.1    Wang, L.2    Geiger, H.3    Cancelas, J.A.4    Mo, J.5    Zheng, Y.6
  • 129
    • 34247163959 scopus 로고    scopus 로고
    • Allogeneic marrow stem-cell transplantation from human leukocyte antigen-identical siblings versus human leukocyte antigen-allelic-matched unrelated donors (10/10) in patients with standard-risk hematologic malignancy: a prospective study from the French Society of Bone Marrow Transplantation and Cell Therapy
    • Yakoub-Agha I., Mesnil F., Kuentz M., Boiron J.M., Ifrah N., Milpied N., Chehata S., Esperou H., Vernant J.P., Michallet M., Buzyn A., Gratecos N., Cahn J.Y., Bourhis J.H., Chir Z., Raffoux C., Socie G., Golmard J.L., and Jouet J.P. Allogeneic marrow stem-cell transplantation from human leukocyte antigen-identical siblings versus human leukocyte antigen-allelic-matched unrelated donors (10/10) in patients with standard-risk hematologic malignancy: a prospective study from the French Society of Bone Marrow Transplantation and Cell Therapy. J. Clin. Oncol. 24 (2006) 5695-5702
    • (2006) J. Clin. Oncol. , vol.24 , pp. 5695-5702
    • Yakoub-Agha, I.1    Mesnil, F.2    Kuentz, M.3    Boiron, J.M.4    Ifrah, N.5    Milpied, N.6    Chehata, S.7    Esperou, H.8    Vernant, J.P.9    Michallet, M.10    Buzyn, A.11    Gratecos, N.12    Cahn, J.Y.13    Bourhis, J.H.14    Chir, Z.15    Raffoux, C.16    Socie, G.17    Golmard, J.L.18    Jouet, J.P.19
  • 130
    • 34548030239 scopus 로고    scopus 로고
    • Multiple prethymic defects underlie age-related loss of T progenitor competence
    • Zediak V.P., Maillard I., and Bhandoola A. Multiple prethymic defects underlie age-related loss of T progenitor competence. Blood 110 (2007) 1161-1167
    • (2007) Blood , vol.110 , pp. 1161-1167
    • Zediak, V.P.1    Maillard, I.2    Bhandoola, A.3
  • 132
    • 43449113881 scopus 로고    scopus 로고
    • Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila
    • Zhao R., Xuan Y., Li X., and Xi R. Age-related changes of germline stem cell activity, niche signaling activity and egg production in Drosophila. Aging Cell 7 (2008) 344-354
    • (2008) Aging Cell , vol.7 , pp. 344-354
    • Zhao, R.1    Xuan, Y.2    Li, X.3    Xi, R.4
  • 133
    • 18044380667 scopus 로고    scopus 로고
    • Telomere dynamics in hematopoietic stem cells
    • Zimmermann S., and Martens U.M. Telomere dynamics in hematopoietic stem cells. Curr. Mol. Med. 5 (2005) 179-185
    • (2005) Curr. Mol. Med. , vol.5 , pp. 179-185
    • Zimmermann, S.1    Martens, U.M.2
  • 134
    • 3342972121 scopus 로고    scopus 로고
    • Does a sentinel or a subset of short telomeres determine replicative senescence?
    • Zou Y., Sfeir A., Gryaznov S.M., Shay J.W., and Wright W.E. Does a sentinel or a subset of short telomeres determine replicative senescence?. Mol. Biol. Cell. 15 (2004) 3709-3718
    • (2004) Mol. Biol. Cell. , vol.15 , pp. 3709-3718
    • Zou, Y.1    Sfeir, A.2    Gryaznov, S.M.3    Shay, J.W.4    Wright, W.E.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.