Decline in Self-Renewal Factors Contributes to Aging of the Stem Cell Niche in the Drosophila Testis

Cell Stem Cell

Volumn 1, Issue 4, 2007, Pages 470-478

  Boyle, Monica ^a   Wong, Chihunt ^a,b   Rocha, Michael ^a   Jones, D Leanne ^a,b  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

STEMCELL

Indexed keywords

GENE PRODUCT; UVOMORULIN;

ARTICLE; CELL ACTIVITY; CELL AGING; CELL COUNT; CELL RENEWAL; CONTROLLED STUDY; CORRELATION ANALYSIS; DROSOPHILA; GENE EXPRESSION REGULATION; GENETIC CODE; HOMEOSTASIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; STEM CELL; TESTIS CELL; TISSUE REGENERATION;

ANIMALS; CELL AGING; CELL DIVISION; CELL PROLIFERATION; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; JANUS KINASES; MALE; SIGNAL TRANSDUCTION; SPERMATOGENESIS; STAT TRANSCRIPTION FACTORS; STEM CELLS; TESTIS;

EID: 34848836428     PISSN: 19345909     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stem.2007.08.002     Document Type: Article

References (38)

1. Brand A.H., Manoukian A.S., and Perrimon N. Ectopic expression in Drosophila. In: Goldstein L.S.B., and Fyrberg E.A. (Eds). Drosophila melanogaster: Practical Uses in Cell and Molecular Biology (1994), Academic Press, San Diego 635-654
2. Brawley C., and Matunis E. Regeneration of male germline stem cells by spermatogonial dedifferentiation in vivo. Science 304 (2004) 1331-1334
3. Conboy I.M., Conboy M.J., Wagers A.J., Girma E.R., Weissman I.L., and Rando T.A. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433 (2005) 760-764
4. de Nooij J.C., Letendre M.A., and Hariharan I.K. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 87 (1996) 1237-1247
5. Gönczy P., and DiNardo S. The germ line regulates somatic cyst cell proliferation and fate during Drosophila spermatogenesis. Development 122 (1996) 2437-2447
6. Gönczy P., Matunis E., and DiNardo S. bag-of-marbles and benign gonial cell neoplasm act in the germline to restrict proliferation during Drosophila spermatogenesis. Development 124 (1997) 4361-4371
7. Grotewiel M.S., Martin I., Bhandari P., and Cook-Wiens E. Functional senescence in Drosophila melanogaster. Ageing Res. Rev. 4 (2005) 372-397
8. Hardy R.W., Tokuyasu K.T., Lindsley D.L., and Garavito M. The germinal proliferation center in the testis of Drosophila melanogaster. J. Ultrastruct. Res. 69 (1979) 180-190
9. Harrison D.A., McCoon P.E., Binari R., Gilman M., and Perrimon N. Drosophila unpaired encodes a secreted protein that activates the JAK signaling pathway. Genes Dev. 12 (1998) 3252-3263
10. Hatfield S.D., Shcherbata H.R., Fischer K.A., Nakahara K., Carthew R.W., and Ruohola-Baker H. Stem cell division is regulated by the microRNA pathway. Nature 435 (2005) 974-978
11. Helfand S.L., and Rogina B. Molecular genetics of aging in the fly: Is this the end of the beginning?. Bioessays 25 (2003) 134-141
12. Janzen V., Forkert R., Fleming H.E., Saito Y., Waring M.T., Dombkowski D.M., Cheng T., Depinho R.A., Sharpless N.E., and Scadden D.T. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16(INK4a). Nature 7110 (2006) 421-426
13. Kiger A.A., Jones D.L., Schulz C., Rogers M.B., and Fuller M.T. Stem cell self-renewal specified by JAK-STAT activation in response to a support cell cue. Science 294 (2001) 2542-2545
14. LaFever L., and Drummond-Barbosa D. Direct control of germline stem cell division and cyst growth by neural insulin in Drosophila. Science 309 (2005) 1071-1073
15. Lane M.E., Sauer K., Wallace K., Jan Y.N., Lehner C.F., and Vaessin H. Dacapo, a cyclin-dependent kinase inhibitor, stops cell proliferation during Drosophila development. Cell 87 (1996) 1225-1235
16. Le Bras S., and Van Doren M. Development of the male germline stem cell niche in Drosophila. Dev. Biol. 294 (2006) 92-103
17. Li L., and Neaves W.B. Normal stem cells and cancer stem cells: The niche matters. Cancer Res. 66 (2006) 4553-4557
18. Lin H., Yue L., and Spradling A.C. The Drosophila fusome, a germline-specific organelle, contains membrane skeletal proteins and functions in cyst formation. Development 120 (1994) 947-956
19. Margolis J., and Spradling A. Identification and behavior of epithelial stem cells in the Drosophila ovary. Development 121 (1995) 3797-3807
20. McGregor J.R., Xi R., and Harrison D.A. JAK signaling is somatically required for follicle cell differentiation in Drosophila. Development 129 (2002) 705-717
21. McKearin D., and Ohlstein B. A role for the Drosophila bag-of-marbles protein in the differentiation of cystoblasts from germline stem cells. Development 121 (1995) 2937-2947
22. Meyer C.A., Kramer I., Dittrich R., Marzodko S., Emmerich J., and Lehner C.F. Drosophila p27Dacapo expression during embryogenesis is controlled by a complex regulatory region independent of cell cycle progression. Development 129 (2002) 319-328
23. Molofsky A.V., Slutsky S.G., Joseph N.M., He S., Pardal R., Krishnamurthy J., Sharpless N.E., and Morrison S.J. Increasing p16(INK4a) expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443 (2006) 404-405
24. Morrison S.J., Shah N.M., and Anderson D.J. Regulatory mechanisms in stem cell biology. Cell 88 (1997) 287-298
25. Rando T.A. Stem cells, ageing and the quest for immortality. Nature 441 (2006) 1080-1086
26. Ryu B.Y., Orwig K.E., Oatley J.M., Avarbock M.R., and Brinster R.L. Effects of aging and niche microenvironment on spermatogonial stem cell self-renewal. Stem Cells 24 (2006) 1505-1511
27. Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 4 (1978) 7-25
28. Silver D.L., and Montell D.J. Paracrine signaling through the JAK/STAT pathway activates invasive behavior of ovarian epithelial cells in Drosophila. Cell 107 (2001) 831-841
29. Song X., and Xie T. DE-cadherin-mediated cell adhesion is essential for maintaining somatic stem cells in the Drosophila ovary. Proc. Natl. Acad. Sci. USA 99 (2002) 14813-14818
30. Song X., Zhu C.H., Doan C., and Xie T. Germline stem cells anchored by adherens junctions in the Drosophila ovary niches. Science 296 (2002) 1855-1857
31. Tran J., Brenner T.J., and DiNardo S. Somatic control over the germline stem cell lineage during Drosophila spermatogenesis. Nature 407 (2000) 754-757
32. Tulina N., and Matunis E. Control of stem cell self-renewal in Drosophila spermatogenesis by JAK-STAT signaling. Science 294 (2001) 2546-2549
33. Wallenfang M., Nayak R., and DiNardo S. Dynamics of the male germline stem cell population during aging of Drosophila melanogaster. Aging Cell 5 (2006) 297-304
34. Wawersik M., Milutinovich A., Casper A.L., Matunis E., Williams B., and Van Doren M. Somatic control of germline sexual development is mediated by the JAK/STAT pathway. Nature 436 (2005) 563-567
35. Xie T., and Spradling A.C. decapentaplegic is essential for the maintenance and division of germline stem cells in the Drosophila ovary. Cell 94 (1998) 251-260
36. Xie T., and Spradling A.C. A niche maintaining germ line stem cells in the Drosophila ovary. Science 290 (2000) 328-330
37. Yamashita Y.M., Fuller M.T., and Jones D.L. Signaling in stem cell niches: Lessons from the Drosophila germline. J. Cell Sci. 118 (2005) 665-672
38. Zhang X., Ebata K.T., Robaire B., and Nagano M.C. Aging of male germ line stem cells in mice. Biol. Reprod. 74 (2006) 119-124